Childhood obesity is a serious problem for increasing numbers of children around the world. According to the International Obesity Task Force, 1 of 10 schoolaged children worldwide is overweight or obese, a number totaling 155 million; of these, 2-3% are obese. Prevalence is highest in the Americas and Europe, followed by the Near/Middle East, with smaller but growing numbers in the Asia-Pacific and Sub-Saharan regions of the world.In the United States, which provides the data for much of this report, (...) prevalence continues to rise. The most recent nationally representative data indicate that 33.6% of individuals aged 2-19 years were overweight and 17.1% were at risk for overweight in 2003-2004, compared to 28.2% and 13.9% in 1999-2000, respectively. In this age group, the prevalence of overweight or at risk for overweight was highest among Mexican Americans, followed by Non-Hispanic blacks and Non-Hispanic whites, and a higher percentage of males were overweight compared to females. (shrink)

Childhood obesity is a serious problem for increasing numbers of children around the world. According to the International Obesity Task Force, 1 of 10 schoolaged children worldwide is overweight or obese, a number totaling 155 million; of these, 2-3% are obese. Prevalence is highest in the Americas and Europe, followed by the Near/Middle East, with smaller but growing numbers in the Asia-Pacific and Sub-Saharan regions of the world.In the United States, which provides the data for much of this report, (...) prevalence continues to rise. The most recent nationally representative data indicate that 33.6% of individuals aged 2-19 years were overweight and 17.1% were at risk for overweight in 2003-2004, compared to 28.2% and 13.9% in 1999-2000, respectively. In this age group, the prevalence of overweight or at risk for overweight was highest among Mexican Americans, followed by Non-Hispanic blacks and Non-Hispanic whites, and a higher percentage of males were overweight compared to females. (shrink)

Under today's conditions, when the Soviet Union is successfully engaged in the comprehensive construction of a communist society, and the prospect of uniform advancement toward communism seems possible for the socialist countries, the theoretical problems relating to the transition from socialism to communism acquire major importance. In our day, problems of scientific communism are resolved in practice, in the creative activity of tens and hundreds of millions of people. The success of the construction of communism depends to a very large (...) degree upon the correct theoretical solution of these problems. (shrink)

The present epoch is a turning point in world history not only in the sense that a new, communist socio-economic system is coming into being and a new type of societal relationships among men is coming into being on a foundation of profound revolutionary changes, but also in the sense that mankind has come face to face with a global alternative touching upon the fate of all nations: either the progressive development of each people under peaceful conditions must be assured, (...) or an atomic catastrophe occurs that would threaten the achievements of civilization as a whole. Awareness of this circumstance has roused millions of people in all lands to struggle for peace. This same circumstance necessitates a scientific study of the problem of war and peace, with which the problem of the future of all mankind is now directly connected. (shrink)

We all know that doctors accept gifts from drug companies, ranging from pens and coffee mugs to free vacations at luxurious resorts. But as the former Editor-in-Chief of The New England Journal of Medicine reveals in this shocking expose, these innocuous-seeming gifts are just the tip of an iceberg that is distorting the practice of medicine and jeopardizing the health of millions of Americans today. In On the Take, Dr. Jerome Kassirer offers an unsettling look at the pervasive payoffs that (...) physicians take from big drug companies and other medical suppliers, arguing that the billion-dollar onslaught of industry money has deflected many physicians' moral compasses and directly impacted the everyday care we receive from the doctors and institutions we trust most. Underscored by countless chilling untold stories, the book illuminates the financial connections between the wealthy companies that make drugs and the doctors who prescribe them. Kassirer details the shocking extent of these financial enticements and explains how they encourage bias, promote dangerously misleading medical information, raise the cost of medical care, and breed distrust. Among the questionable practices he describes are: the disturbing number of senior academic physicians who have financial arrangements with drug companies; the unregulated "front" organizations that advocate certain drugs; the creation of biased medical education materials by the drug companies themselves; and the use of financially conflicted physicians to write clinical practice guidelines or to testify before the FDA in support of a particular drug. A brilliant diagnosis of an epidemic of greed, On the Take offers insight into how we can cure the medical profession and restore our trust in doctors and hospitals. (shrink)

The body-oriented approach in the philosophy of cognitive sciences is gaining in importance in the conditions of the formation of new high-tech contexts. The problem of interoception and integration of bodily data into socio-economic processes requires a comprehensive analysis and ethical assessment. This article examines the conceptual foundations of the body-oriented approach and its impact on the essence of cognitive processes. The main advantages and disadvantages of this approach are presented. We consider the methodological conflict zones of the bodily paradigm (...) and traditional methodological attitudes of the cognitive sciences. The system ofinteroceptive sensations is a special «layer» of bodily experience. The social functions of interoceptive sensations are an interdisciplinary research area that focuses on the mechanisms of interaction between the private content of bodily experience and systems of social interaction. The regularity between interoceptive sensations and human behavioral patterns reflects the importance of examining bodily data. Today, the market for bodily data is just beginning to form, but at the same time it is already playing an important role in global digital transformation processes. A multitude of applications and wearable digital devices that track bodily activity and generate gigantic amounts of data are used today by millions of people around the world. The identification of bodily activity leads to the emergence of new forms of interaction between a person and socio-institutional systems, the specific properties of which are also considered in this article. (shrink)

Conversational Artificial Intelligence (CAI) systems (also known as AI “chatbots”) are among the most promising examples of the use of technology in mental health care. With already millions of users worldwide, CAI is likely to change the landscape of psychological help. Most researchers agree that existing CAIs are not “digital therapists” and using them is not a substitute for psychotherapy delivered by a human. But if they are not therapists, what are they, and what role can they play in mental (...) health care? To answer these questions, we appeal to two well-established and widely discussed concepts: cognitive and affective artifacts. Cognitive artifacts are artificial devices contributing functionally to the performance of a cognitive task. Affective artifacts are objects which have the capacity to alter subjects’ affective state. We argue that therapeutic CAIs are a kind of cognitive-affective artifacts which contribute to positive therapeutic change by (i) simulating a (quasi-)therapeutic interaction, (ii) supporting the performance of cognitive tasks, and (iii) altering the affective condition of their users. This sheds new light on why virtually all existing mental health CAIs implement principles and techniques of Cognitive Behavioral Therapy — a therapeutic orientation according to which affective change and, ultimately, positive therapeutic change is mediated by cognitive change. Simultaneously, it allows us to conceptualize better the potential and limitations of applying these technologies in therapy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:328 HUME, MIRACLES AND LOTTERIES This paper addresses recent criticisms of Hume's skepticism with regard to miracles, by 1 2 Sorensen and Hambourger who argue that there are counterexamples, illustrated by lotteries, to Hume's account of how the truth of reports of improbable events (either first or second hand) must be evaluated. They believe these counterexamples are sufficient to prove that Hume's argument against the believability of miracles, defined (...) as violations of laws of nature caused by God, is unsound. Their arguments merit consideration not only in their own right but also on the basis of historical precedent, since they have in common an assumption that is found in Butler's criticism of Hume's predecessors in this debate. The bulk of my paper deals with Hambourger, who presents the most detailed version of the 'Butler' criticism. Sorensen's version can be answered in light of the evaluation of Hambourger 's argument. Hume's Argument Hume's argument is not against the possibility of miracles but against the possibility that it could ever be reasonable to believe a miracle 4 had occurred. His argument can be summed up as follows: in judging the credibility of a report of an improbable event, the probability of the event must be weighed against the probability that the report could be mistaken. The probability of an event is determined by the degree to which it conforms to known laws of nature. Laws of nature are formulated on the basis of uniform experience. Assuming that a miracle is a violation of laws of nature, any judgment that an event is miraculous presupposes a 329 judgment that there exists a uniform pattern of causation to which it is opposed, which pattern would constitute empirical proof against the miracle's occurrence. Testimony, on the other hand, is shown by experience not to be uniformly reliable. Consequently, no report of a miracle will have credibility since there will always be a uniform experience that is full proof against it, which therefore outweighs whatever merits testimony may have. In Hume's words, [N]o testimony is sufficient to establish a miracle, unless the testimony be of such a kind, that its falsehood would be more miraculous, than the fact, which it endeavors to establish.... When anyone tells me, that he saw a dead man restored to life, I immediately consider with myself, whether it be more probable, that this person should either deceive or be deceived, or that the fact, which he relates, should really have happened.... If the falsehood of his testimony would be more miraculous, than the event which he relates; then, and not till- then, can he pretend to command my belief or opinion (E 115-116). Hambourger 's Criticism Hambourger maintains that Hume's argument depends on a principle which he calls the "principle of relative likelihood." He restates this principle as follows: Suppose that someone or, perhaps, a group of people testify to the truth of a proposition P that, considered by itself, is improbable. Then to evaluate the testimony, one must weight (sic) the probability that P is true against the probability that the informants are lying or mistaken. If it is more likely that P is true than that the informants are lying or mistaken, then, on balance, the 330 testimony renders P more likely than not, and it may be reasonable for one to believe that P. However, if it is as likely, or even more likely, that the informants are lying or mistaken than it is that P is true, then, on balance, the testimony does not render P more likely true than false, and it would not be,reasonable for one to believe that P. As a counterexample to this principle, Hambourger asks us to suppose that a lottery is held in which there are one million entrants, each of whom has a one in a million chance of winning, and that a reliable newspaper, the New York Times, reports that the winner of the lottery is Smith. He further asks us to suppose that the Times errs only once out of every 10,000 times. Thus, the probability that the Times ' report is wrong is... (shrink)

Charles Darwin questions whether conflicts between species palpably captured by the conflict between Ichneumonidae and the caterpillars on which they prey could be compatible with the existence of an all-good, all-powerful God. He also questioned whether the suffering of millions of lower animals throughout our almost endless prehistory could be compatible with an all-good, all-powerful God. In this paper, I show that these two problems of natural evil that Darwin raised in his work can be resolved so as to present (...) no objection to theism once it is recognized what the moral principles are that should govern our relationship to the natural world and analogously should govern God’s relationship to the natural world. (shrink)

The set of 60 real rays in four dimensions derived from the vertices of a 600-cell is shown to possess numerous subsets of rays and bases that provide basis-critical parity proofs of the Bell-Kochen-Specker (BKS) theorem (a basis-critical proof is one that fails if even a single basis is deleted from it). The proofs vary considerably in size, with the smallest having 26 rays and 13 bases and the largest 60 rays and 41 bases. There are at least 90 basic (...) types of proofs, with each coming in a number of geometrically distinct varieties. The replicas of all the proofs under the symmetries of the 600-cell yield a total of almost a hundred million parity proofs of the BKS theorem. The proofs are all very transparent and take no more than simple counting to verify. A few of the proofs are exhibited, both in tabular form as well as in the form of MMP hypergraphs that assist in their visualization. A survey of the proofs is given, simple procedures for generating some of them are described and their applications are discussed. It is shown that all four-dimensional parity proofs of the BKS theorem can be turned into experimental disproofs of noncontextuality. (shrink)

There is something embarrassing about money. Everybody is seeking it but at the same time they are reluctant to talk about their bank balances and stock holdings. As a society we have so much of it that we can install 7000 saffron curtains all over Central Park, send tourists into outer space, and analyze the gas on the surface of Titan, yet we fail to spend it on millions of poverty-stricken people who die of disease or starvation each year. We (...) do open our pocketbooks sometimes, but only when television images of massive destruction overwhelm our sensibilities. Money often dominates our consciousness and bombards us in the headlines: Our national debt is 7.7 trillion dollars and it's increasing by more than 2 billion dollars a day; corporate executives of Enron walk away with millions while their employees lose their jobs and their pensions; and we had an endless fascination with Martha Stewart, who is worth millions, but went to jail trying to save a few thousand. (shrink)

Professor Gostin is a leading authority on health law, whose writing and teaching are among the most authoritative in the United States, as exemplified by his recent work, Public Health Law: Power, Duty, Restraint. Gostin's article in this issue of the Journal of Law, Medicine & Ethics pays homage to Jonathan Mann by expressing the debt he feels toward this extraordinary doctor and public health official with whom he had collaborated on several projects.As many will remember, Mann held high-level positions (...) at the Centers for Disease Control and worked on AIDS research in Central Africa before setting up the World Health Organization's Global Programme on AIDS, which he ran from 1986 to 1990. Thanks to his profound commitment and consummate communication skills, he achieved the unprecedented feat of raising the budget within two years to almost $100 million from the initial set-up of “himself, a secretary, and one typewriter,” as described by Daniel Tarantola. (shrink)

Recent technological developments in automation threaten to eliminate the jobs of millions of workers in the near future, raising worrisome questions about how to satisfy their welfare. One proposal for addressing this issue is to provide all citizens with a “universal basic income” (UBI) that ensures everyone with a social minimum. The aim is to give all individuals an unrestricted cash grant that provides them with an income that does not depend on status, wealth, or employment. The question this paper (...) explores is whether UBI can replace work in the age of automation. Work has financial and non-pecuniary benefits that provide individuals with an income, as well as self-realization, self-respect, and community. While the provision of UBI will supplement the financial benefits of work, the question remains whether such a grant can replace these non-pecuniary benefits. The first section outlines the benefits and burdens of work. The second section considers the effects of technology on work in the context of automation. The third section examines the arguments for UBI that make it a philosophically attractive alternative to traditional welfare policies. Finally, the last section evaluates whether the benefits of UBI can replace the loss of work in terms of its non-pecuniary benefits. (shrink)

Since its debut in 1964, Jeopardy! has been one of America's favorite and longest-running daytime quiz shows. It turns the question-answer format of traditional quiz shows on its head and requires contestants to pose correct questions to answers in selected categories. While mining information and facts from Alchemy to Zoology, Jeopardy!, is a uniquely intellectual, erudite, and challenging daytime television program. Far beyond entertaining its fans with nail-biting contests of knowledge, memory, and speed, it all but requires them to participate. (...) Few people watch Jeopardy! without pressing an invisible button and blurting out questions to their TV screen. Because of this personal and intellectual investment, most Jeopardy! fans are devout. Watching the show is valued as a daily ritual in which genuine intellectual skill and encyclopedic knowledge are not only respected and placed in the spotlight, but also rewarded with national prestige and prize winnings. Champion Ken Jennings has won over three million dollars and remained champion seventy-four times. For those who embrace Jeopardy! as an intellectual oasis in the arid desert of popular culture, it is the geeks who shall inherit the earth. Jeopardy!'s celebration of intellect and forward-thinking is well recognized throughout popular culture and among all age groups. Ken Jennings, Chuck Forrest, and other all-time champions are near celebrities, while the show itself regularly reaches out through special tournaments to different segments of American culture, such as actors and musicians, high-school and college students and senior citizens. Still, despite its widespread respect and, some might complain, smug self-respect, neither the show nor its fans take themselves too seriously. Jokes about host Alex Trebek's hair and famous parodies of Jeopardy! on Saturday Night Live are as familiar as Weird Al Yankovic's MTV-mainstay "I Lost on Jeopardy!" : Don't know what I was thinkin' of, I guess I just wasn't too bright. Well, I sure hope I do better Next weekend on The Price Is Right. (shrink)

Soil is fragile and nonrenewable but the most basic of natural resources. It has a capacity to tolerate continuous use but only with proper management. Improper soil management and indiscriminate use of chemicals have contributed to some severe global environmental issues, e.g., volatilization losses and contamination of natural waters by sediments and agricultural fertilizers and pesticides. The increasing substitution of energy for labor and other cultural inputs in agriculture is another issue. Fertilizers and chemicals account for about 25% of the (...) production energy investment in agriculture. An additional 60% is accounted for by machinery, gasoline, electricity, and power-related inputs. Fertilizer additions to cropland are not utilized fully and significant amounts, depending on conditions, are either lost in surface runoff or leached into the ground water. The annual discharge of dissolved solids from agricultural lands to the waterways in the USA is substantial. The increasing use of herbicides in agriculture is a threat to the quality of surface and ground water, although this threat is dependent upon both the chemistry of the compound and the ecosystem in which it is used. Especially within the Third World, development of an environmental ethic and environmental laws have not kept pace with the increase in pesticide use. Above all is the severe and global problem of soil degradation currently occurring at the rate of five to seven million hectares per year. The policy and moral aspects of these issues are discussed. (shrink)

The Financial Crisis in Europe puts pressure on welfare states and its tax systems as well as on considerations of social justice. In this paper, we would like to explore the status of the idea of progressive taxation and its justification (especially the ‘ability-to-pay’ principle) in times of a financial crisis. We will discuss it within a social justice framework following David Miller—using the principles of (i) need, (ii) merit, and (iii) equality. We will conclude that progressive taxation can be (...) justified in the light of these three principles, even more so in the situation of a financial crisis that undermines decent living conditions for millions. The principle of need has to be given priority even if this move violates the principles of equality and desert. (shrink)

Corporations, through their products and behaviors, exert a strong effect on the wellbeing of populations. Public health practitioners and academics have long recognized the harms associated with some corporations’ products. For example, firearms are associated with approximately 30,000 deaths in the United States each year1 and over 200,000 deaths globally. Motor vehicles are associated with about 40,000 deaths in the United States each year and over 1.2 million deaths globally. Tobacco products kill about 438,000 people each year in the (...) United States5 and about 4.9 million people worldwide. In addition to producing unsafe or harmful products, some corporations behave in ways that negatively impact the public’s health, such as marketing alcohol to youth and other vulnerable populations. Given these observations, one can conclude that it is possible to quantify the public health impact of individual industries, such as firearms, motor vehicles, tobacco, and alcohol. Health professionals can then target these individual industries to prevent or lessen the harms they cause. (shrink)

Hunting is typically valued for its instrumentality for food procurement, wildlife management, conservation, heurism, and atavism. More importantly, some hunting is valued intrinsically. A particular form of hunting is a game and game playing, categorically, is often valued intrinsically. This view can be further supported with an application of a concept of caring and an accompanying argument that hunting generally, and fair-chase hunting in particular, is cared about deeply by millions of its practitioners. There are normative grounds for a shift (...) in the way that hunting is valued. While hunting as game playing is valued and cared about deeply by millions of fair-chase practitioners, which is far more important than any of its various instrumentalities, the position that such hunting is morally villainous can be sustained. (shrink)

Drawing on the distinction between dominance and prestige as two evolutionarily grounded strategies for attaining status in human groups, this essay examines an underappreciated feature of Donald Trump's appeal to the millions of American voters who elected him president in 2016—his uncanny ability to channel primal dominance. Like the alpha male of a chimpanzee colony, Trump leads through intimidation, bluster, and threat, and through the establishment of short-term, opportunistic relationships with other high-status agents. Whereas domain-specific expertise confers status in the (...) prestige paradigm, dominant leaders derogate expertise in order to establish a direct, authoritarian connection to their constituency. Trump's leadership style derives readily from his personality makeup, which entails a combustible temperament mixture of high extraversion and low agreeableness, a motivational agenda centered on extreme narcissism, and an internalized life story that tracks the exploits of an intrepid warrior who must forever fight to win in a Hobbesian world of carnage. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Scientism, Certitude, and the Recovery of PoliticsChristopher Justin Brophy O.P.In Natural Law and Human Rights, Pierre Manent begins his analysis of the contemporary political situation by discussing the intractable tension between the relativism surrounding moral action and the absolutism surrounding "human rights." Later, drawing heavily from Aristotle's Politics, Manent discusses the necessity of a command-obey structure to resolve the tension such that human beings can fruitfully engage in political (...) life. These two claims, one about the tension between relativism and absolutism and the other about the command-obey structure, are closely linked. If it is true that human beings have an innate need for authority, then it is also the case that the extreme abuses of that need, as they manifest themselves in the political realm, will be either wholesale embrace of such authority (absolutism) or wholesale rejection (relativism). We should be clear that the authority Manent discusses is not arbitrary or autocratic exercise of power, but a legitimate authority towards which citizens can offer rational assent. But any human need or desire can be abused and knowledge of the abuses is necessary to understand the proper object.It is the contention of this piece that Manent, in his explication of command-obey, wrote better than he knew. Manent authored his text before the COVID-19 pandemic. Yet, his analysis provides some of the best explanatory power for understanding the politics surrounding COVID. This politics has significance that transcends the particular crisis of the pandemic and merits serious attention. Specifically, Manent's analysis of the human need for a command-obey structure both offers an explanation for the concurrent tension between relativism and absolutism, at least as it pertains to the relationship between science and politics, and gives explanatory [End Page 239] power for the rise of scientism in contemporary society. The widespread conception that the natural sciences have the potential to answer questions that reside out of their proper purviews leads to abuses of authority in both directions, by both sides—the political left and political right. I will flesh out my argument first by showing the usefulness of Manent's analysis for explaining how easily so many in the United States fall prey to a false conception of "science" that undermines a healthy politics and reveals, at root, a dangerous aversion to ambiguity. I will then explain the implications of the elevation of scientism for the relationship between politics and Christianity. I will conclude with some reflections on the common good and the future of politics in the United States given Manent's important observations. I anticipate that a common criticism of Manent's book will be that it lacks clear prescriptions for the political problems that ail us. I will argue that clear prescriptions cannot follow from the logic of Manent's argument, and ultimately that the lack of prescription is one of the strengths of the book.Before I begin, I wish to make two qualifications. First, Manent's argument ultimately is about the (un)tenability of liberalism without some common conception of the good. He treats several moral and political problems in his book that fall outside of the scope of this short paper. I am not attempting in the analysis that follows to reduce the moral scope of Manent's claims or even to take up the mantle of his argument. I simply wish to show how his analysis is helpful in explaining a contemporary political problem and how the implications of this analysis should affect the way Christians think about political practice in the United States. Second, I want to make clear at the outset that I positively wish to avoid a discussion about the various policies enacted as responses to COVID-19. I also want to avoid any cavalier political discussion of COVID that does not sufficiently respect the over one million persons (given the latest CDC tally) who have lost their lives in this country and the hardships that many more have endured due to the pandemic. It is essential for our purposes here though to treat the political significance of the pandemic. I will attempt to do that now.The Appeal of ScientismNumerous thinkers... (shrink)

Of all global problems world population growth is the most significant. The growth of the number of people expresses the sum outcome of all economic, social and cultural activities that comprise human history. Demographic data in a concise and quantitative way describe this process in the past and present. By applying the concepts of nonlinear dynamics and synergetics, it is possible to work out a mathematical model for a phenomenological description of the global demographic process and project its trends into (...) the future. Assuming self-similarity as the dynamic principle of development, growth can be described over practically the whole of human history, with a growth rate proportional to the square of the number of people. This is due to a collective interaction, responsible for the growth of human numbers, as the result of the informational nature of development. The large parameter of the theory and the effective size of a coherent population group is of the order of 105. As the microscopic parameter of the phenomenology, the human life span is introduced into the theory. Estimates of the beginning of human development 4-5 million years ago and of the total number of people who have ever lived since then ≈ 100 billion are made. In the framework of the model, large scale cycles defined by history and anthropology are shown to follow an exponential pattern of growth, culminating in the demographic transition, a veritable revolution when population growth is to stabilize at 10 to 12 billion. (shrink)

This case study examines the failure of top management at Putnam to exercise ethical behavior in the face of their clear knowledge of corruption in the company. Market timing by employees was expressly forbidden by Putnam. Six employees, including two portfolio managers, repeatedly engaged in market timing activities from 1998 to 2003, garnering over a million dollars in personal profit. The CEO and key senior executives had factual knowledge of the abuses. Management failed to stop the abuses or to (...) discipline those involved until faced with charges from government regulators. By failing to do so, top management breached ethical duties to its shareholders and inflicted serious damage on the organization. The end results of top management's failure to address ethical violations were significant outflow of assets from Putnam's funds, payment of penalties, and loss of trust among investors. This case raises awareness about ethical issues surrounding mutual fund trading practices and the impact that top management can have on the ethical behavior of employees. (shrink)

This article presents the results of methodological experimentation that utilises machine learning to investigate automated copyright enforcement on YouTube. Using a dataset of 76.7 million YouTube videos, we explore how digital and computational methods can be leveraged to better understand content moderation and copyright enforcement at a large scale.We used the BERT language model to train a machine learning classifier to identify videos in categories that reflect ongoing controversies in copyright takedowns. We use this to explore, in a granular (...) way, how copyright is enforced on YouTube, using both statistical methods and qualitative analysis of our categorised dataset. We provide a large-scale systematic analysis of removals rates from Content ID’s automated detection system and the largely automated, text search based, Digital Millennium Copyright Act notice and takedown system. These are complex systems that are often difficult to analyse, and YouTube only makes available data at high levels of abstraction. Our analysis provides a comparison of different types of automation in content moderation, and we show how these different systems play out across different categories of content. We hope that this work provides a methodological base for continued experimentation with the use of digital and computational methods to enable large-scale analysis of the operation of automated systems. (shrink)

The fate of the half a million or so free-ranging elephants in Africa depends on the choices people will make. What ‘moral standing’ do elephants deserve, and thus what constraints should we impose on our behaviour towards them? To assess the state of our knowledge about ethics and elephants is no easy affair. Different views on the moral standing of elephants and thus the obligations humans owe elephants, are not really a matter of scientific knowledge, although such knowledge might (...) deeply influence our chosen ethics. At stake are human value choices that are developed through argument and discussion into ethical positions that suggest, prescribe, or legislate acceptable behaviour, and proscribe or discourage unacceptable treatment of elephants. The point of this assessment is thus to determine which ethical positions have been developed on various matters concerning the management of elephants and have been justified through reasoning. This chapter portrays the different ethical views relevant to the management of elephants that are present in some or other form in the public domain. The aim is to make readers aware of the multiplicity of ethical issues involved in elephant management, as seen from a variety of ethical viewpoints. The complexity of the benefits and harm that accompany different management options will be clarified. The chapter is divided into five sections: (1) our human responsibility towards elephants, (2) the accountability of elephant custodians, (3) the moral standing of elephants, (4) ethical theories, and (5) ethics and management options. (shrink)

This essay considers and rejects the hypothesis of Fackenheim, Wiesel and others that the Jewish Holocaust contains some qualitatively or quantitatively distinct moral evil. The Holocaust was not qualitatively distinct because the intentions and vices of the mass murderer are qualitatively indistinguishable from the intentions and vices of the common murderer. The Holocaust was not quantitatively distinct either because the sum of the evils of the Holocaust is quantitatively indistinguishable from six million randomly selected individual murders or because the (...) notion of a ‘sum’ of moral evils is conceptually incoherent. (shrink)

Conflicts have arisen between communities and operators of confined animal feeding as farms have become bigger in order to maintain their competitiveness. These conflicts have been difficult to resolve because measuring and allocating the benefits and costs of livestock production is difficult. This papers demonstrates a policy tool for promoting compromise whereby the community gets reduced negative impacts from livestock while at the same time continues to benefit from livestock jobs, taxes, and related economic activity. Public economic benefits and public (...) economic costs of confined animal feeding operations are estimated for every farm and affected house in Craven County, North Carolina. The results show public economic benefits of $5.7 million and public economic costs of $2.2 million, but that the ratio of benefits to costs for individual farm-house pairs varies in important ways across the 26 hog farms in Craven County. (shrink)

At once feared and revered, sharks have captivated people since our earliest human encounters. Children and adults alike stand awed before aquarium shark tanks, fascinated by the giant teeth and unnerving eyes. And no swim in the ocean is undertaken without a slight shiver of anxiety about the very real—and very cinematic—dangers of shark bites. But our interactions with sharks are not entirely one-sided: the threats we pose to sharks through fisheries, organized hunts, and gill nets on coastlines are more (...) deadly and far-reaching than any bite. In Sharks and People acclaimed wildlife photographer Thomas Peschak presents stunning photographs that capture the relationship between people and sharks around the globe. A contributing photographer to National Geographic, Peschak is best known for his unusual photographs of sharks—his iconic image of a great white shark following a researcher in a small yellow kayak is one of the most recognizable shark photographs in the world. The other images gathered here are no less riveting, bringing us as close as possible to sharks in the wild. Alongside the photographs, Sharks and People tells the compelling story of the natural history of sharks. Sharks have roamed the oceans for more than four hundred million years, and in this time they have never stopped adapting to the ever-changing world—their unique cartilage skeletons and array of super-senses mark them as one of the most evolved groups of animals. Scientists have recently discovered that sharks play an important role in balancing the ocean, including maintaining the health of coral reefs. Yet, tens of millions of sharks are killed every year just to fill the demand for shark fin soup alone. Today more than sixty species of sharks, including hammerhead, mako, and oceanic white-tip sharks, are listed as vulnerable or in danger of extinction. The need to understand the significant part sharks play in the oceanic ecosystem has never been so urgent, and Peschak’s photographs bear witness to the thrilling strength and unique attraction of sharks. They are certain to enthrall and inspire. (shrink)

The co-occurrence of stress-induced posttraumatic stress disorder and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understanding of the pathways connecting stress to PTSD and obesity is focused largely on behavioral mediators alone with little consideration of the biological regulatory mechanisms that underlie their co-occurrence. In this work, we leverage prior knowledge to systematically (...) highlight such bio-behavioral mechanisms and inform on the design of confirmatory pilot studies. We use natural language processing to extract documented regulatory interactions involved in the metabolic response to stress and its impact on obesity and PTSD from over 8 million peer-reviewed papers. The resulting network describes the propagation of stress to PTSD and obesity through 34 metabolic mediators using 302 documented regulatory interactions supported by over 10,000 citations. Stress jointly affected both conditions through 21 distinct pathways involving only two intermediate metabolic mediators out of a total of 76 available paths through this network. Moreover, oxytocin, Neuropeptide-Y, and cortisol supported an almost direct propagation of stress to PTSD and obesity with different net effects. Although stress upregulated both NPY and cortisol, the downstream effects of both markers are reported to relieve PTSD severity but exacerbate obesity. The stress-mediated release of oxytocin, however, was found to concurrently downregulate the severity of both conditions. These findings highlight how a network-informed approach that leverages prior knowledge might be used effectively in identifying key mediators like OXT though experimental verification of signal transmission dynamics through each path will be needed to determine the actual likelihood and extent of each marker’s participation. (shrink)

For those who like to locate a subject matter within some familiar context before plunging into its content, this book offers a formidable barrier. Bahm has provided neither preface nor introduction to his work. His book presents three loosely connected studies dealing with polarity, dialectic, and negation, with a final chapter on "Organicity," where we discover that Bahm is introducing us to a new philosophy which he calls "organicism." Organicism distinguishes the categories of existence and experience as ultimate and interdependent. (...) It aims "to be anti-reductionistic, i.e. to refuse to reduce existence to experience and to reduce experience to existence whether experienced or not." "As a both-and philosophy," organicism "claims to account for both existence and experience; and for both experienced existence and unexperienced existence, and for both what is experienced as existing and what is experienced as not existing (million dollars in my pocket." Bahm proposes "two lists of categorial polarities for further study. "The two lists will serve as an outline for a work program by the author who aims to explore each pair, both in itself and in relation to every other pair in the same list. That is, two sets of volumes, one on Existence and one on Experience, are projected." The three studies presented in the volume under review are interesting in their own right. However, the book suffers for lack of an introductory essay.--D. R. P. (shrink)

More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function duringchildhood(lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between (...) participants who suffered from early PEM and controls. In order to determine whether similar differences persisted intoadulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45–51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n= 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood. (shrink)

In 1990, the comptroller of the Catholic Diocese of Buffalo was charged with the embezzlement of eight million dollars of money belonging to the Diocese, He was subsequently convicted and served several years in state prison. Using this case as a starting point, this paper looks at several examples of white-collar crime and religious institutions. Should justice or mercy be the operative virtue in dealing with such criminals?

ObjectiveViolent conflict forced millions of Syrians to flee their homes to host countries. This study examines Syrian refugee women’s experiences from the war’s outset through their journey to Jordan. It addresses the toll this journey had on their lives.MethodsTwenty-four in-depth interviews were completed with Syrian refugee women who currently reside in urban areas of Jordan. Researchers translated, transcribed, and analyzed the interviews using group narrative methodology.ResultsThe Syrian women had unique nostalgic memories of times before the war. They experienced atrocities during (...) the war that forced their decision to escape Syria. Their journey narratives testify of internal displacement, personal and collective traumatic journeys via legal and illegal routes. Almost all the women were placed in refugee camps during their transitions to host country residency. In Jordan, they faced diverse hurdles of displacement and extremely different realities compared to the ones they had in Syria. Despite how very different but difficult each of their journeys were, every single woman longed to return home to Syria.ConclusionsThis study presents a new understanding of the role and process of the journeys undertaken and highlights the concept of “return” as the defining element for Syrian refugee women. Regardless of the hardships women endured to escape their homeland to find safety, “return” marks an ending to their horror journey and the beginning of a new journey of hope for a better future. (shrink)

For at least the past three decades, injuries have been recognized as an important public health problem in the United States. In 2001, there were approximately 157,000 deaths due to injuries in the US. There were also almost 30 million non-fatal injury incidents.Injuries have been defined as: “…any unintentional or intentional damage to the body resulting from acute exposure to thermal, mechanical, electrical, or chemical energy or from the absence of such essentials as heat or oxygen”. Within public health, (...) the field of injury prevention and control is dedicated to reducing the burden of injuries on the lives of people around the world.Injury prevention seeks to reduce injuries by: 1) identifying risk factors, 2) designing interventions to address the risk factors, 3) implementing those interventions, 4) evaluating their effectiveness, and 5) replicating those that work. As with many other public health problems, interventions can target factors associated with the human or host, vehicle or vector, and the physical or social environment. (shrink)

Development of a vaccine for schistosomiasis, a parasitic disease currently affecting over 200 million people worldwide, has been targeted as a priority by the World Health Organisation. Research demonstrating the ability of humans to acquire natural immunity to schistosome infection, together with the successful use of attenuated vaccines in animals both under laboratory and field conditions, suggest that development of a human vaccine is feasible. Attenuated vaccines for schistosomiasis are considered neither safe nor practicable for human use, however, and (...) therefore other approaches must be considered. This review examines progress currently being undertaken in a number of different areas towards achieving the goal of a safe and effective human vaccine for schistosomiasis. (shrink)

Prior to the COVID-19 pandemic, the United States housed 2.3 million inmates in 7,147 incarceration structures that, because of age, overcrowding, and poor ventilation, exacerbated the spread of airborne infections. The flow of individuals into and out of correctional facilities compounded the challenges in keeping them COVID-free. This article focuses on the work of the health and administrative leadership, in partnership with judicial and police personnel, to prevent COVID-19 inside the Albemarle-Charlottesville Regional Jail and to mitigate its spread when (...) the jail population and/or its staff became infected. From the onset, implementing science-based policies and upholding the human right to health and healthcare for all were priorities. (shrink)

For at least the past three decades, injuries have been recognized as an important public health problem in the United States. In 2001, there were approximately 157,000 deaths due to injuries in the US. There were also almost 30 million non-fatal injury incidents.Injuries have been defined as: “…any unintentional or intentional damage to the body resulting from acute exposure to thermal, mechanical, electrical, or chemical energy or from the absence of such essentials as heat or oxygen”. Within public health, (...) the field of injury prevention and control is dedicated to reducing the burden of injuries on the lives of people around the world.Injury prevention seeks to reduce injuries by: 1) identifying risk factors, 2) designing interventions to address the risk factors, 3) implementing those interventions, 4) evaluating their effectiveness, and 5) replicating those that work. As with many other public health problems, interventions can target factors associated with the human or host, vehicle or vector, and the physical or social environment. (shrink)

In the 1970s, R.D. MacElroy coined the term ‘extremophile’ to describe microorganisms that thrive under extreme conditions (MacElroy 1974). This hybrid word transliterates to ‘love of extremes’ and has been studied as a straightforward concept for the past 40 years. In this paper, we discuss several ways the term has been understood in the scientific literature, each of which has different consequences for the distribution and importance of extremophiles. They are, briefly, Human-Centric, at the Edge of life’s habitation of Morphospace, (...) by appeal to Statistical Rarity, described by Objective Limits, and at the Limits of Impossibility for metabolic processes. Importantly, these concepts have co-existed, unacknowledged and conflated, for decades. Confusion and equivocation threaten to follow from the wildly varied inclusion or exclusion of organisms as extremophiles depending on the concept used. Under some conceptions, entire kinds of extremophiles become meaningless. Since our understanding of how life works is shaped by what we take to be its extremes, clarifying extremophily is key for many large-scale projects in biology, ecology, biotechnology and astrobiology. In what follows, we proceed as if a noncontroversial account of life is possible and that it is possible to find complex chemistry in the Universe that is similar enough to Life on Earth such that both may be considered instances of ‘life’ (but see Mariscal & Doolittle 2018). We raise, but do not address, the questions of whether the distribution of Life on Earth is representative of what we may find elsewhere in the Universe, whether the same kinds of extremophiles would exist given a replay of the tape of life. Additionally, each of these concepts assumes life based on some sort of biochemistry in this universe, effectively setting aside claims made by some artificial life proponents that their digital organisms are genuine examples of life (Langton 1989, Ray 1995). On the distinction between extremophilic and extremotolerant, we note that all accounts accept the latter as a broader category than the former, since ‘phily’ means love and tolerance is a prerequisite for love under any conception. Indeed, there will be many extremely impoverished environments where tolerance is the only option and thriving is precluded, e.g. Bacillus marismortui was extracted and grown from 250-million-year-old salt crystals in the Permian Salado Formation in an inactive yet persistent state (Vreeland et al., 2000). We also note that extremophily, as a functional category, is potentially applicable at many levels of the biological hierarchy. Extremophily at one level does not necessarily extend to higher and lower levels. For instance, a microorganism in isolation might be quite intolerant to certain environmental conditions yet flourish when subjected to the same conditions as a community or natural biofilm. Alternatively, a protein molecule might be quite stable or active under certain conditions even if the optimal environment for the organism containing it is far more mesophilic. There is an industry of artificially selecting organisms and proteins to adapt to extreme environments (see van den Burg & Eijsink 2002), providing some justification to consider ‘functioning at extremes’ as a worthwhile category of investigation. Finally, we also note certain physico-chemical ranges are rarely considered with respect to extremophily – timespan, size, nutrient availability (Hoehler & Jørgensen 2013), etc. – as well as some biological parameters – abundance, isolation, competition, etc. Perhaps scientific interest must also come into play as to the reason these criteria are not considered relevant. We return to this issue later. In the next section, we give five definitions of extremophily, show their benefits, drawbacks, and unintended yet unavoidable consequences. These arguments are summarized in Table 1 and represented visually in Figures 1 and 2. Given research on polyextremophiles, it seems Figure 2 is a more plausible representation of the state of current knowledge than Figure 1 (Harrison et al. 2013). Life is patchily distributed across various dimensions, which may reflect its contingent history, poor sampling, or (perhaps) fundamental limits. Figure 3 shows the conceptual flowchart for all of these views. In the following section, we take a step back to ask whether we should choose between these definitions and how such a judgment could be made. We argue for a limited pluralism, in which some, but not all, of the concepts are acceptable relative to certain practical and theoretical aims. (shrink)

Little is known about health of the growing subpopulation of the working poor in Japan. We aimed to evaluate health status and healthcare utilization in relation to income among Japanese working adults. We conducted a one-month prospective cohort study using a health diary in working adults from a nationally representative random sample in Japan. Based on the government criterion, the working poor group was defined as earning an equivalent annual income of less than 1.48 million Japanese-yen. For health status, (...) we measured symptomatic episodes and health-related quality of life (HRQOL). For healthcare utilization, we measured frequencies of visits to a physician or pharmacy, and use of complementary and alternative medicine (CAM). We constructed multiple linear regression models for these measures adjusted for age, gender, and co-morbidity, using annual equivalent income as a 4-level categorical variable. (shrink)

Online courses attract thousands, even millions of students from all corners of the Earth. As such, they have the potential to educate many people. Education, however, is not neutral. Knowledge is embedded in contexts and perspectives, carrying ideological baggage, and so is teaching and learning. Teaching can no longer be the mere provision of content. The knowledge explosion implies that the ability to master content should become part and parcel of the course curriculum. In the same vein, the fact that (...) online courses attract students from many different contexts necessitates that lecturer and student alike should be aware of the underlying ideologies in the course content. To this end, in this conceptual article it is argued that discourse analysis of not only the written course content but also of images used to illustrate the content can be helpful; these are often not scrutinised for ideological baggage. If not, the online educated human might become the online indoctrinated human, to the detriment of all. (shrink)

The paper considers the intellectual computer mathematics system InparSolver, which is designed to automatically explore and solve basic classes of computational mathematics problems on multi-core computers with graphics accelerators. The problems of results reliability of solving problems with approximate input data are outlined. The features of the use of existing computer mathematics systems are analyzed, their weaknesses are found. The functionality of InparSolver, some innovative approaches to the implementation of effective solutions to problems in a hybrid architecture are described. Examples (...) of applied usage of InparSolver for processes mathematical modeling in various subject areas are given. Nowadays, new more complex objects and phenomena in many subject areas are constantly emerging, which are subject to mathematical research on a computer. This encourages the development of new numerical methods and technologies of mathematical modeling, as well as the creation of more powerful computers for their implementation. With the advent and constant development of supercomputers of various architectures, the problems of their effective use, expansion of tasks range should be solved, ensuring the reliability of computer results and increasing the level of intellectual information support for users ‒ specialists in various fields. Today, the issues of solving these problems are given special attention by many specialists in the fields of information technology and parallel programming. The world's leadingscientists in the field of computer technology see the solution to the problems of efficient usage of modern supercomputers in algorithmic software creation that easily adapts to different computer architectures with different types of memory and coprocessors, supports efficient parallelism on millions of cores etc. In addition, improving the efficiency of high-performance computing on modern supercomputers is provided by their intellectualization, transferring to the computer to perform a significant part of the functions. The industry of development and usage of intelligent computer technologies is one of the main directions of science and technology development in modern society. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly (...) released DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

In this third volume of a monumental four book survey of Phenome­ nology world-wide fifty years after the death of its chief founder, Edmund Husserl, we have a collection of studies which, in the first place, consider Husserl's legacy in the postmodern world. The extent of our indebtedness to the Master is shown in explora­ tions of the archeology of knowledge, hermeneutics, and critical studies of language by A. Ales Bello, P. Pefialver, P. Million, V. Martinez Guzman, H. Rodriguez (...) Pifiero, Y. Vlaisavlevich, and others. There follow calls for renewing the critique of reason by C. Schrag, F. Bosio, and J. Lerin Riera and discussion by D. Laskey, K. G6rniak-Kocikowska, M. R. Barral, Y. Park, and N. Delle Site on A-T. Tymieniecka's phe­ nomenology of life, which proposes a total reorientation of phenome­ nology by introducing a conception of the human condition in which the human creative act is the Archimedean point for philosophy. (shrink)

Millions of pounds are spent on educational research each year in the UK alone. By far the greatest proportion of this expenditure is on research which is thought to have practical relevance to educational problems and the vast majority of this is spent on empirical educational research, that is educational research which examines and seeks explanations for actual or proposed educational practices or the kinds of activities, institutions or policies that prepare young people for life (Pring, 2015, p. 27). Invariably, (...) the aim of such research is not merely to gain understanding of these practices, but to improve or replace them with better ones. This practical aspect of educational research exercises most commentators, although it should not be forgotten that educational research can be carried out in a relatively disinterested manner, out of intellectual curiosity (Hammersley, 2006). There are two related issues to be considered here: 1] is it possible to gain knowledge of how educational practices work?; 2] is it possible to use such knowledge to improve existing practices, replace existing ones with better ones or introduce practices which will improve the overall practice of education? In this book, both these questions will be addressed. If the answer to 1] is negative, then it is futile to address 2]. By implication then the answer to 1] will be positive. The answer to 2] will not be negative, but there are degrees of positivity attached to a positive answer and what those degrees are will be crucial to the ultimate claims of the book. It is no exaggeration to say that in recent decades educational research has undergone a crisis of confidence, particularly but not exclusively within the world of educational policymaking. Dissatisfaction has been expressed both with the quality and the usefulness of such research. Conceptual research on education tends to be regarded with some suspicion as something that is either of little practical value or which undermines existing practices. But empirical research fares little better, with scepticism expressed both about its quality (Tooley and Darby, 1998) and about its applicability (Hillage et al., 1998). More recently there have been moves to tie funding to preferred approaches to empirical research such as intervention studies and randomised control trials (RCTs) and to disseminate in accessible form what the findings of such studies are and how they are relevant to the improvement of educational practice. In the UK alone we see organisations such as the Educational Policy Institute (EPI), the Educational Endowment Foundation (EEF), and the Sutton Trust, not to mention meta-researchers Robert Slavin and John Hattie gaining a significant amount of influence in the propagation of studies of 'what works' in educational practice. One should also mention the rising interest in the deliverances of educational research from within the teaching profession, such as ResearchEd in the UK, which betoken a wish by teachers to become more active. (shrink)

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1902 Excerpt:...earth. r' = radius of moon, or other body. P = moon's horizontal parallax = earth's angular semidiameter as seen from the moon. f = moon's angular semidiameter. Now = P (in circular measure), r'-r = r (in circular measure);.'. r: r':: P: P', or (radius of earth): (radios of (...) moon):: (moon's parallax): (moon's semidiameter). Examples. 1. Taking the moon's horizontal parallax as 57', and its angular diameter as 32', find its radius in miles, assuming the earth's radius to be 4000 miles. Here moon's semidiameter = 16';.-. 4000::: 57': 16';.-. r = 400 16 = 1123 miles. 2. The sun's horizontal parallax being 8"8, and his angular diameter 32V find his diameter in miles. ' Am. 872,727 miles. 3. The synodic period of Venus being 584 days, find the angle gained in each minute of time on the earth round the sun as centre. Am. l"-54 per minute. 4. Find the angular velocity with which Venus crosses the sun's disc, assuming the distances of Venus and the earth from the sun are as 7 to 10, as given by Bode's Law. Since (fig. 50) S V: VA:: 7: 3. But Srhas a relative angular velocity round the sun of l"-54 per minute (see Example 3); therefore, the relative angular velocity of A V round A is greater than this in the ratio of 7: 3, which gives an approximate result of 3"-6 per minute, the true rate being about 4" per minute. Annual ParaUax. 95. We have already seen that no displacement of the observer due to a change of position on the earth's surface could apparently affect the direction of a fixed star. However, as the earth in its annual motion describes an orbit of about 92 million miles radius round the sun, the different positions in space from which an observer views the fixed stars from time to time throughout the year must be separated... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:332 BOOK REVIEWS toral inventions (such as basic Christian communities), and the religious backgrounds of millions who help to make up the churches, Catholic and Protestant, of the United States. Providence College Providence, RI EDWARD L. CLEARY, O.P. Springs of Action: Understanding Intentional Behavior. By ALFRED R. MELE. New York and Oxford: Oxford University Press, 1992. Pp. 272 + ix. $39.95 (cloth). Alfred Mele's overarching aim in this book (...) is to offer an account of the role of intentions in the explanation of intentional action. He works within the familiar terms of causal theories of action, and is particularly indebted to Donald Davidson. In Part I, Mele borrows a set of theses from Davidson's desire/belief model of intentional action, and in the process of addressing problems associated with these theses, he progressively refines an account of action that understands an agent's reasons to have explanatory force by virtue of being among the causes of action. In Part II, Mele argues that desire/belief models are insufficient as they stand and need to be filled out by recognizing that intentions provide a crucial link between reasons and actions. The discussion begins with the vexed question of how the content of mental states can be relevant to the causal explanation of action. We constantly appeal to our desires, beliefs, plans, and so on (i.e., to various propositional, or intentional, attitudes) in explaining our behavior. But how does, say, my appetite for good wine and my belief that the house chardonnay is such a wine figure in the causal order that brings about my act of ordering a glass of it? Presumably, these intentional states supervene upon certain physical states of my body, and the latter do the causal work of producing wine-ordering behavior. However, there are good reasons to think that, with certain sorts of changes in my history and environment (viz., of the sort described in twin earth thought experiments), these physical states could be the realization of different intentional states. So can a causal theory of action actually accord my desires and beliefs any role in explaining my action? Mele argues that even if we hold (with externalists) that the agent's history and environment help to fix the content of her intentional states, we can nonetheless say that unless the agent had intended what she did, she would not have acted as she did. The behavior is intentional action by virtue of issuing (in the right way) from physical processes BOOK REVIEWS 333 that realize the agent's reasons for acting, and these processes realize these reasons only if the processes have an appropriate causal history. The result is that what we desire, believe, and intend does after all make a systematic difference in what we do. Mele makes some helpful refinements in the standard account of the causal role of desire in intentional action. It has typically been claimed that when an agent's wants compete, the "strongest" of them deter· mines the action; if an agent wants to do A more than anything else that she takes herself to be able to do, then if she acts intentionally she will do A. Mele points out that this general claim must be qualified so as to index desires to times, to accommodate both unsuccessful at· tempts and the agent's estimates of the likelihood of success, and to deal with the complex relations between desires. He explores the way in which agents are able to control the motivational strength of their desires, and he works out a definition of irresistible desire. One of the deepest challenges to the claim that action is caused by what we most desire arises in considering "motivational ties." How, on this account, is intentional action possible when we equally desire each of two incompatible alternatives? An arbitrary decision procedure can be adopted (e.g., a coin toss), but this alone does not en· hance the attractiveness of the randomly selected alternative. Here Mele introduces his thesis about intentions: viz., that intentions have an "executive quality that is not reducible to desire-strength" (p. 72), so that even when there is no preponderant motivation to do A... (shrink)

There is a section in Samuel Delany’s magnificent autobiographical meditation, The Motion of Light in Water, that dramatically raises the problem of writing the history of difference, the history, that is, of the designation of “other,” of the attribution of characteristics that distinguish categories of people from some presumed norm.1 Delany recounts his reaction to his first visit to the St. Marks bathhouse in 1963. He remembers standing on the threshold of a “gym-sized room” dimly lit by blue bulbs. The (...) room was full of people, some standing, the rest an undulating mass of naked, male bodies, spread wall to wall. My first response was a kind of heart-thudding astonishment very close to fear. I have written of a space at certain libidinal saturation before. That was not what frightened me. It was rather that the saturation was not only kinesthetic but visible.2Watching the scene establishes for Delany a “fact that flew in the face” of the prevailing representation of homosexuals in the 1950s as “isolated perverts,” as subjects “gone awry.” The “apprehension of massed bodies” gave him a “sense of political power”:what this experience said was that there was a population—not of individual homosexuals … not of hundreds, not of thousands, but rather of millions of gay men, and that history had, actively and already, created for us whole galleries of institutions, good and bad, to accommodate our sex. [M, p. 174] 2. Samuel R. Delany, The Motion of Light in Water: Sex and Science Fiction Writing in the East Village, 1957-1965 , p. 173; hereafter abbreviated M. Joan W. Scott is professor of social science at the Institute for Advanced Study in Princeton, New Jersey. She is the author, most recently, of Gender and the Politics of History and is currently at work on a history of feminist claims for political rights in France during the period 1789-1945 as a way of exploring arguments about equality and difference. (shrink)

The slime mould Physarum polycephalum has been used in developing unconventional computing devices for in which the slime mould played a role of a sensing, actuating, and computing device. These devices treated the slime mould as an active living substrate, yet it is a self-consistent living creature which evolved over millions of years and occupied most parts of the world, but in any case, that living entity did not own true cognition, just automated biochemical mechanisms. To “rehabilitate” slime mould from (...) the rank of a purely living electronics element to a “creature of thoughts” we are analyzing the cognitive potential of P. polycephalum. We base our theory of minimal cognition of the slime mould on a bottom-up approach, from the biological and biophysical nature of the slime mould and its regulatory systems using frameworks such as Lyon’s biogenic cognition, Muller, di Primio-Lengelerś modifiable pathways, Bateson's “patterns that connect” framework, Maturana's autopoietic network, or proto-consciousness and Morgan's Canon. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Ethical, Legal, and Social Implications Research Program at the National Human Genome Research InstituteEric M. Meslin (bio), Elizabeth J. Thomson (bio), and Joy T. Boyer (bio)Organizers of the Human Genome Project (HGP) understood from the beginning that the scientific activities of mapping and sequencing the human genome would raise ethical, legal, and social issues that would require careful attention by scientists, health care professionals, government officials, and the (...) public. The establishment of the ELSI (ethical, legal, and social implications) programs at the National Human Genome Research Institute (NHGRI) and the Department of Energy (DOE) was thought to be vital to the success of the HGP in the United States. It also provided a novel approach to the simultaneous study of ethical, legal, and social issues and basic scientific issues. Eric Juengst, the first director of the ELSI program, described its origins in a previous issue of the Kennedy Institute of Ethics Journal (Juengst 1991). Now in its seventh year, the ELSI program has accomplished much. This article summarizes the evolution and goals of the ELSI program at NHGRI, outlines the program’s current research priorities with examples of activities within each priority area, and provides a look to the future, including the initiation of a strategic planning process.Evolution and Goals of the ELSI Research ProgramThe HGP’s “genomic” goals are unique: to map and sequence the entire human genome—some 3 billion base pairs that make up approximately 80–100,000 genes—and the genomes of related model organisms by the year 2005. This goal was particularly ambitious since, when it was proposed, the technologies for mapping and sequencing had yet to be developed. When the HGP was first established, its organizers also elaborated a set of ELSI goals, which they saw as vital to the success of the genome project. The original ELSI goals were: (1) to anticipate and address the implications of the HGP for individuals and society and (2) to examine the ELSI consequences of mapping and sequencing the human genome in order to stimulate public discussion. To meet these goals, the NHGRI created its ELSI research program in 1990. Along with mapping, sequencing, [End Page 291] and mammalian genetics, ELSI was one of four original branches in the NHGRI Division of Extramural Research that funded research in those areas. Although the individual “branches” no longer exist, the mechanisms for funding research remain much the same. While the overall goals of the program have not changed, the specific ways of achieving the goals have continued to evolve. The importance of the ELSI program lies not in the collection of a full set of data that will be valuable in and of itself, but in the value of using and interpreting this new set of information.Early on, the NHGRI described a set of somewhat more specific goals: (1) to develop a program to help understand the ethical, legal, and social implications of the human genome project and (2) to identify and define the major issues of concern and develop policy options to address them. These more specific goals have been largely met. As the most recent biennial NHGRI Progress Report notes, “a robust ELSI research and education program has been established, many of the most urgent ELSI issues have been identified, and many policy options to address these issues have been proposed” (NCHGR 1995, p. 21). Between 1990 and 1996, ELSI provided more than $32.5 million in funding through 128 research and education grants in more than 30 states and in Canada (Table 1). The ELSI research budget is unique in that when originally created, it was specifically tied to the amount of money provided for the overall NHGRI budget. The NHGRI originally devoted 3 percent of its extramural budget to fund ELSI projects, but in FY 1991, it increased the ELSI budget to 5 percent, a figure that remains today. Table 2 lists the expenditures for each fiscal year since 1990 and the cumulative expenditures to date. The ELSI research budget at NHGRI this year will be about $7 million. When other sources of funding—e.g., co-funding arrangements with other institutes and agencies and the funding of ELSI... (shrink)

BackgroundFinancial interactions between pharmaceutical companies and physicians lead to conflicts of interest. This study examines the extent and trends of non-research payments made by pharmaceutical companies to board-certified allergists in Japan between 2016 and 2020.MethodsA retrospective analysis of disclosed payment data from pharmaceutical companies affiliated with the Japanese Pharmaceutical Manufacturers Association was conducted. The study focused on non-research payments for lecturing, consulting, and manuscript drafting made to board-certified allergists from 2016 to 2020. We performed descriptive analyses on payment data. Trends (...) were analyzed using generalized estimating equation models.ResultsOf the 3,943 board-certified allergists, 2,398 (60.8%) received non-research payments totaling $43.4 million over five years. Lecturing fees comprised 85.7% ($37.2 million) of the total payment amounts. For allergists who received at least one payment, the median amount per allergist was $3,106 (interquartile range: $966 – $12,124), in contrast to a mean of $18,092 (standard deviation: $49,233) over the five-year span. The top 1% and 10% of these allergists accounted for 20.8% and 68.8% of all non-research payments, respectively. The annual payment amounts significantly increased by 7.2% annual increase (95% CI: 4.4 – 10.0%, p < 0.001) each year until 2019, but saw a significant decrease in 2020 amid the COVID-19 pandemic.ConclusionThe majority of allergists received non-research payments, with a notable concentration among a small group. Payments increased annually until the pandemic’s onset, which coincided with a substantial decrease. Further research is needed to explore the implications of these financial interactions on clinical practice and patient care in Japan. (shrink)