This paper offers a new way to make sense of disagreement expansion from a polylogical perspective by incorporating various places in addition to players and positions into the analysis. The concepts build on prior implicit ideas about disagreement space by suggesting how to more fully account for argumentative context, and its construction, in large-scale complex controversies. As a basis for our polylogical analysis, we use a New York Times news story reporting on an oil train explosion—a significant point in the (...) broader controversy over producing oil and gas via hydraulic fracturing. (shrink)

The article focuses on the role of civil society in the aggregate of causes that eventually brought about the collapse of the communist block and — in consequence — changed the global balance of power. The concept of ‘ethical civil society’ is introduced in explaining the path to democracy of former Soviet bloc countries. The article also explores cultural determinants of democratisation in Central and Eastern Europe after 1989; in particular the relation between religious confession and likelihood of democratic outcome (...) of post-communist transformation is examined. (shrink)

The aim of the paper is to describe possible e-learning activities that a university can develop. Examples of projects carried out in Warsaw School of Economics have been presented with conclusions and experience gathered during their implementation. In the last part, trends for the future of academic e-learning have been discussed.

The aim of this paper is to propose foundations for a formal model of representation and numerical evaluation of a possibly broad class of arguments, including those that occur in natural discourse. Since one of the most characteristic features of everyday argumentation is the occurrence of convergent reasoning, special attention should be paid to the operation ⊕, which allows us to calculate the logical force of convergent arguments with an accuracy not offered by other approaches.

The discussion around dignity in nursing philosophy has been underway for many years. The literature still lacks philosophical arguments that would justify the thesis that all people have dignity. Scholars who defend dignity as an intrinsic value most often refer to Kant. However, Kant does not seem to be the most suitable candidate to defend the thesis that all human beings possess dignity. In this paper, I attempt to show that Aristotle's and Aquinas's views can help justify this thesis. To (...) this end, I distinguish between actual dignity, potential dignity, and existential dignity. I state that all human beings have existential dignity or potential dignity. (shrink)

Spatial metaphors of affect display remarkable consistencies across languages in mapping sensorimotor experiences onto emotional states, reflecting a great degree of similarity in how our bodies register affect. At the same time, however, affect is complex and there is more than a single possible mapping from vertical spatial concepts to affective states. Here we consider a previously unreported case of spatial metaphors mapping down onto desirable, and up undesirable emotional experiences in Mlabri, an Austroasiatic language of Thailand and Laos, making (...) a novel contribution to the study of metaphor and Cognitive Linguistics. Using first-hand corpus and elicitation data, we examine the metaphorical expressions: klol jur ‘heart going down’ and klol khɯn ‘heart going up’/klol kɔbɔ jur ‘heart not going down’. Though reflecting a metaphorical mapping opposite to the commonly reported happy is up metaphor, which is said to link to universal bodily correlates of emotion, the Mlabri metaphors are far from idiosyncratic. Rather, they are grounded in the bodily experience of positive low-arousal states, and in that reflect an emic view of ideal affect centered on contentment and tranquility. This underscores the complexity of bodily experience of affect, demonstrating that cultures draw on the available sensorimotor correlates of emotion in distinct ways. (shrink)

Since 1989, clinical ethics consultation in form of hospital ethics committees was established in most of the transition countries of Central and Eastern Europe. Up to now, the similarities and differences between HECs in Central and Eastern Europe and their counterparts in the U.S. and Western Europe have not been determined. Through search in literature databases, we have identified studies that document the implementation of clinical ethics consultation in Central and Eastern Europe. These studies have been analyzed under the following (...) aspects: mode of establishment of HECs, character of consultation they provide, and their composition. The results show that HECs in the transition countries of Central and Eastern Europe differ from their western-European or U.S. counterparts with regard to these three aspects. HECs were established because of centrally imposed legal regulations. Little initiatives in this area were taken by medical professionals interested in resolving emerging ethical issues. HECs in the transition countries concentrate mostly on review of research protocols or resolution of administrative conflicts in healthcare institutions. Moreover, integration of non-professional third parties in the workings of HECs is often neglected. We argue that these differences can be attributed to the historical background and the role of medicine in these countries under the communist regime. Political and organizational structures of healthcare as well as education of healthcare staff during this period influenced current functioning of clinical ethics consultation in the transition countries. (shrink)

Our new journal Philosophies is devoted to the search for a synthesis of philosophical and scientific inquiry. It promotes philosophical work derived from the experience of diverse scientific disciplines. [...].

This is a short presentation by the Guest Editors of the series of Special Issues of the journal _Philosophies_ under the common title “Contemporary Natural Philosophy and Philosophies” in which we present Part 2. The series will continue, and the call for contributions to the next Special Issue will appear shortly.

When discussing the safety of research subjects, including their exploitation and vulnerability as well as failures in clinical research, recent commentators have focused mostly on countries with low or middle-income economies. High-income countries are seen as relatively safe and well-regulated. This article presents irregularities in clinical trials in an EU member state, Poland, which were revealed by the Supreme Audit Office of Poland (the NIK). Despite adopting many European Union regulations, including European Commission directives concerning Good Clinical Practice, these irregularities (...) occurred. Causes as well as potential solutions to make clinical trials more ethical and safer are discussed. (shrink)

Despite the continuous emphasis on globalization, we witness increasing divisions and divisiveness in all domains of human activities. One of the reasons, if not the main one, is the intellectual fragmentation of humanity, compared in the title to the failed attempt at building the Biblical Tower of Babel. The attempts to reintegrate worldview, fragmented by the specialization of education and expected to be achieved through reforms in curricula at all levels of education, were based on the assumption that the design (...) of a curriculum should focus on the wide distribution of subjects of study, as if the distribution was the goal. The key point is not the distribution of themes, but the development of skills in the integration of knowledge. The quantitative assessment of the width of knowledge by the number of disciplines is of secondary importance. We cannot expect the miracle that students without any intellectual tools developed for this purpose would perform the job of integration, which their teachers do not promote or demonstrate, and which they cannot achieve for themselves. There are many other reasons for the increasing interest in making inquiries interdisciplinary, but there is little progress in the methodology of the integration of knowledge. This paper is a study of the transition from multidisciplinarity to interdisciplinarity, and further, to transdisciplinarity, with some suggestions regarding the use of methodological tools of structuralism and the choice of a conceptual framework. (shrink)

Application of either the harm principle or the best interest standard to medical decision making conflicts with some types of pediatric research that pose elevated risk without the reasonable prob...

W 1983 roku Benjamin Libet wraz ze współpracownikami po raz pierwszy wykazał, że w prostym działaniu dobrowolnym świadoma intencja nie pełni funkcji inicjującej. Czasowy przebieg tego typu działania wskazuje również, że intencja oraz samo działanie to produkty procesów nieświadomych. Na podstawie wyniku Libeta oraz wybranych koncepcji psychologicznych Daniel Wegner zaproponował teorię pozornej mentalnej przyczynowości, w ramach której intencja to rodzaj konstruktu umożliwiającego agentowi zrozumienie własnego zachowania w kategoriach przyczynowych, gdzie jego stan mentalny (intencja) jawi mu się jako przyczyna, a działanie (...) jako skutek. Ujęcie Wegnera rodzi jednak pytanie, jaka jest faktyczna relacja pomiędzy intencjami, a celami kształtującymi nasze decyzje. Biorąc pod uwagę wyjaśnienie amerykańskiego psychologa, nie możemy być pewni, że te dwa elementy mają ze sobą jakiś związek. Może to prowadzić do zaskakującego wniosku, że nasza świadoma wola jest w gruncie rzeczy iluzją. Korzystając z wyników badań Read’a Montague nad mechanizmami ustanawiania i osiągania celów wskazuję na alternatywną możliwość rozumienia roli intencji. Zgodnie z analizą Montague, możemy postulować, że przynajmniej w wybranych przypadkach treść intencji działania oraz przebieg zachowań celowych oparte są na tej samej abstrakcyjnej reprezentacji. Znaczy to, że interpretacja świadomej woli, jako przydatnej iluzji jest za szeroka, gdyż znamy (wskazane w tekście) przypadki, kiedy treść intencji jest tożsama z reprezentacją pełniącą rolę nagrody w systemie ustanawiania i osiągania celów. (shrink)

Résumé L’article presente les changements qui se sont manifestes dans la recherche polonaise, essentiellement en litterature et histoire des Lumieres, entre 1945 et 1990. L’accent est mis sur l’impact du contexte politique sur la recherche. Les annees 1945-1956 ont ete marquees par de fortes contraintes ideologiques car le regime communiste imposait aux chercheurs une vision simplifiee des Lumieres censee repondre aux besoins de ses plans. Apres l’epoque stalinienne, la pression ideologique et institutionnelle s’est progressivement reduite, ouvrant la voie a davantage (...) de liberte de recherche et d’interpretation des Lumieres. Si certains episodes historiques continuaient a faire l’objet de debats publics, la vision des Lumieres produite par les travaux s’effectuait desormais sans ingerence directe du pouvoir. (shrink)

This article presents the works of great Polish philosopher, Mieczysław Albert Krąpiec, whose creative output can be applied to professional nursing practice. Krąpiec's philosophical heritage is extensive and encompasses many philosophical fields: metaphysics, philosophical anthropology, philosophy of law, philosophy of culture, philosophy of politics and philosophy of language. Krąpiec created an original philosophical synthesis characterized by a realistic approach. In this paper, I present only one of several original philosophical concepts developed by Krąpiec: the theory of the person based on (...) seven essential characteristics, that is the ability for cognition, love, freedom, religion, legal subjectivity, completeness and dignity. I attempt to show how these personal characteristics correspond to various patient needs. I argue that the qualitative deficit of any personal characteristics indicated by Krąpiec corresponds to a patient's real need that must be satisfied. I also stress that the skilful diagnosing of all—not only selected—qualitative deficits of characteristics can be defined as holistic care in the nursing profession. (shrink)

Contemporary Natural Philosophy is understood here as a project of the pursuit of the integrated description of reality distinguished by the precisely formulated criteria of objectivity, and by the assumption that the statements of this description can be assessed only as true or false according to clearly specified verification procedures established with the exclusive goal of the discrimination between these two logical values, but not with respect to any other norms or values established by the preferences of human collectives or (...) by the individual choices. This distinction assumes only logical consistency, but not completeness. Completeness (i.e., the feasibility to assign true or false value to all possible statements) is desirable, but may be impossible. This paper is not intended as a comprehensive program for the development of the Contemporary Natural Philosophy but rather as a preparation for such program advocating some necessary revisions and extensions of the methodology currently considered as the scientific method. This is the actual focus of the paper and the reason for the reference to Baconian _idola mentis_. Francis Bacon wrote in _Novum Organum_ about the fallacies obstructing progress of science. The present paper is an attempt to remove obstacles for the Contemporary Natural Philosophy project to which we have assigned the names of the Idols of the Number, the Idols of the Common Sense, and the Idols of the Elephant. (shrink)

In the book, I argue that the mind can be explained computationally because it is itself computational—whether it engages in mental arithmetic, parses natural language, or processes the auditory signals that allow us to experience music. All these capacities arise from complex information-processing operations of the mind. By analyzing the state of the art in cognitive science, I develop an account of computational explanation used to explain the capacities in question.

The article describes Mieczysław Albert Krąpiec's perspective on four classic philosophical images of man and the resulting theoretical and practical implications for the nursing profession. The first three images, namely man as a set of elements, man as a soul imprisoned in the body and man as a rational animal, are regarded by Krąpiec as reductionist anthropologies and are thus inadequate for nursing. The first image reduces man to a biological element. The second one reduces man to a soul and (...) treats a body as something an obstacle in personal development. The third image absolutizes reason in man. While the body is not rejected in this image, it is viewed as an indifferent mass. The last image, which regards man as a person, is an adequate image for nursing. The exceptional character of man emphasized in this image is determined by the following personal qualities: the ability for cognition, freedom, love, religiousness, dignity, subjectivity to law and completeness. These characteristics reveal the specificity of personal being in both the body and the spirit. By viewing man as a person, a nurse discovers a wide range of possibilities of providing effective help to the patient. (shrink)

Artykuł omawia analizę fenomenu życia religijnego w filozofii Williama Jamesa (1842-1910). Wskazano na kalwińskie korzenie twórcy pragmatyzmu a zwłaszcza na prezbiteriański schemat zwany sylogizmem praktycznym, który w powodzeniu życiowym szukał potwierdzenia posiadania łaski religijnej. Twórca pragmatyzmu, rozpoczął swoje badania od analizy przeżyć ludzkich z perspektywy psychologicznej. Pod koniec życia coraz więcej uwagi poświęcił analizie fenomenu życia religijnego. Poglądy swoje wyłożył w wykładach edynburskich w roku 1901, które zostały wydane w książce Doświadczenia religijne. Analizie przeżyć religijnych poświęcone są też końcowe partie (...) Pragmatyzmu (1907). James wskazuje na znaczenie przeżyć religijnych w życiu człowieka. Uważa, że istotę religii stanowi poczucie zależności, odczucie obecności tego, co nadprzyrodzone. W religii nie chodzi o dogmaty, instytucje czy rytuały, lecz o pożytek, jaki przynosi ona jednostce, porządkując jej życie. Głównym celem religii pozytywnych jest wyzwolenie człowieka od zła. Tak opisana religijność jawi się jako swoista sapientia, życiowa mądrość, która porządkuje ludzkie życie i wnosi w nie wartość dodatnią. Stąd takie rozumienie religii zostaje określone w artykule mianem sapientia pragmatica. (shrink)

This paper addresses the following question: Can one and the same utterance token, in one unique speech situation, intentionally and conventionally perform a plurality of illocutionary acts? While some of the recent literature has considered such a possibility Perspectives on pragmatics and philosophy. Springer, Cham, pp 227–244, 2013; Johnson in Synthese 196:1151–1165, 2019), I build a case for it by drawing attention to common conversational complexities unrecognized in speech acts analysis. Traditional speech act theory treats communication as: a dyadic exchange (...) between a Speaker and a Hearer who trade illocutionary acts endowed with one and only one primary force. I first challenge assumption by discussing two contexts where plural illocutionary forces are performed in dyadic discussions: dilemmatic deliberations and strategic ambiguity. Further, I challenge assumption by analyzing poly-adic discussions, where a speaker can target various participants with different illocutionary acts performed via the same utterance. Together, these analyses defend illocutionary pluralism as a significant but overlooked fact about communication. I conclude by showing how some phenomena recently analyzed in speech act theory—back-door speech acts New work on speech acts. Oxford University Press, Oxford, pp 144–164, 2018) and dog-whistles New work on speech acts. Oxford University Press, Oxford, pp 360–383, 2018)—implicitly presuppose illocutionary pluralism without recognizing it. (shrink)

Assent is an important ethical and legal requirement of paediatric research. Unfortunately, there are significant differences between the guidelines on the details of assent.

In this paper, we closely examine the various ways in which a multi-party argumentative discussion—argumentative polylogue—can be analyzed in a dialectical framework. Our chief concern is that while multi-party and multi-position discussions are characteristic of a large class of argumentative activities, dialectical approaches would analyze and evaluate them in terms of dyadic exchanges between two parties: pro and con. Using as an example an academic committee arguing about the researcher of the year as well as other cases from argumentation literature, (...) we scrutinize the advantages and pitfalls of applying a dialectical framework to polylogue analysis and evaluation. We recognize two basic dialectical methods: interpreting polylogues as exchanges between two main camps and splitting polylogues into a multitude of dual encounters. On the basis of this critical inquiry, we lay out an argument expressing the need for an improved polylogical model and propose its basic elements. (shrink)

The author argues that behind the apparent randomness of interactions between cabdrivers and their fares in Warsaw is a temporal structure. To capture this temporal structure, the author introduces the notion of a linking ecology. He argues that the Warsaw taxi market is a linking ecology, which is structured by religious time, state time, and family time. The author then focuses on waiting time, arguing that it too structures the interactions between cabdrivers and their fares. The author makes a processual (...) argument that waiting time has been restructured by the postsocialist transformation, but only because this transformation has been continually encoded through the defensive and adaptive strategies of cabdrivers responding to the repetitive and unique events located across the social space. The author concludes with the claim that linking ecologies are a recurring structure of the social process and that they form the backbone of globalization, financialization, and mediatization. (shrink)

We compared the processing of natural language quantifiers in a group of patients with schizophrenia and a healthy control group. In both groups, the difficulty of the quantifiers was consistent with computational predictions, and patients with schizophrenia took more time to solve the problems. However, they were significantly less accurate only with proportional quantifiers, like more than half. This can be explained by noting that, according to the complexity perspective, only proportional quantifiers require working memory engagement.

This editorial complements the editorial opening Philosophies eight years ago. The success of the original vision of the journal has been confirmed by the high quality of published works and its institutional recognition. The journal Philosophies evolves, but this evolution is an adaptation to the conditions of better realization of its original mission to promote the reintegration of fragmented by specialization knowledge guided by philosophy. In contrast to the editorial published at the time of the opening of the journal presenting (...) general philosophical principles guiding its early development which are equally valid today as eight years ago, the present editorial focuses on philosophical but also more practical aspects of its operation and its role in the academic community together with an extensive clarification of their misunderstanding in decisions regarding submission of contributions. (shrink)

We present a temporal logic of branching time with four primitive operators: |$\exists {\mathcal {C}}$| – it may change whether; |$\forall {\mathcal {C}} $| – it must change whether; |$\exists \Box $| – it may be endlessly unchangeable that; and |$\forall \Box $| – it must be endlessly unchangeable that. Semantically, operator |$\forall {\mathcal {C}}$| expresses a change in the logical value of the given formula in every state that may be an immediate successor of the one considered, while |$\exists (...) {\mathcal {C}}$| expresses a change in the logical value of the given formula in some state that is a possible immediate successor. |$\forall {\mathcal {C}} $| and |$\exists {\mathcal {C}}$| are not normal operators, they are not mutually definable and have unusual properties: |$\forall {\mathcal {C}} A\leftrightarrow \forall {\mathcal {C}} \neg A$| and |$\exists {\mathcal {C}} A \leftrightarrow \exists {\mathcal {C}} \neg A$| are axioms. Operators |$\exists \Box $| and |$\forall \Box $| express endless unchangeability in some and all paths, respectively. Our axiomatization contains two infinitary rules that allow one to obtain |$\exists \Box A$| from infinitely many combinations of formulas with |$A, \neg, \forall {\mathcal {C}}, \land $|⁠, and to get |$\forall \Box A$| from infinitely many combinations of formulas with |$A, \neg, \exists {\mathcal {C}}, \land $|⁠. We show that our formalism is complete by presenting a bridge between our logic and logic |$\textsf {UB}$|⁠, which is a fragment of |$\textsf {CTL}$| in which until operators does not occur. (shrink)

This paper offers an analysis of metalinguistic comparatives such as more dumb than crazy in which they differ from ordinary comparatives in the scale on which they compare: ordinary comparatives use scales lexically determined by particular adjectives, but metalinguistic ones use a generally-available scale of imprecision or ‘pragmatic slack’. To implement this idea, I propose a novel compositional implementation of the Lasersohnian pragmatic-halos account of imprecision—one that represents clusters of similar meanings as Hamblin alternatives. In the theory that results, existential (...) closure over alternatives mediates between alternative-sets and meanings in which imprecision has been resolved. I then articulate a version of this theory in which the alternatives are not related meanings but rather related utterances, departing significantly from Lasersohn’s original conception. Although such a theory of imprecision is more clearly ‘metalinguistic’, the evidence for it from metalinguistic comparatives in English is surprisingly limited. The overall picture that emerges is one in which the grammatical distinction between ordinary and metalinguistic comparatives tracks the independently motivated distinction between vagueness and imprecision. (shrink)

In this paper, we focus on the development of geometric cognition. We argue that to understand how geometric cognition has been constituted, one must appreciate not only individual cognitive factors, such as phylogenetically ancient and ontogenetically early core cognitive systems, but also the social history of the spread and use of cognitive artifacts. In particular, we show that the development of Greek mathematics, enshrined in Euclid’s Elements, was driven by the use of two tightly intertwined cognitive artifacts: the use of (...) lettered diagrams; and the creation of linguistic formulae. Together, these artifacts formed the professional language of geometry. In this respect, the case of Greek geometry clearly shows that explanations of geometric reasoning have to go beyond the confines of methodological individualism to account for how the distributed practice of artifact use has stabilized over time. This practice, as we suggest, has also contributed heavily to the understanding of what mathematical proof is; classically, it has been assumed that proofs are not merely deductively correct but also remain invariant over various individuals sharing the same cognitive practice. Cognitive artifacts in Greek geometry constrained the repertoire of admissible inferential operations, which made these proofs inter-subjectively testable and compelling. By focusing on the cognitive operations on artifacts, we also stress that mental mechanisms that contribute to these operations are still poorly understood, in contrast to those mechanisms which drive symbolic logical inference. (shrink)

The ability of an agent to overcome limitations caused by complexity can be identified with intelligence. Yet, the study of complexity is dominated by the issues not really associated with authentic intelligence. In search of the methods to overcome limitations of complexity it is necessary to find a sufficiently general conceptual framework for its study, to identify its characteristics and sources, and then to explore alternatives to the currently used methods. The present paper is using for this purpose the conceptual (...) framework of information, its integration, and dynamics developed by the author in his earlier publications. Using this framework, complexity is characterized in both quantitative and qualitative ways, and in both static and dynamic perspectives. The main objective is to propose an approach to transcending limitations of complexity through reverse engineering of the effectiveness in overcoming complexity by natural, living organisms. Since the most striking characteristic of life is its hierarchic organization, the use of multi-level hierarchic information systems in information processing is explored. Theoretical design of such multi-level systems becomes possible with the use of generalized Turing machines as components performing concurrent computation on all levels of the hierarchy. (shrink)

We present the propositional logic LEC for the two epistemic modalities of current and stable knowledge used by an agent who system-atically enriches his language. A change in the linguistic resources of an agent as a result of certain cognitive processes is something that commonly happens. Our system is based on the logic LC intended to formalize the idea that the occurrence of changes induces the passage of time. Here, the primitive operator C read as: it changes that, defines the (...) temporal succession of states of the world. The notion of current knowledge concerns variable components of the world and it may change over time. We represent it by the primitive operator k read as: the agent currently knows that, and assume that it has S5 properties. The second type of knowledge, symbolized by the primitive operator K read as: the agent stably knows that, relates to constant components of the world and it does not change. As a result of the axiomatic entanglement of C, K and k we show that stable knowledge satisfies axioms of S4.3. K and k modalities are not mutually definable, stable knowledge implies the current one and if the latter never changes, then it comes to be stable. The combination of K and k with the idea of an expanding language allows questioning of the so-called perfect recall principle. It cannot be maintained for both types of knowledge just because of changes in the vocabulary of the agent and possibly the growing spectrum of possible states of the world. We interpret LEC in the semantics of histories of epistemic changes and show that it is complete. Finally, we compare our logic with selected epistemic logics based on the concept of linear discrete time. (shrink)

In this paper, we argue that several recent ‘wide’ perspectives on cognition (embodied, embedded, extended, enactive, and distributed) are only partially relevant to the study of cognition. While these wide accounts override traditional methodological individualism, the study of cognition has already progressed beyond these proposed perspectives towards building integrated explanations of the mechanisms involved, including not only internal submechanisms but also interactions with others, groups, cognitive artifacts, and their environment. The claim is substantiated with reference to recent developments in the (...) study of “mindreading” and debates on emotions. We claim that the current practice in cognitive (neuro)science has undergone, in effect, a silent mechanistic revolution, and has turned from initial binary oppositions and abstract proposals towards the integration of wide perspectives with the rest of the cognitive (neuro)sciences. (shrink)

The logic of change formulated by K. Świętorzecka, has its motivation coming from the Aristotelian theory of substantial change which is undrstood as a transformation consisting in the disappearing and becoming of individual substances. The transition: becoming/disapearing (and conversely) is expressed in by the primitive operator C, to be read: it changes that …, and it is mapped by the progressively expanding language. We are interested in attributive changes of individual substances. We consider a formalism with two non-normal and not (...) mutually definable operators of possible and necessary change, inspired by Aristotelian distinction of accidental and essential attributes. From we adopt the idea that temporal concepts are defined via change operators, and the idea of an expanding language. In what follows, We axiomatise our new logic and describe its semantics, giving the proof of its completeness. We compare our formalism with selected modal logics. (shrink)

We consider the notion of everyday language. We claim that everyday language is semantically bounded by the properties expressible in the existential fragment of second–order logic. Two arguments for this thesis are formulated. Firstly, we show that so–called Barwise's test of negation normality works properly only when assuming our main thesis. Secondly, we discuss the argument from practical computability for finite universes. Everyday language sentences are directly or indirectly verifiable. We show that in both cases they are bounded by second–order (...) existential properties. Moreover, there are known examples of everyday language sentences which are the most difficult in this class (NPTIME–complete). (shrink)

The Gram-negative outer membrane is a potent permeability barrier against antibiotics, limiting clinical options amid mounting rates of resistance. The Lol transport pathway delivers lipoproteins to the OM. All the OM assembly machines require one or more OM lipoprotein to function, making the Lol pathway central for all aspects of OM biogenesis. The Lol pathways of many medically important species clearly deviate from the Escherichia coli paradigm, perhaps with implications for efforts to develop novel antibiotics. Moreover, recent work reveals the (...) existence of an undiscovered alternate route for bringing lipoproteins to the OM. Here, lipoprotein transport mechanisms, and the quality control systems that underpin them, is re-examined in context of their diversity. All essential outer membrane assembly machines require lipoproteins to function. Hence, the transport mechanisms supplying these lipoproteins are critical for maintaining the integrity of the outer membrane barrier against antibiotics. Lipoprotein transport strategies of diverse Gram-negative bacteria will be reviewed in the context of recent discoveries. (shrink)

The use of an elaborate system of co-verbial constructions is the hallmark of the Hungarian language and one of the biggest challenges a translator or a learner of this language has to face. Co-verbial constructions consist of verbs, or their derivates, accompanied by a limited number of prefixes or particles that modify their meanings. They not only perform numerous syntactic and lexical functions, which is important in terms of language production, but also are able to change the meaning of the (...) verb completely. The aim of this study is to trace the cognitive motivation behind the use of Hungarian co-verbial constructions with össze/szét and to show that the meanings developed by these constructions can be organized with reference to prototypical scenes structured in the form of a radial category. (shrink)

The term “personhood” has a long history and is deeply rooted in the bioethical debate. Jennifer Blumenthal-Barby argues that bioethicists should abandon the concept of personhood, because “‘person...