Modeling metastasis in animal systems has been an important focus for developing cancer therapeutics. Xenopus laevis is a well‐established model, known for its use in identifying genetic mechanisms underlying diseases and disorders in humans. Prior literature has suggested that the drug, ivermectin, can be used in Xenopus to induce melanocytes to convert into a metastatic melanoma‐like state, and thus could be ideal for testing possible melanoma therapies in vivo. However, there are notable inconsistencies between ivermectin studies in Xenopus and the (...) application of ivermectin in mammalian systems, that are relevant to cancer and melanoma research. In this review, we examine the ivermectin‐induced phenotypes in Xenopus, and we explore the current uses of ivermectin in human research. We conclude that while ivermectin may be a useful drug for many biomedical purposes, it is not ideal to induce a metastatic melanocyte phenotype in Xenopus for testing the effects of potential melanoma therapeutics. (shrink)

Occupying a space in-between conventional scholarship and imaginative storytelling, The University in Crumbs: A Register of Things Seen and Heard is an experimental work that dramatizes the everyday life of the academy.

This article analyses a specific piece of computer code, the Linux operating system kernel, as an example of how technical operationality figures in contemporary culture. The analysis works at two levels. First of all, it attempts to account for the increasing visibility and significance of code or software-related events. Second, it seeks to extend familiar concepts of performativity to include cultural processes in which the creation of meaning is not central, and in which processes of circulation play a primary role. (...) The analysis concentrates on the practices and patterns of circulation of Linux through versions, distributions, clones and reconfigurations. It argues that technical ‘culture-objects’ such as Linux take on a social existence within contemporary technological cultures because of the authorizing contexts in which the reading, writing and execution of code occur. The ‘force’ or performance of certain technical objects, their operationality, can be understood more as the stabilized nexus of diverse social practices, rules and personae than as a formal property of the objects themselves. (shrink)

Plato's Socrates denies that he knows. Yet he frequently claims that he does have certainty and knowledge. How can he avoid contradiction between his general stance about knowledge and his particular claims to have it? Socrates' disavowal of knowledge is central to his defence in the Apology. For here he rebuts the accusation that he teaches – and thus corrupts – the young by telling the jury that he cannot teach just because he knows nothing. Hence his disavowal of knowledge (...) is important to Socrates. Why does he make this claim? And how then can he justify engaging in any philosophical activity at all? (shrink)

We are unlikely to stop seeking pleasure, as this would prejudice our health and well-being. Yet many psychoactive substances providing pleasure are outlawed as illicit recreational drugs, despite the fact that only some of them are addictive to some people. Efforts to redress their prohibition, or to reform legislation so that penalties are proportionate to harm have largely failed. Yet, if choices over seeking pleasure are ethical insofar as they avoid harm to oneself or others, public health strategies should foster (...) ethical choice by moving beyond current risk management practices embodied in the harm reduction movement. The neuroscience of pleasure has much to offer neuroethics and public health strategies. Distinguishing between ‘wanting’ and ‘liking’ fosters new understandings of addiction. These hold promise for directing the search for pharmacotherapies which prevent addiction and relapse or disrupt associated neuromechanisms. They could inform new research into creating lawful psychoactive substances which give us pleasure without provoking addiction. As the health and well being of human and other animals rests upon the experience of pleasure, this would be an ethical objective within public health strategy. Were ethical and neurobiological obstacles to ending addiction to be overcome, problems associated with excessive consumption, the lure of unlawful psychoactive substances and the paucity of lawful means to achieve pleasurable altered states would remain. Non-addictive designer drugs, which reliably provided lawful access to pleasures and altered states, would ameliorate these public health concerns insofar as they fostered citizens’ informed, ethical choices according to a neurobiological taxonomy of pleasures. (shrink)

Metaphysics is usually taken to be that part of analytical philosophy which offers an account of the most basic and persuasive concepts we use, an inventory and analysis of such fundamental structural features of our world as existence, substance, change and quality. But there is a revisionary as well as a descriptive metaphysics. Some philosophers and theologians have sought to reach beyond these familiar conceptual categories and to extend the scope of human understanding and language. What sort of an intellectual (...) enterprise would that be, and what sort of facts, truths or understanding could it yield? Professor MacKinnon devotes this book to a study of these questions - the nature and possibility of a revisionary metaphysics. (shrink)

Traditional memory strategy training interventions improve older adults’ performance on tests of episodic memory, but have limited transfer to episodic memory tasks, let alone to everyday memory. We argue that an alternative approach is needed to assist older adults to compensate for age-related cognitive declines and to maintain functional capacity in their own natural ecologies. We outline a set of principles regarding how interventions can successfully train older adults to increase successful goal pursuit to reduce risks of everyday memory failures. (...) We argue that training individuals to use metacognitive self-regulatory strategies to proactively manage formulation and pursuit of daily goals can compensate for age-related cognitive changes and increase the likelihood of goal attainment. We then describe an intervention approach that instantiates these principles in a multi-modal intervention that is unique in its three-phase approach: individualized assessment of an individual’s current approaches to self-regulation; training memory strategies, self-management skills, and new habits of mind in a group training context; and a behavioral shaping period in which individuals receive coaching and feedback on their efforts to use trained procedures to improve everyday cognition. A recently completed study conducted an initial test of the intervention, with highly encouraging results. We advocate further efforts to replicate, extend, and fine-tune this type of intervention. The ultimate goal is to be able to deliver the intervention in a way that increases its potential reach, including to subpopulations of older adults at risk for everyday cognitive impairments. (shrink)

ABSTRACTThis paper consists of a story about unorthodox assessment procedures in theology, and a discussion of their implications. Among the issues raised are the possibility of testing values, the relationship of test validity to test reliability and ethical questions involved in assessment.

Summary Peter Bowler's account of the biology and social views of E. W. MacBride is to be welcomed. He is correct in saying that the case of MacBride, who was both a Lamarckian and a Right-wing eugenist, ought to remind us that scientific theories bear no intrinsic, logically inherent, political implications. But it would be wholly mistaken to attribute the view that theories do contain such implications to the sociology of scientific knowledge. It is one that no consistent proponent of (...) the sociology of scientific knowledge can or does accept. As Bowler says, and as sociologists of scientific knowledge have long asserted, links between scientific theories and political positions are features of particular social circumstances. These connections can always, in principle, be broken or revised, and in practice they fairly frequently are. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The author discusses why the philosophy of the subject has been important\nto postmodernists. The author commences with a discussion on the\nintellectual background of postmodernism and its relations with other\nkinds of philosophy and with history. This paper concludes with a\ndiscussion about Michel Foucault's views on education and training\nand what impact this had on development of policy in New Zealand.

Contemporary complexity sciences claim a literal, non-metaphorical applicability to physical, economic, social and cultural events. They envision the development of a general social or historical physics. Conversely, in the social sciences and humanities, complexity sciences have been typically treated as a source of new metaphors or tropes to be used in theory-building. Can there be a critical social or historical physics that is not a world-view and that does not treat science as a source of metaphors? The Lorenz attractor figures (...) centrally in the history of complexity science as a popular image of ‘deterministic chaos’ and the ‘butterfly effect’, as an indication of how far complexity science has progressed in the last two decades, and, as this article argues, as an event whose multiplicity of interpretations attests to the problem it raises, the problem of generality associated with complexity. Via the Lorenz attractor, the article examines three attempts to treat complexity non-metaphorically in recent theoretical work. In these accounts, the attractor performs several different functions. It forms part of a re-engineered concept of multiplicity, it helps conceptualize feeling or sensitivity, and it raises the general problem of practice in theory-building. (shrink)

Extensively annotated, and including a biographical and critical Introduction to Hulme and his work, this is the first collected edition of the writings of the poet, critic, and philosopher T. E. Hulme.

This chapter contains section titled: “Imagining Oneself Otherwise”.

When our nearest and dearest experience medical crises, we may need to step into caregiving roles. But in doing so, we may find that our new caregiving relationship is actually in tension with the loving relationship that motivated us towards care. What we owe and are entitled to as friends, spouses, and family members, can be different from what we owe and are entitled to as caregivers. For this reason, caregiving carries with it the risk of a type of moral (...) distress that I call “role conflict distress.” Rather than view role conflict distress as a sign that we are falling short, I suggest that it actually speaks to the commitment that we have to the loving relationship that grounds our duty of care. (shrink)

Powered by ‘big health data’ and enormous gains in computing power, artificial intelligence and related technologies are already changing the healthcare landscape. Harnessing the potential of these technologies will necessitate partnerships between health institutions and commercial companies, particularly as it relates to sharing health data. The need for commercial companies to be trustworthy users of data has been argued to be critical to the success of this endeavour. I argue that this approach is mistaken. Our interactions with commercial companies need (...) not, and should not, be based on trust. Rather, they should be based on confidence. I begin by elucidating the differences between trust, reliability, and confidence, and argue that trust is not the appropriate attitude to adopt when it comes to sharing data with commercial companies. I argue that what we really should want is confidence in a system of data sharing. I then provide an outline of what a confidence-worthy system of data sharing with commercial companies might look like, and conclude with some remarks about the role of trust within this system. (shrink)

This is the first collected edition of the writings of the poet, critic, and philosopher T.E. Hulme (1883-1917). Hulme wrote some of the first "modernist" poems in English, helped introduce the philosophy of Henri Bergson to Britain and the U.S., and was one of the first English critics to write about modern art. This edition contains extensive notes to Hulme's writings, together with a substantial biographical and critical introduction.

Four studies tested the hypothesis that a weaker belief in free will would be related to feeling less gratitude. In Studies 1a and 1b, a trait measure of free will belief was positively correlated with a measure of dispositional gratitude. In Study 2, participants whose free will belief was weakened (vs. unchanged or bolstered) reported feeling less grateful for events in their past. Study 3 used a laboratory induction of gratitude. Participants with an experimentally reduced (vs. increased) belief in free (...) will reported feeling less grateful for the favor. In Study 4, a reduced (vs. increased) belief in free will led to less gratitude in a hypothetical favor scenario. This effect was serially mediated by perceiving the benefactor as having less free will and therefore as being less sincerely motivated. These findings suggest that belief in free will is an important part of being able to feel gratitude. (shrink)

The UK government has recently committed to adopting a new policy—dubbed ‘Martha’s Rule’—which has been characterised as providing patients the right to rapidly access a second clinical opinion in urgent or contested cases. Support for the rule emerged following the death of Martha Mills in 2021, after doctors failed to admit her to intensive care despite concerns raised by her parents. We argue that framing this issue in terms of patient rights is not productive, and should be avoided. Insofar as (...) the ultimate goal of Martha’s Rule is the provision of a clinical service that protects patient safety, an approach that focuses on the obligations of the health system—rather than the individual rights of patients—will better serve this goal. We outline an alternative approach that situates rapid clinical review as part of a suite of services aimed at enhancing and protecting patient care. This approach would make greater progress towards addressing the difficult systemic issues that Martha’s Rule does not, while also better engaging with the constraints of clinical practice. (shrink)

How can one ‘see’ the operationalization of contemporary visual culture, given the imperceptibility and apparent automation of so many processes and dimensions of visuality? Seeing – as a position from a singular mode of observation – has become problematic since many visual elements, techniques, and forms of observing are highly distributed through data practices of collection, analysis and prediction. Such practices are subtended by visual cultural techniques that are grounded in the development of image collections, image formatting and hardware design. (...) In this article, we analyze recent transformations in forms of prediction and data analytics associated with spectacular performances of computation. We analyze how transformations in the collection and accumulation of images as ensembles by platforms have a qualitative and material effect on the emergent sociotechnicality of platform ‘life’ and ‘perception’. Reconstructing the visual transformations that allow artificial intelligence assemblages to operate allows some sense of their heteronomous materiality and contingency. (shrink)

Philosophers have often understood self-knowledge's value in instrumentalist terms. Self-knowledge may be valuable as a means to moral self-improvement and self-satisfaction, while its absence can lead to viciousness and frustration. These explanations, while compelling, do not fully explain the value that many of us place in self-knowledge. Rather, we have a tendency to treat self-knowledge as its own end. In this article, I vindicate this tendency by identifying a moral reason that we have to value and seek self-knowledge that is (...) independent of the reason that we have to value the beneficial ends that it helps us achieve. I argue that we are in an inescapable relationship with ourselves that requires both self-love and self-respect. Self-love gives us a noninstrumental reason to know ourselves, while self-respect demands that we take this reason seriously. To pursue a project of self-discovery carefully and for its own sake, then, is part of what it is to stand in a loving and respectful relationship with ourselves. -/- . (shrink)

In our recent paper ‘Trust and the Goldacre Review: Why TREs are not about trust’1 we argue that trusted research environments (TREs) reduce the need for trust in the use and sharing of health data, and that referring to these data storage systems as ‘trusted’ raises a number of concerns. Recent replies to our paper have raised several objections to this argument. In this reply, we seek to build on the arguments presented in our original paper, address some of the (...) misunderstanding of our position expressed in these replies, and sketch out where further research is needed. One of the central arguments of our original paper was that the language we use to describe data-sharing initiatives matters, because the way things like TREs are presented and framed makes a difference to what people can, and should, expect from them. However, there is a more basic and obvious problem with referring to these institutions as ‘trusted’: it begs the question about whether these institutions are, in fact, trusted. We cannot know in advance of these initiatives being implemented, established, and appropriate assessments completed, whether they are actually trusted. Further questions abound: whom might TREs eventually be trusted by? If some people end up trusting them, but not others, is it appropriate to call them ‘trusted’? At best, this is simply a case of wishful thinking (and a more accurate name would be ‘hopefully-TREs’). More problematically, this may be an instance of ‘trustworthiness-signalling’: an attempt to convince others to trust, without meeting the requirements for genuine trustworthiness. By calling TREs ‘trusted’, the implication seems to be that placing our trust in them is perfectly fine: they are the kinds of things that are trusted by others and can safely be trusted by us. But not only does simply calling something ‘trusted’ …. (shrink)

In this paper, I defend the view that self-deception is a moral failure. Instead of saying that self-deception is bad because it undermines our moral character or leads to morally deleterious consequences, as has been argued by Butler, Kant, Smith, and others, I argue the distinctive badness of self-deception lies in the tragic relationship that it bears to our own values. On the one hand, self-deception is motivated by what we value. On the other hand, it prevents us from valuing (...) those things properly. I argue that we owe it ourselves to take seriously our own values, by striving to properly value them. This gives us both prudential and moral reasons to avoid self-deception. (shrink)

Plato and Aristotle both grant and deny the status of techne to farming. How can we resolve this apparent inconsistency? The answer is by construing techne as a folk concept and farming as a marginal member of this category: farming is a techne in the sense of a specialized, rational practice, but it is a non-central case of techne because it is tied to the land and involves work outdoors.

Jim Mackenzie; Because R. T. Allen says so, Journal of Philosophy of Education, Volume 22, Issue 1, 30 May 2006, Pages 107–113, https://doi.org/10.1111/j.1467-9.