Defining experiment was particularly vexed in the realm of anatomical dissection and vivisection. Was dissection merely descriptive, or something more? Harvey's discovery of the circulation of the blood and Aselli's discovery of the so-called lacteal veins shaped much anatomical research between the late 1620s and the 1650s. While the techniques of dissection and vivisection gained wide use, there was much debate on the validity of the circulation in particular, and its relationship to the lacteal veins. Critics, (...) particularly the French anatomist Jean Riolan, but also the natural philosopher Pierre Gassendi, focused on the lack of causation in Harvey's method and the lack of medical use and not on his use of vivisection. Jean Pecquet's discovery of the thoracic duct in 1651 changed the terms of the debate by definitively connecting the circulation with the lacteals. Riolan's critiques of Pecquet in the 1650s show profoundly differing notions of the purpose of dissection. While Gassendi eventually accepted Harvey's concept of the circulation, Riolan never did. (shrink)

A tree‐like hierarchical branching structure is present in many biological systems, such as the kidney, lung, mammary gland, and blood vessels. Most of these organs form through branching morphogenesis, where outward growth results in smaller and smaller branches. However, the blood vasculature is unique in that it exists as two trees (arterial and venous) connected at their tips. Obtaining this organization might therefore require unique developmental mechanisms. As reviewed here, recent data indicate that arterial trees often form in reverse order. (...) Accordingly, initial arterial endothelial cell differentiation occurs outside of arterial vessels. These pre‐artery cells then build trees by following a migratory path from smaller into larger arteries, a process guided by the forces imparted by blood flow. Thus, in comparison to other branched organs, arteries can obtain their structure through inward growth and coalescence. Here, new information on the underlying mechanisms is discussed, and how defects can lead to pathologies, such as hypoplastic arteries and arteriovenous malformations. -/- . (shrink)

ObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrated that RVO was accompanied by cerebral changes, and was related to stroke. The purpose of the study is to investigate synchronous neural activity changes in patients with RVO.MethodsA total of 50 patients with RVO and 48 healthy subjects (...) with matched sex, age, and education were enrolled in the study. The ReHo method was applied to investigate synchronous neural activity changes in patients with RVO.ResultsCompared with HC, patients with RVO showed increased ReHo values in the bilateral cerebellum_4_5. On the contrary, patients with RVO had decreased ReHo values in the bilateral middle occipital gyrus, right cerebelum_crus1, and right inferior temporal gyrus.ConclusionOur study demonstrated that patients with RVO were associated with abnormal synchronous neural activities in the cerebellum, middle occipital gyrus, and inferior temporal gyrus. These findings shed new insight into neural mechanisms of vision loss in patients with RVO. (shrink)

The growth of the vein system of the leaf ofTropaeolum peltophorum was studied (i) at the vein level (analysis of the growth kinetics and of the growth field of the 7 primary veins) and (ii) at the limb level (comparison of the growth of the veins).The vein growth kinetics depend on the position of the vein on the leaf: there is a proximal/distal gradient and a bilateral gradient of the growth parameters (=variation of the temporal organization of the (...) kinetics). The growth field of the veins (=local growth pattern) is also dependent on time and on vein position. (shrink)

The veins are cuticular structures that differentiate in precise patterns in insect wings. The genetic and molecular basis of vein pattern formation in Drosophila melanogaster is beginning to be unravelled with the identification and characterisation of the gene products that position the veins and direct their differentiation. Genes affecting the veins fall into two groups: transcriptional regulators that specify individual veins, and members of signalling pathways involved in patterning and differentiation of the veins. The elaboration (...) of the vein pattern is progressive in time and requires the coordinated activities of these signalling pathways and the transcription factors regulated by them. Although the network of genetic interactions that determine vein cell fate is well understood, very little is known about the cellular biology underlying the acquisition of vein histotype. BioEssays 25:443–451, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Volume 26, Issue 2, June 2019, Page 163-167.

In this essay, I explore Justus Buchler’s ordinal naturalism with the goal of establishing how his phenomenological approach extends the range of human inquiry to include the many and varied traits of natural phenomena that are not “simply” the result of sensate experience or material functions. To achieve this goal I critically assess Buchler’s notion of “ontological parity”–the idea that abstract phenomena such as values, relations, ideals, and other mental contents are just as relevant as sense-data when one attempts to (...) provide an adequate description of the world in naturalistic terms. I argue that certain phenomena, subsisting within what Buchler calls the “proceptive domain,” are legitimate objects of knowledge as they are par t of a larger domain of phenomenological analysis: nature more broadly and justly understood. It is my view that in the attempt to describe the natural world Buchler’s ordinal naturalism succeeds where other forms of naturalism fail because his form of naturalism offers a more capacious view of nature that attempts to describe whatever is in any way, not just focus on what is readily apparent to speci?c forms of observation that may privilege one domain of analysis over another. I draw the conclusion that because Buchler’s ordinal naturalism contains within it a working principle of ontological parity, his approach to nature ful?lls the criteria of the phenomenological method, and so I title his ordinal naturalism an ordinal phenomenology (Corrington 1992, 1-6, 9-14). Ultimately it is my aim to bring Buchler’s thought into closer connection with continental phenomenology, as well as to illustrate a more just and open understanding of nature through an analysis of his unique variety of philosophical naturalism. (shrink)

Abstract:Translating and commenting on two poems by Han Bo, “Modern Organ” and “The Big Killer,” that both focus on techno-scientific modernity and anxiety in the contemporary time and its impact on female subjectivity, this essay reflects on such an asymmetrically gendered burden of modern material progress to show that the embedded and added patriarchal obstacles, undeniably there, should be taken seriously. How, then, to achieve a more balanced gender equality in the modern time is a question that remains challenging for (...) all. (shrink)

Adenosine transport in cultured human umbilical vein endothelial cells (HUVEC) was characterized and shown to be mediated by a single facilitated diffusion mechanism. Initial rates of adenosine influx at 22 degrees C were saturable [apparent Michaelis constant, 69 +/- 10 mu M; maximum velocity (V-max), 600 +/- 70 pmol.10(6) cells(-1).s(-1)] and inhibited by nitrobenzylthioinosine (NBMPR). Formycin B had an unusually high affinity [inhibitory constant K-i), 18 +/- 4.3 mu M], whereas inosine had a low affinity (K-i, 440 +/- 68 mu (...) M) and nucleobases were without effect on adenosine influx. The number of transporters (1.2 x 10(6) sites/cell) was estimated by NBMPR equilibrium binding (apparent dissociation constant, 0.11 +/- 0.01 nM; maximum binding, 2.0 +/- 0.15 pmol/10(6) cells). In addition, we compared these endothelial cells with those obtained from cords from pregnancies complicated by diabetes (HUVEC-D), since embriopathy may occur in these conditions. HUVEC-D exhibited a 2.3-fold reduction in both the V-max for adenosine influx and the maximum number of NBMPR binding sites (260 +/- 40 pmol.10(6) cells(-1).s(-1) and 0.86 +/- 0.08 pmol/10(6) cells, respectively). However, the turnover number for each nucleoside transporter in normal and diabetic HUVEC was similar (approximate to 300 adenosine molecules/s). Adenosine metabolism at 10 mu M in HUVEC-D was modified compared with normal cells. Intracellular phosphorylation (> 90%) was the predominant pathway in normal HUVEC, whereas in HUVEC-D, substantial levels of adenine and adenosine were detected. The present results demonstrate therefore the downregulation of the NBMPR-sensitive nucleoside transporter and changes in adenosine metabolism in HUVEC from diabetic pregnancies. (shrink)

Journal Name: Apeiron Issue: Ahead of print.

Robot-assisted retinal cannulation is an eye surgical procedure which can dissolve the obstruction by using robot to inject anticoagulant into occluded vessel. The current research on the critical parameters of cannulation for human is scarce because of the immature technology. Considering the influence of microneedle, this work investigated the effects of drug concentration, injection velocity, injection position, and size of clot on cannulation by theoretical analysis and finite element analysis. For finite element analysis, the multiphysics continuum model was established to (...) demonstrate species transport and reaction which simulates the entire lytic process of the occlusive clot, and four cell zones were established to describe the generation of plasmin with the addition of tissue-type plasminogen activator and fibrinolysis of clot by importing subroutines into each cell zone under the conditions of constant clot size and variable size, respectively. The results imply that the most efficient value of tPA concentration is 50 nM, injection velocity is 60 mm/s for clot length of 0.1 mm, and the best position to insert the cannula is 0.5 mm in front of the thrombus. For different clot lengths of 0.1 mm to 0.6 mm, the optimal range of tPA concentration and injection velocity is from 20 nM to 70 nM and from 40 mm/s to 60 mm/s, respectively, and explores the reasonable injection position of 0.3 mm to 0.5 mm in front of clot in a vein of 100 μm. This conclusion can be used to perform robot-assisted cannulation surgery to improve fibrinolytic efficiency. (shrink)

Presenting a realistic interpretation of quantum mechanics and, in particular, a realistic view of quantum waves, this book defends, with one exception, ...

En este ensayo exploro cierta veta reduccionista del enfoque enactivo de Noë. Primero argumento que su concepción de nuestro encuentro perceptual con las propiedades intrínsecas de los objetos requiere una metafísica relacional revisionista para ser exitosa. Luego argumento que la propuesta de Noë sobre el rol de la percepción para el pensamiento espacial exige una concepción revisionista de nuestros conceptos espaciales cotidianos. Finalmente, sugiero que a la base de estas formas de revisionismo está una comprensión reduccionista de la egocentricidad perceptual (...) que debe abandonarse si queremos una concepción más substantiva de la percepción y su rol explicativo en el pensamiento. (shrink)

In this paper I will defend an approach to the thought experiment known as ‘Maxwell’s Demon’ based on a Maxwellian conception of statistical mechanics. Instead of assuming that thermodynamic descriptions depend reductively on the dynamics of molecular components, I will adopt a conception of thermophysics as a ‘resource theory’ in the Maxwellian line recently defended by Myrvold (2011) and Wallace (2017). From this interpretative stance, Maxwell’s demon would not lead directly to the plausibility of violating the second law of thermodynamics, (...) but to show the pragmatic impossibility of knowing deterministically the exact microscopic of thermal systems. (shrink)

Franciscan commitments -- Creation: a metaphysics of the particular -- Cognition, language, and reality -- Divine existence and perfections -- What is theology? -- Freedom and the will -- Moral goodness and beauty -- Practical wisdom and discernment -- Creation, incarnation, and divine desire.

El presente trabajo presenta la evolución del concepto de Estado dentro del pensamiento marxista durante el siglo veinte. A través de la metodología de Koselleck de la historia de los conceptos, se tienen en cuenta los cambios en la realidad político social para interpretar cuales fueron las transformaciones teóricas que sufrió el concepto Estado.

Ecofeminism, a new vein in feminist theory, critiques the ontology of domination, whereby living beings are reduced to the status of objects, which diminishes their moral significance, enabling their exploitation, abuse, and destruction. This article explores the possibility of an ecofeminist literary and cultural practice, whereby the text is not reduced to an "it" but rather recognized as a "thou," and where new modes of relationship-dialogue, conversation, and meditative attentiveness-are developed.

Soren Kierkegaard’s Lutheran existentialism represents a distinctively postmetaphysical philosophy of religion, focused in particular on a Christian vision of ethical authenticity. His philosophy continues to pose challenging questions for postmetaphysical philosophers in contemporary pluralistic settings. Focusing on specific works of Kierkegaard, this essay develops three such questions: (1) Can philosophy in a postmetaphysical vein still give advice for the pursuit of the good life, today’s diversity of life styles and values notwithstanding? (2) How can a postmetaphysical philosophy relate to the (...) ethical teachings and truth claims of religious doctrines? (3) Is postmetaphysical philosophy still capable of an “upbuilding and awakening” discourse that can induce and stabilize an ethical self-consciousness? (shrink)

In the vein of Peirce’s communication philosophy, language communication inevitably suffers from its vagueness and uncertainty. Paradoxically, what enables this vagueness and uncertainty to be solved, and the condition of communication to be sufficiently met, is not language itself, but “collateral experience” communicators may weave, exchange, and share in communication. Collateral experience is forceful in penetrating the “universe,” in which communicators may be engaged, and in helping them in the wake of communication to acquire knowledge current in the community. Consequently, (...) generality for a communicative act becomes established as the final goal of communication. Generality overcomes the vagueness and uncertainty arising from local and partial contingencies of context, and transcends beyond it. Due to communication, people become capable of finally resolving puzzlement, and of establishing their beliefs, with a guidance for their action. (shrink)

In The Contemplative Foundations of Classical Daoism, Harold D. Roth explores the origins and nature of the Daoist tradition, arguing that its creators and innovators were not abstract philosophers but, rather, mystics engaged in self-exploration and self-cultivation, which in turn provided the insights embodied in such famed works as the Daodejing and Zhuangzi. In this compilation of essays and chapters representing nearly thirty years of scholarship, Roth examines the historical and intellectual origins of Daoism and demonstrates how this distinctive philosophy (...) emerged directly from practices that were essentially contemplative in nature. In the first part of the book, Roth applies text-critical methods to derive the hidden contemplative dimensions of classical Daoism. In the second part, he applies a "contemplative hermeneutic" to explore the relationship between contemplative practices and classical Daoist philosophy and, in so doing, brings early Daoist writings into conversation with contemporary contemplative studies. To this he adds an introduction in which he reflects on the arc and influence on the field of early Chinese thought of this rich vein of scholarship and an afterword in which he applies both interpretive methods to the vexing question of the authorship of the Inner Chapters of the Zhuangzi. The Contemplative Foundations of Classical Daoism brings to fruition the cumulative investigations and observations of a leading figure in the emerging field of contemplative studies as they pertain to a core component of early Chinese thought. (shrink)

One of the most talked-about scholarly works of the past fifty years, Judith Butler’s _Gender Trouble_ is as celebrated as it is controversial. Arguing that traditional feminism is wrong to look to a natural, 'essential' notion of the female, or indeed of sex or gender, Butler starts by questioning the category 'woman' and continues in this vein with examinations of 'the masculine' and 'the feminine'. Best known however, but also most often misinterpreted, is Butler's concept of gender as a reiterated (...) social _performance _rather than the expression of a prior reality. Thrilling and provocative, few other academic works have roused passions to the same extent. (shrink)

Recent work on mood choice considers fine-grained semantic differences among desire predicates (notably, ‘want’ and ‘hope’) and their consequences for the distribution of indicative and subjunctive complement clauses. In that vein, this paper takes a close look at ‘intend’. I show that cross-linguistically, ‘intend’ accepts nonfinite and subjunctive complements and rejects indicative complements. This fact poses difficulties for recent approaches to mood choice. Toward a solution, a broad aim of this paper is to argue that—while ‘intend’ is loosely in the (...) family of desire predicates—it differs from ‘want’ and ‘hope’ in that it has a causative component, and this is relevant to its mood choice behavior, given that causative predicates also systematically reject indicative complements. More concretely, my analysis has three ingredients: (i) following related proposals in philosophy, intention reports have causally self-referential content; (ii) encoding causal self-reference requires abstraction over the complement clause’s eventuality argument; and (iii) nonfinite and subjunctive clauses enable such abstraction but indicative clauses do not. Aside from causative predicates, independent support for the proposal comes from the syntax of belief-/intention-hybrid attitude predicates like ‘decide’ and ‘convince’, anankastic conditional antecedents, aspectual predicates, and memory and perception reports. Synthesizing this result with that of previous literature, the emergent generalization is that subjunctive mood occurs in attitude reports that involve either comparison or eventuality abstraction. Toward a unified theory of mood choice, I suggest that both comparison and eventuality abstraction represent departures from the clausal semantics of unembedded assertions and consequently that subjunctive mood signals such a departure. (shrink)

One of the most talked-about scholarly works of the past fifty years, Judith Butler’s _Gender Trouble_ is as celebrated as it is controversial. Arguing that traditional feminism is wrong to look to a natural, 'essential' notion of the female, or indeed of sex or gender, Butler starts by questioning the category 'woman' and continues in this vein with examinations of 'the masculine' and 'the feminine'. Best known however, but also most often misinterpreted, is Butler's concept of gender as a reiterated (...) social _performance _rather than the expression of a prior reality. Thrilling and provocative, few other academic works have roused passions to the same extent. (shrink)

In contrast to previous conceptualizations of episodic self-esteem as a cognitive assessment of one’s own self, recent proposals have categorized this phenomenon as an affective state. In this vein, self-esteem has been regarded as a self-conscious emotion (Salice 2020) and an existential feeling (Bortolan 2018, 2020). While concurring with these recent accounts on the affective nature of self-esteem, this chapter also argues that none of them fully captures its nature. It argues that self-esteem is better understood as an umbrella term (...) for a group of intentional feelings in which the subject valuates herself and senses fluctuations in her own value. The chapter also discusses the place of self-esteem feelings within the affective mind. (shrink)

Jenkins has observed that “The impression has begun to get about that the Industrial Revolution is not going to work out after all.” In light of the profound malaise of blue and white collar workers, the decline of output per worker since 1973, and increasing signs of a pervasive anti-union sentiment complementing anti-management restiveness, Jenkins' remark does not seem so shocking. The 1973 Health, Education and Welfare report, Work In America, remarked, in a similar vein, that “absenteeism, wildcat strikes, turnover, (...) and industrial sabotage (have) become an increasingly significant part of the cost of doing business.” The location of this quote from the HEW report in the section tided, “The Anachronism of Taylorism” is suggestive. (shrink)

Current debates about the replication crisis in psychology take it for granted that direct replication is valuable and focus their attention on questionable research practices in regard to statistical analyses. This paper takes a broader look at the notion of replication as such. It is argued that all experimentation/replication involves individuation judgments and that research in experimental psychology frequently turns on probing the adequacy of such judgments. In this vein, I highlight the ubiquity of conceptual and material questions in research, (...) and I argue that replication is not as central to psychological research as it is sometimes taken to be. (shrink)

In the vein of a renewed interest in diagrammatic reasoning, this paper challenges an opposition between logic diagrams and formal languages that has traditionally been the common view in philosophy of logic and linguistics. We examine, from a philosophical point of view, what we call five dogmas of logic diagrams. These are as follows: (1) diagrams are non-linguistic; (2) diagrams are visual representations; (3) diagrams are iconic, and not symbolic; (4) diagrams are non-linear; (5) diagrams are heterogenous, and not homogenous. (...) Using historical examples, we argue that none of these dogmas is an adequate criterion to distinguish logic diagrams from formal languages. Instead, we advocate that there is a common core between linguistic and diagrammatic representation and reasoning. (shrink)