For five individuals, a social network was constructed from a series of his or her dreams. Three important network measures were calculated for each network: transitivity, assortativity, and giant component proportion. These were monotonically related; over the five networks as transitivity increased, assortativity increased and giant component proportion decreased. The relations indicate that characters appear in dreams systematically. Systematicity likely arises from the dreamer's memory of people and their relations, which is from the dreamer's cognitive social (...) network. But the dream social network is not a copy of the cognitive social network. Waking life social networks tend to have positive assortativity; that is, people tend to be connected to others with similar connectivity. Instead, in our sample of dream social networks assortativity is more often negative or near 0, as in online social networks. We show that if characters appear via a random walk, negative assortativity can result, particularly if the random walk is biased as suggested by remote associations. (shrink)

The recent scholarly promotion of Pierre Gassendi to a key position in the formative modern period raises doubts about the portrayal of Descartes as “the father” of the post-Scholastic philosophical conceptualization. I defend the Cartesio-centric account against Thomas M. Lennon’s elliptical alternative. The defense necessitates a reassessment of the root nature of Descartes’s contribution—specifically of the interplay between philosophy and science, the latter being the crucial extraphilosophical component of the new practico-cognitive ensemble. This raises questions about the “philosophically” of (...) Descartes’s activity, and with that questions about the quality of modernity. By way of explaining Gassendis nonoriginative position, his attitude toward the post-Scholastic Humanist thought that Descartes simply repudiated is examined. (shrink)

In 1988, David Hull presented an evolutionary account of science. This was a direct analogy to evolutionary accounts of biological adaptation, and part of a generalized view of Darwinian selection accounts that he based upon the Universal Darwinism of Richard Dawkins. Criticisms of this view were made by, among others, Kim Sterelny, which led to it gaining only limited acceptance. Some of these criticisms are, I will argue, no longer valid in the light of developments in the formal modeling of (...) evolution, in particular that of Sergey Gavrilets’ work on adaptive landscapes. If we can usefully recast the Hullian view of science as being driven by selection in terms of Gavrilets’ and Kaufmann’s view of there being “giant components” of high-fitness networks through any realistic adaptive landscape, we may now find it useful to ask what the adaptive pressures on science are, and to extend the metaphor into a full analogy. This is in effect to reconcile the Fisherianism of the Dawkins–Hull approach to selection and replicators, with a Wrightean drift account of social constructionist views of science, preserving, it is to be hoped, the valuable aspects of both. (shrink)

This work analyzes and characterizes the spread of the COVID-19 disease in Mexico, using complex networks and optimization approaches. Specifically, we present two methodologies based on the principle of the rupture for the GC and Newton's law of motion to quantify the robustness and identify the Mexican municipalities whose population causes a fast spread of the SARS-CoV-2 virus. Specifically, the first methodology is based on several characteristics of the original version of the Vertex Separator Problem, and the second is based (...) on a new mathematical model. By solving VSP, we can find nodes that cause the rupture of the giant component. On the other hand, solving the NLM can find more influential nodes for the entire system’s development. Specifically, we present an analysis using a coupled social network model with information about the main characteristics of the contagion and deaths caused by COVID-19 in Mexico for 19 months. This work aims to show through the approach of complex networks how the spread of the disease behaves, and, thus, researchers from other areas can delve into the characteristics that cause this behavior. (shrink)

Silicon Valley is both object of intense fascination and stark criticism. Academic observers have described it as a unique amalgamation of hippie culture, libertarian thinking, wild experimentation, but also scientific rigor, high-tech precision, and turbo-capitalism – a seemingly improbable, even paradoxical combination. Nevertheless, Silicon Valley continues to be an economic powerhouse and a global innovation hub. The current study explores its socio-cultural and ideological foundations through the lens of an insider perspective to find explanations for its stability and sustained success (...) in light of conflicting components. Based on 15 interviews with Silicon Valley experts from start-ups, tech giants, and academic institutions, the study identifies several paradoxes on the level of ideology and environment, structure(s), and actors. These can be grouped into a binary, oppositional view, indeed describing the Silicon Valley paradox. However, alternative explanations are given, including the conceptualization as a non-dualist phenomenon. (shrink)

Needs of our country in the «Ukrainian national idea – XXI » is increasing; the possibility of its creation is doubted even by our former presidents. Fortunately, progress in the last 20 years, the exact sciences created an opportunity for us to put in its basis not myths and lies of the enemy, but proven facts. The author offers scientifical UNI-XXI project, based on the noohistory and the noosciences, as a combination of new discoveries with better cultural heritage and directed (...) to the future, not the past. Achievements of geneticists, physicists and other scientists in the recovery story of agriculture and animal husbandry are highlighted. It is proved that Ukrainians are direct descendants of those who created productive agriculture in the Middle East. By choosing place on the black soil for the Motherland and combined with hunter-Aryans, formed Trypillians. They are the only in the world who domesticated horse, invented the wheeled transport, organized by the Big Trypillia giant space through a combination of copper mines Kargaly, «country towns» and other agricultural areas. Two thousand years protoindoevropean language had been increased, cultural and economic unity suddenly was interrupted by «volcanic winter». This was the impetus for the famous Aryan migrations with many linguistic and cultural consequences. The author proposes to build future component for UNI-XXI based on the development of education and scientific discoveries of recent years, which will make free and publicly solar photovoltaics and «family» production on natural substances for 3D-printers. (shrink)

The German scholar Dieter Schuh is one of the contemporary giants of Tibetan studies. His seminal and ground-breaking work Untersuchungen zur Geschichte der tibetischen Kalenderrechnung, published in 1973, has made a lasting contribution to the field of Tibetan astronomical and historical research, clarifying the essence and calculation bases of Indo-Tibetan astronomy in Tibet (skar rtsis). Further, he has pioneered such new fields in Tibetology as sino-tibetan astrology (nag rtsis), manuscripts and xylographs, historical documents, the diplomatic history between Tibet and Mongolia, (...) law, demography, research into Western Tibet, etc. In this work, I attempt to show the integral components of his scholarship on Indo-Tibetan astronomy by means of presenting the structure and outline of his works. Because I focus on showing the main ideas and contents according to his line of thinking in each work, readers may benefit from easily spotting parts they are interested in. Thereby, this work may serve as a guideline for further research into the details of each work. The amount I assign to each work may vary in accordance with the gravity and importance I subjectively assume. Lastly, the aim of this work is simple: numerous quality non-English writings are not easily used simply because they were not written in English. The depth and breadth of the time-honored German tibetology based on high-level philology has been a great source of inspiration to Tibetan scholars in the world. As a part of bridging the gap between English and non-English scholarship, this work, which introduces Dieter Schuh’s research into Indo-Tibetan astronomy, may be helpful to enrich and foster future research, being another source of inspiration. (shrink)

Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and neoplastic overgrowth of tissues. The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but (...) there is some evidence that epithelial polarisation is required for this regulation. Dlg, Scrib and Lgl are highly conserved between human and Drosophila, and we discuss evidence that these proteins also play a role in cancer progression in humans. BioEssays 25:542–553, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Antonio Gramsci is one of those philosophers, like Socrates, whose philosophizing consists in the critical examination of particular practical problems in terms of certain fundamental concepts. To Socrates' well known moral problems correspond Gramsci's concern with such things as improving the condition of subaltern classes, the interaction between intellectual elites and popular masses, the democratic operation of a political party, the viability of alternative models of revolution which differ from Bolshevism, and the religious component of political activity and political (...) aspects of religions. And to the Socratic concepts that are so familiar to philosophers correspond Gramsci's notions of hegemony, passive revolution, the modern "Prince," philosophy of praxis, integral journalism, Americanism and Fordism, the national-popular, Jacobinism, and folklore. Thus the proper philosophical appreciation of Gramsci has to overcome the widespread equation of philosophy with system, as well as two more external obstacles: the Franco-German hegemony over "continental philosophy" has the effect of relegating this Italian giant to the status of an unavoidably minor, however quaint, figure; and Gramsci's personal involvement with the political fortunes and misfortunes of the Italian Communist Party leads many philosophers to dismiss him as being merely a political leader. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Beyond Personal Identity: Dōgen, Nishida, and a Phenomenology of No-SelfSteven HeineGereon Kopf. Beyond Personal Identity: Dōgen, Nishida, and a Phenomenology of No-Self. Richmond, Surrey, UK: Curzon Press, 2001. Pp. xx + 298.Beyond Personal Identity by Gereon Kopf is in many ways a brilliant work of comparative philosophy that does an outstanding job in taking on the challenge of relating the complex thought of Japanese giants Dōgen and Nishida (...) to various Western conceptions of the person. Kopf succeeds in developing his own philosophical approach to the main issues of nonduality and present-oriented self-awareness, while staying true to the respective thinkers involved in the examination. He is clearly bucking recent trends in the field of Buddhist studies that have emphasized increasingly social-historical methods, but has pulled off a major coup by adhering to his vision of the role of scholarship. Along with Dan Lusthaus' Buddhist Phenomenology: A Philosophical Investigation of Yogacara Buddhism and the Ch'eng Wei-Shih Lun (Curzon, 2003), which deconstructs the issue of idealism, this work goes a along way toward rehabilitating philosophical approaches to Buddhist doctrine by analyzing text as text rather than trying to relate-and in some cases reduce-text to a reflection or expression of its reconstructed context. At the same time, Kopf's work, understandably as it is his first book, has some basic limitations, which I will address with constructive criticism.The main value of this book is that it takes the reader on a fascinating journey through a wide variety of Western and Buddhist notions of what constitutes the person and the person's relation to the world. Kopf's "theory of personal identity investigates three central questions: How is it possible to identify a person (myself and others) as an individual human being? How is it possible to distinguish between two individual persons? What guarantees the constancy and identity of an individual person over time?" (p. 7). Chapter 1 is primarily dedicated to critiquing Western notions that have substantialist implications, either deliberately and directly or indirectly in an embedded fashion by favoring an essentialist view that personal identity persists over time. Here Kopf demonstrates a mastery of contemporary philosophical materials and of how to examine them critically.The four chapters in part 2 of the book simultaneously unveil Kopf's theory of the tripartite structure of the person-selfhood, otherness, and continuity-and the reasons why he considers that Dōgen and Nishida overcome the flaws and lacunae in Western views of a false sense of constancy. The reason for the fourth chapter (chapter 5) is that Kopf goes into more depth on the third part of the structure, that is, the matter of how the person seems to maintain its identity over a prolonged period, by dividing this into the issues of "continuity of experience" and "temporality." In each chapter, he makes it clear how Dōgen and Nishida appropriate the basic Buddhist doctrines of no-self, dependent origination, and impermanence in formulating their unique perspectives. He convincingly shows that Dōgen's notion of [End Page 569] the dharma-stage (jū-hōi) as articulated in the "Genjōkōan" and Nishida's notion of the discontinuity of continuity stake out the distinctive Zen view. According to Kopf, "the Zen Buddhist notion of immediate now and non-relative present should not be mistaken for a merely atemporal oneness, which melts all individual time-moments into an undifferentiated oneness, but rather as the dialectic of linear temporality and mystical atemporality" (p. 198).In part 3 Kopf fleshes out the meaning of the Zen phenomenology of temporal existence as the central component of a philosophy of personal identity-or, rather, of transpersonal nonessentialist experience-by providing a highly original interpretation of Dōgen's doctrines of the "presencing" (genjō) of "total-working" (zenki) in light of Nishida's paradox or self-contradictory identity of "walking eastward by walking westward." He concludes with a stimulating comparison of Derek Parfit's survivalist philosophy, which represents a Western approach to present-oriented experience, with the Zen view that "the experiential 'I' discovers in its process of self-awakening that it does not... (shrink)

The essay is a comparative look at Descartes' and Pascal's epistemology. For so vast a topic, I shall confine myself to comparing three crucial epistemological topics, through which I hope to evince Descartes' and Pascal's differences and points of contact. Firstly, I will concentrate on the philosophers' engagement with skepticism, which, for each, had different functions and motivations. Secondly, the thinkers' relation to Reason shall be examined, since it is the fulcrum of their thought—and the main aspect that separates them. (...) Lastly, I will examine each philosopher's theist epistemology; this section, of course, will focus on how and by what means Descartes and Pascal set out to prove God's existence. The latter aspect shall take us back to each philosopher's relationship to Doubt: the title, " The Giants of Doubt ", in fact, implies a fundamental link between Descartes and Pascal through Doubt. In addition, and most importantly, the contrast between the two thinkers' epistemology inaugurates a decisive scission in modern thought of enormous repercussion: Descartes' sturdy rationalism initiated the great branch of modern scientific inquiry , while Pascal's appeal to the power of intuition and feelings would eventually be the precursor of the reaction to the enlightenment that invested Europe by the second half of the eighteenth century. This departure of thought, which in my view may be traced back to them, has not been the common conceit of the history of philosophy: the reaction to the enlightenment has customarily been regarded as stemming from its internal contradictions or at best from its more radical doctrines. The essay shall show that these strands of thought were both parallel and born out of the antithetical epistemologies of Descartes and Pascal. (shrink)

We have investigated the nonlinear low-frequency microwave absorption of an ensemble of small metallic grains. Earlier Zhou et al. [Phys. Rev. Lett. 77, 1958 (1996)] have proved that linear absorption by such a system is due to a mesoscopic relaxation mechanism for which important contribution is from the grains with small level spacings between the ground state and the first excited state. Here we have shown further that such grains are anomalously sensitive to the field amplitude and the distribution of (...) level spacings. Since such a behavior depends on external magnetic field, we expect the appearance of a giant nonlinear magnetoresistance, as well as a very strong temperature dependence of the nonlinear microwave conductivity. (shrink)

_ Source: _Volume 30, Issue 2, pp 223 - 235 Scholarship on _Leviathan_ has not fully explored the distinctive pattern of language that Hobbes used to invoke the central conceit of the treatise—“that great LEVIATHAN called a COMMONWEALTH.” This note highlights an earlier instance of that rare linguistic construction, one that presented a similar image of political monstrosity several years before Hobbes’s metaphor was published. _Verses in Honour of the Reverend and Learned Judge of the Law, Judge Jenkin_ celebrated the (...) jurist David Jenkins as a royalist martyr in the fight against “That Giant monster call’d a multitude.” It is possible that the pamphlet might have circulated among the network of English exiles in France, offering Hobbes a linguistic model with which to reconceptualize the early modern understanding of political community. (shrink)

The story of David and Goliath is one of the most famous biblical stories. It had an impact on many branches of contemporary art. It is also an inevitable part of religious education and general education in all schools. Knowing the fact that the Church Fathers have an essential part in the lives of many Christians today (in the Orthodox Church, they were role models from the very beginning), it is interesting to see how did they, these original theologians, read (...) and interpret the story of David and Goliath. Was it for them, in the time when the Bible was the most sacred book for all, important as it is for us today? Did people during the sports events of that time talk on the markets about the underdog who struck the giant? Additionally, if one looks at the ancient Greek and Hebrew text, one will find out that the Hebrew version, which was used as the source for most modern translations, is 40% longer than the Greek one. Could the works of the Fathers help us to determine which version of the story is the Holy Scripture for Christians today? (shrink)

Microfluidic technology – the manipulation of fluids at micrometer scales – has revolutionized many areas of synthetic biology. The bottom‐up synthesis of “minimal” cell models has traditionally suffered from poor control of assembly conditions. Giant unilamellar vesicles (GUVs) are good models of living cells on account of their size and unilamellar membrane structure. In recent years, a number of microfluidic approaches for constructing GUVs has emerged. These provide control over traditionally elusive parameters of vesicular structure, such as size, lamellarity, (...) membrane composition, and internal contents. They also address sophisticated cellular functions such as division and protein synthesis. Microfluidic techniques for GUV synthesis can broadly be categorized as continuous‐flow based approaches and droplet‐based approaches. This review presents the state‐of‐the‐art of microfluidic technology, a robust platform for recapitulating complex cellular structure and function in synthetic models of biological cells. (shrink)

Giant bones unearthed throughout the Mesoamerican countryside provoked early modern thinkers to grapple with the earth’s ages, partially syncretizing Nahua histories of human conquest with Spanish colonial medicinal and natural historical knowledge. European naturalists’ willingness to accept the giant remains required them to embrace localized Mesoamerican cosmologies. The fossilized landscape provided evidence that conquest and eradication had happened before at the hands of the peoples whom the Spaniards had conquered in turn. Lost from early modern collections and failing (...) to translate far beyond New Spain during the sixteenth century, the giant remains highlight the possibilities and challenges of integrating Mesoamerican knowledge into the global history of science, with an emphasis on emplaced thinking, medicine and the body, and deeper temporal frameworks. Moving beyond itinerary histories to globalizing cosmologies in the history of science can better explain the compromises Europeans and Mesoamericans were required to make to enter into a syncretic intellectual contract, as well as the non-European concept of time that came with local reckonings with the human and more-than-human natural world. (shrink)

The fitness of a eukaryote hinges on the coordinated function of the products of its nuclear and mitochondrial genomes in achieving oxidative phosphorylation. I propose that sexual selection plays a key role in the maintenance of mitonuclear coadaptation across generations because it enables pre-zygotic sorting for coadapted mitonuclear genotypes. At each new generation, sexual reproduction creates new combinations of nuclear and mitochondrial genes, and the potential arises for mitonuclear incompatibilities and reduced fitness. In reviewing the literature, I hypothesize that individuals (...) engaged in mate choice select partners with correct species-typical mitochondrial and nuclear genotypes as well as individuals with highly functional cellular respiration. The implication is that mate choice for compatible nuclear and mitochondrial genes can play a significant role in generating the patterns of ornamentation and preferences observed in animals. A number of testable predictions emerge from this mitonuclear compatibility hypothesis of sexual selection. Products of mitochondrial and nuclear genes co-function to enable cellular respiration, so it is critical that compatible mitochondrial and nuclear genes be matched each generation. I propose that a core function of mate choice is selection for mitochondrial and nuclear genes that create compatible and functional combinations in offspring. (shrink)

Athenaeus preserves an intriguing description by the otherwise unknown writerMoschion of a giant grain-ship, the Syracusia, built by Hiero II of Syracuse in thelater third century B.C.1 The account is extremely circumstantial. Besides a fulldescription of the ship's layout, Moschion gives such details as the name of thearchitect , the size of the construction-force , the construction time , details of the launching arrangements devised byArchimedes, and even the procedure for judging crimes committed on board.

Athenaeus preserves an intriguing description by the otherwise unknown writerMoschion of a giant grain-ship, the Syracusia, built by Hiero II of Syracuse in thelater third century B.C.1 The account is extremely circumstantial. Besides a fulldescription of the ship's layout, Moschion gives such details as the name of thearchitect, the size of the construction-force, the construction time, details of the launching arrangements devised byArchimedes, and even the procedure for judging crimes committed on board.

Marcel Proust’s In Search of Lost Time, raises an interesting philosophical issue, namely, how can one be in touch with past things if they no longer exist? It provides us with a way to address this issue by outlining an ontological view according to which past things still exist within a four-dimensional world. Although one cannot be in touch with past things by means of ordinary perception, one can do so by combining perception and memory. In this sense, In Search (...) of Lost Time helps us to reconcile a four-dimensionalist ontology according to which things have both spatial and temporal parts with a realist phenomenology according to which experience gives us access to things as they are. In so doing, Proust’s masterpiece allows us to shed some light on what it means for a subject of experience to exist in a four-dimensional world. (shrink)

Volume 20, Issue 8, August 2020, Page 67-69.

The general notion of relative freedom is introduced. It is a kind of freedom that is observed everywhere in nature. In biology, incomplete knowledge is defined for all organisms. They cope with the problem by Popper’s trial-and-error processes. One source of their success is the relative freedom of choice from the basic option ranges: mutations, motions and neuron connections. After the conjecture is adopted that communicability can be used as a criterion of consciousness, free will is defined as a conscious (...) version of relative freedom. The resulting notion is logically self-consistent and it describes an observable phenomenon that agrees with our experience. (shrink)

Wakefield’s harmful dysfunction analysis asserts that the concept of medical disorder includes a naturalistic component of dysfunction and a value component, both of which are required for disorder attributions. Muckler and Taylor, defending a purely naturalist, value-free understanding of disorder, argue that harm is not necessary for disorder. They provide three examples of dysfunctions that, they claim, are considered disorders but are entirely harmless: mild mononucleosis, cowpox that prevents smallpox, and minor perceptual deficits. They also reject the proposal (...) that dysfunctions need only be typically harmful to qualify as disorders. We argue that the proposed counterexamples are, in fact, considered harmful; thus, they fail to disconfirm the harm requirement: incapacity for exertion is inherently harmful, whether or not exertion occurs, cowpox is directly harmful irrespective of indirect benefits, and colorblindness and anosmia are considered harmful by those who consider them disorders. We also defend the typicality qualifier as viably addressing some apparently harmless disorders and argue that a dysfunction’s harmfulness is best understood in dispositional terms. (shrink)

When do two sentences say the same thing, that is, express the same content? We defend two-component (2C) semantics: the view that propositional contents comprise (at least) two irreducibly distinct constituents, (1) truth-conditions, and (2) subject-matter. We contrast 2C with one-component (1C) semantics, focusing on the view that subject-matter is reducible to truth- conditions. We identify exponents of this view and argue in favor of 2C. An appendix proposes a general formal template for propositional 2C semantics.

On the Shoulders of Giants collects previously unpublished essays from the last fifteen years of Umberto Eco's life. With humor and erudition, one of the great contemporary thinkers takes on the roots of Western culture, the origin of language, the nature of beauty and ugliness, the imperfections of art, and the lure of mysteries.

In ‘Rethinking Disease’, Powell and Scarffe1 propose what in effect is a modification of Jerome Wakefield’s2 3 harmful dysfunction analysis of medical disorder. The HDA maintains that ‘disorder’ is a hybrid factual and value concept requiring that a biological dysfunction, understood as a failure of some feature to perform a naturally selected function, causes harm to the individual as evaluated by social values. Powell and Scarffe accept both the HDA’s evolutionary biological function component and its incorporation of a value (...) component. Their proposed ‘new twist’ is to revise the value component: ‘Our proposed definition of disease is as follows: a biomedical state is a disease only if it implicates a biological dysfunction that is, or would be, properly disvalued’. So, they propose that a disorder is a ‘properly disvalued dysfunction’ rather than a ‘harmful dysfunction’, an approach they term ‘thickly normative’ in contrast to the thin normative approach of the HDA. There has been a surge of interest recently in better understanding the ‘harm’ component of the HDA. Powell and Scarffe’s analysis is a helpful contribution to this discussion. We focus here exclusively on their proposal regarding the analysis of the concept of disorder and ignore many important related issues that the authors address, ranging from prioritising resource allocation between disorders and non-disorders to whether the concept of disorder should be replaced by a generic welfarist concept. The resolution of these additional issues depends on first understanding ‘disorder’. The authors’ proposed changes to the HDA also deserve evaluation because the HDA, which has been endorsed by leading nosologists,4 plays an influential role in nosological debate across categories of disorder ranging, for example, from sexual paraphilias5 to psychopathy.6 A basic problem is that Powell and Scarffe misinterpret …. (shrink)

This paper discusses three relevant logics that obey Component Homogeneity - a principle that Goddard and Routley introduce in their project of a logic of significance. The paper establishes two main results. First, it establishes a general characterization result for two families of logic that obey Component Homogeneity - that is, we provide a set of necessary and sufficient conditions for their consequence relations. From this, we derive characterization results for S*fde, dS*fde, crossS*fde. Second, the paper establishes complete (...) sequent calculi for S*fde, dS*fde, crossS*fde. Among the other accomplishments of the paper, we generalize the semantics from Bochvar, Hallden, Deutsch and Daniels, we provide a general recipe to define containment logics, we explore the single-premise/single-conclusion fragment of S*fde, dS*fde, crossS*fdeand the connections between crossS*fde and the logic Eq of equality by Epstein. Also, we present S*fde as a relevant logic of meaninglessness that follows the main philosophical tenets of Goddard and Routley, and we briefly examine three further systems that are closely related to our main logics. Finally, we discuss Routley's criticism to containment logic in light of our results, and overview some open issues. (shrink)