BackgroundThe role of consent for research use of health information is contentious. Most discussion has focused on when project-specific consent may be waived but, recently, a broader range of consent options has been entertained, including broad opt-in for multiple studies with restrictions and notification with opt-out. We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues.MethodsWe conducted seven (...) day-long public dialogues, involving 98 participants across Canada. Immediately before and after each dialogue, participants completed a fixed-response questionnaire rating individuals' support for 3 approaches to consent in the abstract and their consent choices for 5 health research scenarios using personal information. They also rated how confident different safeguards made them feel that their information was being used responsibly.ResultsBroad opt-in consent for use of personal information garnered the greatest support in the abstract. When presented with specific research scenarios, no one approach to consent predominated. When profit was introduced into the scenarios, consent choices shifted toward greater control over use. Despite lively and constructive dialogues, and considerable shifting in opinion at the individual level, at the end of the day, there was no substantive aggregate movement in opinion. Personal controls were among the most commonly cited approaches to improving people's confidence in the responsible use of their information for research.ConclusionBecause no one approach to consent satisfied even a simple majority of dialogue participants and the importance placed on personal controls, a mechanism should be developed for documenting consent choice for different types of research, including ways for individuals to check who has accessed their medical record for purposes other than clinical care. This could be done, for example, through a web-based patient portal to their electronic health record. Researchers and policy makers should continue to engage the public to promote greater public understanding of the research process and to look for feasible alternatives to existing approaches to project-specific consent for observational research. (shrink)

BackgroundStigma refers to a distinguishing personal trait that is perceived as or actually is physically, socially, or psychologically disadvantageous. Little is known about the opinion of those who have more or less stigmatizing health conditions regarding the need for consent for use of their personal information for health research.MethodsWe surveyed the opinions of people 18 years and older with seven health conditions. Participants were drawn from: physicians' offices and clinics in southern Ontario; and from a cross-Canada marketing panel of individuals (...) with the target health conditions. For each of five research scenarios presented, respondents chose one of five consent choices: (1) no need for me to know; (2) notice with opt-out; (3) broad opt-in; (4) project-specific permission; and (5) this information should not be used. Consent choices were regressed onto: demographics; health condition; and attitude measures of privacy, disclosure concern, and the benefits of health research. We conducted focus groups to discuss possible reasons for observed consent choices.ResultsWe observed substantial variation in the control that people wish to have over use of their personal information for research. However, consent choice profiles were similar across health conditions, possibly due to sampling bias. Research involving profit or requiring linkage of health information with income, education, or occupation were associated with more restrictive consent choices. People were more willing to link their health information with biological samples than with information about their income, occupation, or education.ConclusionsThe heterogeneity in consent choices suggests individuals should be offered some choice in use of their information for different types of health research, even if limited to selectively opting-out. Some of the implementation challenges could be designed into the interoperable electronic health record. However, many questions remain, including how best to capture the opinions of those who are more privacy sensitive. (shrink)

Objective We sought to understand ethics and education needs of emergency nurses and physicians in paediatric and adult emergency departments in order to build ethics capacity and provide a foundation for the development of an ethics education programme. Methods This was a prospective cross-sectional survey of all staff nurses and physicians in three tertiary care EDs. The survey tool, called Clinical Ethics Needs Assessment Survey, was pilot tested on a similar target audience for question content and clarity. Results Of the (...) 123 participants surveyed, 72% and 84% of nurses and physicians fully/somewhat agreed with an overall positive ethical climate, respectively. 69% of participants reported encountering daily or weekly ethical challenges. Participants expressed the greatest need for additional support to address moral distress, conflict management with patients or families and resource issues. Of the 23 reported occurrences of moral distress, 61% were associated with paediatric mental health cases. When asked how the ethics consultation service could be used in the ED, providing education to teams was the most desired method. Conclusions Nurses report a greater need for ethics education and resources compared with their physician colleagues. Ethical challenges in paediatric EDs are more prevalent than adult EDs and nurses voice specific moral distress that are different than adult EDs. These results highlight the need for a suitable educational strategy, which can be developed in collaboration with the leadership of each ED and team of hospital ethicists. (shrink)

AimResting state functional magnetic resonance imaging was used to analyze changes in functional connectivity within various brain networks and functional network connectivity among various brain regions in patients with high myopia.Methodsrs-fMRI was used to scan 82 patients with HM and 59 healthy control volunteers matched for age, sex, and education level. Fourteen resting state networks were extracted, of which 11 were positive. Then, the FCs and FNCs of RSNs in HM patients were examined by independent component analysis.ResultsCompared with the HC (...) group, FC in visual network 1, dorsal attention network, auditory network 2, visual network 3, and sensorimotor network significantly increased in the HM group. FC in default mode network 1 significantly decreased. Furthermore, some brain regions in default mode network 2, default mode network 3, auditory network 1, executive control network, and significance network increased while others decreased. FNC analysis also showed that the network connection between the default mode network and cerebellar network was enhanced in the HM group.ConclusionCompared with HCs, HM patients showed neural activity dysfunction within and between specific brain networks, particularly in the DMN and CER. Thus, HM patients may have deficits in visual, cognitive, and motor balance functions. (shrink)

AimPatients with high myopia reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls via dynamic regional homogeneity analysis.MethodsResting-state functional magnetic resonance imaging scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. (...) The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.ResultsIn the left fusiform gyrus, right inferior temporal gyrus, right Rolandic operculum, right postcentral gyrus, and right precentral gyrus, dReHo values were significantly greater in patients with HM than in HCs.ConclusionPatients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM. (shrink)

Robust techniques critically improve bearing-only target localization when the relevant measurements are being corrupted by impulsive noise. Resistance to isolated gross errors refers to the conventional least absolute residual method, and its estimate can be determined by linear programming when pseudolinear equations are set. The LAR approach, however, cannot reduce the bias attributed to the correlation between system matrices and noise vectors. In the present study, perturbations are introduced into the elements of the system matrix and the data vector simultaneously, (...) and the total optimization problem is formulated based on least absolute deviations. Subsequently, an equivalent form of total least absolute residuals is obtained, and an algorithm is developed to calculate the robust estimate by dual ascent algorithms. Moreover, the performance of the proposed method is verified through the numerical simulations by using two types of localization geometries, i.e., random and linear. As revealed from the results, the TLAR algorithm is capable of exhibiting significantly higher localization accuracy as compared with the LAR method. (shrink)

Urban networks have been widely examined using infrastructure connection and firm connection data. In particular, urban networks constructed based on firm connection data have been used to depict the circulation of capital, information, personnel, and products between cities. Existing studies on firm connection networks rely on either inter- or intrafirm relationships. However, there exist various important extra-firm relationships, such as those between firms and governments, research institutions, and nonprofit organizations. This study innovatively incorporates the extra-firm relationships between governments and firms (...) into urban network construction to provide new insights into the field of urban network research. Using Northeast China as a case study, we construct government procurement activity connection networks for both central projects and local projects at the regional and national scales. Social network analysis and regression analysis are used to analyze the network characteristics and factors associated with the network structure. The results show that three provincial capitals hold dominant positions across all the networks. While these capitals serve as GPA suppliers in the region, they are mainly GPA consumers nationally. The factors of spatial proximity, economic development, population, and provincial boundaries were found to be significantly associated with GPA connections. Our study provides important insights into the role of cities in firm-government supply-demand networks. This research can be used to help formulate effective strategies to improve a city’s competitiveness and cities’ cooperation in the GPA supply-demand network. (shrink)

Ethics, Policy & Environment, Volume 14, Issue 2, Page 259-262, June 2011.

The cellular internal ribosomal entry site (IRES) is one of the most important elements to mediate cap‐independent translational initiation, especially under conditions of stress and pathology. However, a high‐throughput method to discover IRESs in these conditions is still lacking. Here, a possible way IRES long‐read sequencing based on the latest high‐throughput technologies is proposed to solve this problem. Based on this design, diversity and integrity of the transcriptome from original samples can be kept. The micro‐environment that stimulates or inhibits IRES (...) activity can also be mimicked. By using long read‐length sequencing technology, additional experiments that are essential for ruling out the cryptic promoters or splicing events in routine IRES identification processes can be circumvented. It is hoped that this proposed methodology may be adopted for IRES element discovery, hence uncovering the full extent of the role of IRESs in disease, development, and stress. Also see the video abstract here https://youtu.be/JuWBbMzWXS8. (shrink)

Graphical AbstractCellular internal ribosomal entry site (IRES) is important for cap-independent translational initiation during stress and pathology. In article number 1900180, Lei-Yun Wang et al. propose an idea to discover IRES based on the latest high-throughput technologies, hence facilitating the understanding of IRES in disease development and treatment.

本书对方法论研究中的一些基本范畴、结构、功能和原理, 做出了科学的界定和阐发, 并在此基础上建立了方法学的理论体系.

本书以欧洲的社会政治、经济历史为背景,以技术史为基础,以欧洲哲学史的历史脉络为主线,研究从古希腊到19世纪中叶哲学的技术思想,揭示出技术哲学由萌芽到产生的历史过程。.

本書收錄了作者近年來撰寫的文章二十多篇，包括書評、隨筆、評論文章等。本文集以中國傳統士人的氣節與傳統行政權力下的尊師重道為切入點，論及近代以來的時風、士風與學風，類比西方學術制度與自由思想之形塑，針對 近代變革中的知識份子之際遇與現代學人急躁求進之學風、近代以來“士”風日下與道德重塑，闡發了學者“曲學阿世”的責任與使命。全書的核心問題是試圖討論如何構建一個更好的學術外部、內部環境。.

1 juan, lun Zhong xi zhe xue jing shen -- 2 juan, ru xue yu xin ru xue -- 3 juan, lun li yu guan li -- 4 juan, ben ti quan shi xue.

Confucius must have inspired his disciples to identify the process and structure of the human self and required self-cultivation in embodying and developing virtues within and practicing virtues as potential ways for its full self-realization. My discussion will be carried out through a conceptual and onto-hermeneutic analysis of the underlying self (ji) structure and its born nature and mind as content as deliberated in the Lunyu (the Analects). On the basis of this approach we will come to see how a (...) moral psychology of virtues is founded and how such a moral psychology has implications for moral onto-generative metaphysics and onto-generative ethics. (shrink)

本书共分四辑,收录了美在关系中,谈审美与人的全面发展,论审美知觉及其形成过程,审美想象的生成机制,艺术想象的意向性和认识性等文章.