The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether gene activity is a cause or a consequence of genome folding in space. In this regard, the phenomena of X‐chromosome inactivation and reactivation open a unique window of investigation because of the singularities of the inactive X chromosome. Here we focus on the cause–consequence nexus between genome conformation and transcription (...) and explain how recent results about the structural changes associated with inactivation and reactivation of the X chromosome shed light on this problem. (shrink)

A good commentary will protect against arbitrary interpretation by exposing its user to the larger community of interpretation where private views are checked, enriched, corrected, and deepened.

This paper outlines the basic traits of a responsive phenomenology by focusing on the issue of originary substitution. On the one hand, a phenomenology of alienness or otherness and an ethics of the other in the sense of Levinas will prove to be closely bound up with this sort of substitution. On the other side, this substitution can be concretised by transitional figures such as the advocate, the therapist, the translator, the witness, or the field researcher; they all intervene from (...) the position of a Third without closing the fissure which opens between ourselves and the Other, between the own and the alien. Precisely by focussing on the issue of substitution, we have the opportunity to outline the basis traits of a responsive phenomenology and to discuss some of its institutional consequences. (shrink)

Die Einführung von Längengraden auf den Weltmeeren wurde vom 16. bis ins 18. Jahrhundert als die größte wissenschaftliche Herausforderung angesehen. Der Beitrag skizziert ihren Einfluss auf die Erschaffung des Britischen Imperiums, die Physik, und die frühe Philosophie Martin Heideggers. Vor dem Hintergrund dieser Geschichte wird eine historische Ontologie der Uhr entwickelt. Während die Uhr im Mittelalter eine Maschine war, wurde sie in der frühen Moderne zum Instrument und im 19. und 20. Jahrhundert zum Medium. Als Medium des Daseins ist die (...) Uhr nicht nur ein ontisches Zeitmessgerät, sondern auch ein ontologisches Ding, das dem Dasein sein eigenes technisches Wesen zugänglich macht. (shrink)

In Roman literature, the Argo commonly ranks as the first ship. The Flavian poet Valerius Flaccus seems to place himself in this line of tradition too by constantly stressing the Argo’s pioneer status. Yet it has rightly been noted that nowhere in the Argonautica is the Argo explicitly said to be the first ever ship. Her exceptional role is based rather on her status as the first sea-going ship to sail across the open sea from Europe to Asia, opening the (...) seas to global marine trade. From this perspective, the hitherto inadequately explained mentions of ships in the Phlegyas simile (3,124–132) and the Lemnos episode (2,107–114; 285–305) can also be analysed as only apparent inconsistencies. The interpretive effort required here draws the attention of the reader or audience, which is called upon to compare the earlier ships to the Argo. In this, the poet suggests a pessimistic judgement: a consequence of the opening of the seas was shipping disasters and human tragedies. Also, it did not only lead to the expansion of civilising achievements, but also held the danger that rituals and customs of a periphery which is read as barbaric would penetrate into the cultural space of the Mediterranean world. (shrink)

Certamente, desde que o ser humano existe, a vida nunca esteve isenta de manipulação técnica. Todavia, formas recentes de biotecnologia vão mais longe, tendendo a tornar indiscernível as distinções clássicas entre crescimento natural e produção artificial. Ars sive natura, este poderia ser o novo slogan. Neste sentido, em oposição à bioética corrente que tenta compensar o monismo tecnológico através de um dualismo prático, discutiremos a idéia de que, quando age sobre o Outro (Fremdeneinwirkung), a biotecnologia nunca é puramente técnica, sendo (...) imediatamente prática, ética e política. Por outro lado, confrontada com novos desafios tecnológicos, a fenomenologia necessita assumir certas características de fenomenotecnologia; ações não são nunca meramente práticas. Uma tal combinação entre fenomenologia e fenomenotecnologia abre especiais perspectivas no que diz respeito ao trato da questão da vida humana. Primeiramente, descreveremos o eu corporal como gerador de sua própria história, na medida que evidencia graus de identidade e se constitui como altamente vulnerável. Em segundo lugar, distinguiremos entre a atitude técnica, restrita ao fato de que algo se modifica, e a atitude terapêutica, que se dirige a alguém que sofre: o paciente. A seguir, ultrapassaremos os limites do enquadramento clínico ao considerar novas conquistas no que diz respeito à produção da vida (por exemplo, clonagem e manipulação genética). Antes de simplesmente argumentar pró ou contra, temos de indagar o que significa produzir um eu vivo. Neste contexto, o tempo da poiesis será contrastado com o do pathos. Examinaremos o lugar desde o qual um ser vivo ou pessoal pode ser definido como alguém em si, e pretendemos tencionar simultaneamente o caráter paradoxal de atribuição de um eu ao Outro (Fremdezuschreibung), que assemelha-se ao paradoxo de ter a experiência do Outro como Outro (Fremderfahrung). Pois a pré-história e a pós-história de um alguém específico, incluindo nascimento e morte, é apenas acessível a nós em termos de substituição. Reduzidos a conjuntos de células, seres humanos seriam liberados de tudo isto. Restaria algo sobre o que falamos, mas de modo algum alguém falando a nós. PALAVRAS-CHAVE – Biotecnologia. Terapia. Fenomenologia. Fenomenotecnologia. ABSTRACT Certainly, as long as human beings exist, life has never been exempt from technical manipulations. However, recent forms of biotechnology go further, tending to blur the classical distinction between natural growth and artificial production. Ars sive natura, that may be the new slogan. Now, in opposition to current bioethics which try to compensate the technological monism by means of a practical dualism, we will argue that by acting upon the Other (Fremdeinwirkung) biotechnology is never purely technical, it is immediately practical, ethical and political. On the other side, faced with new technological challenges, phenomenology needs certain features of phenomenotechnology; actions are never merely practical. Such an intertwining of phenomenology and phenomenotechnology opens up special perspectives in dealing with the issue of human life. Firstly, we will describe the bodily self as generating its own history, as showing grades of selfhood and as being highly vulnerable. Secondly, we will distinguish between the technological attitude, restricted on something to be changed, and the therapeutic attitude, addressed to somebody suffering, namely the patient. In the end, we cross the limits of the clinical frame by considering new attempts of life production (e.g. cloning and gene manipulation). Before simply arguing pro and con we have to ask what does it mean to produce a living self. In this context the time of poiesis will be contrasted with the time of pathos. We will examine the place from where a living or personal being may be defined as somebody in itself, and we will simultaneously stress the paradoxical character of ascribing the status of a self to the Other (Fremdzuschreibung), which resembles the paradox of experiencing the Other as an Other (Fremderfahrung). At last, the pre-history and the post-history of a oneself, including birth and death, is only accessible for us by means of substitution. Reduced to cell ensembles, human beings would get rid of all that. There would be left something we speak about, but by no means somebody speaking to us. KEY WORDS – Biotechnology. Therapy. Phenomenology. Phenomenotecnology. (shrink)

À contre-courant des querelles fratricides qui opposèrent structuralistes et phénoménologues, l'auteur rappelle, tout d'abord, les motifs centraux qui dominent le débat entre les deux courants, avant de dégager une problématique nouvelle dans laquelle les perspectives phénoménologiques et structuralistes s'entrecroisent. Il s'agit de la problématique de la normalisation, entendue comme processus d'incarnation et de genèse des normes, qui thématise de façon centrale la différence entre l'Ordinaire et l'extraordinaire.