This review addresses the 100-year-old Hill equation (published in January 22, 1910), the first formula relating the result of a reversible association (e.g., concentration of a complex, magnitude of an effect) to the variable concentration of one of the associating substances (the other being present in a constant and relatively low concentration). In addition, the Hill equation was the first (and is the simplest) quantitative receptor model in pharmacology. Although the Hill equation is an empirical receptor model (its parameters have (...) only physico-chemical meaning for a simple ligand binding reaction), it requires only minor a priori knowledge about the mechanism of action for the investigated agonist to reliably fit concentration-response curve data and to yield useful results (in contrast to most of the advanced receptor models). Thus, the Hill equation has remained an important tool for physiological and pharmacological investigations including drug discovery, moreover it serves as a theoretical basis for the development of new pharmacological models. (shrink)

Many favor representationalism about color experience. To a first approximation, this view holds that experiencing is like believing. In particular, like believing, experiencing is a matter of representing the world to be a certain way. Once you view color experience along these lines, you face a big question: do our color experiences represent the world as it really is? For instance, suppose you see a tomato. Representationalists claim that having an experience with this sensory character is necessarily connected with representing (...) a distinctive quality as pervading a round area out there in external space. Let us call it “sensible redness” to highlight the fact that the representation of this property is necessarily connected with the sensory character of the experience. Is this property, sensible redness, really co-instantiated with roundness out there in the space before you? (shrink)

The claim of this paper is that the everyday functions of knowledge make most sense if we see knowledge as contrastive. That is, we can best understand how the concept does what it does by thinking in terms of a relation “a knows that p rather than q.” There is always a contrast with an alternative. Contrastive interpretations of knowledge, and objections to them, have become fairly common in recent philosophy. The version defended here is fairly mild in that there (...) is no suggestion that we cannot think in terms of a simpler not explicitly contrastive relation “a knows that p.” Some, for instance Schaffer (2005) and Karjalainen and Morton (2003), have hinted that this stronger possibility may be right. But all that I am arguing now is that facts that are easily expressed in contrastive terms are vital to understanding why we need the concept of knowledge. In a piece that is in some ways a companion to this one ("Contrastivism" in Duncan Pritchard and Sven Bernecker, eds. The Routledge Companion to Epistemology. Routledge 2010, 513-522), I give a general survey of theories of contrastive knowledge and the differences between them. (shrink)

In this paper, I do a few things. I develop a (largely) empirical argument against naïve realism (Campbell, Martin, others) and for representationalism. I answer Papineau’s recent paper “Against Representationalism (about Experience)”. And I develop a new puzzle for representationalists.

This book argues against the conventional idea that Protestantism effectively ceased to play an important role in American higher education around the end of the 19th century. Employing Princeton as an example, the study shows that Protestantism was not abandoned but rather modified to conform to the educational values and intellectual standards of the modern university. Drawing upon a wealth of neglected primary sources, Kemeny sheds new light on the role of religion in higher education by examining what was (...) happening both inside and outside the classroom, and by illustrating that religious and secular commitments were not neatly divisible but rather commingled. (shrink)

The problem of trust in social relationships was central to the emergence of the modern form of civil society and much discussed by social and political philosophers of the early modern period. Over the past few years, in response to the profound changes associated with postmodernity, trust has returned to the attention of political scientists, sociologists, economists, and public policy analysts. In this sequel to his widely admired book, The Idea of Civil Society, Adam Seligman analyzes trust as a (...) fundamental issue of our present social relationships. Setting his discussion in historical and intellectual context, Seligman asks whether trust--which many contemporary critics, from Robert Putnam through Francis Fukuyama, identify as essential in creating a cohesive society--can continue to serve this vital role. Seligman traverses a wide range of examples, from the minutiae of everyday manners to central problems of political and economic life, showing throughout how civility and trust are being displaced in contemporary life by new "external' system constraints inimical to the development of trust. Disturbingly, Seligman shows that trust is losing its unifying power precisely because the individual, long assumed to be the ultimate repository of rights and values, is being reduced to a sum of group identities and an abstract matrix of rules. The irony for Seligman is that, in becoming postmodern, we seem to be moving backward to a premodern condition in which group sanctions rather than trust are the basis of group life. (shrink)

This paper introduces a novel strategy for responding to skeptical arguments based on the epistemic possibility of error or lack of certainty. I show that a nonclassical logic motivated by recent work on epistemic modals can be used to render such skeptical arguments invalid. That is, one can grant that knowledge is incompatible with the possibility of error and grant that error is possible, all while avoiding the skeptic’s conclusion that we lack knowledge.

Discusses recent work on representationalism, including: the case for a representationalist theory of consciousness, which explains consciousness in terms of content; rivals such as neurobiological type-type identity theory (Papineau, McLaughlin) and naive realism (Allen, Campbell, Brewer); John Campbell and David Papineau's recent objections to representationalism; the problem of the "laws of appearance"; externalist vs internalist versions of representationalism; the relation between representationalism and the mind-body problem.

We investigate properties of accessible categories with directed colimits and their relationship with categories arising from ShelahʼsElementary Classes. We also investigate ranks of objects in accessible categories, and the effect of accessible functors on ranks.

“Moorean Dogmatist” responses to external world skepticism endorse courses of reasoning that many people find objectionable. This paper seeks to locate this dissatisfaction in considerations about epistemic responsibility. I sketch a theory of immediate warrant and show how it can be combined with plausible “inferential internalist” demands arising from considerations of epistemic responsibility. The resulting view endorses immediate perceptual warrant but forbids the sort of reasoning that “Moorean Dogmatism” would allow. A surprising result is that Dogmatism’s commitment to immediate epistemic (...) warrant isn’t enough to avoid certain standard arguments for skepticism about the external world. (shrink)

The book analyzes the sources of widespread dissatisfaction with democracies around the world and identifies directions for feasible reforms"--Provided by publisher.

No fight over what gets taught in American classrooms is more heated than the battle over humanity’s origins. For more than a century we have argued about evolutionary theory and creationism (and its successor theory, intelligent design), yet we seem no closer to a resolution than we were in Darwin’s day. In this thoughtful examination of how we teach origins, historian Adam Laats and philosopher Harvey Siegel offer crucial new ways to think not just about the evolution debate but (...) how science and religion can make peace in the classroom. Laats and Siegel agree with most scientists: creationism is flawed, as science. But, they argue, students who believe it nevertheless need to be accommodated in public school science classes. Scientific or not, creationism maintains an important role in American history and culture as a point of religious dissent, a sustained form of protest that has weathered a century of broad—and often dramatic—social changes. At the same time, evolutionary theory has become a critical building block of modern knowledge. The key to accommodating both viewpoints, they show, is to disentangle belief from knowledge. A student does not need to believe in evolution in order to understand its tenets and evidence, and in this way can be fully literate in modern scientific thought and still maintain contrary religious or cultural views. Altogether, Laats and Siegel offer the kind of level-headed analysis that is crucial to finding a way out of our culture-war deadlock. (shrink)

Organizations have neither a right to the vote nor a weighty right to life. We need not enfranchise Goldman Sachs. We should feel few scruples in dissolving Standard Oil. But they are not without rights altogether. We can owe it to them to keep our promises. We can owe them debts of gratitude. Thus, we can owe some things to organizations. But we cannot owe them everything we can owe to people. They seem to have a peculiar, fragmented moral status. (...) What explains this? Individualistic views explain this in terms of individualistic notions alone. Such notions don’t invoke any distinctive features of organizations. They just invoke the features of individual members of organizations. Collectivistic views, instead, explain this in terms of collective notions alone. Such notions don’t invoke the features of individual members of organizations. They just invoke the features of those organizations. We argue that neither approach works. Instead, one needs to synthesize the two approaches. Some individual interests, we think, are distinctively collective. We, as individuals, have a distinctive interest in playing a part in successful collective action. From this, so we argue, flows the apparently peculiar, fragmented moral status of organizations. (shrink)

It is commonly supposed that metaphysical modal claims are to be evaluated with respect to a single domain of possible worlds: a claim is metaphysically necessary just in case it is true in every possible world, and metaphysically possible just in case it is true in some possible world. We argue that the standard understanding is incorrect; rather, whether a given claim is metaphysically necessary or possible is relative to which world is indicatively actual. We motivate our view by attention (...) to discussions in Salmon 1989 and Fine 2005, in which various data are taken to support rejecting the transitivity of accessibility and modal monism ; we argue that relativized metaphysical modality can accommodate these data compatible with both standard modal logic and modal monism. Noting an analogy with two-dimensional semantics, we argue that metaphysical modality has a complex structure, reflecting what is counterfactually possible, relative to each indicatively actual world. In arguing for the need for relativization, we are broadly on the same side as Crossley and Humberstone and Davies and Humberstone ; our contribution here is, first, to offer distinctively metaphysical reasons for relativization, and second, to show that relativization can be incorporated in ways minimally departing from standard modal logic. (shrink)

This paper considers the possibility that ‘epistemic hypocrisy’ could be relevant to our blaming practices. It argues that agents who culpably violate an epistemic norm can lack the standing to blame other agents who culpably violate similar norms. After disentangling our criticism of epistemic hypocrites from various other fitting responses, and the different ways some norms can bear on the legitimacy of our blame, I argue that a commitment account of standing to blame allows us to understand our objections to (...) epistemic hypocrisy. Agents lack the epistemic standing to blame when they are not sufficiently committed to the epistemic norms they are blaming others for violating. This not only gives us a convincing account of epistemic standing to blame, it leaves us with a unified account of moral and epistemic standing. (shrink)

I investigate the extent to which perspectival realism agrees with frequentist statistical methodology and philosophy, with an emphasis on J. Neyman’s views. Based on the example of the stopping rule problem, I show how PR can naturally be associated with frequentist statistics in general. I also show that there are some aspects of Neyman’s thought that seem to confirm PR and others that disconfirm it. I argue that epistemic PR is consistent with Neyman’s frequentism to a satisfactory degree and that (...) on the grounds of Neyman’s frequentist methodology one is dealing with genuine and non-trivial perspectives. I also argue that universality and normativity of PR are weakened when analysed from the point of view of Neyman’s statistical methodology. (shrink)

The acquisition of complex motor, cognitive, and social skills, like playing a musical instrument or mastering sports or a language, is generally associated with implicit skill learning . Although it is a general view that SL is most effective in childhood, and such skills are best acquired if learning starts early, this idea has rarely been tested by systematic empirical studies on the developmental pathways of SL from childhood to old age. In this paper, we challenge the view that childhood (...) and early school years are the prime time for skill learning by tracking age-related changes in performance in three different paradigms of SL. We collected data from participants between 7 and 87 years for a Serial Reaction Time Task testing the learning of motor sequences, an Artificial Grammar Learning task testing the extraction of regularities from auditory sequences, and Probabilistic Category Learning in the Weather Prediction task , a non-sequential categorization task. Results on all three tasks show that adolescence and adulthood are the most efficient periods for skill learning, since instead of becoming less and less effective with age, SL improves from childhood into adulthood and then later declines with aging. (shrink)

This book offers a novel account of grace, framed in terms of Bruno Latour's "principle of irreduction.

The foundation for a system of morals, this 1749 work is a landmark of moral and political thought. Its highly original theories of conscience, moral judgment, and virtue offer a reconstruction of the Enlightenment concept of social science, embracing both political economy and theories of law and government.

Due to natural phenomena like global warming and climate change, agricultural production is increasingly faced with threats that transcend farm boundaries. Management practices at the landscape or community level are often required to adequately respond to these new challenges (e.g., pest migration). Such decision-making at a community or beyond-farm level—i.e., practices that are jointly developed by farmers within a community—can be aided by computing and communications technology. In this study, we employ a translational research process to examine the social and (...) behavioral drivers of adoption of smart and connected farm networks among commodity crop farmers in the United States. We implement focus groups and questionnaires to bring to the fore views on the use of digital technologies in collaborative contexts. We find that participating farmers are concerned with several issues about the potential features of the network (e.g., the ability to ensure data validity while maintaining data privacy) and the nature of their interactions with the various stakeholders involved in the network management. The participatory approach we adopt helps provide insights into the process of developing technologies that are both actionable and trusted by potential end users. (shrink)

Attempts to characterize unarticulated constituents (henceforth: UCs) by means of quantification over the parts of a sentence and the constituents of the proposition it expresses come to grief in more complicated cases than are commonly considered. In particular, UC definitions are inadequate when we consider cases in which the same constituent appears more than once in a proposition that only has one word with the constituent as its semantic value. This article explores some consequences of trying to repair the formal (...) definitions. (shrink)

A scholarly edition of a work by Adam Smith. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

The author offers a comprehensive interpretation of Aquinas's claim that the human intellect is immaterial and assessment of his arguments on behalf of this claim, also positioning Aquinas's thought alongside recent work in hylomorphic metaphysics and philosophy of mind.

For a world mired in catastrophe, nothing could be more urgent than the question of survival. In this theoretically and methodologically groundbreaking book, Adam Y. Stern calls for a critical reevaluation of survival as a contemporary regime of representation. In Survival, Stern asks what texts, what institutions, and what traditions have made survival a recognizable element of our current political vocabulary. The book begins by suggesting that the interpretive key lies in the discursive prominence of "Jewish survival." Yet the (...) Jewish example, he argues, is less a marker of Jewish history than an index of Christianity's impact on the modern, secular, political imagination. With this inversion, the book repositions Jewish survival as the supplemental effect and mask of a more capacious political theology of Christian survival. The argument proceeds by taking major moments in twentieth-century philosophy, theology, and political theory as occasions for collecting the scattered elements of survival's theological-political archive. Through readings of canonical texts by secular and Jewish thinkers—Hannah Arendt, Walter Benjamin, Franz Rosenzweig, and Sigmund Freud—Stern shows that survival belongs to a history of debates about the sovereignty and subjection of Christ's body. Interrogating survival as a rhetorical formation, the book intervenes in discussions about biopolitics, secularism, political theology, and the philosophy of religion. (shrink)

In his excellent book *The Metaphysics of Sensory Experience* (2021), David Papineau argues against standard theories of sensory experience: the sense datum view, representationalism, naïve realism, and so on. The only view left standing is his own “qualitative view”. On Papineau’s physicalist version, all experiences are nothing but neural states, and the only features essentially involved in experience are intrinsic neural properties (29-30, 95-97). In my book *Perception* (2021), I developed an argument from spatial experience against this kind of view (...) (also Pautz 2010, 2017). Here I elaborate on that argument in the light of Papineau’s discussion. (shrink)

In Merleau-Ponty and Nishida, Adam Loughnane initiates a dialogue between two of the twentieth century's most important phenomenologists from the Eastern and Western philosophical worlds. Loughnane guides the reader through the complexities and innovations of Nishida's and Merleau-Ponty's theories of artistic expression and their rarely explored concepts of faith. The intricacies of both philosophers' views are illuminated by analyses of artists, including Cézanne, Sesshū, Rodin, Hasegawa, and other major figures of European, Chinese, and Japanese art history, who enact a (...) radical form of expression that Loughnane calls the practice of "motor-perceptual faith." He argues that the artist's motor-perceptual body, as poetically articulated in Nishida's and Merleau-Ponty's early works, enacts a form of faith that can be parsed in the final writings of both philosophers. The concept of faith is enlarged through its enactment by the artist, while the concept of artistic expression is broadened by casting it as a motor-perceptual conception of faith. Merleau-Ponty and Nishida is an exciting new intercultural reading of these philosophers' writings that opens up under-explored areas of their projects. It forms an important conceptual bridge between the two, while challenging distinctions between art, philosophy, and religion, and ultimately philosophy East and West. (shrink)

The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. (...) A better understanding of the impact of reprogramming on cancer cell-specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology. (shrink)

The aim of this book is the analysis of Kazimierz Ajdukiewicz's meta-epistemological project of the semantic theory of knowledge and its implementations to solve certain traditional epistemological problems and their metaphysical consequences. This project claims that cognitive problems need to be approached from the perspective of language. One of the results of this analysis is the thesis that the philosophical-linguistic legitimisation for the meta-epistemological project is the philosophy of Edmund Husserl from his Logical Investigations. This is the philosophy that makes (...) it possible to speak reasonably of a close relation between thinking and language and provides thereby the legitimisation for this project. (shrink)