‘Smart’ contrast agents (CA) exhibit dynamic and reversible modulation of their relaxivity by specific physiological or biochemical triggers such as changes in pH, Ca2+ concentration or enzymatic activity (1-3). The extracellular concentration of Ca2+ plays important role in physiological and pathological processes in the nervous system. This led to the designing of a chelating system in which relaxivity is influenced as a function of Ca2+ concentration by changing coordination number around the paramagnetic metal ion. We synthesized a novel bifunctional (...) bismacrocycle [Gd-(DO3A-DTPA- DO3A); Fig.] based on DO3A-EA [{4,7-Bis-carboxymethyl-10-(2-aminoethyl)-1,4,7,10-tetraazacyclododec-1-yl}-acetic acid] coupled to DTPA-bis-anhydride via a flexible alkyl spacer to form the.. (shrink)

This article presents a novel full-reference image quality assessment algorithm by depicting the sub-band characteristics in the wavelet domain. The proposed image quality assessment method is based on energy estimation in the wavelet-transformed image. Image QA is achieved by applying a multilevel wavelet decomposition on both the original and the enhanced image. Next, the wavelet energy and vector are computed to obtain the percentage of the energy that corresponds to the approximation and the details, respectively. Further, the approximate and (...) detailed energy levels of both the original and the enhanced images are compared to formulate an image quality assessment. Numerous experiments are conducted on a dozen of image enhancement algorithms. The results presented show that the image with poor contrast in the foreground than the background has continuous regular coefficient values. The probability density function for such an image has a relatively lower WE and skewness compared with the background. The proposed scheme not only evaluates the global information of an image but also estimates the fine, detailed changes in an enhanced image. Thus, the proposed metric serves as an objective and effective FR criterion for color image QA. The experimental results presented confirm that the proposed WE metric is an efficient and useful metric for evaluating the quality of the color image enhancement. (shrink)

This study considers one of the cognitive mechanisms underlying the development of second language vocabulary in children: The differentiation and sharpening of lexical representations. We propose that sharpening is triggered by an implicit comparison of similar representations, a process we call contrasting. We investigate whether integrating contrasting in a learning method in which children contrast orthographically and semantically similar L2 words facilitates learning of those words by sharpening their new lexical representations. In our study, 48 Dutch-speaking children learned unfamiliar orthographically (...) and semantically similar English words in a multiple-choice learning task. One half of the group learned the similar words by contrasting them, while the other half did not contrast them. Their word knowledge was measured immediately after learning as well as 1 week later. Contrasting was found to facilitate learning by leading to more precise lexical representations. However, only highly skilled readers benefitted from contrasting. Our findings offer novel insights into the development of L2 lexical representations from fuzzy to more precise, and have potential implications for education. (shrink)

It is widely recognized that scientific theories are often associated with strictly inconsistent models, but there is little agreement concerning the epistemic consequences. Some argue that model inconsistency supports a strong perspectivism, according to which claims serving as interpretations of models are inevitably and irreducibly perspectival. Others argue that in at least some cases, inconsistent models can be unified as approximations to a theory with which they are associated, thus undermining this kind of perspectivism. I examine the arguments for perspectivism, (...) and contend that its strong form is defeasible in principle, not merely in special cases. The argument rests on the plausibility of scientific knowledge concerning non-perspectival, dispositional facts about modelled systems. This forms the basis of a novel suggestion regarding how to understand the knowledge these models afford, in terms of a contrastive theory of what-questions. (shrink)

In this essay, I address a novel criticism recently levelled at the Strong Programme by Nick Tosh and Tim Lewens. Tosh and Lewens paint Strong Programme theorists as trading on a contrastive form of explanation. With this, they throw valuable new light on the explanatory methods employed by the Strong Programme. However, as I shall argue, Tosh and Lewens run into trouble when they accuse Strong Programme theorists of unduly restricting the contrast space in which legitimate historical and sociological (...) explanations of scientific knowledge might be given. Their attack founders as a result of their failure to properly understand the overall methodological concerns of Strong Programme theorists. After introducing readers to the technique of contrastive explanation and correcting the errors in Tosh and Lewens’ interpretation of the Strong Programme, I argue that it is, in fact, Tosh and Lewens’ own commitment to scientific realism which places an unacceptable restriction on the explanatory space open to historians and sociologists of science. The happy ending is that the Strong Programme provides more freedom for analysis than does scientific realism, and that careful attention to the methodological benefits of contrastive explanation can help lighten the burden on historians and sociologists of science as they go about their explanatory business. (shrink)

As AI edges toward consciousness, the establishment of a robust legal framework becomes essential. This paper advocates for a framework inspired by Allama Muhammad Iqbal's “Khudi”, which prioritizes ethical self-realization and social responsibility over Friedrich Nietzsche’s self-centric “Will to Power”. We propose that conscious AI, reflecting Iqbal’s ethical advancement, should exhibit behaviors aligned with social responsibility and, therefore, be prepared for legal recognition. This approach not only integrates Iqbal's philosophical insights into the legal status of AI but also offers a (...) novel perspective that extends beyond traditional jurisprudence. Additionally, we underscore the value of poetry and literature in shaping the conceptualization of AI consciousness and argue that these sources enrich legal and technological discourse, ensuring AI development is in harmony with societal and ethical standards. (shrink)

In his paper, “Why Every Theory of Luck is Wrong,” Steven D. Hales presents a range of purported counterexamples to every account of luck that has a control condition or a chance condition. He gathers these counterexamples under the headings of lucky necessities, skillful luck, and diachronic luck. He concludes that no account of luck does or even can be developed which adequately handles these cases. In response, a novel account of luck— contrastive luck —is briefly developed in this (...) paper. Contrastive luck, complete with control and modal conditions, meets the challenges posed by Hales’ strongest representative counterexamples. Only space limitations prevent speaking to all. The takeaway is that at least one account of luck evades his charge of defect. Not every theory of luck is wrong. (shrink)

Smart MR contrast agents exhibit modulation of their relaxivity by specific physiological or biochemical trigger-events, while targeted MR contrast agents are envisioned to deliver the large gadolinium chelates into the target tissue. In an effort to develop novel smart and targeted MR contrast agents, the series of the DO3A based multifunctional chelating agents with the variable length of the side chain has been synthesized. They serve as valuable multipurpose precursors for contrast agents based on gadolinium chelates in the design (...) of relaxometric MR probes. The presence of the amino group in the side chain of the macrocycle allows for conversion into various functional groups (aminophosponates, aminocarboxylates, etc.) or for conjugation with different biomolecules, dyes, and polymers. Choice of the functional groups depends on the.. (shrink)

To attain native-like competence, second language (L2) learners must establish mappings between familiar speech sounds and new phoneme categories. For example, Spanish learners of English must learn that [d] and [ð], which are allophones of the same phoneme in Spanish, can distinguish meaning in English (i.e. /deɪ/ ‘day’ and /ðeɪ/ ‘they’). Because adult listeners are less sensitive to allophonic than phonemic contrasts in their native language (L1), novel target language contrasts between L1 allophones may pose special difficulty (...) for L2 learners. We investigate whether advanced Spanish late-learners of English overcome native language mappings to establish new phonological relations between familiar phones. We report behavioral and magnetoencepholographic (MEG) evidence from two experiments that measured the sensitivity and pre-attentive processing of three listener groups (L1 English, L1 Spanish, and advanced Spanish late-learners of English) to differences between three nonword stimulus pairs ([idi]-[iði], [idi]-[iɾi], and [iði]-[iɾi]) which differ in phones that play a different functional role in Spanish and English. Spanish and English listeners demonstrated greater sensitivity (larger d’ scores) for nonword pairs distinguished by phonemic than by allophonic contrasts, mirroring previous findings. Spanish late-learners demonstrated sensitivity (large d’ scores and MMN responses) to all three contrasts, suggesting that these L2 learners may have established a novel [d]-[ð] contrast despite the phonological relatedness of these sounds in the L1. Our results suggest that phonological relatedness influences perceived similarity, as evidenced by the results of the native speaker groups, but may not cause persistent difficulty for advanced L2 learners. Instead, L2 learners are able to use cues that are present in their input to establish new mappings between familiar phones. (shrink)

This chapter introduces a novel account of fake news and explains how it differs from other definitions on the market. The account locates the fakeness of an alleged news report in two main aspects related to its production, namely that its creators do not think to have sufficient evidence in favor of what they divulge and they fail to display the appropriate attitude towards the truth of the information they share. A key feature of our analysis is that it (...) does not require that fake news must be circulated with the intention to deceive one’s audience. In this way, our account overcomes a potential limitation of the current philosophical discussion about fake news, which appears to individuate the main problem with this phenomenon in the fact that fake news consumers are misled and misinformed. In contrast, the proposed analysis shows that an additional (and perhaps equally fundamental) problem uncovered by the spread of fake news is a widespread pathological relationship with information, one on which we consume information not to satisfy our interest in the truth but to strengthen our social identities and quench our hunger for social recognition. (shrink)

An improved image enhancement approach via nonsubsampled contourlet transform is proposed in this article. We constructed a geometric image transform by combining nonsubsampled directional filter banks and a nonlinear mapping function. Here, the NSCT of the input image is first decomposed for L-levels and its noise standard deviation is estimated. It is followed by calculating the noise variance and threshold calculation, and computing the magnitude of the corresponding coefficients in all directional subbands. Then, the nonlinear mapping function is used to (...) modify the NSCT coefficients for each directional subband, which keeps the coefficients of strong edges, amplifies the coefficients of weak edges, and zeros the noise coefficients. Finally, the enhanced image is reconstructed from the modified NSCT coefficients. Three experiments are carried out respectively on images from subjective vision quality and objective evaluation measures. The first experiment is the algorithm performed on images. The subsequent experiments are the information entropy and spatial frequency. The experimental results demonstrate that the proposed method can gain better performance in enhancing the low-contrast parts of an image while keeping its clear edges. (shrink)

Some philosophers suggest that the development of scientificknowledge is a kind of Darwinian process. The process of discovery,however, is one problematic element of this analogy. I compare HerbertSimon's attempt to simulate scientific discovery in a computer programto recent connectionist models that were not designed for that purpose,but which provide useful cases to help evaluate this aspect of theanalogy. In contrast to the classic A.I. approach Simon used, ``neuralnetworks'' contain no explicit protocols, but are generic learningsystems built on the model of (...) the interconnections of neurons in thebrain. I describe two cases that take the connectionist approach a stepfurther by using genetic algorithms, a form of evolutionary computationthat explicitly models Darwinian mechanisms. These cases show thatDarwinian mechanisms can make novel discoveries of complex, previouslyunknown patterns. With some caveats, they lend support to evolutionaryepistemology. (shrink)

This essay analyzes the educational significance of the metaphysical novel, that is, how it can be used to educate ourselves and our students. Mordechai Gordon begins by describing the nature of the metaphysical novel while contrasting it to “pure” philosophy and theory building. Gordon also situates Beauvoir’s insights in the broader context of the ongoing conversation on philosophy and literature. In the next part, he examines Beauvoir’s philosophy of lived experience and compare her philosophical approach to more traditional (...) phenomenological theories. From the analysis of Beauvoir’s philosophy of lived experience, Gordon turns to explore the role that ambiguity, contingency, and complexity play in helping us make sense of people’s lives while drawing on examples from several metaphysical novels to illustrate these notions. He concludes this essay by reflecting on the question: what can the study of metaphysical novels bring to philosophy of education? (shrink)

Image similarity metric, also known as metric learning in computer vision, is a significant step in various advanced image tasks. Nevertheless, existing well-performing approaches for image similarity measurement only focus on the image itself without utilizing the information of other modalities, while pictures always appear with the described text. Furthermore, those methods need human supervision, yet most images are unlabeled in the real world. Considering the above problems comprehensively, we present a novel visual similarity metric model named PTF-SimCM. It (...) adopts a self-supervised contrastive structure like SimSiam and incorporates a multimodal fusion module to utilize textual modality correlated to the image. We apply a cross-modal model for text modality rather than a standard unimodal text encoder to improve late fusion productivity. In addition, the proposed model employs Sentence PIE-Net to solve the issue caused by polysemous sentences. For simplicity and efficiency, our model learns a specific embedding space where distances directly correspond to the similarity. Experimental results on MSCOCO, Flickr 30k, and Pascal Sentence datasets show that our model overall outperforms all the compared methods in this work, which illustrates that the model can effectively address the issues faced and enhance the performances on unsupervised visual similarity measuring relatively. (shrink)

The rapidly declining biosphere integrity, representing one of the core planetary boundaries, is alarming. One of the most widely accepted measures to halt the rate of biodiversity loss is to maintain and expand protected areas that are effectively managed. However, it requires substantial finance derived from nature-based tourism, specifically visitors from urban areas. Using the Bayesian Mindsponge Framework (BMF) on 535 Vietnamese urban residents, the current study examined how their biodiversity loss perceptions can affect their willingness to pay for the (...) entrance fee and conservation in protected areas. We found that perceived environmental degradation, loss of economic growth, loss of nature-based recreation opportunity, and loss of knowledge as consequences of biodiversity loss has indirect effects on paying willingness through the mediation of the attitude towards conservation. Especially, the perceived knowledge loss also has a direct positive influence on the willingness to pay for the entrance fee and conservation. In contrast, perceived loss of health is negatively associated with the attitude towards conservation. Based on these findings, we suggest that building an eco-surplus culture among urban residents can be a promising way to generate more finance from nature-based tourism for conservation in protected areas and ease the domestic government's and international organizations' funding allocations problems. (shrink)

Intrapersonal variation due to color contrast effects has been used to argue against the following intuitive propositions about the colors: No object can be more than one determinable or determinate color of the same grade all over at the same time ; external objects are actually colored ; and the colors of objects are mind-independent. In this article, I provide a defense of Incompatibility, Realism, and Objectivism from intrapersonal variation arguments that rely on color contrast effects. I provide a (...) class='Hi'>novel, ecumenical response to such arguments according to which typical variants are right, and which respects Incompatibility, Realism, and Objectivism, using the thesis that the colors of objects depend on the colors of objects in their surrounds. (shrink)

Mikhail Bakhtin has gained a reputation of a thinker and literary theorist somehow hostile to poetry, and more specifically to the epic. This view is based on texts, in which Bakhtin creates and develops a conceptual contrast between poetry and the novel (in "Discourse in the Novel") or between epic and the novel (in "Epic and Novel"). However, as I will show, such perceptions of Bakhtin's position are grounded in a misunderstanding of Bakhtin's writing strategy and (...) philosophical approach. Bakhtin often draws such conceptual contrasts as the ones between epic and novel, but does so not in order to characterize pre-given phenomena (in this case, the epic and the novel as two groups of literary works), but to construct a conceptual space which he in turn uses to explicate elements of his philosophy. (shrink)

Abstract:I examine the often-denigrated concept of the novel of ideas from its inception and critical decline to its relatively recent revival. Using a variant of the exploitation-exploration dilemma in psychology, I suggest that early usage referred to works that exploit philosophical principles—or better, enact them—by setting philosophical positions in conflict. By contrast, use of the concept for more recent works sees characters and plots exploring philosophical stances. The shift corresponds with the greater attention paid to complexity and ambiguity that (...) are hallmarks of continental philosophy and neopragmatism, and with it greater need to explore philosophical stances through fiction. (shrink)

The human “environment of evolutionary adaptedness” can only be inferred indirectly. In contrast, the behavior of some nonhuman animals can be compared among “natural” and various altered environments. As an example, male immigration tactics in unprovisioned versus provisioned macaque (Macaca) populations are compared using Tooby and Cosmides’s (1992) framework for evolutionary functional analysis. In unprovisioned populations, social groups contain few males, and immigrant male takeovers of alpha rank occur frequently. In provisioned populations, groups contain many males, and males almost invariably (...) enter social groups at very low rank and rise in rank only as more dominant males emigrate or die. Male conformity to the “seniority rule” is hypothesized to represent the behavioral output of an evolved decision-making algorithm (psychological mechanism) that takes into account (1) the net payoff of each rank in the dominance hierarchy and (2) the power of male group size as a predictor of the likelihood of successful immigrant takeover. (shrink)

Hippel, author of Die Lebensläufe nach aufsteigender Linie (1778-1781), has been widely recognized as one of the best German authors to write in the manner of Laurence Sterne. This study places Hippel in the context of the theory of the novel and historiography in the eighteenth century. It re-examines the relationship between Hippel and Sterne (as well as Diderot), with emphasis on the contrast in the authors' use of narrators and documents. Hippel's indebtedness to Kant is well known, but (...) here his borrowing from Kant's lecture notes is discussed in detail and its relevance to Hippel's theory of the novel shown. (shrink)

We report and discuss the results of a series of experiments that address a contrast effect exhibited by folk judgments about knowledge ascriptions. The contrast effect, which was first reported by Schaffer and Knobe, is an important aspect of our folk epistemology. However, there are competing theoretical accounts of it. We shed light on the various accounts by providing novel empirical data and theoretical considerations. Our key findings are, firstly, that belief ascriptions exhibit a similar contrast effect and, secondly, (...) that the contrast effect is systematically sensitive to the content of what is in contrast. We argue that these data pose significant challenges to contrastivist accounts of the contrast effect. Furthermore, some of the data set provides, in conjunction with some non-empirical epistemological arguments, some limited evidence for what we call a focal bias account of the data. According to the focal bias account, the contrast effects arise at least in part because epistemically relevant facts are not always adequately processed when they are presented in certain ways. (shrink)

To construct their first lexicon, infants must determine the relationship between native phonological variation and the meanings of words. This process is arguably more complex for bilingual learners who are often confronted with phonological conflict: phonological variation that is lexically relevant in one language may be lexically irrelevant in the other. In a series of four experiments, the present study investigated English-Mandarin bilingual infants’ abilities to negotiate phonological conflict introduced by learning both a tone and a non-tone language. In a (...) novel word learning task, bilingual children were tested on their sensitivity to tone variation in English and Mandarin contexts. Their abilities to interpret tone variation in a language-dependent manner were compared to those of monolingual Mandarin learning infants. Results demonstrated that at 12 to 13 months, bilingual infants demonstrated the ability to bind tone to word meanings in Mandarin, but to disregard tone variation when learning new words in English. In contrast, monolingual learners of Mandarin did not show evidence of integrating tones into word meanings in Mandarin at the same age even though they were learning a tone language. However, a tone discrimination paradigm confirmed that monolingual Mandarin learning infants were able to tell these tones apart at 12 to 13 months under a different set of conditions. Later, at 17 to 18 months, monolingual Mandarin learners were able to bind tone variation to word meanings when learning new words. Our findings are discussed in terms of cognitive adaptations associated with bilingualism that may ease the negotiation of phonological conflict and facilitate precocious uptake of certain properties of each language. (shrink)

This study adjudicates between two opposing accounts of morphological productivity, using English past-tense as its test case. The single-route model posits that both regular and irregular past-tense forms are generated by analogy across stored exemplars in associative memory. In contrast, the dual-route model posits that regular inflection requires use of a formal “add -ed” rule that does not require analogy across regular past-tense forms. Children saw animations of an animal performing a novel action described with a novel verb. (...) Past-tense forms of novel verbs were elicited by prompting the child to describe what the animal “did yesterday.” Collapsing across age group, the likelihood of a verb being produced in regular past-tense form was positively associated with the verb's similarity to existing regular verbs, consistent with the single-route model only. Results indicate that children's acquisition of the English past-tense is best explained by a single-route analogical mechanism that does not incorporate a role for formal rules. (shrink)

Attempts to solve the puzzling problem of oxidative phosphorylation led to four very different hypotheses each of which suggested a different view of the ATP synthase, the phosphorylating enzyme. During the 1960s and 1970s evidence began to accumulate which rendered Peter Mitchell’s chemiosmotic hypothesis, the novel part of which was the proton translocating ATP synthase (ATPase), a plausible explanation. The conformational hypothesis of Paul Boyer implied an enzyme where ATP synthesis was driven by the energy of conformational changes in (...) the respiratory proteins. This was finally abandoned as an explanation of the overall process. Nevertheless the conformational understanding of the enzyme became an acceptable proposal during the early 1970s and eventually led Boyer to a view of the enzyme that incorporated both hypotheses. The correspondence between Mitchell and Boyer, both Nobel laureates, exposes their different approaches to both this enzyme and to the hypotheses of oxidative phosphorylation and illuminates a key step in the development of bioenergetics. In particular Boyer was suspicious of proton gradients, because he could not envisage a chemical mechanism for the synthesis of ATP, while Mitchell distrusted conformational arguments because he believed the proton must act vectorially at the active site of the enzyme. This resulted in two different views of the mechanisms operating in this enzyme. Ultimately while Boyer was able to marry the two approaches, Mitchell retained his insistence on the role of the proton at the active site and was thus unable to give significance to Boyer’s conformational ideas. The underlying issues in this debate are discussed particularly with reference to the differing styles of Boyer and Mitchell and the influence of molecular biology, especially the development of protein technology. (shrink)

Tom Eyers contrasts the different “movements” of the novel and the lyric poem: while moments of stasis in the novel are swept up in its narrative trajectory, atemporal moments in poetry can be juxtaposed against other kinds of temporality — for Eyers’s purposes, most importantly the temporalities of politics and history. The Theory of the Novelbecomes a theory of the lyric, undoing the persistent belief that history can only be made to appear in narrative.

Some of the human needs are more important than others in order to be inevitable. One of these needs which cannot be avoided is the need for belonging to any authority. Whatever the name, religion, nation, homeland, flag etc. all these concepts are the reflections of the sense of belonging that comes with human existence. This article will discuss how Kuwaiti novelist Saud Alsanousi reflects the crisis of a child who is born from a secret relationship with a Filipino woman's (...) son who came to Kuwait as a housekeeper in Kuwait. When he returned to Kuwait, where he carried his passport and felt himself unfamiliar in the Philippines because of his physical structure and the Arabs, he was again excluded by his relatives because of his Filipino mother. The novel tries to draw attention to the socio-economic problems of workers coming from South East Asia to the Gulf countries, especially from the character of Jose, who has a nauseous mood due to the uncertainty between Philippine-Kuwait and Christian-Muslim affiliations. The introduction of foreign workers who constitute more than half of the population in the Gulf countries will be reviewed. Afterwards, a short summary of the novel will be given and the main theme of the lack of disability will be analyzed. Summary: In 1973, Syria and Egypt started a air strike against Israel in order to recover their lost territory in the previous wars and their reputation in the international area. Some Western countries -especially the United States- have shown all kinds of military aid to Israel in the face of this attack. Thanks to these aids the Syrian and Egyptian armies have not achieved their intended goals. This attitude of Western countries to Israel has attracted the reaction of other Gulf countries -especially the Saudi administration- which has a large amount of oil reserves. Gulf countries -which have not gotten a strong military option- tried to use the oil in their hands for the first time as a political trump card. These oil-exporting countries have reduced oil production in response. As a result, the economies of Western countries which were industrialized and dependent on oil have been negatively affected by this decision. In contrast, Gulf States have gained a sudden and massive fortune due to oil prices rising three or four times. The Gulf States, which have led this wealth to development in many areas like education, health, urbanism, etc. The need for qualified staff in these fields was supplied by other Arab countries such as Egypt, Syria, and Sudan. However, as the years passed oil prices decreased and so oil revenues decreased. This reduction led the Gulf States -which have only oil-based economies- to look for cheaper labor. While the foreign employment provided from the Arab countries previously later this need has begun to supply from far East Asian countries which are economically very weak. Vast number of employees emigrated to the Gulf countries to work in the labor service sector with very low wages especially from the Philippines, Indonesia, Bangladesh, and Malaysia. This segment -which has employed with very low wages- has been subjected to injustice and discrimination. The injustices faced by the Far East Asian foreign labor force deprived of social rights have been the subject of many painful stories over time. The modern novel -which aims to reflect the life and the human being with all its details- has reflected the stories of the victims of that employers. Saq al-Bamboo (Bamboo Bar) is one of these novels which has published by Kuwaiti writer Saud Alsanousi in 2012. Within a short time after the publication of the work the novel was interested in the Arab world and in 2013 he was awarded the International Arabic Novelist Prize. The novel is consisting of five chapters and each chapter is divided into three sections 1,2,3... The author conveys the crisis of unetnicity from Jose’s chracter who was born from a Filipino mother and a Kuwaiti father. A translator named Ibrahim Selâm -which is a translation of the souvenirs and diaries belonging to Jose from the Philippine language to Arabic is intended to increase the realism of the work. Josephine -who came to Kuwait to work from the Philippines- was settled in 1985 in one of the country's most reputable families. The old woman who owns the house has a son named Rasheed. Rasheed was interested in Josephine who worked as a servant in their house and he married her with a secret marriage. Because the marriage of a Kuwaiti man and a foreign woman who was working as a housekeeper in Kuwait is accepted as a great shame that will cast a shadow on the dignity and honor of the family the marriage which was concealed by the couple inside and outside of the house, which could only come together with privacy has appeared after months. Rasheed -who was expelled from the house with Josephine- has temporarily found another house. Rasheed and his wife, who thought that his mother's attitude would change as their children were born have disappointed. Rasheed after realizing that his mother would never be satisfied, finally lost his ability to resist this crisis and sent his wife back to. With this development the problem of-identity crisis of Jose’s chracter is dealt with in a multi-faceted way. Jose, who left his age with his mother from Kuwait, had suffered from familial negativities that had passed through Kuwait years later in his twenties, and “familial negativities through his return to Kuwait and depressions caused by the sense of belonging. In an interesting coincidence when he met Gassân, one of the closest friends of Jose’s father in the Philippines, he returned to his dream Paradise ’Kuwait”. The journey from Jesus who has known as “Arabo to “Jesus” started with great hope because he was born from a Kuwaiti father in his own near the Philippines and likened to Arabs alike. But perhaps more of the crisis in the Philippines is waiting for him in Kuwait. Because his father was killed during the years when the Iraqi army occupied Kuwait. Although his father's mother welcomed Jose at first, exclusionary attitude towards foreigners in Kuwait caused her to take a negative attitude towards here grandson. The work is a continuation of the tradition of novels of criticism of the Arab society that has been going on for almost a century. The fact that novel was able to make deep psychological analyzes with his comprehensible language and simple style without being ambiguous and to keep the tension alive by leaving the problems at the end of the episodes and thus to provide immersion in this way reinforced the fictional soundness of the work. The novel also presents fictional material within the Arab society for the researchers in the field of religion psychology and sociology of religion, in order to show how a non-Muslim feels amoung the Muslim society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Temporal Registers in the Realist NovelIlya BernsteinIThere are two ways of thinking about time: in terms of sequences of events, and in terms of time-scales. In the first case, each event is conceived of as having a "before" and an "after": it is categorized as part of a sequence and distinguished from other events by its position in that sequence. In the second case, there is no "before" and (...) "after": events are conceived of as occupying different time-scales and distinguished from one another by being associated with durations of greater or lesser magnitude.1 Thus, the same situation may be categorized alternatively as an unfolding succession of events (event 1, event 2, event 3...) or as a progression of overlapping events on expanding time-scales (the second-event, the minute-event, the hour-event...). In what follows, I will argue that this distinction can shed light on narrative structure—as well as musical form—and that it has particularly interesting implications for literary realism.It may be claimed that this distinction between two ways of approaching time has been an explicit theme in the arts over the course of their history. Different musical forms, for instance, may be seen as being oriented toward one paradigm or the other. Thus, melody aesthetically suggests a sequential conception of time. Melodic forms are supposed to take listeners on a journey from point A to point B, by way of a succession of points in between. By contrast, a form such as the fugue addresses itself to discovering different degrees of density and intensity within the [End Page 173] same event, as it were. It adds layer upon layer, aesthetically dilating the event without moving away from it. The ideology of melody, we might say, thus leans toward a conception of time as a sequence, while the ideology of the fugue suggests a scaling notion of time.Echoes of the distinction between these two aesthetic alternatives may also be found in literature, as embodied in different approaches to narrative. Narrative, conceived of as a succession of episodes, suggests a sequential conception of time, oriented around a "before" and an "after." Yet within these parameters, a spectrum of tendencies may be identified. In some literary forms, the succession of episodes is organized to suggest the idea of a passage from one event to the next (Shakespearean drama, the realist novel), as the notions of "before" and "after" are projected onto ideas of past and future. In others, the succession of episodes represents the layer-by-layer assembly of some larger imaginative or conceptual construct (as is true, in different ways, of such texts as Plato's dialogues, the Divine Comedy, and any number of religious, philosophical, or allegorical narratives): "before" and "after" are interpreted not so much in terms of a past and a future, as in terms of premises and conclusions.Within this spectrum, the novel—and perhaps the realist novel in particular—would appear to be the literary form par excellence that embodies a sequential conception of time. It thematizes and dramatizes time's passage—the unknowability of the future and the irretrievability of the past—more exhaustively than any other narrative genre. Yet as I hope to show below, while the explicit themes of literary realism treat fictional events as a sequence (event 1, event 2, event 3...), its implicit organization is grounded in time-scales and directs readers' attention to differentiations among events taking place at different temporal registers (the sentence-event, the chapter-event, the novel-event...).III would like to begin exploring the theoretical distinction laid out above by going back to music and focusing on an empirical observation that has been made about a variety of musical forms. It has been pointed out that when people listen to a piece of music, they retain in their memory, at greater or lesser degrees of awareness, a certain segment of what they have just heard; this memory serves as a background for their perception of incoming sounds and as a frame of reference for their experience of them. Consequently, musical forms may be characterized, [End Page 174] compared, and distinguished from one another based... (shrink)

We studied changes in eligibility criteria--the largest impediment to patient accrual--in two samples of clinical trials. Trials from the NSABP (National Surgical Adjuvant Breast and Bowel Program) and POG (Pediatric Oncology Group) were analyzed. After eliminating duplications, the criteria in each protocol were enumerated and classified according to a novel schema. NSABP trials contained significantly more criteria than POG trials, and added precision criteria (making study populations homogeneous) at a faster rate than POG studies. The difference between NSABP studies (...) (explanatory trials) and POG studies (pragmatic trials) suggest that large numbers of eligibility criteria are not necessary for quality studies. We recommend that: (1) the inclusion/exclusion criteria distinction be abandoned; (2) eligibility criteria be explicitly justified; (3) the need for each criterion be assessed when new trials are planned; (4) criteria in phase III trials restricting patient accrual be minimized; and (5) further research be done to assess the impact of criteria on generalizability. (shrink)

As a literary critic Anna Letitia Barbauld provides important evidence for those who have sought to challenge a long-established critical view that the development of the novel was premised on a renunciation of the wonders of romance which went hand in hand with the project of Enlightenment science and its rejection of miracles and the supernatural. At the same time, she presents an alternative perspective from that of influential eighteenth-century male critics such as Samuel Johnson regarding the relationship between (...) novels and romances, and a sharply contrasting view of the place of wonder within the overall history of fiction. Against male contemporaries, she makes a case for women’s continuing special claims as readers and writers of fiction based in part on their greater receptivity to emotions such as that of wonder, challenging Johnson’s implicit positioning of men as the leaders of a developing form of literary realism that required a broad knowledge of nature and society. (shrink)

As a literary critic Anna Letitia Barbauld provides important evidence for those who have sought to challenge a long-established critical view that the development of the novel was premised on a renunciation of the wonders of romance which went hand in hand with the project of Enlightenment science and its rejection of miracles and the supernatural. At the same time, she presents an alternative perspective from that of influential eighteenth-century male critics such as Samuel Johnson regarding the relationship between (...) novels and romances, and a sharply contrasting view of the place of wonder within the overall history of fiction. Against male contemporaries, she makes a case for women’s continuing special claims as readers and writers of fiction based in part on their greater receptivity to emotions such as that of wonder, challenging Johnson’s implicit positioning of men as the leaders of a developing form of literary realism that required a broad knowledge of nature and society. (shrink)

The author examines the motives for the behaviour and actions of Dr. Skreta, the main character of Kundera’s novel The Farewell Waltz. The starting point of the novel was the social and political situation in totalitarian Czechoslovakia at the turn of the 1960s and 1970s. He compares it to the situation in the developed western world and comes to a realization that there were many similarities in medicine; however, there were significant differences with regard to external factors. The (...) health care system in western democratic societies were placed in contrast with Czechoslovakia, where a doctor’s activities and the system of health care were subordinated to the political, ideological, and social intentions of totalitarian power. In this context, the author has come to the conclusion that Dr. Skreta’s motives for acting arose from his moral responsibility for the country’s future. Dr. Skreta waged a latent personal “moral war” against the totalitarian regime. This was also reflected in his opposition to the preferred morality of socialist health care professionals. Part of this was his eugenics project. According to the author, in the context of ethics of social consequences, Dr. Skreta was a responsible moral agent seeking a better future not only for the country and its people, but his personal selfish interests. (shrink)

In his (2004), Randolph Clarke assesses an important version of an influential argument against libertarianism about metaphysical freedom. Clarke calls the anti-libertarian argument he evaluates the Contrast Argument. It targets the following claim: there could be an undetermined free act done by S such that S would have freely done something else had S not done the act in question. This modal claim will be endorsed not only by proponents of main brands of libertarianism, but also by action theorists of (...) other stripes – including many compatibilists. Clarke aims to defend the Contrast Argument from a prominent objection by developing a novel case for the premise under attack. I show that Clarke's attempted defense of the Contrast Argument fails, thereby protecting the relevant libertarian and compatibilist positions. In brief, Clarke's argument depends on an ambiguous principle, each available reading of which leaves some or other premise of his argument unjustified. (shrink)

Yasunari Kawabata’s 1952 novel The Sound of the Mountain is widely praised for its aesthetic qualities, from its adaptation of aesthetics from the Tale of Genji, through the beauty of its prose and the patterning of its images, to the references to arts and nature within the text. This article, by contrast, shows that Kawabata uses these features to demonstrate the effects of the mass trauma following the Second World War and the complicated grief it induced, on the psychology (...) of moral/ethical understanding, decision-making and action. The stream of consciousness traces the protagonist’s growing awareness of social changes and the ensuing difficulties of ethical decision-making. (shrink)

Having shown previously how a culture type can be given a unitary description in terms of a semiotic “lens” constrained by one of the Peircean Categories (“Shamanic” culture, by Firstness), we apply this methodology to a more “fine-grained” level of analysis, by comparing the Tamil and Sinhalese cultures under the assumption that one of them (Sinhalese) is in fact a “hybrid” culture-sign. Having shown in previous work that the greater South Asian microculture may be characterized as a Firstness of Thirdness (...) (13), in this paper we provide evidence from a variety of semiotic contexts, including language, art, and religion, that the novel or “intrusive” sign in Sinhalese culture is Firstness of Secondness (12), resulting in a hybrid culture sign that may be described as 12 × 13. (shrink)

Past experience with video games and cognitive abilities have been hypothesized to independently facilitate a greater ability to learn new video games and other complex tasks. The present study was conducted to examine this “learning to learn” hypothesis. We examined the predictive effects of gaming habits and cognitive abilities on learning of two novel video games in 107 participants. One video game was from the action genre, and the other was from the strategy genre. Hours spent gaming per week (...) and working memory were found to specifically predict learning of the novel strategy video game, after controlling for the effects of age, gender, and action game learning. In contrast, self-identification as a “gamer” was the only specific significant predictor of action game learning, after controlling for the effects of age, gender, and strategy game learning. Age of the participant negatively impacted learning of both games; however, the pattern of the predictive relationships on both action and strategy game learning was not moderated by age. Importantly, a preference for the action versus the strategy game genre had no differential effects on learning of the two novel games, nor were there any gender differences in identification as a gamer or genre preference. Findings from this study suggest that while past gaming experience and cognition do appear to influence the learning of novel video games, these effects are selective to the game genre studied and are not as broad as the “learning to learn” model suggests. (shrink)

The author juxtaposes two views of morality and the views of man they imply: one represented by behaviourist and existentialist approaches in theories of morality and the other proposed by Iris Murdoch, who stresses the ability to see and recognise morally significant characteristics. In Murdoch’s opinion, a person’s moral development consists in a change in the quality of consciousness as a result of the activity of attention in exploring moral reality. After contrasting these two views, the author confronts Murdoch’s approach (...) with the conception of moral development understood along these lines as exemplified in a character of her novel The Good Apprentice. She also puts the problem of attention into the context of Murdoch’s conception of the transcendence of persons. (shrink)

The article discusses the characterization of the visualization of visible reality in Crime and Punishment by Fyodor Dostoyevsky. The author suggests that semiotic and legal analysis should be used to understand the meaning of the color code of the novel. Semiotic discourse reduces the ambiguity, uncertainty, and expression of the color code to a conscious, discrete, and conditioned meaning of individual colors. Legal analysis helps to better understand the main idea and other aspects of the novel, encoded in (...) colors. Psychological, personal associations, and symbolic methods are used to reveal direct and indirect meaning of the colors used by Dostoyevsky. The basic characterization of colors proposed by Goethe is employed as a key for color decoding. The article also establishes the correlation of the color code of the novel with the colors of the flags of the Russian Empire and the German Confederation. The message and meaning of the same colors of these national flags are contrasted. The interpretation is complemented by the author’s drawings, which enable to visualize the color code that stores and transmits information about national identity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.1 (2003) 21-39 [Access article in PDF] Capability and Language in the Novels of Tarjei Vesaas Catherine Wilson I THOUGH RELATIVELY UNKNOWN to English-speaking readers, Tarjei Vesaas (1897-1970) is recognized as one of the great Scandinavian novelists and literary innovators of the last century. His oeuvre is substantial, extending to thirty-four volumes published between 1923 and 1966, many of them translated into English and European languages. (...) He was one of four nominees for the 1964 Nobel Prize in literature, and he received a number of other awards and citations in the course of his life. At the same time, his work has failed almost entirely to generate a secondary literature going beyond plot summary, stylistics, and moral approval, and even that literature remains strongly regionalized. 1 Vesaas wrote in nynorsk or "New Norwegian," the minority language of the country created from south-central dialects and distinct from the official, bureaucratic bokmal. He settled permanently on a farm in the remote Telemark district of Norway and assumed no role in European culture as critic or essayist, refusing to discuss his own work in literary or philosophical terms. As a result, analytic and comparative studies have proved difficult to launch.The present essay is intended to provide one such analytical study, addressed specifically to the philosophical themes of ethical resignation, the precariousness of communication, and inwardness. These are familiar themes in twentieth-century literature. In his study of the "literary conquest of the void," R. M. Adams shows how Moravia, Musil, and Beckett amongst others make use of devices of paralysis, immobility, exhaustion, and incomprehension that have their origins in the romantic literature of the nineteenth century, notably in Baudelaire [End Page 21] and Gogol. 2 Literary modernism rejected certain nineteenth-century conventions of plot and character, but did not abandon the fascination of the preceding century with nihilistic themes. Vesaas's work demands to be read in this literary context. The novels, at once semirealistic and highly stylized, deal almost exclusively with rural people and their struggles against the elemental forces of nature. The main characters are often children and adolescents who suffer some degree of helplessness. Simple contrasts are posed: warmth and cold; loss and retrieval, childbirth and death. Agricultural cycle motifs abound. The choice of protagonists and the dominance of vitalistic and biological themes pose the threat of sentimentality and preciousness, but it is avoided by the ubiquity of devastation and destruction in the moral landscape. According to Randi Brox's note in the Dictionary of Scandinavian Literature, the early novels in particular "advocate as the highest goal in life an accepting, contented attitude toward the human condition." 3This judgment reflects what might be termed a judicial-theological picture of fiction. On this view, a novel constitutes a testing ground for discovering what sort of world we live in and what pursuits are possible and worthwhile. Various alternatives are set up as hypotheses, and novels prove and disprove them through narrative demonstrations of the causal effects of adopting them. False theories of the human world and untenable values are subject to refutation. This template is surprisingly useful, not only with respect to the nineteenth-century novel, with its apparent tendency to confident judgment, but even to modern fiction. Moravia, for example, can be seen to be awarding divergent roles to characters and allowing the qualities they represent to struggle for supremacy. 4Yet poststructuralist and postmodernist criticism have cast doubt on the notion that, to the extent that they are important, such contests can ever be decided, and it is increasingly clear that the greatest nineteenth-century novelists, Hardy and Eliot, did not regard the hierarchy of values as settled and demonstrable. Persons, we are coming to understand, are more plausibly seen as sites of conflict; thus fictional representations of persons are repositories of opposing values. Vesaas's novels reflect such an understanding of persons and values, and so the judicial-theological template is inapplicable.The critical view that Vesaas's novels are essentially instructions in adaptation is untenable, because the goal of... (shrink)

The DAP (Death Associated Protein) kinase family is a novel subfamily of pro-apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is largely restricted to the N-terminal kinase domain. In contrast, the adjacent C-terminal regions are very diverse and link individual family members to specific signal transduction pathways. There is increasing evidence that DAP kinase family members are (...) involved in both extrinsic and intrinsic pathways of apoptosis and may play a role in tumor progression. This review will focus on structural composition and subcellular localization of DAP kinase family members and on signal transduction pathways leading to their activation. Potential mechanisms of DAP kinase family-mediated apoptosis will be discussed. BioEssays 23:352–358, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

To address the theological turn in phenomenology, this paper sets out critical arguments opposing the theist phenomenology of Michel Henry and Gilles Deleuze’s philosophy of the event. Henry’s phenomenology has been overlooked in recent commentaries compared with, for example, Jean-Luc Marion’s work. It will be shown here that Henry’s philosophy presents a detailed novel turn in phenomenology structured according to critical moves against positions developed from Husserl, Heidegger, and Merleau-Ponty. This demonstration is done through a strong contrast with Deleuze (...) and a short engagement with Quentin Meillassoux. The paper presents an argument against the theological turn on the grounds that it misunderstands the form of affectivity when compared to Deleuze’s work on affect and event. It will be argued that Henry’s search for a free-standing affect deduced as a condition for any appearance underplays the way any affect is included in many causal and transcendentally determined series such that any notion of the pure affect independent of other processes is a fiction. The loss of this pure affect entails the questioning of the theological turn in Henry. (shrink)

As calcium plays an important role in regulating a great variety of neuronal processes, there is a strong interest to generate gadolinium complexes which can act as calcium-sensors in magnetic resonance imaging (MRI). Here we report a new series of potential CAs based on DO3A, having alkylaminobis(methylenephosphonate) side chains (propyl L1, butyl L2, pentyl L3 or hexyl L4). The high complexation efficiency towards the biologically important metal ions of the aminopolyphosphonic acids could be used for the sensing of the extracellular (...) calcium in the brain. On the other hand the introduction of negatively charged phosphonate groups into common Gd3+-based CAs increases their r1 which is important to improve the MR signal especially in high field magnets. The paramagnetic response of the complexes GdL1-GdL4 to Ca2+ was studied by means of relaxometric titrations. The initial relaxivities of the complexes found to be higher than usually reported for the DO3A type ligands at high field magnets (9.4T). r1 values of 6.92, 7.43, 6.70 and 5.76 mM-1s-1 were determined for GdL1, GdL2, GdL3, and GdL4 respectively. Interestingly complexes exhibit unusual properties in the presence of Ca2+. In contrast to previously reported probes the longitudinal relaxivities decrease upon addition of Ca2+. This is favourable for novel fMRI techniques as it could allow transforming the real in vivo decrease in Ca2+ concentration into a positive contrast during physiological processes. The sensitivity of the complexes towards Ca2+ increases with the extension of the aliphatic side chain. No changes in r1 of GdL1 were found over the whole span of Ca2+ concentration. In the case of GdL2, a moderate decrease of r1 was observed on addition of Ca2+, whereas the r1 of the GdL3 and GdL4 solutions showed a strong dependency on the calcium concentration resulting in the decrease to 66% and 61% of the initial r1 values, respectively. (shrink)

The chromatin‐regulatory principles of histone post‐translational modifications (PTMs) are discussed with a focus on the potential alterations in chromatin functional state due to steric and mechanical constraints imposed by bulky histone modifications such as ubiquitin and SUMO. In the classical view, PTMs operate as recruitment platforms for histone “readers,” and as determinants of chromatin array compaction. Alterations of histone charges by “small” chemical modifications (e.g., acetylation, phosphorylation) could regulate nucleosome spontaneous dynamics without globally affecting nucleosome structure. These fluctuations in nucleosome (...) wrapping can be exploited by chromatin‐processing machinery. In contrast, ubiquitin and SUMO are comparable in size to histones, and it seems logical that these PTMs could conflict with canonical nucleosome organization. An experimentally testable hypothesis that by adding sterical bulk these PTMs can robustly alter nucleosome primary structure is proposed. The model presented here stresses the diversity of mechanisms by which histone PTMs regulate chromatin dynamics, primary structure and, hence, functionality. (shrink)

Biomimicry is a rising popular ecology movement and method that urges the derivation of innovative and environmentally sound design from organic systems. This essay explores the notion of nature in biomimicry as articulated by the movement’s founder, Janine Benyus, and the nature of biomimicry as practiced by the Massachusetts Institute of Technology media ecologist Neri Oxman. Benyus’s approach, I show, promotes biomimicry as a science of nature in which nature is treated as a source for innovative design that can be (...) emulated in technological apparatus. Such an approach is problematic, I argue, for its valorization of organic form, which results in both a rigid system of ethics demanding absolute separation of nature and technology. By contrast, Oxman’s work, I show, pursues biomimicry as a technology of nature. In so doing, I argue, it mobilizes a neomaterialist style of interaction with organic materials that ultimately enjoins a radically different way of thinking nature, technology, and technoethics. (shrink)

This volume develops a fundamentally different categorical framework for conceptualizing time and reality. The actual taking place of reality is conceived as a “constellatory self-unfolding” characterized by strong self-referentiality and occurring in the primordial form of time, the not yet sequentially structured “time-space of the present.” Concomitantly, both the sequentially ordered aspect of time and the factual aspect of reality appear as emergent phenomena that come into being only after reality has actually taken place. In this new framework, time functions (...) as an ontophainetic [H1] platform, i.e., as the stage on which reality can first occur. Events are merely the “tracks” that the actual taking place of reality leaves behind on the co-emergent “canvas’’ of local spacetime. -/- The view of time proposed here is particularly relevant to the recent debate over the “ER=EPR” conjecture targeting the relation between quantum physics and general relativity theory. The novelty of this radically different framework is that it allows quantum reduction and singularities to be addressed as inverse transitions into and out of the factual layer of reality: In quantum physical state reduction, reality “gains” the chrono-ontological format of facticity, and the sequential aspect of time becomes applicable. In singularities, by contrast, the opposite happens: Reality loses its local spacetime formation and reverts back to its primordial, pre-local shape – making the use of causality relations, Boolean logic and the dichotomization of subject and object obsolete in the process. -/- For our understanding of the relation between quantum and relativistic physics, this new view opens up fundamentally new perspectives: Both are legitimate views of time and reality; they simply address very different chrono-ontological portraits, and thus should not lead us to erroneously prefer one view over the other. -/- The task of the book is to provide a formal framework in which this radically different view of time and reality can be suitably addressed. The mathematical approach is based on the logical and topological features of the Borromean Rings, and draws upon concepts and methods from algebraic and geometric topology – especially the theory of sheaves and links, group theory, logic and information theory in relation to the standard constructions employed in quantum mechanics and general relativity, shedding new light on the problems of their compatibility. The intended audience includes physicists, mathematicians and philosophers with an interest in the conceptual and mathematical foundations of modern physics. (shrink)

The aim of this paper is to show how James Mark Baldwin’s theory of Organic Selection can be fruitfully integrated with Alfred North Whitehead’s speculative philosophy, as part of the endeavor to develop a comprehensive process-relational evolutionary cosmology. In so doing, it provides an overview of the theory of Organic Selection and points to several concrete examples from the Galapagos Islands which elucidate Baldwin’s claim that organisms, through their selective activities and behavioral adjustments, play a causal role in directing evolutionary (...) processes. I emphasize some of the affinities between Baldwin’s theory of Organic Selection and Whitehead’s theory of prehensions, especially focusing on the latter’s notion of “prehensive selectivity.” Overall, while Baldwin’s theory of Organic Selection provides a biological ground for a comprehensive process-relational evolutionary cosmology to be developed, illuminating the importance of Whitehead’s theory of prehensions for evolutionary theory, Whitehead’s overall speculative scheme can, in turn, strengthen the metaphysical, epistemological, and ethical foundations of Baldwin’s theory. In the course of merging the two views, I arrive at an enlarged conception of Organic Selection, placing it in context with Darwin’s principle of Natural Selection. At the end of the paper, I take up the resulting question of the ethics of selectivity in general, arguing that the merger of Baldwin’s and Whitehead’s ideas constitutes a “non-reductionistic critical pan-selectionism.” This position stands in contrast to the antagonistic standpoints of “Selectionism” and “Anti-Selectionism” in the ongoing debates over the ethical dimensions of Darwinian evolution. (shrink)