‘Neuroeconomics’ can be broadly defined as the research of how the brain interacts with the environment to make decisions that are functional given individual and contextual constraints. Deciphering such brain-environment transactions requires mechanistic understandings of the neurobiological processes that implement value-dependent decision making. To this end, a common empirical approach is to investigate neural mechanisms of reward-based decision making. Flexible updating of choices and associated expected outcomes in ways that are adaptive for a given task (or a given set of (...) tasks) at hand relies on dynamic neurochemical tuning of the brain’s functional circuitries involved in the representation of tasks, goals and reward prediction. Empirical evidence as well as computational theories indicate that various neurotransmitter systems (e.g., dopamine, norepinephrine, and serotonin) play important roles in reward-based decision making. In light of the apparent aging-related decline in various aspects of the dopaminergic system as well as the effects of neuromodulation on reward-related processes, this article focuses selectively on the literature that highlights the triadic relations between dopaminergic modulation, reward-based decision making, and aging. Directions for future research on aging and neuroeconomoics are discussed. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral (...) NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

The article is a review of Hauke Brunkhorst’s book on a _Critical Theory of Legal Revolutions_. The author addresses three points: Hauke Brunkhorst’s notion of history, and of what remains unseen; the dialectics of evolution and revolution, and whether the approach is sufficiently dialectic, according to its own promise; and the implicit notion of critique.

The complex figure of Theodor Adorno has made a lasting impact on modern political and philosphical development. Deeply interested in the flowering of modern art and an accomplished musician who was close to Schoenberg's circle, he was profoundly affected by revolutionary Marxism, although he always resisted its institutionalized manifestations. Adorno sought to highlight the negative characteristics of the Enlightenment while at the same time emphasizing its positive and empancipatory aspects. In both politics and philosophy he preferred the spontaneous to the (...) orthodox, the experimental to the conventional. His life's work rejects the capitalist system of the twentieth-century while at the same time acknowledging and affirming its creative cultural achievements. Hauke Brunkhorst's book is the first English-language assessment of Adorno's life and work. He stresses the links between Adorno and the dialectical thinking of Hegel and Marx, but also emphasizes the connection between Kant and Adorno. The book sheds new light on Adorno's negative dialectic and is an important contribution to the debate on this celebrated philosopher. (shrink)

The psychological writing of Jung and the post-Jungians is all too often ignored as anachronistic, archaic and mystic. In Jung and the Postmodern, Christopher Hauke challenges this, arguing that Jungian psychology is more relevant now than ever before - not only can it be a response to modernity, but it can offer a critique of modernity and Enlightenment values which brings it in line with the postmodern critique of contemporary culture. After introducing Jungians to postmodern themes in Jameson, Baudrillard, (...) Jencks and Foucault, the author introduces postmodernists to Jung's cultural critique and post-Jungian discussions of representation, individuation, consciousness, and the alternatives to Enlightenment rationality. He also takes a totally fresh approach to topics such as hysteria and the body, Jung and Nietzsche, architecture and affect, Princess Diana and the 'death' of the subject, postmodern science and synchronicity, and to psychosis and alternative 'rationalities'. Jung and the Postmodern is vital reading for everyone interested in contemporary culture, not only Jungians and other psychotherapists who want to explore the social relevance of their discipline, but anyone who shares a assionate concern for where we are heading in postmodern times. (shrink)

This article aims to make progress towards an account of social cohesion and participation in terms of which we can better understand how groups of people come to constitute stable social orders. It argues for a conceptual distinction between "inclusion" and "integration" and sheds new light on their theoretical relationship. While "integration" refers to group members' willingness to act in accordance with the given norms of a social structure, "inclusion" is linked to their participation opportunities. Although inclusion also plays an (...) essential role in integrating a normative order, levels of inclusiveness necessary for social cohesion may vary across different contexts. (shrink)

This essay is part of a dossier on Cristina Lafont's book Democracy without Shortcuts.

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

Wie lässt sich der Bereich des Privaten heute genau beschreiben? Welchen Wert besitzt Privatheit in digitalisierten Gesellschaften für den Einzelnen und die Gesellschaft als Ganzes? Welche Werte und Lebensformen werden durch Privatheit geschützt, welche eingeschränkt? Entstehen durch die Informationsasymmetrie zwischen Technologieunternehmen, staatlichen Verdatungsinstitutionen und Verbrauchern/Bürgern möglicherweise neue Machtstrukturen? Welche rechtlichen Implikationen ergeben sich hieraus? Dieser Band geht diesen und anderen Fragen, die sich im Hinblick auf die etablierte Gleichung von Freiheit und Privatheit stellen, nach und versucht Antworten zu finden.

The purpose of this paper is to defend an understanding of social participation that spells out inclusion as a dispositional property. I assume that an agent must occupy at least one position within a social order so that he is leastways partially included. The fact that a social position is open to someone means that he has the opportunity to take it. However, disputed is how "having the opportunity" should be understood exactly. My thesis, which I will develop and defend (...) in the context of this article, is: Since the appropriate application context decides whether the role characteristics of an agent actually become manifest, participation is a dispositional property. Therefore, a role is not open to someone only if he cannot claim a certain status for himself, even though he is in the relevant context. It is thus not a logical or metaphysical modality, but a normative modality that is relevant in terms of the openness of a role. Hence, social participation consists in a normative status that takes effect when certain conditions occure. (shrink)

Bekanntester deutscher Philosoph der Gegenwart. Seit mehr als fünfzig Jahren prägt Jürgen Habermas das intellektuelle Leben Deutschlands und darüber hinaus. Mit seinem Werk nimmt er entscheidenden Einfluss auf die Wissenschaften, auf Politik und aktuelle gesellschaftliche Diskussionen. Neben einem Überblick zur Biografie stellt das Handbuch Habermas intellektuelle Kontexte, wie z. B. die Frankfurter Schule, vor und beleuchtet die wichtigsten Stationen seines komplexen Werkes. Der Schlussteil informiert über Begriffe und Konzepte, die sich durch das gesamte Werk ziehen.

This paper asks how ‚image‘ and ‚imagination‘ relate to each other. The first part deals with important aspects such as ‚visuality‘, ‚reference‘, ‚order‘, ‚mediation‘ and ‚constructivity‘. The connection between ‚image‘ and ‚imagination‘ is then explored in texts on metaphysics and aesthetics by Christian Gottfried Bardili and Wilhelm Traugott Krug. With his ‚Law of Complementation‘, Bardili offers a solution to the problem of the mediation of the senses and the intellect. For Krug, ‚image‘ is a modality in which imagination in the (...) field of art proceeds with the aim of creating order and unity in diversity. (shrink)

In 1913 the British Idealist Sir Henry Jones (1852-1922) spoke of journalism as an 'organic filament'2 that helped unite individuals in a greater citizenship. This Idealist perception of the media coalesced with the contemporaneous growth of a broader notion of journalism as a fourth estate. Beginning with the social philosophy of Edward Caird (1835-1908) and its extension into the Idealist conception of journalism, this article explores the attitudes of Idealist thinkers in Britain and Australia toward print and radio media. It (...) further examines how Idealist belief in journalism translated into publication of Idealist thought. The media and academic publications of four Australian Idealists are considered. Also identified is a sympathetic Australian media environment. Through this study emerges an Australian Idealism that, whilst anchored within the broader empire of Idealist philosophy, acquired a local, public form through a consistent and, at times, intensive use of print and radio media. (shrink)

A political sociologist examines the concept of universal, egalitarian citizenship and assesses the prospects for developing democratic solidarity at the global level.

Die Autorinnen und Autoren widmen sich der Frage nach dem Verhältnis von Kunst und Moral. Wie weit darf künstlerische Freiheit gehen? Lassen sich ästhetischer und moralischer Wert eines Kunstwerks trennen oder ist Kunst immer im Licht der Absicht.

Wie lässt sich der Bereich des Privaten heute genau beschreiben? Welchen Wert besitzt Privatheit in digitalisierten Gesellschaften für den Einzelnen und die Gesellschaft als Ganzes? Welche Werte und Lebensformen werden durch Privatheit geschützt, welche eingeschränkt? Entstehen durch die Informationsasymmetrie zwischen Technologieunternehmen, staatlichen Verdatungsinstitutionen und Verbrauchern/Bürgern möglicherweise neue Machtstrukturen? Welche rechtlichen Implikationen ergeben sich hieraus? Dieser Band geht diesen und anderen Fragen, die sich im Hinblick auf die etablierte Gleichung von Freiheit und Privatheit stellen, nach und versucht Antworten zu finden.

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 67 Heft: 3 Seiten: 464-489.

Cartesian separation and enlightenment have led to a widespread conceptual separation of science and technology. Consequently a certain philosophical tradition holds pure science as a metaphysical striving for irrefutable truth that is morally neutral and only ( dirty?) applications as morally accountable. An opposite extreme position holds scientists responsible for everything that is done with their discoveries. Based on an interpretation of science to be a social construct and the observation that moral criteria are the results of social processes the (...) paper demonstrates by the example of synthetic chemistry that science is not an elite end in itself and as such is not free from obligation to moral criteria. The moral responsibility of a scientist, which arises from his professional expertise, is limited to the available knowledge of his discipline. The moral responsibility, which he carries beyond that as responsible acting human, derives from the cultural identity and the normative values under which his action is carried out. This conclusion is illustrated by the examples of DDT, Aspirin and Heroin. (shrink)

Eine Neuverortung des Privaten, wie im Titel dieses Bands angekündigt – was hat es damit auf sich? Wer oder was sind die treibenden Kräfte hinter dieser Entwicklung? Warum ist sie notwendig oder zumindest sinnvoll? Was steht dabei auf dem Spiel?

Most scholars dealing with neo-Kantianism emphasize the existence of an explicit origin that characterizes neo-Kantianism as a clearly defined ‘movement’ with certain objects. In spite of the fact that differences between various neo-Kantian authors are mentioned in the current discourse (e. g. ‘Südwestdeutsche’ and ‘Marburger Schule’) scholars claim a singular unity of all neo-Kantian debates represented in the problem of ‘Geltung’. This is used to construct a certain relevance of neo-Kantianism in today’s philosophy. My contribution will pursue a historical approach (...) following Klaus Christian Köhnke’s and Ulrich Sieg’s demands. Instead of sketching systematic topics I pay further attention to the context in which an essence of neo-Kantianism was claimed or rejected. In doing so I will examine the discussions on the doctrine of postulates in Kant’s philosophy mainly led by Hans Vaihinger’s ‘Philosophy of As If’ and the impact of Eduard von Hartmann on the genesis of neo-Kantianism. I conclude that the definition of a consistent neo-Kantian ‘movement’ was an effect of rejecting spiritualist interpretations of the doctrine of postulates and in the following a rejection of the whole doctrine as ‘mysticism’ in canonical Kant interpretations. (shrink)

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

ABSTRACT: This paper presents a discourse analysis of 40 semi-structured interviews with scientists on their views of Occam's razor and simplicity. It finds that there are many different interpretations and thoughts about the precise meaning of the principle as well as many scientists who reject it outright, or only a very limited version. In light of the variation of scientists' opinions, the paper looks at the discursive uses of simplicity in scientists' thinking and how scientists' interpretations of Occam's razor impact (...) on philosophy's representation of the principle and affects the communication between philosophy and science. (shrink)

ABSTRACT: This paper presents a discourse analysis of 40 semi-structured interviews with scientists on their views of Occam's razor and simplicity. It finds that there are many different interpretations and thoughts about the precise meaning of the principle as well as many scientists who reject it outright, or only a very limited version. In light of the variation of scientists' opinions, the paper looks at the discursive uses of simplicity in scientists' thinking and how scientists' interpretations of Occam's razor impact (...) on philosophy's representation of the principle and affects the communication between philosophy and science. (shrink)

The paper starts with a thesis on the dialectical structure of modern law that goes back the European revolutionary tradition and constitutes a legal structure that is at once emancipatory and repressive. Once it became democratic the modern nation states has solved more or less successfully the crises that emerged in modern Europe since the 16th Century. Yet, this state did not escape the dialectical snares of modern law and modern legal regimes. It’s greatest advance, the exclusion of inequalities presupposed (...) the exclusion of the internal other of blacks, workers, women etc, and the other that stemmed from the non-European world that furthermore was under European colonial rule or other forms of European, Northamerican and Japanese imperial control. Yet, the wars and revolutions of the 20th Century let to a complete reconstruction, new foundation and globalization of all national and international law. The evolutionary advance of the 20th Century was the emergence of world law, and this enabled the construction of international and national welfarism and the global expansion of the exclusion of inequalities. Nevertheless the dialectic of enlightenment came back again and led to new forms of postnational domination, hegemony, oppression and exclusion. The final section tries to detect some ideas and principles how to overcome the crisis. (shrink)