Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

ISBN 0-7914-3529-6 (hard : alk. paper). — ISBN 0-7914-3530-X (pbk. : alk. paper ) 1. Dewey, John, 1854-1952. I. Title. II. Series: SUNY series in philosophy of education. B945.D4B65 1997 191— dc 21 96-52291 CIP 10 987654321 For Jayne ...

Whitehead's response to the epistemological challenges of Hume and Kant, written in a style devoid of the metaphysical intricacies of his later works, Symbolism makes accessible his theory of perception and his more general insights into the function of symbols in culture and society.

Raymond Boisvert's very Aristotelian look at John Dewey's metaphysics.

In a field dominated by research on moral prescription and moral prediction, there is poor understanding of the place of moral perceptions in organizations alongside philosophical ethics and causal models of ethical outcomes. As leadership failures continue to plague organizational health and firms recognize the wide-ranging impact of subjective bias, scholars and practitioners need a renewed frame of reference from which to reconceptualize their current understanding of ethics as perceived in individuals. Based on an assessment and selection perspective from the (...) field of human resource management, an alternative to conventional deductive-prescriptive approaches is proposed based on a pluralistic concept referred to as moral goodness. An inductive-descriptive theory-building framework is constructed based on three interrelated streams of inquiry to yield insight concerning both formal and informal instances of assessment. Recommendations are proposed for the application of the framework to future research and practice. (shrink)

A key theme in Michael Pollan's first two books dealing with food, The Botany of Desire and The Omnivore's Dilemma, is the notion of "co-evolution." The first book deals with it somewhat humorously, suggesting that we are manipulated by our plants. These, the claim goes, have gotten us to co-evolve so that we will take good care of them. All they need to do in return is sort of relax and throw us bits of nutrition or beauty now and then. (...) In The Omnivore's Dilemma, a more mitigated tone prevails. This one lays out how important, for a vibrant farm, are all of the components that must function together. The book even highlights a plant whose relationship to humans is one great example of co-evolution: corn. Corn .. (shrink)

Recipient of Choice Magazine's 1996 Outstanding Academic Book Award Author Raymond Morrow outlines and recounts the development of the major tenets of critical theory, exemplifying them through the works of two of their most influential, recent adherents: Jürgen Habermas and Anthony Giddens. Beginning with a comprehensive yet meticulous explication of critical theory and its history, the author next discusses it within the context of a research program; his work concludes with an examination of empirical methods. Emphasizing the connections between (...) critical theory, empirical research, and social science methodology, Morrow's volume offers refreshing insights on traditional and current material. (shrink)

First: there is ample precedent for what I am doing. Socrates, for example, examined the religious beliefs of his contemporaries-- especially the belief that we ought to do what the gods command--and showed them to be both ill-founded and conceptually confused. I wish to follow in his footsteps though not to share in his fate. A glass of wine, not of poison, would be my preferred reward.

The Ancient Mariner’s killing of the albatross is described by Coleridge as a great act of “inhospitality.” The central virtue dealt with in The Odyssey is hospitality.Religious traditions and cultures throughout the world prize hospitality as a major virtue. Philosophy, for some reason, has proven the exception. Hospitalityis missing from just about any philosopher’s list of virtues. Few discussions of ethics pay attention to it. This essay explores why hospitality has been so prominent in literature but ignored in philosophy. What (...) Santayana called the “sedentary city mind,” typical of Modern thought, which replaced the medieval “pilgrim mind,”is seen as a key move leading philosophers to marginalize hospitality. The move to rehabilitate hospitality, I claim, can draw inspiration and sustenance from asurprising source: Jacques Derrida. (shrink)

Philosophical theses are sometimes assailed from so many sides that, even if they have not been refuted, it becomes difficult for them to gain a fair hearing. A case in point seems to be the thesis that the sentence ‘Every event has a cause' may on occasion be used to assert something which, as a matter of contingent fact, is either true or false. In the interests of logical chivalry, I want to take up its defence.My aim, it should be (...) noted, is not to defend the truth of the Causal Principle, to claim that our world is one in which every event is causally determined by another event or set of events. So I shall have nothing to say about the arguments of those who—like the quantum physicists, Heisenberg, Bohr, and Born—claim to have shown that the Causal Principle is false; claim, that is, that our world is fundamentally indeterministic. My concern is only to establish the right of determinists and indeterminists alike to take seriously the question whether our world is in fact one in which every event has a cause. (shrink)

early march 2020: i'm in a french village on the Mediterranean near the Spanish border. The outdoor marché, thronged, is active twice a week. The cafés are crowded. On my morning walk, I am buoyed by the sounds of schoolchildren. The village's only grocery, a small outlet of a major chain, is well-stocked.Mid-March: pandemic. "Non-essential" vendors are banned from the marché. The cafés are shuttered. The school is closed. The little store has depleted shelves. There is a mandate to stay (...) home. Anyone venturing out must carry an attestation certifying the reason for being in public.Fortunately, there is the Internet. There are books. The local wine store offers home delivery. Fortunately, also, I'm in the final... (shrink)

Naoko Saito has made a good case for emphasising the ‘tragic’ dimension within Dewey’s pragmatism. My response suggests ways in which Saito has not gone far enough. She does not adequately move beyond ‘procedural pragmatism’ to a ‘programmatic pragmatism’ which offers substantive articulations about the human good. In addition, her emphasis on ‘Emersonian perfectionism’ is misguided. Both the language of ‘perfectionism’ and the figure of Emerson are unsuitable for the project she intends. Speaking more concretely of a ‘tragic–comic meliorism’ allied (...) to the novelist Hawthorne, it is suggested, provides a more fruitful path. (shrink)

Naoko Saito has made a good case for emphasising the ‘tragic’ dimension within Dewey’s pragmatism. My response suggests ways in which Saito has not gone far enough. She does not adequately move beyond ‘procedural pragmatism’ to a ‘programmatic pragmatism’ which offers substantive articulations about the human good. In addition, her emphasis on ‘Emersonian perfectionism’ is misguided. Both the language of ‘perfectionism’ and the figure of Emerson are unsuitable for the project she intends. Speaking more concretely of a ‘tragic–comic meliorism’ allied (...) to the novelist Hawthorne, it is suggested, provides a more fruitful path. (shrink)

This essay reads Camus’s novel The Fall as a reductio ad absurdum for two major strands in Western intellectual culture, the hyper-Augustinian “we are all depraved” strand and, more decisively, what I call the “hyper-Sartrean” strand of existentialist humanism. Many commentators have identified Sartre as a target of Camus’s novel, but a detailed exploration of the critique is rarely undertaken. Examining Sartre’s Existentialism is a Humanism reveals an understanding of the human condition as involving a double disconnection: from nature and (...) from other people. Camus’s protagonist is just such a doubly detached individual. With little subtlety, Camus depicts his protagonist, as “Satanic,” i.e., the fallen one, the universal accuser, the friend of destruction, the enemy of connection. Such a “Fall” into self-isolation represents the all too alluring temptation against which Camus wishes to warn us. (shrink)

This essay reads Camus’s novel The Fall as a reductio ad absurdum for two major strands in Western intellectual culture, the hyper-Augustinian “we are all depraved” strand and, more decisively, what I call the “hyper-Sartrean” strand of existentialist humanism. Many commentators have identified Sartre as a target of Camus’s novel, but a detailed exploration of the critique is rarely undertaken. Examining Sartre’s Existentialism is a Humanism reveals an understanding of the human condition as involving a double disconnection: from nature and (...) from other people. Camus’s protagonist is just such a doubly detached individual. With little subtlety, Camus depicts his protagonist, as “Satanic,” i.e., the fallen one, the universal accuser, the friend of destruction, the enemy of connection. Such a “Fall” into self-isolation represents the all too alluring temptation against which Camus wishes to warn us. (shrink)

Kripke, Putnam and others have proposed what is often called The New Theory of Reference. Professor Matthen thinks that this theory needs to be modified in various ways: so as to avert misunderstandings about the New Theory's commitment to essentialism; so as to clarify the semantic function of what he calls “nonconnoting terms”; so as to answer Quinean doubts about the determinacy of ostension; so as to correct Putnam's “simplistic” account of ostension; so as to solve Kripke's puzzle about the (...) seemingly inconsistent beliefs of the bilingual Pierre; and so as to show how many ordinary names, contra Kripke and Putnam, can be treated as “equivalent” to definite descriptions. No doubt many of the other things he says in his paper are clever, and perhaps even true. But as to the six modifications I have listed, I have run into difficulties. To the extent that I am able to understand them, I have been forced to conclude that they are neither needed nor helpful. (shrink)

In the Tractatus Logico-Philosophicus Wittgenstein writes:2.022 It is obvious that an imagined world, however different it may be from the real one, must have something – a form – in common with it.2.023 Objects are just what constitute this unalterable form.As F.P. Ramsey pointed out, in his insightful review of the Tractatus, it is evident:[i]that Wittgenstein is here envisaging a multitude of possible worlds other than the real one;[ii]that Wittgenstein is claiming that, notwithstanding their diversity, all such worlds have a (...) common form; and[iii]that Wittgenstein believes this form to be somehow 'constituted' by the simple objects that exist in these worlds. (shrink)

In the Tractatus Logico-Philosophicus Wittgenstein writes:2.022 It is obvious that an imagined world, however different it may be from the real one, must have something – a form – in common with it.2.023 Objects are just what constitute this unalterable form.As F.P. Ramsey pointed out, in his insightful review of the Tractatus, it is evident:[i]that Wittgenstein is here envisaging a multitude of possible worlds other than the real one;[ii]that Wittgenstein is claiming that, notwithstanding their diversity, all such worlds have a (...) common form; and[iii]that Wittgenstein believes this form to be somehow 'constituted' by the simple objects that exist in these worlds. (shrink)

This paper argues that God is not logically able to condemn a person to Hell by considering what is entailed by accepting the best argument to the contrary, the so-called free will defense expounded by Christian apologists Alvin Plantinga and William Lane Craig. It argues that the free will defense is logically fallacious, involves a philosophical fiction, and is based on a fraudulent account of Scripture, concluding that the problem of postmortem evil puts would-be believers in a logical and moral (...) straightjacket from which there is no escape without heresy or contradiction. -/- 1. Imagining an Afterlife in Hell -- 2. Essential Doctrines of Christianity -- 3. The Logical Puzzle Involved -- 4. Plumbing the Depths of Christian Doctrine a Little - 4.1 Christianity’s Commitment to Theism - 4.1.1 God’s Omnipotence - 4.1.2 God’s Omniscience - 4.1.3 God’s Omnibenevolence (Moral Perfection) - 4.2 The Doctrines of Salvation and Damnation - 4.2.1 Salvation and Heaven - 4.2.2 Damnation and Hell - 4.2.3 The Inhabitants of Hell – 5. The Issue of Inconsistency Again - 5.1 The Missing Concept of Responsibility - 5.2 God’s Responsibility for Evil in General - 5.3 The Charge of Inconsistency Reinforced -- 6. The Christian Cross: A Logical Straightjacket -- 7. The Art of Apologetics -- 8. Craig’s Apologetics - 8.1 Craig’s Purported Proof of Consistency - 8.1.1 A Problem with the Entailment Condition - 8.1.2 A Problem with the Consistency Condition - 8.1.3 Is Craig’s Optimal World the Best God Could Create? - 8.1.4 A Heavenly Refutation - 8.1.5 “Heaven Isn’t a Possible World” - 8.1.6 “Heaven Isn’t a Feasible World” -- 9. Free Will, Foreknowledge, and Predestination - 9.1 Compatibilist versus Incompatibilist Meanings of “Free Will” - 9.2 Free Will, Predestination, and Being Sent to Hell - 9.3 Consequences of Being Predestined to Hell -- 10. Summary. (shrink)

The Ancient Mariner’s killing of the albatross is described by Coleridge as a great act of “inhospitality.” The central virtue dealt with in The Odyssey is hospitality.Religious traditions and cultures throughout the world prize hospitality as a major virtue. Philosophy, for some reason, has proven the exception. Hospitalityis missing from just about any philosopher’s list of virtues. Few discussions of ethics pay attention to it. This essay explores why hospitality has been so prominent in literature but ignored in philosophy. What (...) Santayana called the “sedentary city mind,” typical of Modern thought, which replaced the medieval “pilgrim mind,”is seen as a key move leading philosophers to marginalize hospitality. The move to rehabilitate hospitality, I claim, can draw inspiration and sustenance from asurprising source: Jacques Derrida. (shrink)