Despite heroic efforts, philosophers have found it increasingly difficult to evade discussion of metaphysical topics. Take the philosophy of mind. Take, in particular, the mind-body problem in its latest guise: the problem of causal relevance. If mental properties are not reducible to physical properties, how can we reconcile the role such properties seem to have in producing bodily motions that constitute actions with the apparent fact that the very same motions are entirely explicable on the basis of purely physical properties (...) of purely physical events in the nervous system? Familiar approaches to the problem include appeals to “supervenient causation,” to “higher-level” laws governing putatively higher-level entities and events, and to “realizing” relations that make room in objects for overlapping properties. (shrink)

There is growing interest in developing co-operation between adult literacy researchers and practitioners to further research skills and approaches. Canada’s National Literacy Secretariat has recently initiated a series of policy debates that suggested several possibilities: targeted research grants, research internships for practitioners, practical sabbaticals for researchers, support for networking between literacy researchers and practitioners, and joint seminars and workshops between researchers and practitioners. A common theme throughout these discussions is the need to develop critical thinking about both collaborative research and (...) adult literacy. In this paper we discuss two collaborative initiatives between university-based researchers and adult literacy groups in the provinces of British Columbia and Ontario. Each project was based on the notion of “research circles” and specifically designed to enhance research capacity and critical thinking about literacy research. (shrink)

Recruiting patients to participate in health research is challenging, and most studies struggle. Failure to recruit can jeopardise the quality of research, and threatens efforts to improve healthcare. Despite this, recruitment materials tend to be conservatively designed and unimaginative. One reason for this is ethical concerns regarding the risk of coercion and offence posed by recruitment materials. The OXTEXT research programme gave patients a leading role in the design of new recruitment materials, in an area where stigma and discrimination make (...) ethical risks particularly acute. We discovered that our patient-designed recruitment materials were much bolder than usual, and they put the existing ethical boundaries to the test. The materials were effective and well liked – patients regarded them as neither unacceptable nor coercive. This suggests we may need to rethink the ethics of recruitment to research such that we permit more creative recruitment materials. In addition, it suggests a new role for patient input into research as designers of recruitment materials. (shrink)

At first glance, legislation intended to shape American adult Iiteracy programs appears egalitarian and hopeful. After a more thorough reading, the legislative objectives are Iimited, culturally biased, and largely unattainable. In order to develop coherent Iiteracy pedagogy, we explore Paulo Freire’s definition of critical thinking. From a critical theory perspective, we argue that a vocational education of learning basic skills is insufficient. Furthermore, we believe that more is needed to help adult learners beconle self-sufficient in a modern, dynamic economy. Critical (...) thinking, as defined by Freire, along with vocational education allows individuaIs to develop their ontological right to become aware of historical and social forces. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

A new model for environmental and urban sustainability living architecture that connects artifice with the natural world through the use of materials that possess some of the properties of living systems, and can therefore actively exchange energy with the ecosphere, is proposed.

A long-standing position in philosophy, law, and theology is that a person can be held morally responsible for an action only if they had the freedom to choose and to act otherwise. Thus, many philosophers consider freedom to be a necessary condition for moral responsibility. However, empirical findings suggest that this assumption might not be in line with common sense thinking. For example, in a recent study we used surveys to show that – counter to positions held by many philosophers (...) – lay people consider actions to be free when they are spontaneous rather than being based on reasons. In contrast, responsibility is often considered to require that someone has thought about the alternative options. In this study we use an online survey to directly test to which degree lay judgements of freedom and responsibility match. Specifically, we test whether manipulations of deliberation affect freedom and responsibility judgements in the same way. Furthermore, we also test the dependency of these judgements on a person’s belief that their decision had consequences for their personal life. We find that people are generally considered to be more responsible for their actions than they are considered free, across most of the conditions tested. Furthermore, we found that deliberation had an opposite effect on freedom and responsibility judgements. People were considered more free when they acted spontaneously, whereas they were considered more responsible when they deliberated about their actions. These results seem to suggest that deliberating about reasons is crucially important for the lay concept of responsibility, while it is not obviously …. (shrink)

Is Goodness Without God Good Enough contains a lively debate between William Lane Craig and Paul Kurtz on the relationship between God and ethics, followed by seven new essays that both comment on the debate and advance the broader discussion of this important issue. Written in an accessible style by eminent scholars, this book will appeal to students and academics alike.

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these three volumes bring together some of the most innovative work by both philosophers and psychologists (...) in this emerging interdisciplinary field. The neuroscience of morality is in its infancy, with the first brain imaging studies of moral development undertaken only in 2001. The contributors to volume 3 sample the best work in this very new field, discussing a variety of approaches, including functional imaging, lesion studies, abnormal psychology, and developmental neuroscience. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include the neural basis of moral emotions and moral judgments as well as comparisons of normal adult moral judgments with those made by children, adolescents, and people with psychopathy, brain damage, and autism. Contributors to Volume 3 Abigail Baird, William Casebeer, Cordelia Fine, Nathan Fox, Uta Frith, Jordan Grafman, Joshua Greene, Catherine Hynes, Fatima Azavedo Ignacio, Richard Joyce, Jerome Kagan, Leonard Katz, Kent Kiehl, Jeanette Kennett, Melanie Killen, Daniel Lapsley, Heidi Maibom, Victoria McGeer, John Mikhail, Jorge Moll, Shaun Nichols, Ricardo de Oliveira-Souza, Adina Roskies, Jana Schaich Borg, Katrina Sifferd, Walter Sinnott-Armstrong, Michael Smith, Mark Timmons, Frederick de Vignemont, Paul Whalen, Roland Zahn. (shrink)

Philosophers and psychologists discuss new collaborative work in moral philosophy that draws on evolutionary psychology, cognitive science, and neuroscience. For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in (...) moral philosophy, and these volumes bring together some of the most innovative work by both philosophers and psychologists in this emerging interdisciplinary field. The contributors to volume 1 discuss recent work on the evolution of moral beliefs, attitudes, and emotions. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include a version of naturalism that avoids supposed fallacies, distinct neurocomputational systems for deontic reasoning, the evolutionary psychology of moral sentiments regarding incest, the sexual selection of moral virtues, the evolution of symbolic thought, and arguments both for and against innate morality. Taken together, the chapters demonstrate the value for both philosophy and psychology of collaborative efforts to understand the many complex aspects of morality. Contributors William Casebeer, Leda Cosmides, Oliver Curry, Michael Dietrich, Catherine Driscoll, Susan Dwyer, Owen Flanagan, Jerry Fodor, Gilbert Harman, Richard Joyce, Debra Lieberman, Ron Mallon, John Mikhail, Geoffrey Miller, Jesse Prinz, Peter Railton, Michael Ruse, Hagop Sarkissian, Walter Sinnott-Armstrong, Chandra Sekhar Sripada, Valerie Tiberius, John Tooby, Peter Tse, Kathleen Wallace, Arthur Wolf, David Wong. (shrink)

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these three volumes bring together some of the most innovative work by both philosophers and psychologists (...) in this emerging interdisciplinary field. The contributors to volume 2 discuss recent empirical research that uses the diverse methods of cognitive science to investigate moral judgments, emotions, and actions. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include moral intuitions as a kind of fast and frugal heuristics, framing effects in moral judgments, an analogy between Chomsky's universal grammar and moral principles, the role of emotions in moral beliefs, moral disagreements, the semantics of moral language, and moral responsibility. Walter Sinnott-Armstrong is Professor of Philosophy and Hardy Professor of Legal Studies at Dartmouth College. Contributors to volume 2: Fredrik Bjorklund, James Blair, Paul Bloomfield, Fiery Cushman, Justin D'Arms, John Deigh, John Doris, Julia Driver, Ben Fraser, Gerd Gigerenzer, Michael Gill, Jonathan Haidt, Marc Hauser, Daniel Jacobson, Joshua Knobe, Brian Leiter, Don Loeb, Ron Mallon, Darcia Narvaez, Shaun Nichols, Alexandra Plakias, Jesse Prinz, Geoffrey Sayre-McCord, Russ Shafer-Landau, Walter Sinnott-Armstrong, Cass Sunstein, William Tolhurst, Liane Young. (shrink)

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these volumes bring together some of the most innovative work by both philosophers and psychologists in (...) this emerging interdisciplinary field. The contributors to volume 1 discuss recent work on the evolution of moral beliefs, attitudes, and emotions. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include a version of naturalism that avoids supposed fallacies, distinct neurocomputational systems for deontic reasoning, the evolutionary psychology of moral sentiments regarding incest, the sexual selection of moral virtues, the evolution of symbolic thought, and arguments both for and against innate morality. Taken together, the chapters demonstrate the value for both philosophy and psychology of collaborative efforts to understand the many complex aspects of morality. Contributors: William Casebeer, Leda Cosmides, Oliver Curry, Michael Dietrich, Catherine Driscoll, Susan Dwyer, Owen Flanagan, Jerry Fodor, Gilbert Harman, Richard Joyce, Debra Lieberman, Ron Mallon, John Mikhail, Geoffrey Miller, Jesse Prinz, Peter Railton, Michael Ruse, Hagop Sarkissian, Walter Sinnott-Armstrong, Chandra Sekhar Sripada, Valerie Tiberius, John Tooby, Peter Tse, Kathleen Wallace, Arthur Wolf, David Wong Walter Sinnott-Armstrong is Professor of Philosophy and Hardy Professor of Legal Studies at Dartmouth College. (shrink)

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these three volumes bring together some of the most innovative work by both philosophers and psychologists (...) in this emerging interdisciplinary field. The neuroscience of morality is in its infancy, with the first brain imaging studies of moral development undertaken only in 2001. The contributors to volume 3 sample the best work in this very new field, discussing a variety of approaches, including functional imaging, lesion studies, abnormal psychology, and developmental neuroscience. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include the neural basis of moral emotions and moral judgments as well as comparisons of normal adult moral judgments with those made by children, adolescents, and people with psychopathy, brain damage, and autism. Contributors to volume 3:_ _Abigail Baird, William Casebeer, Cordelia Fine, Nathan Fox, Uta Frith, Jordan Grafman, Joshua Greene, Catherine Hynes, Fatima Azavedo Ignacio, Richard Joyce, Jerome Kagan, Leonard Katz, Kent Kiehl, Jeanette Kennett, Melanie Killen, Daniel Lapsley, Heidi Maibom, Victoria McGeer, John Mikhail, Jorge Moll, Shaun Nichols, Ricardo de Oliveira-Souza, Adina Roskies, Jana Schaich Borg, Katrina Sifferd, Walter Sinnott-Armstrong, Michael Smith, Mark Timmons, Frederick de Vignemont, Paul Whalen, Roland Zahn. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Veils: The Poetics of John Rawls*George Armstrong KellyPlutarch recounts in Sais, a holy place of Egypt, the image of Isis, understood by the Greeks to be a version of Pallas Athena, bore the inscription: “I am everything that has been, that is, and that shall ever be: no human mortal has discovered me behind my veil.” 1 This recalls a very different god, Yahweh, whose claim is also (...) to compress all knowledge into an eternal present and whose dwelling, in Solomon’s temple, is in a special sanctuary, the Holy of Holies, also guarded by a veil.There, one might say, the similarity ends. Yahweh is a masculine diety (“the father of his people”), though imagistically he remains a space or an absence filled by a name (“I Am That I Am”) indicative of the transcendent distance of the eternal. Isis is a female shape imaging carnal knowledge behind her veil (with its Machiavellian, Baconian temptations). Her truth, as Plutarch makes clear, is driven by desire, truth being a “desire for divinity,” “a study... and work more holy than the vow and obligation of chastity or the guarding and sealing of any....” 2 The almost certain wages, however, for the would-be ravisher is unfulfillment and death, whereas Yahweh, having become the God of the Christians, promises eternal life through the sacrifice of his only-begotten son and a truth above knowledge “that shall make you free” (John 8:32). [End Page 343]To the Semitic mind the name expressed and represented the power of the person: God was present in a special way wherever the “Name of Yahweh” was. 3 The content of the Holy of Holies, originally portable in the ancient Ark of the Covenant, was the two stone tablets of the Law received by Moses at Horeb (1 Kings 8:9). God’s presence, once installed in the Temple of Jerusalem, was represented as “a cloud [that] filled the house of the Lord” (ibid, 8:10; cf. 2 Chronicles 5:10, 13). God was cloud; knowledge was duty. Of the physical place of this indwelling principle of knowledge, Jesus said (John 2:19): “Destroy this sanctuary: within three days I shall raise it up again.” The evangelist explains that his metaphor is transferred to the new Christian idea of the word made flesh. 4 John’s gospel does not cite the rendering of the veil of the temple, but the synoptic gospels all recount that it was “rent in twain from top to bottom” (Matthew 27:51, Mark 16:38, Luke 23:45) at Christ’s Crucifixion. The idea is essentially that knowledge as command and duty has been surpassed by a knowledge that is love in the crucified revelation of the Son of God. This returns us, ambiguously, to the image of the goddess Isis; for even in Hebrew scripture it is foretold: “The watchmen that went about the city found me, they smote me, they wounded me; the keepers of the walls took away my veil from me” (Song of Solomon 5:7). If there is here a clear prefiguration of the fate of both Christ and the temple, there is also an echo of the likely fate of the harlot Rahab, who let Joshua’s spies into Jericho, had God not saved her from the ruin of that city (Joshua 6:17).The purpose of this essay is not to dwell on obvious imagistic and psychological attachments between wisdom and sexual knowledge, but early notice of this liaison is needed to connect the philosophical discourse on veils with motifs disclosed in figurative literature. For the veil that hides the object of desire may also hide the reality of the name or of naming; preserving the veil may be a mode of love, just as challenging it is also. For example, when John Rawls writes: “The principles of justice are chosen behind a veil of ignorance. This ensures that no one is advantaged or disadvantaged in the choice of principles by the outcome of natural chance or the contingency of social circumstances,” 5 what does his image of the veil intend to convey? What exactly is on each side of this veil? From... (shrink)

In this paper I put forward what I think is a new approach to the problem of induction. I sketched the approach in brief sections of a book published in 1983. The same idea had occurred to the English philosopher John Foster and he presented it in a paper at about the same time.

D. M. Armstrong is an eminent Australian philosopher whose work over many years has dealt with such subjects as: the nature of possibility, concepts of the particular and the general, causes and laws of nature, and the nature of human consciousness. This collection of essays explores the many facets of Armstrong's work, concentrating on his more recent interests. There are four sections to the book: possibility and identity, universals, laws and causality, and philosophy of mind. The contributors comprise an international (...) group of philosophers from the United States, England and Australia. An interesting feature of the volume is that Armstrong himself has written responses to each of the essays. There is also a complete bibliography of Armstrong's writings. (shrink)

Challenging the myth that mathematical objects can be defined into existence, Bigelow here employs Armstrong's metaphysical materialism to cast new light on mathematics. He identifies natural, real, and imaginary numbers and sets with specified physical properties and relations and, by so doing, draws mathematics back from its sterile, abstract exile into the midst of the physical world.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Cambridge History of Philosophy in Late AntiquityJohn RistLloyd P. Gerson, editor. The Cambridge History of Philosophy in Late Antiquity. 2 vols. Cambridge-New York: Cambridge University Press, 2010. Pp. 1313. Cloth, $240.00.1313 pages, including 915 pages of text and 200 of bibliography; 51 authors—in about 800 words! The editor of the present Cambridge History makes plain that his new two-volume monument is the successor to Armstrong’s Cambridge History (...) of Late Greek and Early Medieval Philosophy—8 contributors—and is intended to build on its strengths and correct its deficiencies in the light of some 40 years of highly successful investigation of the thought of late antiquity. The result is a professional structure in which the “giants” (Plotinus and Augustine) are awarded comparatively modest coverage, while figures often neglected, such as Damascius, of whom our understanding has greatly increased of late, are given much more space. Damascius secures 30 pages: the only individual to get more is Porphyry (33), while Augustine has 29 and Plotinus 24 (four more than Hierocles). There are those (as Tacitus might have put it) who will fear that the wood has been lost for the trees, and at least it must be said that one overall impression of these volumes is that some of their authors are recounting what will be of interest to a worldwide group of aficionados whose number can be counted on the fingers of a mutilated hand—and the importance of which lies less in philosophical achievement than in the handing on of a great tradition.Gilbert Ryle is supposed to have asserted that in France everyone can talk about philosophy but that there are no philosophers; some of Gerson’s more philosophically minded readers may find their prejudices confirmed that in late antiquity there were many who talked about Plato and Aristotle but few who understood what they were trying to do. For it is clear that a general theme of the present volumes is that in late antiquity philosophers were largely concerned to “interpret” Plato and (especially after Porphyry) Aristotle while occasionally seizing the opportunity not merely to rubbish their similarly-engaged predecessors but to add (if shamefacedly) something of their own. Except, that is, for the Christians, whose enterprise was very different and who, quite properly, are more visible in Gerson’s account of late antique thought than in that of Armstrong (though there remain strange omissions in a work on this scale: Methodius, Ambrose, Evagrius).Gerson has tried to contextualize his story by including short (and helpful) historical introductions by Elizabeth DePalma Digeser to the various epochs with which his volumes are concerned, and which can perhaps be divided into four sections: pre-Plotinian Platonism [End Page 136] (plus extras) from Cicero to Numenius; later pagan Platonism, including extensive treatment of the Neoplatonic commentators on Aristotle; Christian thought before Constantine; and later Christian philosophy-cum-theology. Rounding off the volume are introductions to the transition from “ancient” to “medieval” thought in the Latin West (Gersh), in Byzantium—a remarkably honest presentation of a largely stagnant philosophical world by Ierodiakonou and Zografidis—and (in a magisterial improvement on what is to be found in Armstrong) in Islam (Cristina d’Ancona) where (inter multa alia) the roots of the virtually inevitable later destruction of a flourishing philosophical tradition founded by al-Kindi and al-Farabi are identified in the more “orthodox” and theocratic approach—here there are Byzantine parallels—of the followers of al-Ash’ari (885).Gerson’s readers can inspect philosophical wisdom and conceptual muddle among late antique intellectuals—Christians, a few Muslims, pagans—down to Scotus Eriugena and al-Farabi. But some of them may suspect that an opportunity has been lost to reflect on the origins and nature of early Christian thought, and to ask why Christians soon jumped for Platonism rather than Stoicism (Aristotle, let alone Epicurus, was not—yet—considered a serious option)—and that is not intended as criticism of the excellent, if brief, treatment of important Christian thinkers such as Origen. But it was an adventure for Christians to begin to philosophize, and when they embarked on this adventure—here the significance... (shrink)

John Foster’s book, The Nature of Perception, is written to defend his Idealist, or Berkeleyan, theory of perception. One view that he is concerned to reject is what he usefully calls the ‘Cognitivist’ theory of perception. I am named as one of its defenders. His critique of the theory serves me as a good starting point and as a stimulus for a new defense of the theory.

One Protestant Looks At Centesimus Annus is an attempt to analyze Pope John Paul II''s centennial encylical on economic justicein context. It relates the early contributions of Reformation thought to the emergence of laissez-faire capitalism. It describes the social gospel as a convergence of the radical implications of 19th century German Protestant scholarship and the harsh economic/social realities of the industrial revolution. Then it compares the economic teachings of the institutional church from Leo XIII and the old Federal Council (...) of Churches to John Paul II and the World Council of Churches one hundred years later. All of this prepares the way for a critical analysis ofCentesimus Annus with a special emphasis on the Pope''s understanding of Christian truth. Finally there is a postscript relating the encyclical to the ethical challenges facing multinational corporations in developing countries. (shrink)

On September 27, 2016 people across the world looked down at their buzzing phones to see the AP Alert: “Baby born with DNA from 3 people, first from new technique.” It was an announcement met with confusion by many, but one that polarized the scientific community almost instantly. Some celebrated the birth as an advancement that could help women with a family history of mitochondrial diseases prevent the transmission of the disease to future generations; others held it unethical, citing medical (...) tourism and consequences for the future of the therapy. The child in question was actually born a few months earlier on April 6, 2016, but the research was published a few months later in the October edition of Fertility and Sterility. The mother carries DNA that could have given the baby Leigh Syndrome, a severe neurological disorder characterized by psychomotor regression that typically results in death between ages two and three.[1] Also known as subacute necrotizing encephalomyelopathy, Leigh Syndrome is caused by genetic mutations in mitochondrial DNA, which causes defective oxidative phosphorylation. Because people with this condition cannot re-form ATP, “demyleniation, gliosis, necrosis, spongiosis, or capillary proliferation”[2] can occur, thereby producing bilateral lesions across the central nervous system. The 36-year-old mother previously had four miscarriages and successfully birthed two children, both of whom survived less than six years due to the syndrome. For religious reasons, the mother opted for Spindle Nuclear Transfer instead of Pronuclear Transfer,[3] which many religious organizations oppose because it entails the destruction of fertilized eggs.[4] In Pronuclear Transfer, both the parent and donor egg are fertilized. The parent’s nuclear material is then removed from the egg containing mutated mitochondria and inserted into the fertilized donor egg—from which the original nuclear material has been removed and destroyed. Spindle Nuclear Transfer, on the other hand, removes the mother’s nuclear material from the egg with unhealthy mitochondria, then implants it into a donor’s egg. The newly created egg is then fertilized with the father’s sperm. This Spindle Nuclear Transfer was performed in Mexico by a team of doctors led by Dr. John Zhang, the founder of the New Hope Fertility Center in New York City. In their report, the doctors outline that five oocytes were successfully reconstituted, four of which developed into blastocysts. Only one was euploid: containing 46 XY chromosomes. Researchers then biopsied that blastocyst and found that the transmission rate of maternal mtDNA was, “5.10 ± 1.11% and the heteroplasmy level for 8993T>G was 5.73%.”[5] This indicates that at the blastocyst stage, around five percent of the mitochondria are from the original maternal egg with the mutation for Leigh Syndrome. After birth, they biopsied different tissues and found that they had an average of less than 1.60 ± 0.92% of transmitted mtDNA from the original maternal egg. The baby is reportedly doing well and the team of doctors concluded that “[h]uman oocytes reconstituted by SNT are capable of producing a healthy live birth. SNT may provide a novel treatment option in minimizing pathogenic mtDNA transmission from mothers to their babies."[6] Even when considered theoretically, Spindle Nuclear Transfer is controversial. Many doctors believe that the risks at this stage of research are too great. Dr. Trevor Stammers, a bioethicist at St. Mary’s University in London, points out: “We do not yet have a clear picture of the interaction between nuclear DNA and mitochondria.”[7] Others hold that faulty mitochondrial DNA can still be transferred during the procedure. Still more argue this technology could create problems because of germline modification.[8] Dr. Paul Knoepfler, a cell biologist at the UC Davis School of Medicine, explains: “Since this is uncharted territory and the children born from this technology would have heritable genetic changes, there are also significant unknown risks to future generations.”[9] However, proponents counter these arguments. They say the benefits outweigh the risks, as “mitochondrial replacement techniques [like Spindle Nuclear Transfer] would eliminate maternal transmission of mitochondrial disease… allowing a woman with a family history of mitochondrial diseases to ensure her children would not be affected.”[10] Additionally, experts say that no symptoms will occur if less than 20% of the transferred mitochondrial DNA is faulty.[11] And while opponents see potential germline modification as a problem, advocates answer that this could stop a family history of mitochondrial disease, which they deem a more serious concern. In this case specifically, however, there are more issues at hand. While the team of doctors did eliminate the possibility of germline modification by selecting a male embryo, there are other ethical concerns. Some argue that this case could be described as “medical tourism.” While New Hope Medical Clinic does maintain a branch in Mexico, Dr. Zhang stated that Mexico has “no rules.”[12] It is a country with underdeveloped regulations, making it difficult to confirm that doctors adhere to widely-held medical and ethical standards. Furthermore, while it is highly unlikely that the child will develop Leigh’s Syndrome, Dr. Dietrich Egli of the New York Stem Cell Foundation says the 5% mitochondrial transfer rate indicates that the technique “was not carried out well.”[13] He points to studies of embryos where the rate of mtDNA transfer was almost ten times lower. Spindle Nuclear Transfer is currently legal in the UK,[14] and many are hoping to see it legalized in the US, although Congress currently prohibits the FDA from considering applications that would entail trials in people.[15] While Dr. Zhang’s work is arguably revolutionary, many wonder if the manner in which this study was performed—in Mexico and with a high mitochondrial transfer rate—will impact the technology’s future in the US. Last week, Dr. Zhang presented the report to scientists gathered in Salt Lake City, saying that while science isn’t a race, it is “in a sense, a race for the family to find a cure, to find hope.”[16] Only time will tell if this study set back other families racing and hoping for a cure. References 1. "Leigh Syndrome." Genetics Home Reference, US National Library of Medicine, 25 Oct. 2016. Accessed 26 Oct. 2016. 2. McKusick, Victor A., and Ada Hamosh. "LEIGH SYNDROME; LS." Online Mendelian Inheritance in Man, Johns Hopkins University, 20 Jan. 2016. Accessed 30 Oct. 2016. 3. Zhang, J, H Liu, S Luo, A Chavez-Badiola, and Z Liu. "First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome." Fertility and Sterility, vol. 106, no. 3, 2016, pp. e375-76. Accessed 30 Oct. 2016. 4. Sample, Ian. "‘Three-parent’ babies explained: what are the concerns and are they justified?" The Guardian, 2 Feb. 2015. Accessed 30 Oct. 2016. 5. Zhang, et al. 6. Ibid. 7. Knapton, Sarah. "Three-parent babies: the arguments for and against." The Telegraph, 3 Feb. 2015. 8. Ibid. 9. Ibid. 10. "Mitochondrial Replacement Therapy FAQs." New York Stem Cell Foundation Research Institute, New York Stem Cell Foundation. Accessed 30 Oct. 2016. 11. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 12. Hamzelou, Jessica. "Exclusive: World’s first baby born with new “3 parent” technique." New Scientist, 27 Sept. 2016. Accessed 30 Oct. 2016. 13. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 14. "3-Person IVF: A Resource Page." Center for Genetics and Society, 24 Oct. 2016. Accessed 30 Oct. 2016. 15. Ritter, Malcolm. "Baby born with DNA from 3 people, first from new technique." Associated Press, 27 Sept. 2016. Accessed 30 Oct. 2016. 16. Chen, Daphne. "Controversy swirls around first three-parent baby." Deseret News, 19 Oct. 2016. Accessed 30 Oct. 2016. Works consulted Swetlitz, Ike. "FDA urged to approve ‘three-parent embryos,’ a new frontier in reproduction." STAT, 3 Feb. 2016. Accessed 30 Oct. 2016. (shrink)

In his new book What is a Law of Nature?, David Armstrong gives an account of functional laws on the basis of the theory, originally proposed independently by Armstrong himself, Dretske, and Tooley, and further developed in this work, which asserts that laws are relations of necessitation between properties. On the theory, properties and relations are universals, and so a law is a relation between universals and is itself a universal. There are two reasons why Armstrong's account of functional laws (...) is worth discussing. First, any theory that purports to be about laws that are investigated by science–I assume that we are only interested in such theories–must cover functional laws and not merely be adequate for generalizations about ravens or grue. Second, Armstrong claims that the main rival to his theory, the regularity theory of laws, cannot give a satisfactory account of functional laws. If this is true, and if Armstrong's theory can provide a satisfactory account of functional laws, then this may incline us towards his point of view. (shrink)

In this paper, our goal is to survey some of the legal contexts within which violence risk assessment already plays a prominent role, explore whether developments in neuroscience could potentially be used to improve our ability to predict violence, and discuss whether neuropredictive models of violence create any unique legal or moral problems above and beyond the well worn problems already associated with prediction more generally. In Violence Risk Assessment and the Law, we briefly examine the role currently played by (...) predictions of violence in three high stakes legal contexts: capital sentencing, civil commitment hearings, and sexual predator statutes. In Clinical vs. Actuarial Violence Risk Assessment, we briefly examine the distinction between traditional clinical methods of predicting violence and more recently developed actuarial methods, exemplified by the Classification of Violence Risk software created by John Monahan and colleagues as part of the MacArthur Study of Mental Disorder and Violence [1]. In The Neural Correlates of Psychopathy, we explore what neuroscience currently tells us about the neural correlates of violence, using the recent neuroscientific research on psychopathy as our focus. We also discuss some recent advances in both data collection and data analysis that we believe will play an important role when it comes to future neuroscientific research on violence. In The Potential Promise of Neuroprediction, we discuss whether neuroscience could potentially be used to improve our ability to predict future violence. Finally, in The Potential Perils of Neuroprediction, we explore some potential evidentiary, constitutional, and moral issues that may arise in the context of the neuroprediction of violence. (shrink)