CRISPR-Cas9 genome editing can and has altered human genomes, bringing bioethical debates about this capability to the forefront of philosophical and policy considerations. Here, I consider the underexplored implications of CRISPR-Cas9 gene drives for heritable human genome editing. Modification gene drives applied to heritable human genome editing would introduce a novel form of involuntary eugenic practice that I term guerrilla eugenics. Once introduced into a genome, stealth genetic editing by a gene drive genetic element would occur each subsequent generation irrespective (...) of whether reproductive partners consent to it and irrespective of whether the genetic change confers any benefit. By overriding the ability to ‘opt in’ to genome editing, gene drives compromise the autonomy of carrier individuals and their reproductive partners to choose to use or avoid genome editing and impose additional burdens on those who hope to ‘opt out’ of further genome editing. High incidence of an initially rare gene drive in small human communities could occur within 200 years, with evolutionary fixation globally in a timeframe that is thousands of times sooner than achievable by non-drive germline editing. Following any introduction of heritable gene drives into human genomes, practices intended for surveillance or reversal also create fundamental ethical problems. Current policy guidelines do not comment explicitly on gene drives in humans. These considerations motivate an explicit moratorium as being warranted on gene drive development in heritable human genome editing. (shrink)

Recent research has filled many gaps about Caenorhabditis natural history, simultaneously exposing how much remains to be discovered. This awareness now provides means of connecting ecological and evolutionary theory with diverse biological patterns within and among species in terms of adaptation, sexual selection, breeding systems, speciation, and other phenomena. Moreover, the heralded laboratory tractability of C. elegans, and Caenorhabditis species generally, provides a powerful case study for experimental hypothesis testing about evolutionary and ecological processes to levels of detail unparalleled by (...) most study systems. Here, I synthesize pertinent theory with what we know and suspect about Caenorhabditis natural history for salient features of biodiversity, phenotypes, population dynamics, and interactions within and between species. I identify topics of pressing concern to advance Caenorhabditis biology and to study general evolutionary processes, including the key opportunities to tackle problems in dispersal dynamics, competition, and the dimensionality of niche space. (shrink)

It is tempting to invoke organismal selection as perpetually optimizing the function of any given gene. However, natural selection can drive genic functional change without improvement of biochemical activity, even to the extinction of gene activity. Detrimental mutations can creep in owing to linkage with other selectively favored loci. Selection can promote functional degradation, irrespective of genetic drift, when adaptation occurs by loss of gene function. Even stabilizing selection on a trait can lead to divergence of the underlying molecular constituents. (...) Selfish genetic elements can also proliferate independent of any functional benefits to the host genome. Here we review the logic and evidence for these diverse processes acting in genome evolution. This collection of distinct evolutionary phenomena – while operating through easily understandable mechanisms – all contribute to the seemingly counterintuitive notion that maintenance or improvement of a gene's biochemical function sometimes do not determine its evolutionary fate. (shrink)

“Metapolitics” is an ambiguous term. Recent philosophers have claimed the concept for neo-conservative, even right-wing agendas, while others have employed it to signal radical discontent with politics altogether. Beginning with Peter Viereck’s characterization of Nazi ideology as “Meta-Politics,” this essay works its way back from an “irrational,” “volkish,” and supposedly “conservative” concept to another use of “Metapolitics” as found in Martin Buber and Hermann Cohen that was rooted in a liberal tradition of the Enlightenment—especially in August Schlözer and Saul Ascher. (...) Both, Buber and Cohen, linked “metapolitical politics” to prophetic and theopolitical sensibilities. As such, the prophetic motif of turning loomed large at the center of their respective philosophies of nationalism. But it was a theme that also connected a wide range of thinkers, including Hans Kohn and Leo Baeck, and which emerged as a Leitmotiv of cultural and spiritual Zionism as well as of the modern Renaissance of Jewish culture. Drawing on Moritz Lazarus, the essay argues that the recurring trope of turning helped establish a paradoxical nationalism founded not upon self-empowerment and political othering but on self-criticism. Concluding with a brief excursion on Abraham Joshua Heschel’s prophetic politics in the Civil Rights Movement, the essay gestures towards the possibility of nationalism as collective introspection and self-reformation. (shrink)

Franz Rosenzweig’s Star of Redemption culminates in an aesthetic configuration of simultaneous presences: world, man, God, creation, revelation, and redemption are viewed in a metahistorical side-by-side, connected by the “factualizing power of the And.” But the idea of simultaneity, which is central to Rosenzweig’s configurative thinking, belongs to the historical imagination as much as it belongs to the theological “breaking through the shackles of time.” Rosenzweig’s “and” belongs to both a tradition of cosmic-aesthetic historicism and the philosophical reconstitution of time (...) as a simultaneous perception. In the co-presence of all historical moments, history’s hidden Gestalt, which only a people that is at once old and young can envision, connects the “and” of history with what Hegel considered history’s end—its ultimate self-recognition. Eternity, then, means neither flight from, nor resistance to, history’s naked fact, but the recognition of history’s Gestalt as an image that “does not tolerate epochs.”. (shrink)

In recent times there have been increasing efforts at reinterpreting core CSR theories such as stakeholder theory with new perspectives as well as applying them to different contexts away from its Western masculinist connotations. This work seeks to add to these efforts by exploring the impacts that the African philosophical worldview of Afro-communitarianism has on small business stakeholder relationships. Specifically it discusses the kinds of relationships that owner/managers of small businesses, in adherence to Afro-communitarianism, maintain with their families, employees, local (...) communities and competitors- all key stakeholders. The contention is that such ethics demand more extensive ethical responsibilities from owner/managers of small businesses than owner/managers motivated by traditional stakeholder theory with its Western masculinist undertones. It is hoped that this effort will add significant perspectives to stakeholder theory as well as having implications for both small and large business practice. (shrink)

Ḳitsur Ḥovat ha-levavot me-Rabenu Asher mi-Lunil -- Ḳitsur Ḥovat ha-levavot mi-sefer Tsedah la-derekh -- Ḳitsur Ḥovat ha-levavot ʻAśarah hilulim -- Ḳitsur Ḥovat ha-levavot Margaliyot ṭovot.

Extreme conditions like savantism, autism or synaesthesia, which have a neurological 2AH, UK basis, challenge the idea that other minds are similar to our own. In this paper we report a single case study of a man in whom all three of these conditions co-occur. We suggest, on the basis of this single case, that when savantism and synaesthesia co- occur, it is worthwhile testing for an undiagnosed Autism Spectrum Condition (ASC). This is because savantism has an established association with (...) ASC, and the combination of ASC with synaesthesia may increase the likelihood of savantism. The implications of these conditions for philosophy of mind are introduced. (shrink)

Philosophy Lab: An Experiential Approach to Conceptual Analysis gives students the skills and strategies needed to do philosophical work in the Analytic tradition. They are presented with a step-by-step method for performing a preliminary conceptual analysis and practice examples to apply the method to standard philosophical problems. Students are introduced to the work of great thinkers including Descartes, Hobbes, Locke, Wittgenstein, and Ryle. These works are complemented by contemporary empirical findings concerning perception, desire, emotion, moral intuition, and other basic elements (...) of explicit intentional cognition. Each chapter features primary source material, commentary, and activity instructions. The activities are designed to allow students to experience each mode of cognition in relative isolation, and then to see how they combine and interrelate in more complex contexts. Finally, students use the template model of conceptual analysis to explore the material. They identify and isolate the concept to be analyzed, determine whether it is simple or complex, and if complex, identify the constituent parts of the concept. Specific topics covered include causal power, sex and marriage, compassion, ambition, justice, and death. Through presentation and modeling the book not only enables student to do conceptual analysis with precision, it helps them understand and interpret philosophical issues. Philosophy Lab is a comprehensive, carefully designed text for first courses in philosophy. It may be used with first-year undergraduate students, advanced high-school students, or adult learners. Asher Walden holds a Ph.D. in philosophy and religion from Drew University. Dr. Walden is currently an adjunct lecturer at the University of Massachusetts, Dartmouth. (shrink)

The volume contributes to the ongoing nanoethics debate in four topical areas. The first part tackles questions of what could be called ‘meta-nanoethics’. Its focus lies on basic concepts and the issue of what - if anything - is truly novel and special about the new field of nanoethics or its subject matter. The second part of this volume presents a selection of interesting perspectives on some of the opportunities and challenges of nanotechnology. Part three takes a more in depth (...) look at one of the most pressing current concerns: how to deal with the risks and uncertainties surrounding nanotechnology in a responsible manner. In its fourth and final part the volume touches on issues of public debate and policy. (shrink)

Recently there has been a renewed interest in the ethical value of literature. However, how exactly does literature contribute to our ethical understanding? In Literature, Ethics, and the Emotions, Kenneth Asher argues that literary scholars should locate this question in the long and various history of moral philosophy. On the basis of his own reading of this history, Asher contends for the centrality of emotions in our ethical lives and shows how literature - novels, poetry, and drama - (...) can each contribute to crucial emotional understanding. Individual chapters on T. S. Eliot, D. H. Lawrence, Virginia Woolf, and George Bernard Shaw give detailed analyses of how this contribution takes shape even in modernist authors who try to reconfigure the very nature of the self. (shrink)

Jay Asher’s novel Thirteen Reasons Why and its Netflix adaptation have enjoyed widespread popularity. While they draw needed attention to issues like bullying and teen estrangement, they may have an unintended effect: they mislead about the etiology of suicide and even glamorize it to a degree. The medical literature has shown that suicide is almost always the result of psychiatric disorder, not provocative stress, in much the same way an asthmatic crisis is primarily the result of an underlying medical (...) condition, not an allergic stimulus. Both the novel and Netflix series ignore this premise and even belittle the idea. Thus, while the story has artistic merits, it also has the potential to be destructive if accessed by young readers and viewers seeking guidance. Approximately ten percent of teens suffer from depression, and suicide recently surpassed homicide as the second-leading cause of death among persons ages ten to twenty-four in the United States. A more balanced view addressing these misconceptions is provided for teens, parents, and mental health professionals. (shrink)

Antes de qualquer coisa, o leitor do presente artigo encontrará uma grande preocupação de David Asher em transmitir o pensamento filosófico de Schopenhauer para o leitor britânico da época (1871), isso fica claro, pois esse empreendimento por vezes levou o autor a fazer citações ultra extensas de Schopenhauer (das quais ele mesmo traduzia da língua alemã para o inglês). Nessas longas citações/traduções que o autor faz do filósofo, tratei de copiá-las da tradução brasileira de Jair Barboza d’O mundo como (...) vontade e como representação. Sempre especifico essas cópias em notas, por isso, meu trabalho foi de fazer uma tradução parcial: traduzir o próprio Asher e não o texto de Schopenhauer traduzido por ele. Outro ponto muitíssimo importante a ser levado em consideração é que o presente texto foi comprovadamente lido pelo próprio Charles Darwin, tal como devidamente mostro na nota de rodapé número 16. (shrink)

This volume is about abstract objects and the ways we refer to them in natural language. Asher develops a semantical and metaphysical analysis of these entities in two stages. The first reflects the rich ontology of abstract objects necessitated by the forms of language in which we think and speak. A second level of analysis maps the ontology of natural language metaphysics onto a sparser domain--a more systematic realm of abstract objects that are fully analyzed. This second level reflects (...) the commitments of real metaphysics. The models for these commitments assign truth conditions to natural language discourse. Annotation copyright by Book News, Inc., Portland, OR. (shrink)

La célébration du cinquantième anniversaire de la fin de la Seconde Guerre mondiale et de l’ouverture des camps donne depuis quelques années l’occasion de revisiter une histoire juive douloureuse et loin d’être dépassionnée. De nombreux déportés, l’âge venu, écrivent leurs témoignages, toujours poignants, et qui éclairent les faits avec la brutalité que donne l’expérience personnelle. Quelques-uns de ces témoignages retiennent particulièrement l’attention par ce qu’ils nous font comprendre de...

La célébration du cinquantième anniversaire de la fin de la Seconde Guerre mondiale et de l’ouverture des camps donne depuis quelques années l’occasion de revisiter une histoire juive douloureuse et loin d’être dépassionnée. De nombreux déportés, l’âge venu, écrivent leurs témoignages, toujours poignants, et qui éclairent les faits avec la brutalité que donne l’expérience personnelle. Quelques-uns de ces témoignages retiennent particulièrement l’attention par ce qu’ils nous font comprendre de...

No quiero dar la impresión de que intentaré una aproximación entre el primero y el segundo Wittgenstein que borre diferencias tan fundamentales cuanto esa. Sin embargo, debo luego aclarar que sí será mi intención hablar de la existencia de "límites" del lenguaje en un sentido que sea asimilable por quien acepta las líneas básicas de argumentación de las Investigaciones Filosóficas. Más exactamente, trataré de redefinir esos límites en términos que sean completamente compatibles con la filosofía madura de Wittgenstein. Asociada a (...) esta nueva definición de la noción de límite, creo que emergirá una nueva concepción de lo Místico, y una suerte muy particular de "teología negativa", que trataré de definir con más exactitud en la parte final mi ponencia. [Fragmento]. (shrink)

The paper offers a new reading of the argument against poetry in Plato’s Republic 10. I argue that Socrates’ corruption charges rely on the tripartite theory of the soul, and that metaphysical doctrines play a role only in the first charge, which demonstrates that the poets are not qualified to teach by reducing tragic poetry to mimetic skill. This accusation clears the way for two corruption charges: the strengthening of appetite, and the softening of spirit (i.e., ‘the greatest charge’). The (...) former focuses on the dangerous association between the poets and the largest appetitive class in the city (hoi polloi), while the latter focuses on the corruption of the educated elite (hoi epieikeis). (shrink)

This paper develops a new argument from consciousness to theism: the argument from psychophysical harmony. Roughly, psychophysical harmony consists in the fact that phenomenal states are correlated with physical states and with one another in strikingly fortunate ways. For example, phenomenal states are correlated with behavior and functioning that is justified or rationalized by those very phenomenal states, and phenomenal states are correlated with verbal reports and judgments that are made true by those very phenomenal states. We argue that psychophysical (...) harmony is strong evidence for theism (or, at least, strong evidence against atheism in its standard naturalistic form). (shrink)

According to a familiar modern view, color and other so-called secondary qualities reside only in consciousness, not in the external physical world. Many have argued that this “Galilean” view is the source of the mind-body problem in its current form. This paper critically examines a radical alternative to the Galilean view, which has recently been defended or sympathetically discussed by several philosophers, a view I call “anti-modernism.” Anti-modernism holds, roughly, that the modern Galilean scientific image is incomplete – in particular, (...) it leaves out certain irreducible qualitative properties, such as colors – and that we can solve (or dissolve) the hard problem of consciousness by accepting these properties as objective features of the external physical world. I argue, first, that anti-modernism cannot fulfill its promise. Even if the outer world is resplendent with primitive colors, color experience remains a mystery. Second, I argue that the theoretical costs of accepting irreducible colors in the world are enormous. Even if irreducible colors in the world could dispel the mysteries surrounding consciousness, the theoretical benefit would not be worth the cost. If the problems of consciousness and color require that we posit irreducible properties somewhere, it would be far more plausible to accept irreducible phenomenal properties on the side of the subject, and to reject irreducible colors on the side of the object. (shrink)

Our universe features a harmonious match between laws and states: applying its laws to its states generates other states. This is a striking fact. Matters might have been otherwise. The universe might have been stillborn in a state unengaged by its laws. The problem of nomological harmony is that of explaining the noted striking fact. After introducing and developing this problem, we canvass candidate solutions and identify some of their virtues and vices. Candidate solutions invoke the likes of a designer, (...) axiarchic meta-laws, multiverses, essential causal powers, and Humean laws. (shrink)

This paper defends a non-reductive realist view of the sensible qualities—roughly, the view that the sensible qualities are really instantiated by the external objects of perception, and not reducible to response-independent physical properties or response-dependent relational properties. I begin by clarifying and motivating the non-reductive realist view. I then consider some familiar difficulties for the view. Addressing these difficulties leads to the development and defence of a general theory, inspired by Russellian Monist theories of consciousness, of how the sensible qualities (...) relate to physical reality. I conclude by showing how this theory, which I call ‘Secondary Quality Russellian Monism’, resolves the most significant difficulties for the non-reductive realist view of the sensible qualities. (shrink)

According to the AI ensoulment hypothesis, some future AI systems will be endowed with immaterial souls. I argue that we should have at least a middling credence in the AI ensoulment hypothesis, conditional on our eventual creation of AGI and the truth of substance dualism in the human case. I offer two arguments. The first relies on an analogy between aliens and AI. The second rests on the conjecture that ensoulment occurs whenever a physical system is “fit to possess” a (...) soul, where very roughly this amounts to being physically structured in such a way that the system can meaningfully cooperate with the operations of the soul. (shrink)

The study of the feeling of knowing may have implications for some of the metatheoretical issues concerning consciousness and control. Assuming a distinction between information-based and experience-based metacognitive judgments, it is argued that the sheer phenomenological experience of knowing (''noetic feeling'') occupies a unique role in mediating between implicit-automatic processes, on the one hand, and explicit-controlled processes, on the other. Rather than reflecting direct access to memory traces, noetic feelings are based on inferential heuristics that operate implicitly and unintentionally. Once (...) such heuristics give rise to a conscious feeling that feeling can then affect controlled action. Examination of the cues that affect noetic feelings suggest that not only do these feelings inform controlled action, but they are also informed by feedback from the outcome of that action. (shrink)