Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, (...) and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)

If updating with E has the same result across all epistemically possible worlds, then the agent has no uncertainty as to the behavior of the update, and we may call it a transparent update. If an agent is uncertain about the behavior of an update, we may call it opaque. In order to model the uncertainty an agent has about the result of an update, the same update must behave differently across different possible worlds. In this paper, I study opaque (...) updates using a simple system of dynamic epistemic logic suitably modified for that purpose. The paper highlights the connection between opaque updates and the dynamic-epistemic principles Perfect-Recall and No-Miracles. I argue that opaque updates are central to contemporary discussions in epistemology, in particular to externalist theories of knowledge and to the related problem of epistemic bootstrapping, or easy knowledge. Opaque updates allow us to explicitly investigate a dynamic form of uncertainty, using simple and precise logical tools. (shrink)

The publication of History and... appears at a critical moment in our efforts to understand the importance of history as it relates to a wide range of scholarly ...

A dynamic epistemic logic is presented in which the single agent can reason about his knowledge stages before and after announcements. The logic is generated by reinterpreting multi agent private announcements in a single agent environment. It is shown that a knowability principle is valid for such logic: any initially true ϕ can be known after a certain number of announcements.

Williamson (2000) argues that the KK principle is inconsistent with knowledge of margin for error in cases of inexact perceptual observations. This paper argues, primarily by analogy to a different scenario, that Williamson’s argument is fallacious. Margin for error principles describe the agent’s knowledge as a result of an inexact perceptual event, not the agent’s knowledge state in general. Therefore, epistemic agents can use their knowledge of margin for error at most once after a perceptual event, but not more. This (...) insight blocks a crucial step in Williamson’s original argument. Along the way, the value of standard epistemic logic for analyzing margin for error reasoning is challenged. (shrink)

Here, we argue that any neurobiological theory based on an experience/function division cannot be empirically confirmed or falsified and is thus outside the scope of science. A ‘perfect experiment’ illustrates this point, highlighting the unbreachable boundaries of the scientific study of consciousness. We describe a more nuanced notion of cognitive access that captures personal experience without positing the existence of inaccessible conscious states. Finally, we discuss the criteria necessary for forming and testing a falsifiable theory of consciousness.

Although our subjective impression is of a richly detailed visual world, numerous empirical results suggest that the amount of visual information observers can perceive and remember at any given moment is limited. How can our subjective impressions be reconciled with these objective observations? Here, we answer this question by arguing that, although we see more than the handful of objects, claimed by prominent models of visual attention and working memory, we still see far less than we think we do. Taken (...) together, we argue that these considerations resolve the apparent conflict between our subjective impressions and empirical data on visual capacity, while also illuminating the nature of the representations underlying perceptual experience. (shrink)

Since its inception the ‘mindblindness’ theory of autism has greatly furthered our understanding of the core social-communication impairments in autism spectrum conditions . However, one of the more subtle issues within the theory that needs to be elaborated is the role of the ‘self’. In this article, we expand on mindblindness in ASC by addressing topics related to the self and its central role in the social world and then review recent research in ASC that has yielded important insights by (...) contrasting processes relating to both self and other. We suggest that new discoveries lie ahead in understanding how self and other are interrelated and/or distinct, and how understanding atypical self-referential and social-cognitive mechanisms may lead to novel ideas as to how to facilitate social-communicative abilities in ASC. (shrink)

Despite Augustine's reputation as the father of Christian intolerance, one finds in his thought the surprising claim that within non-Christian writings there are 'some truths in regard even to the worship of the One God.' The essays here uncover provocative points of comparison and similarity between Christianity and other religions to further such an Augustinian dialogue.

Within psychology, philosophy, and cognitive science, theory of mind refers to the cognitive ability to reason about the mental states of other people, thus recognizing them as having beliefs, knowledge, intentions and emotions of their own. In this project, we construct a natural language inference (NLD) dataset that tests the ability of a state of the art language model, RoBERTa-large finetuned on the MNLI dataset, to make theory of mind inferences related to knowledge and belief. Experimental results suggest that the (...) model struggles with such inferences, including after attempts for further finetuning. (shrink)

Review of Primary Ousia: An Essay on Aristotle's Metaphysics Z and H, by Michael J. Loux (Cornell University Press: 1991).

Cases of inexact observations have been used extensively in the recent literature on higher-order evidence and higher-order knowledge. I argue that the received understanding of inexact observations is mistaken. Although it is convenient to assume that such cases can be modeled statically, they should be analyzed as dynamic cases that involve change of knowledge. Consequently, the underlying logic should be dynamic epistemic logic, not its static counterpart. When reasoning about inexact knowledge, it is easy to confuse the initial situation, the (...) observation process, and the result of the observation; I analyze the three separately. This dynamic approach has far reaching implications: Williamson’s influential argument against the KK principle loses its force, and new insights can be gained regarding synchronic and diachronic introspection principles. (shrink)

How children seek knowledge and evaluate claims may depend on their understanding of the source of knowledge. What shifts in their understandings about why scientists might disagree and how claims about the state of the world are justified? Until about the age of 41/2, knowledge is seen as self-evident. Children believe that knowledge of reality comes directly through our senses and what others tell us. They appeal to these external sources in order to know. The attainment of Theory of Mind (...) (ToM) at this age is commonly seen as the significant shift in development in understanding disagreements in knowledge claims. Children attaining ToM understand that someone exposed to incorrect or incomplete information might have false beliefs. Disagreement, then, is still attributed to objective sources of knowledge. The current study examines the later developing Interpretive Theory of Mind (iToM) as the basis for children’s understanding of how people with access to the same information might disagree and what this means for how to provide justification for a knowledge claim. Fourteen 2nd graders with the most iToM responses to four tasks and 14 with the fewest iToM responses were selected from a larger sample of 91. In analyses of interviews about a story in which two experts make different claims about a scientific phenomenon, those in the high iToM group noted subjective perspective and processes as the source of disagreement and suggested the need for investigation as the means to knowing. In contrast, those in the low iToM group mostly could not explain the source of disagreement and held that knowledge is acquired from external sources. A comparison of the interviews regarding the science story 2 years later allows for a qualitative description of the development. Those in the low iToM group showed more general recognition of subjective and constructive processes in knowing whereas those in the high iToM group identified interpretive processes and the relativity of perspectives with implications for how observations were conducted and interpreted. Only those in the high iToM group referred to the importance of evidence as a basis for knowledge claims at either point in the study. (shrink)

Jonah N. Schupbach and Jan Sprenger and Vincenzo Crupi and Katya Tentori have recently proposed measures of explanatory power and have shown that they are characterized by certain arguably desirable conditions or axioms. I further examine the properties of these two measures, and a third measure considered by I. J. Good and Timothy McGrew . This third measure also has an axiomatic representation. I consider a simple coin-tossing example in which only the Crupi–Tentori measure does not perform well. The Schupbach–Sprenger (...) and Good–McGrew measures are based on different notions of explanatory power, but both are tenable. 1 Introduction2 Measures of Explanatory Power3 The Schupbach–Sprenger Measure4 The Crupi–Tentori Measure5 The Good–McGrew Measure6 Affirmative versus Comprehensive Explanatory Power7 Coin-Flipping Examples8 Decomposition9 Conclusion. (shrink)

V. Alan White and Gertrud Walton have published responses to my note on Einstein's simultaneity Gedankenexperiment, in which I present a version of the argument free of the flaws to be found in that given by Einstein. White thinks I go too far, that no reformulation is necessary; Walton, that I don't go far enough, and that i the inconsistencies in Einstein's exposition are ‘irreconcilable’. I r shall try to explain why I think both are mistaken.

The problem of perception is the problem of explaining how perceptual knowledge is possible. The skeptic has a simple solution: it is not possible. I analyze the weaknesses of one type of skeptical reasoning by making explicit a dynamic epistemic principle from dynamic epistemic logic that is implicitly used in debating the problem, with the aim of offering a novel diagnosis to this skeptical argument. I argue that prominent modest foundationalist responses to perceptual skepticism can be understood as rejecting the (...) dynamic assumption made by the skeptic, that there are independent reasons to doubt the truth of such a principle in the context of skeptical reasoning, and that making the dynamic principle explicit allows for a better understanding of at least one objection to modest foundationalism. (shrink)

Potentiality, Entanglement and Passion-at-a-Distance is a book for theoretical physicists and philosophers of modern physics. It treats a puzzling and provocative aspect of recent quantum physics: the apparent interaction of certain physical events that cannot share any causal connection. These are said to be `entangled' in some way, but an explanation remains elusive. Abner Shimony - to whom the book is dedicated - and others suggest the need to revive the category of what may be seen as a metaphysical potentiality. (...) Abner has described these events without actions to link them as `passion at a distance': not active, but passive. The discussions gathered here are written by a truly remarkable cast of scientists and philosophers and shed new light on the most profound puzzles of our times. (shrink)

Most writers now recognize that mental health policy and the mental health system are extremely resistant to real changes that reflect genuine biopsychosocial paradigms of mental disorder. Writers bemoaning the intransigence of the mental health system tend to focus on a small analytical level, only to find themselves mired in the rationalities of the existing system. Problems are acknowledged to be system-wide, yet few writers have used a method of analysis appropriate for systemic problems. Drawing upon the General System Theory (...) (GST) analytical perspective, this article advances a systematic approach to understand the mental health system and to facilitate the development of reform strategies that recognize the system's complexity and changing nature. The article first discusses the failure of major reform efforts in the mental health system and the limitations of mainstream analysis of mental health politics and policies with respect to the objectives of analysis and reform. This article describes how systems thinking has thus far influenced the study of the mental health policy and politics system, and argues that a systemic perspective is profitable for reconceiving the mental health system, enabling a fresh basis for the development of reform strategies. The mental health system should be seen as a social system influenced by larger political and economic dimensions, not just as a 'delivery system' scientifically constructed by neutral experts. Furthermore, the policy planning process should be viewed as part and parcel of a mental health system modeled as complex and dynamic. The systemic perspective outlined here should help both to clarify the value-based objectives that we hold for the system and, consequently, to plan for the strategic reforms that have so far eluded us. (shrink)

Recent years have witnessed an effort to explicate the concept of explanatory power in a Bayesian framework by constructing explanatory measures. It has been argued that those measures should not violate the principle of explanatory justice, which states that explanatory power cannot be extended “for free.” I argue, by formal means, that one recent measure claiming to be immune from explanatory injustice fails to be so. I end by concluding that the explanatory justice criticism can be dissolved, given a natural (...) interpretation of the concept of negative explanatory power. (shrink)

Epistemic closure refers to the assumption that humans are able to recognize what entails or contradicts what they believe and know, or more accurately, that humans’ epistemic states are closed under logical inferences. Epistemic closure is part of a larger theory of mind ability, which is arguably crucial for downstream NLU tasks, such as inference, QA and conversation. In this project, we introduce a new automatically constructed natural language inference dataset that tests inferences related to epistemic closure. We test and (...) further fine tune the model RoBERTa-large-mnli on the new dataset, with limited positive results. (shrink)

We motivate and formalize the idea of sameness by default: two objects are considered the same if they cannot be proved to be different. This idea turns out to be useful for a number of widely different applications, including natural language processing, reasoning with incomplete information, and even philosophical paradoxes. We consider two formalizations of this notion, both of which are based on Reiter’s Default Logic. The first formalization is a new relation of indistinguishability that is introduced by default. We (...) prove that the corresponding default theory has a unique extension, in which every two objects are indistinguishable if and only if their non-equality cannot be proved from the known facts. We show that the indistinguishability relation has some desirable properties: it is reflexive, symmetric, and, while not transitive, it has a transitive “flavor.” The second formalization is an extension (modification) of the ordinary language equality by a similar default: two objects are equal if and only if their non-equality cannot be proved from the known facts. It appears to be less elegant from a formal point of view. In particular, it gives rise to multiple extensions. However, this extended equality is better suited for most of the applications discussed in this paper. (shrink)

Jonah N. Schupbach and Jan Sprenger have proposed conditions of adequacy for measures of explanatory power. They derive and defend a measure of explanatory power satisfying their conditions of adequacy. This article furthers the development of their measure. The requirement that the measure be multidimensional analytic is avoided. Several proofs are simplified, and gaps in proofs are filled.

Contemporary philosophers are increasingly turning to the work of Emmanuel Levinas to bring a consideration of ethics into their own thinking. As an exponent of the phenomenological tradition, Levinas ranks with Heidegger and Sartre; as a disciple of Husserl, he was one of the most independent and original interpreters, testifying to the fruitfulness of Husserl's phenomenology. In collecting almost all of Levinas's articles on Husserlian phenomenology, this volume gathers together a wealth of thoughtful exposition and interpretation by one of the (...) most important European philosophers of the twentieth century. Levinas's thought is relevant to a broad variety of disciplines and concerns. This volume serves as a reliable introduction for the beginning student, as well as satisfying the expert's more demanding and critical desire for insight into the complexities of Levinas's thought. (shrink)

Laurence Goldstein has ‘re-created’ Wittgenstein's doctoral viva, arguing that had Wittgenstein's dissertation, his Tractatus Logico-Philosophicus, ‘been judged by normal standards of originality and philosophical argumentation, it would have failed’. Goldstein claims that Wittgenstein ‘lifted’ central doctrines from Russell and from Bernard Bolzano. I point out that passages allegedly plagiarized from Russell are actually criticisms of his doctrines, and that there is no evidence that Wittgenstein even knew Bolzano's work, directly or indirectly. I argue that alleged similarities, substantial and stylistic, between (...) his work and Bolzano's give no support even to a weaker claim of influence. (shrink)