In 1957, Francis Crick outlined a startling vision of life in which the great diversity of forms and shapes of macromolecules was encoded in the one-dimensional sequence of nucleic acids. This paper situates Crick's new vision in the debates of the 1950s about protein synthesis and gene action. After exploring the reception of Crick's ideas, it shows how they differed radically from a different model of protein synthesis which enjoyed wide currency in that decade. In this alternative model, advocated by (...) Linus Pauling and other luminaries, three-dimensional templates directed the folding of proteins. Even though it was always considered somewhat speculative, this theory was supported by a number of empirical results originating in different experimental systems. It was eventually replaced by a model in which the forms and shapes of macromolecules resulted solely from their amino acid sequence, dramatically simplifying the problem of protein synthesis which Crick was attempting to solve in 1957. (shrink)

The intellectual origins of molecular biology are usually traced back to the 1930s. By contrast, molecular biology acquired a social reality only around 1960. To understand how it came to designate a community of researchers and a professional identity, I examine the creation of the first institutes of molecular biology, which took place around 1960, in four European countries: Germany, the United Kingdom, France, and Switzerland. This paper shows how the creation of these institutes was linked to the results of (...) post-war economic reconstruction. Then, it compares how the promoters of these different institutional projects delimited the goals of their discipline, reflected on its history, and suggested how research should be organised. I show how they carefully positioned their new discipline within the emerging national science policy discourse of the 1950s, and aligned it with the current vision of scientific modernity. In particular, I discuss how they articulated the meaning of molecular biology with respect to five common themes: the role of physics in the atomic age, the relations between fundamental research and medical applications, the ‘Americanisation’ of scientific research, the value of science in the reconstruction of national identities, and the drive towards interdisciplinary research. This paper thus demonstrates that beyond the local and national accounts there is a European history of molecular biology. (shrink)

Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the rise of (...) molecular evolution in the 1960s, this paper shows that they grew out of research agendas from the previous decade, including the biochemical investigation of the relations between the structures and function of proteins and the theoretical attempt to decipher the genetic code. It also shows how computers became essential for the handling and analysis of sequence data. Finally, this paper reflects on the relationships between experimenting and collecting as two distinct “ways of knowing” that were essential for the transformation of the life sciences in the twentieth century. (shrink)

Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the rise of (...) molecular evolution in the 1960s, this paper shows that they grew out of research agendas from the previous decade, including the biochemical investigation of the relations between the structures and function of proteins and the theoretical attempt to decipher the genetic code. It also shows how computers became essential for the handling and analysis of sequence data. Finally, this paper reflects on the relationships between experimenting and collecting as two distinct "ways of knowing" that were essential for the transformation of the life sciences in the twentieth century. (shrink)

This paper argues that we should solve paradoxes for propositions (such as the Russell–Myhill paradox) in essentially the same way that we solve Russellian paradoxes for sets. That is, the standard, iterative approach to sets is extended to include properties, and then the resulting hierarchy of sets and properties is used to construct propositions. Propositions on this account are structured in the sense of mirroring the sentences that express them, and they would seem to serve the needs of philosophers of (...) language and metaphysicians who rely on such propositions. The resulting account has limitations, comparable to those faced by the iterative approach to sets, but it is argued to be in important ways preferable to others that have been proposed. (shrink)

The aim of the paper is to argue that all—or almost all—logical rules have exceptions. In particular, it is argued that this is a moral that we should draw from the semantic paradoxes. The idea that we should respond to the paradoxes by revising logic in some way is familiar. But previous proposals advocate the replacement of classical logic with some alternative logic. That is, some alternative system of rules, where it is taken for granted that these hold without exception. (...) The present proposal is quite different. According to this, there is no such alternative logic. Rather, classical logic retains the status of the ‘one true logic’, but this status must be reconceived so as to be compatible with (almost) all of its rules admitting of exceptions. This would seem to have significant repercussions for a range of widely held views about logic: e.g. that it is a priori, or that it is necessary. Indeed, if the arguments of the paper succeed, then such views must be given up. (shrink)

Plausibly, mathematical claims are true, but the fundamental furniture of the world does not include mathematical objects. This can be made sense of by providing mathematical claims with paraphrases, which make clear how the truth of such claims does not require the fundamental existence of mathematical objects. This paper explores the consequences of this type of position for explanatory structure. There is an apparently straightforward relationship between this sort of structure, and the logical sort: i.e. logically complex claims are explained (...) by logically simpler ones. For example, disjunctions are explained by their (true) disjuncts, while generalizations are explained by their (true) instances. This would seem as plausible in the case of mathematics as elsewhere. Also, it would seem to be something that the anti-realist approaches at issue would want to preserve. It will be argued, however, that these approaches cannot do this: they lead not merely to violations of the familiar principles relating logical and explanatory structure, but even to reversals of these. That is, there are cases where generalizations explain their instances, or disjunctions their disjuncts. (shrink)

Le 27 avril 1938, Edmund HUSSERL, l'initiateur et principal representant du courant phenomenologique dans la philosophie contemporaine, mourut a Fribourg en Brisgau, age de pres de quatre-vingts ans. Depuis la parution de ses Logische Untersuchungen en 190~ 1901, le monde philosophique international avait suivi, avec UD interet toujours croissant, les exposes successifs et de plus en plus approfondis, que le maUre fribourgeois publiait sur les prin~ cipes de sa methode, dite pMnomenologique, sur les applications concretes de celle-ci aux problemes philosophiques (...) les plus divers, ainsi que sur la phenomenologie comme systeme philo­ sophique autonome et pour ainsi dire "autarchique". Ces publi­ cations, relativement peu nombreuses, mais fort remarquees des leur parution, furent etudiees avec le plus grand soin par les representants les plus autorises des differents courants de la pensee contemporaine. Les critiques, il va sans dire, ne manquerent point. On attira l'attention sur le caractere plutöt programmatique de ces etudes, sur la terminologie fort neuve, quelque peu arbitraire, parfois meme deroutante, dont se servait l'auteur, sur son pen­ chant prononce pour des distinctions subtiles et pour des defini­ tions minutieuses a l'exces, sur la difficulte de son style et les complications parfois inutiles de son expose, enfin et surtout -­ au moins depuis 1913 - sur le caractere audacieux de sa theorie de la reduction, presentee par lui avec une insistance toute par­ ticuliere comme le fondement dernier et indispensable de toute phenomenologie presente ou future. (shrink)

Can large language models produce expert‐quality philosophical texts? To investigate this, we fine‐tuned GPT‐3 with the works of philosopher Daniel Dennett. To evaluate the model, we asked the real Dennett 10 philosophical questions and then posed the same questions to the language model, collecting four responses for each question without cherry‐picking. Experts on Dennett's work succeeded at distinguishing the Dennett‐generated and machine‐generated answers above chance but substantially short of our expectations. Philosophy blog readers performed similarly to the experts, while ordinary (...) research participants were near chance distinguishing GPT‐3's responses from those of an “actual human philosopher”. (shrink)

Professor H. L. Van Breda had hoped to write this preface, but his recent, unexpected and untimely death has left that task in my hands. Although my remarks will not be as eloquent and insightful as his surely would have been, some few words are clearly in order here; for the phenomenological community has not only lost the leadership of Fr. Van Breda these last years, but also the scholarship and leadership of Aron Gurwitsch and Alden Fisher - both contributors (...) to this volume - as well as that of Dorion Cairns and John Wild. Our leaders are fewer now but Herbert Spiegelberg is still very obviously one of them. This volume thus presents the work of some of the past and presently recognized leaders in phenomenology - e. g. Gurwitsch, Straus, and Fisher - but, more important perhaps, it also presents the work of some of those who are sure to be future leaders of our community of phenomenological philosophers, if in fact they have not already achieved this status. Most, if not all, of the contribu tors to this volume are in some way or another indebted to Herbert Spiegelberg and his work in phenomenology. (shrink)

In this book Bruno Latour brings together these different approaches to provide a lively and challenging analysis of science, demonstrating how social context..

This special issue of Grazer Philosophische Studien brings together a number of carefully selected and timely articles that explore the discussion of different facets of self-consciousness from multiple perspectives. The selected articles mainly focus on three topics of the current debate: (1) the relationship between conceptual and nonconceptual ways of self-representation; (2) the role of intersubjectivity for the development of self-consciousness; (3) the temporal structure of self-consciousness. A number of previously underexposed, yet important connections between different approaches are explored. The (...) articles not only represent the state of the art in their respective areas of research and make new insights available, but also provide an overview of different methodologies: ranging from philosophy of language and mind to phenomenology and cognitive science. The volume is of interest for philosophers, cognitive scientists and researchers in related disciplines who are concerned with investigating the nature and origin of self-consciousness. (shrink)

Bruno Latour was once asked : "Do you believe in reality?" This text is an attempt to answer this question.

General-elimination harmony articulates Gentzen’s idea that the elimination-rules are justified if they infer from an assertion no more than can already be inferred from the grounds for making it. Dummett described the rules as not only harmonious but stable if the E-rules allow one to infer no more and no less than the I-rules justify. Pfenning and Davies call the rules locally complete if the E-rules are strong enough to allow one to infer the original judgement. A method is given (...) of generating harmonious general-elimination rules from a collection of I-rules. We show that the general-elimination rules satisfy Pfenning and Davies’ test for local completeness, but question whether that is enough to show that they are stable. Alternative conditions for stability are considered, including equivalence between the introduction- and elimination-meanings of a connective, and recovery of the grounds for assertion, finally generalizing the notion of local completeness to capture Dummett’s notion of stability satisfactorily. We show that the general-elimination rules meet the last of these conditions, and so are indeed not only harmonious but also stable. (shrink)

This book constitutes the outcome of an international conference held at the Otto-Mobes-Volkswirtschaftsschule, Graz-Stifting( Austria), from June 16 to 22, 1974. The conference was initiated by a project group working on determinants and controls of social science development at the In stitute for Advanced Studies and Scientific Research in Vienna and or ganized by the editors of this volume. It was held under the auspices of the Austrian Ministry of Science and Research. The main topics of the conference were those (...) at the forefront of the 'state of argumentation' (to borrow from one of our contributors) in philosophy and sociology of science ever since the controversy between Thomas S. Kuhn and Sir Karl R. Popper has sharpened our awareness for the methodological and substantial presuppositions involved with questions of growth and development in science. Let us give two examples of those topics. The borderline between sociology of science and philo sophy of science has become more and more unclear; while the work of at least some philosophers of science comes to have an empirical flavour, sociologists of science are increasingly apt to include logical and methodo logical components of the research process as their objects of examina tion. Papers included in this volume testify to both tendencies. (shrink)

German classicist's monumental study of the origins of European thought in Greek literature and philosophy. Brilliant, widely influential. Includes "Homer's View of Man," "The Olympian Gods," "The Rise of the Individual in the Early Greek Lyric," "Pindar's Hymn to Zeus," "Myth and Reality in Greek Tragedy," and "Aristophanes and Aesthetic Criticism.".

In a series of papers, 137–158; 1994, Midwest Studies in Philosophy, 23, 61–74, 1999) Fine develops his hylomorphic theory of embodiments. In this article, we supply a formal semantics for this theory that is adequate to the principles laid down for it in. In Section 1, we lay out the theory of embodiments as Fine presents it. In Section 2, we argue on Cantorian grounds that the theory needs to be stabilized, and sketch some ways forward, discussing various choice points (...) in modeling the view. In Section 3, we develop a formal semantics for the theory of embodiments by constructing embodiments in stages and restricting the domain of the second-order quantifiers. In Section 4 we give a few illustrative examples to show how the models deliver Finean hylomorphic consequences. In Section 5, we prove that Fine’s principles are sound with respect to this semantics. In Section 6 we present some inexpressibility results concerning Fine’s various notions of parthood and show that in our formal semantics these notions are all expressible using a single mereological primitive. In Section 7, we prove several mereological results stemming from the model theory, showing that the mereology is surprisingly robust. In Section 8, we draw some philosophical lessons from the formal semantics, and in particular respond to Koslicki’s main objection to Fine’s theory. In the appendix we present proofs of the inexpressibility results of Section 6. (shrink)

The emergence of modern sciences in the seventeenth century profoundly renewed our understanding of Nature. For the last three centuries new ideas of Nature have been continuously developed by theology, politics, economics, and science, especially the sciences of the material world. The situation is even more unstable today, now that we have entered an ecological mutation of unprecedented scale. Some call it the Anthropocene, but it is best described as a new climatic regime. And a new regime it certainly is, (...) since the many unexpected connections between human activity and the natural world oblige every one of us to reopen the earlier notions of Nature and redistribute what had been packed inside. So the question now arises: what will replace the old ways of looking at Nature? This book explores a potential candidate proposed by James Lovelock when he chose the name "Gaia" for the fragile, complex system through which living phenomena modify the Earth. The fact that he was immediately misunderstood proves simply that his readers have tried to fit this new notion into an older frame, transforming Gaia into a single organism, a kind of giant thermostat, some sort of New Age goddess, or even divine Providence. In this series of lectures on "natural religion", Bruno Latour argues that the complex and ambiguous figure of Gaia offers, on the contrary, an ideal way to disentangle the ethical, political, theological, and scientific aspects of the now obsolete notion of Nature. He lays the groundwork for a future collaboration among scientists, theologians, activists, and artists as they, and we, begin to adjust to the new climatic regime. (shrink)

European thought begins with the Greeks. Scientific and philosophic thinking--the pursuit of truth and the grasping of unchanging principles of life--is a historical development, an achievement; and, as Bruno Snell writes in The Discovery of the Mind, nothing less than a revolution. The Greeks did not take mental resources already at their disposal and merely map out new subjects for discussion and investigation. In poetry, drama, and philosophy they in fact discovered the human mind. The stages in man's gradual (...) understanding of himself are revealed in the course of ancient literature from Homer to Virgil. A rational view of the nature of man slowly established itself in the creations of epic and lyric poetry, tragedy and literary criticism, pre-Socratic thought, and early Greek ethics all the way to the discovery of humanitas and the spiritual landscape of Virgil's Arcadia. The Discovery of the Mind is a landmark work in tracing this evolution of consciousness--one of the distinguishing characteristics of the history of man. (shrink)