Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

Spanish translation, introductory study and notes on Charles Leslie Stevenson’s “Persuasive Definitions”. Published in Stevenson, Charles L. “Definiciones persuasivas”. Quaderns de Filosofia, vol. VIII, n. 1 (2021), pp. 105–125. -/- [Introductory study published in Oya, Alberto. “Presentación. Las definiciones persuasivas según Charles L. Stevenson”. Quaderns de Filosofia, vol. VIII, n. 1 (2021), pp. 101–104].

In lieu of an abstract, here is a brief excerpt of the content:Reading and Writing PlatoCharles L. GriswoldThe Play of Character in Plato's Dialogues, by Ruby Blondell; 452 pp. Cambridge: Cambridge University Press, 2002, $55.00Plato's Dialectic at Play: Argument, Structure, and Myth in theSymposium, by Kevin Corrigan and Elena Glazov-Corrigan; 266 pp. University Park: Pennsylvania State University Press, 2004, $25.00Questioning Platonism: Continental Interpretations of Plato, by Drew Hyland; ix & 202 pp. Albany: State University of New York Press, 2004, $44.00The (...) People of Plato: A Prosopography of Plato and Other Socratics, by Debra Nails; 414 pp. Indianapolis: Hackett, 2002, $75.00.Why did Plato write dialogues? How should his dialogues be read (does the literary form matter, for example, to our getting at the heart of what Plato is saying)? These questions are now familiar in contemporary Plato scholarship, and their answers—which undoubtedly are interconnected—are the subject of lively and fascinating exploration. Any doubt that Platonic studies flourishes would quickly be put to rest by the four books under review here.It was once thought that attention to the "dramatic dimension" of Plato's literary-philosophical productions was the province of two much despised schools of thought: "the Straussians," and "the Continentals." The first of these was viewed as advocating a dangerous combination of esotericism (the idea that somehow Plato's meaning is not on the surface of the dialogues, but concealed in them, as though they were a cryptogram), elitism (the idea that the true Plato is only available to [End Page 205] "the few"—such as the Straussians, according to themselves anyhow), and unphilosophical and dilettantish meanderings about this or that literarily cast "teaching." Straussian hermeneutics was thought to open the way to unprincipled appeals to irony whenever it suited the interpreter, so that any text could end up saying pretty much whatever the interpreter wished for it to say, including the opposite of what the surface of the dialogue appeared to say. And further, it was thought (perhaps in a manner at odds with the "unprincipled interpretation" charge) that the Straussians' mode of "taking into account" the dramatic context—and in particular their contextualization of claims made in the dialogues such that this or that claim gets "explained" as a rhetorical gesture addressed by character X to character Y in context Z, a gesture whose content and validity, so to speak, are limited to that exchange—robs the dialogue of its philosophical content. Hence the worry that Straussian hermeneutics leads to skepticism about the possibility of philosophy itself—philosophy understood precisely in the way that it is regularly spoken of in the Platonic dialogues, namely as the effort to transcend perspective and partiality and to grasp through argument the essence of the matter as such. To cap it off, there is the background suspicion that Straussians are politically conservative, in a way that is somehow connected with their interpretation of Plato.There is more than a kernel of truth in the view that Straussians have insisted on the hermeneutic importance of the dialogue form, taking their cue from Strauss's own remarks in such texts as The City and Man. He did argue that Plato's meaning is not on the surface (and thus in some sense is esoteric), that it was intended by Plato to be available to "the few" while not debunking the beliefs of "the many," and that Plato is an ironist. There is also warrant for the worries about unprincipled interpretation, as well as about the reduction of philosophy to a sort of literary sensibility substituting for genuine philosophical argument (where, after all, are Strauss's arguments for any philosophical position, whether or not about a Platonic "teaching"?). And it is by and large true, so far as I can tell, that his self-identified followers are politically conservative (in the contemporary American sense), and in a way somehow tied to their interpretation of Plato.I myself find Strauss's interpretation of Plato to be deeply problematic both in its substance and its method (I put aside the issue of the political conservatism of Strauss's followers, a "teaching" I also find objectionable). And while I join the authors of the four... (shrink)

_The Handbook of Dewey’s Educational Theory and Practice_ provides a comprehensive, accessible, richly theoretical yet practical guide to the educational theories, ideals, and pragmatic implications of the work of John Dewey, America’s preeminent philosopher of education.

A book on the problems of ethics from the perspective of language and meaning.

In hospital rooms across the country, doctors, nurses, patients, and their families grapple with questions of life and death. Recently, they have been joined at the bedside by a new group of professional experts, bioethicists, whose presence raises a host of urgent questions. How has bioethics evolved into a legitimate specialty? When is such expertise necessary? How do bioethicists make their decisions? And whose interests do they serve? Renowned sociologist Charles L. Bosk has been observing medical care for thirty-five (...) years. In What Would You Do? he brings his extensive experience to bear on these questions while reflecting on the ethical dilemmas that his own ethnographic research among surgeons and genetic counselors has provoked. Bosk considers whether the consent given to ethnographers by their subjects can ever be fully voluntary and informed. He questions whether promises of confidentiality and anonymity can or should be made. And he wonders if social scientists overestimate the benefits of their work while downplaying the risks. Vital for practitioners of both the newly prominent field of bioethics and the long-established craft of ethnography, What Would You Do? will also engross anyone concerned with how our society addresses difficult health care issues. (shrink)

Philosophers have debated whether the advance directives of Alzheimer’s patients should be enforced, even if patients seem content in their demented state. The debate raises deep questions about the nature of human autonomy and personal identity. But it tends to proceed on the assumption that the advance directive’s terms are clear, whereas in practice they are often vague or ambiguous, requiring the patient’s healthcare proxy to make difficult judgment calls. This practical wrinkle raises its own, distinct but related, philosophical question: (...) what criteria may the proxy bring to bear when making such interpretive judgments on which the patient’s life may depend? After defending a general policy of enforcing advance directives on normative (rather than metaphysical) grounds, I argue that when advance directives are vague, a patient’s proxy may permissibly make her own fresh evaluation of the patient’s life as a whole and, in so doing, consider how the patient’s character as a demented person contributes or fails to contribute to that life. (shrink)

In this award-winning study of the _Phaedrus_, Charles Griswold focuses on the theme of "self-knowledge." Relying on the principle that form and content are equally important to the dialogue's meaning, Griswold shows how the concept of self-knowledge unifies the profusion of issues set forth by Plato. Included are a new preface and an updated comprehensive bibliography of works on the _Phaedrus_.

Features the full text of "Wittgenstein and Kierkegaard: Religion, Individuality and Philosophical Method," by Charles L. Creegan. Discusses the works and theories of Danish philosopher Soren Kierkegaard (1813-1855) and British philosopher Ludwig Wittgenstein (1889-1951).

Originally published by Routledge in 1988, this pioneering collection of essays now features a new preface and updated bibliography by the editor, reflecting the most significant developments in Plato scholarship during the past decade.

Based on an unfinished manuscript by the late philosopher Dallas Willard, this book makes the case that the 20th century saw a massive shift in Western beliefs and attitudes concerning the possibility of moral knowledge, such that knowledge of the moral life and of its conduct is no longer routinely available from the social institutions long thought to be responsible for it. In this sense, moral knowledge--as a publicly available resource for living--has disappeared. Via a detailed survey of main developments (...) in ethical theory from the late 19th through the late 20th centuries, Willard explains philosophy's role in this shift. In pointing out the shortcomings of these developments, he shows that the shift was not the result of rational argument or discovery, but largely of arational social forces--in other words, there was no good reason for moral knowledge to have disappeared. The Disappearance of Moral Knowledge is a unique contribution to the literature on the history of ethics and social morality. Its review of historical work on moral knowledge covers a wide range of thinkers including T.H Green, G.E Moore, Charles L. Stevenson, John Rawls, and Alasdair MacIntyre. But, most importantly, it concludes with a novel proposal for how we might reclaim moral knowledge that is inspired by the phenomenological approach of Knud Logstrup and Emmanuel Levinas. Edited and eventually completed by three of Willard's former graduate students, this book marks the culmination of Willard's project to find a secure basis in knowledge for the moral life. (shrink)

Jean-Jacques Rousseau and Adam Smith are giants of eighteenth century thought. The heated controversy provoked by their competing visions of human nature and society still resonates today. Smith himself reviewed Rousseau's Discourse on Inequality, and his perceptive remarks raise an intriguing question: what would a conversation between these two great thinkers look like? In this outstanding book Charles Griswold analyses, compares and evaluates some of the key ways in which Rousseau and Smith address what could be termed "the question (...) of the self." Both thinkers discuss what we are by nature, who we have become, whether we can know ourselves or each other, how best to articulate the human condition, what it would mean to be free, and whether there is anything that can be done to remedy our deeply imperfect condition. In the course of examining their rich and contrasting views, Griswold puts Rousseau and Smith in dialogue by imagining what they might say in reply to one another. Griswold's wide-ranging exploration includes discussion of issues such as narcissism, self-falsification, sympathy, the scope of philosophy, and the relation between liberty, religion and civic order. A superb exploration of two major philosophers, Jean-Jacques Rousseau and Adam Smith: A Philosophical Encounter is essential reading for students and scholars of these two figures, eighteenth century philosophy, the Enlightenment, moral philosophy, the history of ideas. It will also be of interest to those in related disciplines such as political theory, economics, and religion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.1 (2002) 84-106 [Access article in PDF] Irony in the Platonic Dialogues Charles L. Griswold, Jr. I INTERPRETERS OF PLATO have arrived at a general consensus to the effect that there exists a problem of interpretation when we read Plato, and that the solution to the problem must in some way incorporate what has tendentiously been called the "literary" and the "philosophical" sides of Plato's (...) writing. The problem is created by the fact that Plato wrote in dialogue form, indeed a specific type of dialogue form. The solution must somehow combine into a coherent theory of the "meaning" of the dialogues, the ways in which these texts work (such as the use of imagery, metaphor, myth, allusion, irony, as well as argument). At the same time, there exists enormous disagreement about how one ought to move from these general observations to interpretation of a particular text. 1The problem of interpretation lies not merely in the fact that Plato wrote dialogues. That alone would not necessarily present any hermeneutical issues of unusual difficulty. Plato's distinctive use of the dialogue form creates the difficulties. The genre that we might call "the Platonic dialogue" is distinguished by several relevant characteristics.First, there is no character called "Plato" who speaks in any of the dialogues; indeed, "Plato" is mentioned twice in the entire corpus, once as being absent (Pho. 59b10), and once as being present (Apol. 38b6). Authorial anonymity is thus an important feature of the dialogues. 2 At least ab initio, we are not justified in identifying Plato with any one of his characters. Indeed, there are positive reasons why he cannot be identified even with Socrates, as I will discuss below. 3 Plato is absent from his own texts; no simple act of reading them will allow us to ascertain what his views are. 4 It does not follow that Plato's views are [End Page 84] entirely absent from the dialogues—say, in the form of some mysterious "esoteric teaching"—and that they cannot be elicited by a complex act of reading. Just how Plato's views are to be extracted has been, again, the subject of a very long debate. 5 I myself think that Plato's views can be so elicited. 6 But the fact of his anonymity as author means that "Plato's meaning" is not ascertainable in the way that, say, "Kant's meaning" may be ascertainable in the Critique of Pure Reason.A second feature of Plato's dialogues contributes to the interpretive puzzle. The dialogues are clearly fictional in character. They are not—they could not be—transcriptions of conversations which took place. Some dialogues could not have taken place even when the interlocutors were historical figures (for example, at the Phaedrus' ostensible dramatic date the real Phaedrus was not in Athens). Not only are many of the characters entirely fictional, there is clear evidence that even "Socrates" is very much a fictionalized version of the historical character. I am referring not just to the famous statement in the (possibly inauthentic) Second Letter, 7 but to the fact that the Socrates of Plato's dialogues is presented as being a super-human character. This is evident from Alcibiades' description of him in the Symposium as well as from a number of subtle fictions. For example, Plato has Socrates narrate the entirety of the Republic from memory, without a single moment of hesitation or (so far as the reader can tell) any lapse of memory. This fantastic feat is complemented by Socrates' equally fantastic stamina in conversation. The lengthy Protagoras, for example, is narrated in its entirety by Socrates immediately after the dialogue itself has occurred. Socrates never shows any fatigue of any sort. It is not just hyperbole to say that Plato's Socrates is heroic; he is carefully compared, in passages I cannot examine here, to both Achilles and Odysseus. Socrates' absolute calm and self-control before death also evidence his superhuman character. The relation between the historical Socrates and the Platonic Socrates is the source of much fruitful controversy. It suffices for... (shrink)

Psychologists can measure normalcy, define madness, develop therapeutic paradigms, and list the nuances of human behavior with utmost precision. We have biofeedback, psychometrics, psychoanalysis, cognitive therapy, positive psychology, behavior modification, and a host of deeply promising projects in the research and development pipeline. To be sure, our discipline has advanced accurate understanding of the soul's essential properties and has scientifically harnessed this knowledge to clinically mitigate the deep agony of the human mind. But, despite our advances and genuine effectiveness, our (...) discipline remains incomplete. Theoretically, scientifically, and therapeutically, we fall short of the fuller effectuality that awaits us. We need Christ. It is through the Christian revelation that psychology will find its maturity. For psychology there are blessings afoot. These blessings stem from our recognition that the Clinical Christ - the activity of the God of the Christian revelation throughout the realms of our discipline - desires to redeem, relate, heal, love, and empower us. The chapters of this book explore different aspects of the Clinical Christ, Christian Holism, and their implications. A central tenet of Christian Holism is that the Holy Spirit is fully present in the clinical situation, with and within the therapist and the client, and is actively engaged in the treatment process. Ten further tenets proceeding from the central tenet are described. Other chapters include treatment of the importance of forgiveness, reconciliation and dream work in the practice of Christian Holism. There is copious material in other chapters citing significant research data validating health benefits of Christian prayer and spirituality, the need for the Church to restore the healing ministry and energetic components of Christian prayer and spirituality. (shrink)

There are intriguing congruities between Kierkegaard and some recent tendencies in feminism and post-modern thought.1 Neither Kierkegaard, feminists, nor post-modernism are systematic (that's one congruity right there!), so the common points can't be neatly tabulated. But (again typically of all the parties concerned) they tend to lie in three areas: methodology, communicative strategy, and the rejection of procrustean metaphysics. In what follows I will try to assemble some fragments which point out these congruities.