Les conferences dont se compose le present ouvrage furent ecrites au profit de jeunes etudiants en philosophie. Par le terme de Platonisme ne s'entend certes pas ici un quelconque Neoplatonisme mais les seuls principes fondateurs de la doctrine de Platon, doctrine que nous avons tente d'observer en un rapport direct avec son auteur tel qu'il se presente au travers de ses propres ecrits. Plongeant aux racines antiques avec une decision toute nitzscheenne, Pater en revient pourtant conforte dans sa distance: (...) pour lui l'esthetique forme bien le primum mobile de l'histoire de l'esprit. Cet ouvrage permet, bien mieux qu'un manuel, d'acquerir une solide connaissance de Platon et d'interessants elements touchant aussi ses deux antipodes: les presocratiques et, comme nous le suggerons, Nietzsche. (shrink)

Studies in the History of the Renaissance is a highly influential defence of aestheticism. Pater redefined the practice of criticism through his readings of some of the paintings, sculptures, and poems of the Renaissance, and shocked contemporaries for sponsoring a hedonistic ethic with his infamous 'Conclusion'.

Exploring the intricacy and complexity of Walter Pater's prose, Transfigured World challenges traditional approaches to Pater and shows precise ways in which the form of his prose expresses its content. Carolyn Williams asserts that Pater's aestheticism and his historicism should be understood as dialectically interrelated critical strategies, inextricable from each other in practice. Williams discusses the explicit and embedded narratives that play a crucial role in Pater's aesthetic criticism and examines the figures that compose these (...) narratives, including rhetorical tropes, structures of argument such as genealogy, and historical or fictional personae. (shrink)

This book examines Pater's deep engagement with Platonism throughout this career. Using the interdisciplinary critical tools of Pater's own educational milieu which combined literature, philosophy, and classics, The Platonism of Walter Pater repositions the importance Pater's contribution to literature and the history of ideas.

Health and illness are not objective concepts but rather issues which depend upon cultural and religious traditions. In Islam there are two traditional approaches to these concepts: prophetic medicine and the medicine of the Islamic Middle Ages, which was strongly influenced by Galen and Hippocrates. Tody, Islam is increasingly looking at modern western orthodox medicine. With regard to Muslim patients, however, it is still necessary to take into account the peculiarities of their religious traditions.

This article introduces and defends the “pathological complexity thesis” as a hypothesis about the evolutionary origins of minimal consciousness, or sentience, that connects the study of animal consciousness closely with work in behavioral ecology and evolutionary biology. I argue that consciousness is an adaptive solution to a design problem that led to the extinction of complex multicellular animal life following the Avalon explosion and that was subsequently solved during the Cambrian explosion. This is the economic trade-off problem of having to (...) deal with a complex body with high degrees of freedom, what I call “pathological complexity.” By modeling the explosion of this computational complexity using the resources of state-based behavioral and life history theory we will be able to provide an evolutionary bottom-up framework to make sense of subjective experience and its function in nature by paying close attention to the ecological lifestyles of different animals. (shrink)

There has been much criticism of the idea that Friston's free-energy principle can unite the life and mind sciences. Here, we argue that perhaps the greatest problem for the totalizing ambitions of its proponents is a failure to recognize the importance of evolutionary dynamics and to provide a convincing adaptive story relating free-energy minimization to organismal fitness.

This paper constitutes a radical departure from the existing philosophical literature on models, modeling-practices, and model-based science. I argue that the various entities and practices called 'models' and 'modeling-practices' are too diverse, too context-sensitive, and serve too many scientific purposes and roles, as to allow for a general philosophical analysis. From this recognition an alternative view emerges that I shall dub model anarchism.

This paper presents the outlines of a phenomenological theory of foundational or non-inferential knowledge according to which the facts or states of affairs towards which our beliefs are intentionally directed can sometimes serve as reasons or evidence for what we believe. This occurs in acts of fulfillment, in which an object or state of affairs is given as it is thought to be. Hopp further argues that the sorts of empirical facts that can serve as reasons for noninferentially justified beliefs (...) are not confined to facts about one’s own occurrent mental states, but include facts about the physical world as well. In the course of defending the view against objections, Hopp argues that we should be internalists about the reasons in virtue of which what we believe is justified but externalists about the factors in virtue of which our states of believing have the status of being justified. He also argues against the claim that mental states, such as perceptual experiences, constitute our evidence for empirical beliefs. (shrink)

Das Problem der absoluten Reflexion -- Die Wandlungen des Freiheitsbegriffs bei Schelling -- Philosophie als absolutes Wissen -- Ethisches Handeln, heute -- Freiheit und Unfreiheit im Horizont menschlicher Selbsterfahrung -- Philosophische Aspekte der Angst -- Zum Problem des Todes.

Through their transcript products genes regulate the rates at which an immense variety of transcripts and subsequent proteins occur. Understanding the mechanisms that determine which genes are expressed, and when they are expressed, is one of the keys to genetic manipulation for many purposes, including the development of new treatments for disease. Viewing each gene in a genome as a distinct variable that is either on or off, or more realistically as a continuous variable, the values of some of these (...) variables influence the values of others through the regulatory proteins they express, including, of course, the possibility that the rate of expression of a gene at one time may, in various circumstances, influence the rate of expression of that same gene at a later time. If we imagine an arrow drawn from each gene expression variable at a given time to a gene variable whose expression it influences a short while after, the result is a network, technically a directed acyclic graph. For example, the DAG in Figure 1 is a representation of a system in which the expression level of gene G1 at time 1 ) causes the expression level of G2, which in turn causes the expression level of G3. The arrows in Figure 1 which do not have a variable at their tails are “error terms” which represent all of the causes of a variable other than the ones explicitly represented in the DAG. The DAG describes more than associations—it describes causal connections among gene expression rates. A shock to a cell—by mutation, heating, chemical treatment, etc. may alter the DAG describing the relations among gene expressions, for example by activating a gene that was otherwise not expressed, producing a cascade of new expression effects. Although “knockout” experiments can reveal some of the underlying causal network of gene expression levels, unless guided by information from other sources, such experiments are limited in how much of the network structure they can reveal, due to the sheer number of possible combinations of experimental manipulations of genes necessary to reveal the complete causal network. Recent developments have made it possible to compare quantitatively the expression of tens of thousands of genes in cells from different sources in a single experiment, and to trace gene expression over time in thousands of genes simultaneously. cDNA microarrays are already producing extensive data, much of it available on the web. Thus there are calls for analytic software that can be applied to microarray and other data to help infer regulatory networks. In this paper we will review current techniques that are available for searching for the causal relations between variables, describe algorithmic and data gathering obstacles to applying these techniques to gene expression levels, and describe the prospects for overcoming these obstacles. (shrink)