In this essay, written for the public presentation of Wilhelm von Humboldt, Scritti filosofici, edited by Giovanni Moretto and Fulvio Tessitore , the author underlines the controversial relationship between Humboldt’s historical-anthropological thought and Kantian criticism, which represents nevertheless a premise both essential and encumbering of Humbolt’s reflection.

Release of the ATP hydrolysis product ortophosphate (Pi) from the active site of myosin is central in chemo‐mechanical energy transduction and closely associated with the main force‐generating structural change, the power‐stroke. Despite intense investigations, the relative timing between Pi‐release and the power‐stroke remains poorly understood. This hampers in depth understanding of force production by myosin in health and disease and our understanding of myosin‐active drugs. Since the 1990s and up to today, models that incorporate the Pi‐release either distinctly before or (...) after the power‐stroke, in unbranched kinetic schemes, have dominated the literature. However, in recent years, alternative models have emerged to explain apparently contradictory findings. Here, we first compare and critically analyze three influential alternative models proposed previously. These are either characterized by a branched kinetic scheme or by partial uncoupling of Pi‐release and the power‐stroke. Finally, we suggest critical tests of the models aiming for a unified picture. (shrink)

In this paper I will compare the concept of explication à la Carnap and the concept of explication à la Kant. This essay should primarily be seen as a comparison of two different philosophical styles, but it is also intended as a vindication of what Kant wrote and what Carnap forgot to read.

A radical reform of the agri-food biotech regulation in the EU is considered in many quarters as a pressing necessity. Indeed, two important decisions on the legal status of the so-called New Breeding Techniques are expected shortly. In order to clarify some basic aspects of the complex scenario, after a brief introduction regarding the “GMO” fallacy, we offer our point of view on the following facets: A faulty approach is frequent in the discussion of the agri-food regulation; NBTs, genome editing (...) may lead to the disappearance of the “GMO” meme; Beyond health and safety issues: socio-economic considerations; Sustainability: the comprehensive, meaningful starting point of a positive reform; The theoretical and legal basis for the reform are already contained in the EU’s general guidelines to legislation. (shrink)

We present an algebraic account of the Tongan kinship terminology (TKT) that provides an insightful journey into the fabric of Tongan culture. We begin with the ethnographic account of a social event. The account provides us with the activities of that day and the centrality of kin relations in the event, but it does not inform us of the conceptual system that the participants bring with them. Rather, it is a slice in time of an ongoing dynamic process that links (...) behavior with a conceptual system of kin relations and vice versa. To understand this interplay, we need an account of the underlying conceptual system that is being activated during the event. Thus, we introduce a formal, algebraically based account of TKT. This account brings to the fore the underlying logic of TKT and allows us to distinguish between features of the kinship system that arise from the logic of TKT as a generative structure and features that must have arisen through cultural intervention. (shrink)

Digital technologies have become a crucial factor in nursing. Given the fact that many tasks could also be done by robots or AI systems, the place for the nurse in this scenario is unclear. In what way and to what extent will the implementation of ever more sophisticated technology affect nursing practice? It is the aim of this paper to analyse the potential challenges of nursing practice in the digital age. The analysis is conducted through the lens of new materialism, (...) a set of theoretical models that understand the relationship between humans and technology as dynamic and performative. According to this view, there is no prefixed essence of technology. Rather, the meaning of technology is enacted in concrete practice. The analysis shows that in past debates on technology use in nursing, the nurses’ role has been defined as guardians of humanity, defending the patient against the dehumanizing effects of technology. This role has been transferred to the digital age, where it is the duty of nurses to cushion the negative effects of digital technology. As an alternative to this outdated role, nurses should be included in processes of technology design and policymaking. Enabling nursing professionals to shape the circumstances of a digitally enhanced holistic practice may empower their status within the healthcare system and also benefit the patient by contributing to a more person‐centred care. (shrink)

Assuming a radical stance on embodied cognition, according to which the information ac- quired through basic cognitive processes is not contentful (Hutto and Myin, 2013), and as- suming that perception is a source of rationally grounded knowledge (Pritchard, 2012), a pluralistic account of perceptual knowledge is developed. The paper explains: (i) how the varieties of perceptual knowledge fall under the same broader category; (ii) how they are subject to the same kind of normative constraints; (iii) why there could not be (...) a conflict between the different varieties of perceptual knowledge; and (iv) why the traditional episte- mological inquiry is inclined to overestimate the role of propositional perceptual knowledge. (shrink)

The paper provides a conceptual distinction between evidence assessment criteria and standards of proof. Evidence must be assessed in order to check whether it satisfies a relevant standard of proof, and the assessment is operated with some criterion; so both criteria and standards are necessary for fact-finding. In addition to this conceptual point, the article addresses three main questions: Why do some scholars and decision-makers take assessment criteria as standards of proof and vice versa? Why do systems differ as to (...) criteria and standards? How can a system work if it neglects one of these things? The answers to the first and second question come from the historical and procedural differences between the systems. The answer to the third focuses on the functional connection between criteria and standards. (shrink)

In March 2019, the German Gemeinsamer Bundesausschuss (G‑BA; Federal Joint Committee) presented the result of the method assessment process on non-invasive prenatal testing (NIPT). The aim of this method assessment process was to decide whether NIPT should become a publicly funded procedure of routine prenatal care. The G‑BA decided in favor of NIPT, making the implementation of NIPT very likely, provided that other healthcare and political institutions also agree. This development could be interpreted as empowering from the perspective of reproductive (...) autonomy, since NIPT allows pregnant women to obtain valuable information on the health of the fetus in a fast and easy manner and without the risks of invasive methods. However, the routinization of NIPT also implies ethical challenges. Will the routinization lead to a normalization of prenatal quality control? Will it lead to an expansion to women outside the high-risk group? What would be the ethical implications of such a development? How should physicians, geneticists, and patients deal with the increased amount of obtainable information? What are the implications for choice and decision-making in the prenatal care context? In this paper, we analyze the ethical aspects of the routinization of NIPT, focusing on information and the counseling process, the burden of choice, and the threats to reproductive autonomy by societal interests linked to NIPT. (shrink)

Based on Pritchard's distinction between favoring and discriminating epistemic grounds, and on how those grounds bear on the elimination of skeptical possibilities, I present the dream argument as a moderate skeptical possibility that can be reasonably motivated. In order to block the dream argument skeptical conclusion, I present a version of phenomenological disjunctivism based on Noë's actionist account of perceptual consciousness. This suggests that perceptual knowledge is rationally grounded because it is a form of embodied achievement - what I call (...) embodied rationality -, which offers a way of dissolving the pseudo-problem of epistemic immodesty, namely, the seemingly counterintuitive thesis that one can acquire rationally grounded knowledge that one is not in a radical skeptical scenario. (shrink)

AgeTech involves the use of emerging technologies to support the health, well-being and independent living of older adults. In this paper we focus on how AgeTech based on artificial intelligence (AI) may better support older adults to remain in their own living environment for longer, provide social connectedness, support wellbeing and mental health, and enable social participation. In order to assess and better understand the positive as well as negative outcomes of AI-based AgeTech, a critical analysis of ethical design, digital (...) equity, and policy pathways is required. A crucial question is how AI-based AgeTech may drive practical, equitable, and inclusive multilevel solutions to support healthy, active ageing. In our paper, we aim to show that a focus on equity is key for AI-based AgeTech if it is to realize its full potential. We propose that equity should not just be an extra benefit or minimum requirement, but the explicit aim of designing AI-based health tech. This means that social determinants that affect the use of or access to these technologies have to be addressed. We will explore how complexity management as a crucial element of AI-based AgeTech may potentially create and exacerbate social inequities by marginalising or ignoring social determinants. We identify bias, standardization, and access as main ethical issues in this context and subsequently, make recommendations as to how inequities that stem form AI-based AgeTech can be addressed. (shrink)

As correctly noticed by Vincent Colapietro, one of the few authors who have approached the topic, pragmatism and psychoanalysis followed parallel paths. The most obvious comparison between James and Freud did not seem to cast new light neither on the understanding of psyche nor on the two movements of thought. However, a different and less obvious comparison between Peirce and Jung might be more fruitful, notwithstanding the progressive antipsychologism of Peirce’s approach to logic. As we are going to see, this (...) unusual comparison is due to the strong epistemic and philosophical import of Jung’s mature theories as well as to Peirce’s tendency to provide a general theory of the mind, both conscious and unconscious. Therefore, this paper will try to understand the attitude that Peirce had towards psychology (I), to recall the part of Jung’s theory that has to do with Peirce’s pragmatism (II), to assess the relationship between the two authors and the reciprocal advantage in mutually integrating their theories (III). (shrink)

The paper defends the theoretical strength and consistency of Rawls's constructivism, showing its ability to articulate and convincingly weave together several key ethical ideas; yet it questions the political relevance of this admirable normative architecture. After having illustrated Rawls's conception of moral agency and practical reason, the paper tackles two criticisms raised by Scheffler. First the allegation of naturalism based on Rawls's disdain of common sense ideas on desert is rebutted. It is then shown that, contrary to Scheffler's contention, Rawls (...) takes proper account of our moral sentiments in the process of constructing his normative theory. Finally, the second criticism is assessed, namely the inability of Rawls's theory to increase consent around liberal policies. Despite disagreement with details of Scheffler's argument, it is suggested that the failure of recent normative liberal theories to have a political impact belies their inability to take into proper consideration the reality of politics. A more realistic appraisal of political life and of historical events and developments are called for if political philosophy wants to be something more than an academic exercise. (shrink)

Reid’s rejection of the “theory of ideas” implies that sensations are not copies of external qualities such as extension and figure. Reid also says that not even the order of sensations is spatial. However, in his early manuscripts Reid did not deny that sensations are arranged spatially. He simply denied that our ideas of extension and figure are copied from any single atomic sensation. Only subsequently did Reid explicitly reject the view that sensations are arranged spatially. The question of the (...) spatiality of color sensation was a central concern of early interpreters of Reid, like Dugald Stewart, John Fearn, and William Hamilton. In particular, John Fearn thought that the denial of the spatiality of color sensations is the result of Reid’s commitment to the immateriality of the soul. Against Reid’s view, Fearn argued that the perception of visible figure necessarily implies the spatiality of color sensations. (shrink)

In normal observers, gazing at one’s own face in the mirror for a few minutes, at a low illumination level, triggers the perception of strange faces, a new visual illusion that has been named ‘strange-face in the mirror’. Individuals see huge distortions of their own faces, but they often see monstrous beings, archetypal faces, faces of relatives and deceased, and animals. In the experiment described here, strange-face illusions were perceived when two individuals, in a dimly lit room, gazed at each (...) other in the face. Inter-subjective gazing compared to mirror-gazing produced a higher number of different strange-faces. Inter-subjective strange-face illusions were always dissociative of the subject’s self and supported moderate feeling of their reality, indicating a temporary lost of self-agency. Unconscious synchronization of event-related responses to illusions was found between members in some pairs. Synchrony of illusions may indicate that unconscious response–coordination is caused by the illusion–conjunction of crossed dissociative strange-faces, which are perceived as projections into each other’s visual face of reciprocal embodied representations within the pair. Inter-subjective strange-face illusions may be explained by the subject’s embodied representations and the other’s visual face binding. Unconscious facial mimicry may promote inter-subjective illusion–conjunction, then unconscious joint-action and response–coordination. (shrink)

In order to illustrate the difference between sensation and perception, Reid imagines a blind man that by ‘some strange distemper’ has lost all his notions of external objects, but has retained the power of sensation and reasoning. Reid argues that since sensations do not resemble external objects, the blind man could not possibly infer from them any notion of primary qualities. Condillac proposed a similar thought experiment in the Treatise on Sensations. I argue that Condillac can reach a conclusion opposite (...) to that of Reid only by assuming that some particular collections of sensations do indeed resemble the qualities of external objects. Reid had considered a similar case in a manuscript, but he again notices that such complex collections sensations do not resemble the qualities of external objects. (shrink)

In his writings about hypergeometric functions Gauss succeeded in moving beyond the restricted domain of eighteenth-century functions by changing several basic notions of analysis. He rejected formal methodology and the traditional notions of functions, complex numbers, infinite numbers, integration, and the sum of a series. Indeed, he thought that analysis derived from a few, intuitively given notions by means of other well-defined concepts which were reducible to intuitive ones. Gauss considered functions to be relations between continuous variable quantities while he (...) regarded integration and summation as appropriate operations with limits. He also regarded infinite and infinitesimal numbers as a façon de parler and used inequalities in order to prove the existence of certain limits. He took complex numbers to have the same legitimacy as real quantities. However, Gauss’s continuum was linked to a revised form of the eighteenth-century notion of continuous quantity: it was not reducible to a set of numbers but was immediately given. (shrink)

In this note a T1 formal space is a formal space whose points are closed as subspaces. Any regular formal space is T1. We introduce the more general notion of a formal space, and prove that the class of points of a weakly set-presentable formal space is a set in the constructive set theory CZF. The same also holds in constructive type theory. We then formulate separation properties for constructive topological spaces , strengthening separation properties discussed elsewhere. Finally we relate (...) the properties for ct-spaces with corresponding properties of formal spaces. (shrink)

We consider the ways humans engage in social epistemic actions, to guide each other's attention, prediction, and learning processes towards salient information, at the timescale of online social interaction and joint action. This parallels the active guidance of other's attention, prediction, and learning processes at the longer timescale of niche construction and cultural practices, as discussed in the target article.

To be successful, the research agenda for a novel control view of cognition should foresee more detailed, computationally specified process models of cognitive operations including higher cognition. These models should cover all domains of cognition, including those cognitive abilities that can be characterized as online interactive loops and detached forms of cognition that depend on internally generated neuronal processing.

Beginning with the origins of Western philosophy, the profound creation of the Hellenic genius, Reale presents an appreciation of the Naturalists, the Sophists, Socrates, and the Minor Socratics.

1. Dalle origini a Socrate.--2. Platone e Aristotele.--3. I sistemi dell'età ellenistica.--4. Le scuole dell'età imperiale.--5. Lessico, indici e bibliografia.