Current models of insulin binding to the insulin receptor (IR) propose (i) that there are two binding sites on the surface of insulin which engage with two binding sites on the receptor and (ii) that ligand binding involves structural changes in both the ligand and the receptor. Many of the features of insulin binding to its receptor, namely B‐chain helix interactions with the leucine‐rich repeat domain and A‐chain residue interactions with peptide loops from another part of the receptor, are also (...) seen in models of relaxin and insulin‐like peptide 3 binding to their receptors. We show that these principles can likely be extended to the group of mimetic peptides described by Schäffer and coworkers, which are reported to have no sequence identity with insulin. This review summarizes our current understanding of ligand‐induced activation of the IR and highlights the key issues that remain to be addressed. (shrink)

Issues of identity and reduction have monopolized much of the philosopher of mind’s time over the past several decades. Interestingly, while investigations of these topics have proceeded at a steady rate, the motivations for doing so have shifted. When the early identity theorists, e.g. U. T. Place ( 1956 ), Herbert Feigl ( 1958 ), and J. J. C. Smart ( 1959 , 1961 ), fi rst gave voice to the idea that mental events might be identical to brain processes, (...) they had as their intended foil the view that minds are immaterial substances. But very few philosophers of mind today take this proposal seriously. Why, then, the continued interest in identity and reduction? Th e concern, as philosophers like Hilary Putnam and Jerry Fodor have expressed it, is that a victory for identity or reduction is a defeat for psychology. For if minds are physical, or if mental events are physical events, then psychologists might as well disassemble their laboratories, making room for the neuroscientists and molecular biologists who are in a better position to explain those phenomena once misdescribed as “psychological.” Th e worry nowadays is not that locating thought in immaterial souls will make psychology intractable, but that locating thoughts in material brains will make it otiose. (shrink)

Since Hilary Putnam offered multiple realization as an empirical hypothesis in the 1960s, philosophical consensus has turned against the idea that mental processes are identifiable with brain processes, and multiple realization has become the keystone of the 'antireductive consensus' across philosophy of science. Thomas W. Polger and Lawrence A. Shapiro offer the first book-length investigation of multiple realization, which serves as a starting point to a series of philosophically sophisticated and empirically informed arguments that cast doubt on the generality (...) of multiple realization in the cognitive sciences. They argue that mind-brain identities have played an important role in the growth and achievements of the cognitive sciences, and suggest that there is little prospect for multiple realization in an empirically-based theory of mind. This leads Polger and Shapiro to offer an alternative framework for understanding explanations in the cognitive sciences, as well as in chemistry, biology, and other non-basic sciences. (shrink)

Prior to the twentieth century, theories of knowledge were inherently perceptual. Since then, developments in logic, statis- tics, and programming languages have inspired amodal theories that rest on principles fundamentally different from those underlying perception. In addition, perceptual approaches have become widely viewed as untenable because they are assumed to implement record- ing systems, not conceptual systems. A perceptual theory of knowledge is developed here in the context of current cognitive science and neuroscience. During perceptual experience, association areas in the (...) brain capture bottom-up patterns of activation in sensory-motor areas. Later, in a top-down manner, association areas partially reactivate sensory-motor areas to implement perceptual symbols. The stor- age and reactivation of perceptual symbols operates at the level of perceptual components – not at the level of holistic perceptual expe- riences. Through the use of selective attention, schematic representations of perceptual components are extracted from experience and stored in memory (e.g., individual memories of green, purr, hot). As memories of the same component become organized around a com- mon frame, they implement a simulator that produces limitless simulations of the component (e.g., simulations of purr). Not only do such simulators develop for aspects of sensory experience, they also develop for aspects of proprioception (e.g., lift, run) and introspec- tion (e.g., compare, memory, happy, hungry). Once established, these simulators implement a basic conceptual system that represents types, supports categorization, and produces categorical inferences. These simulators further support productivity, propositions, and ab- stract concepts, thereby implementing a fully functional conceptual system. Productivity results from integrating simulators combinato- rially and recursively to produce complex simulations. Propositions result from binding simulators to perceived individuals to represent type-token relations. Abstract concepts are grounded in complex simulations of combined physical and introspective events. Thus, a per- ceptual theory of knowledge can implement a fully functional conceptual system while avoiding problems associated with amodal sym- bol systems. Implications for cognition, neuroscience, evolution, development, and artificial intelligence are explored. (shrink)

Title: Breaking the Barrier: The Rise of Solidarity in PolandPublisher: Oxford University PressISBN: 0195061225Author: Lawrence GoodwynTitle: The Roots of Solidarity: A Political Sociology of Poland's Working Class DemocratizationPublisher: Princeton University PressISBN: 0691078629Author: Roman LabaTitle: Solidarity and the Politics of Anti-Politics: Opposition and Reform in Poland since 1968Publisher: Temple University PressISBN: 0877229007Author: David Ost.

According to grounded cognition, words whose semantics contain sensory-motor features activate sensory-motor simulations, which, in turn, interact with spatial responses to produce grounded congruency effects. Growing evidence shows these congruency effects do not always occur, suggesting instead that the grounded features in a word's meaning do not become active automatically across contexts. Researchers sometimes use this as evidence that concepts are not grounded, further concluding that grounded information is peripheral to the amodal cores of concepts. We first review broad evidence (...) that words do not have conceptual cores, and that even the most salient features in a word's meaning are not activated automatically. Then, in three experiments, we provide further evidence that grounded congruency effects rely dynamically on context, with the central grounded features in a concept becoming active only when the current context makes them salient. Even when grounded features are central to a word's meaning, their activation depends on task conditions. (shrink)

Mental and physical causes do not competedthe presence of one does not exclude the efficacy of the other. This point is obvious from the perspective of an interventionist theory of causation, but only when this theory gets its proper due. Doubts about the interventionist justification for concluding that there is both physical and mental causation, we have argued, rest on misunderstandings of interventionism. When looking to interventions to reveal causal structures, care must be taken to consider the right variable sets. (...) Jaegwon Kim’s diagram is the wrong starting point for interventionist causal reasoning because it includes variables that are related by non-causal relations in addition to causal relations. When it comes to understanding exclusion, less is more. (shrink)

According to the multiple realization argument, mental states or processes can be realized in diverse and heterogeneous physical systems; and that fact implies that mental state or process kinds cannot be identified with particular kinds of physical states or processes. More specifically, mental processes cannot be identified with brain processes. Moreover, the argument provides a general model for the autonomy of the special sciences. The multiple realization argument is widely influential, but over the last thirty years it has also faced (...) serious objections. Despite those objections, most philosophers regard the fact of multiple realization and the cogency of the multiple realization argument as plainly correct. Why is that? What is it about the multiple realization argument that makes it so resilient? One reason is that the multiple realization argument is deeply intertwined with a view that minds are, in some sense, computational. But we argue that the sense in which minds are computational does not support the conclusion that they are ipso facto multiply realized. We argue that the sense in which brains compute does not imply that brains implement multiply realizable computational processes, and it does not provide a general model for the autonomy of the special sciences. (shrink)

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

In response to Casasanto, Brookshire, and Ivry, we address four points: First, we engaged in conceptual replications of Brookshire, Casasanto, and Ivry, not direct replications. Second, we did not question the validity of Brookshire et al.'s results, nor the similar findings of other researchers, but instead explained divergent findings within an integrated theoretical framework. Third, challenges to the construct of automaticity, including ours, were widespread, long before Brookshire et al.'s article. Fourth, the planned comparisons that we reported tested our theoretical (...) claims and offered strong evidence for them. (shrink)

A research professor of nuclear physics explores the mysterious essence of time in its two aspects---one of accurate measurement, the other of human sensation-- ...

Grounded cognition offers a natural approach for integrating Bayesian accounts of optimality with mechanistic accounts of cognition, the brain, the body, the physical environment, and the social environment. The constructs of simulator and situated conceptualization illustrate how Bayesian priors and likelihoods arise naturally in grounded mechanisms to predict and control situated action.

Psychiatric research is of critical importance in improving the care of persons with mental illness. Yet it may also raise difficult ethical issues. This article explores those issues in the context of a particular kind of research: psychosocial intervention research with control groups. We discuss 4 broad categories of ethical issues: consent, confidentiality, boundary violations, and risk-benefit issues. We believe that, despite the potential difficulties, psychosocial intervention research is vital and can be accomplished in an ethical manner. Further discussion and (...) research into these issues are warranted. (shrink)

Our response to representational art can be called "aesthetic" even if we are not "detached from cognitive and moral matters." for the pleasure we receive from "huckleberry finn" (dickie's example) is not based on its historical or sociological accuracy, Or on our agreement with its moral statements. We enjoy and value the novel because of its wit and irony, Which subvert and so transcend its cognitive and moral truths.

I agree with much of what is said in this article; and I also will quote Roland Barthes, but for a different purpose. But I believe that it is a mistake to judge contextualism by its theory rather than its practice. If we look carefully at what is actually done in contextualist criticism, we will find that the "contradictions in its basic premises" which trouble Wasiolek have also allowed it to overcome the limitations that a strict construction of "autonomy" would (...) impose. We will also find that what really distinguished contextualism, what the concept of autonomy leads to in practice, is not an impoverishment but a deepening and enrichment of the literary experience and, third, that the theoretical developments in other critical schools have vindicated at least one cardinal principle of contextualism, namely, that the meaning of a literary work is inherently ambivalent or indeterminate. By following the lead, we can, I believe, provide a better theoretical base for contextualism, although I am not sure that it would be or should be one that "includes the world rather than excludes it," as Wasiolek demands it. Lawrence W. Hyman professor of English at Brooklyn College of the City University of New York, is the author of a book on Milton's poetry,The Quarrel Within, and articles on critical theory. He responds in this essay to Edward Wasiolek's "Wanted: A New Contextualism". Hyman has also contributed "CRITICAL RESPONSE: Harpsichord Exercises and My Lai Massacre" to Critical Inquiry. (shrink)

During the Nazi era, most German physicians abrogated their responsibilities to individual patients, and instead chose to advocate the interests of an evil regime. In so doing, several fundamental bioethical principles were violated. Despite gross violations of individual rights, many physicians went on to have successful careers, and in many cases were honored. This paper will review the case of Hans Sewering, a participant in the Nazi euthanasia program who became the President-elect of the World Medical Association. The appropriate stance (...) for the medical and scientific community toward those who violate human rights and ignore fundamental ethical principles of the healing professions will be considered. (shrink)

That there is something not altogether honest about a didactic novel can be seen once we imagine a novel which violates our political sympathies or our moral principles, such as a novel that shows the Nazis or the American soldiers at My Lai as heroes. We certainly would not like this novel. But could we refute it because of our certain knowledge that these men, in real life, were murderers? I don't think so, since a skillful writer could easily make (...) his characters act heroically in the situation—and even make us dislike their victims. Could we say that the situation is false? Perhaps, but since the actions and the characters are fictional, what does it mean to refute them? We can say that a novel is bad or unconvincing if the characters do not resemble people in real life or if the actions do not satisfy our sense of logic or probability. But these are literary objections, not political ones. And because the writer cannot be refuted by evidence from the real world, he cannot make pronouncements about this world. For example, even if there were evidence that no slave resembled Tom and no overseer resembled Legree, such evidence could not refute the novel Uncle Tom's Cabin. And as Moody Prior points out in his essay , our disagreement with the philosophy of spiritual, rather than physical resistance to slavery cannot take away the heroism of Tom's action. His final act of forgiveness is indeed Christ-like, and no philosophy of political activism which is validated by, let us say, our admiration for Tom within the novel cannot validate Tom's kind of inward action in the real world. If it did, then our admiration for Tom, a fictional character, would prelude our support for a more active resistance to oppression. But, of course, it does not, or at least it should not, if we are to see fiction as performing a different role than politics and philosophy. Lawrence W. Hyman, professor of English at Brooklyn College of the City University of New York, is the author of The Quarrel Within: Art and Morality in Milton's Poetry. His previous contribution to Critical Inquiry, "The 'New Contextualism' Has Arrived: A Reply to Edward Wasiolek," appeared in the Winter 1975 issue. (shrink)

Wolfhart Pannenberg has related the concept of the physical field to the idea of God's divine cosmic field in all of creation. In this article I proffer a physicist's viewpoint by treating the subject from a more specific and focused perspective. In particular, I describe how electromagnetic interactions underlie the operation of all earthly nature, including human beings and their brains. I argue that this ubiquity constitutes a compelling physical analogy for the ubiquity of God's indwelling. The discussion includes the (...) role of electromagnetism in quantum theory, concepts of time, and the evolution of life. I suggest the value of such analogical thought as an area of study to be exploited in the development of a theology of nature as well as a significant datum in the pursuit of a tenable natural theology. This article is intended to clarify, refine, and considerably expand upon an earlier article published in Zygon . Included also are discussions on the role of electromagnetism in our sense of evil and eternity. (shrink)

How do attempts to foresee the future actually change it? For thousands of years, humans have called upon foresight to shape their own actions in order to adapt and survive; as Charles Darwin revealed in his theory of natural selection, the capacity to do just that is key to the origin of species. The uses of foresight, however, can also be applied to help us further our understanding across a variety of realms in everything from warfare, journalism and music, to (...) ancient civilizations, space weather and science. In a thought-provoking new addition to the Darwin College Lecture Series, eight distinguished authors each present an essay from their area of expertise devoted to the theme of 'foresight'. This provocative read reveals foresight as a process that can be identified across all areas of human endeavour, an art which can not only predict the future, but make it anything but inevitable. (shrink)

Following a survey of how universal the electromagnetic interaction (EMI) and light, its radiation, are in the living experience and spirituality of men and women, I make a case for the hypothesis that the EMI serves as a physical correlate for the immanence of God. This in turn will be used as partial support for the principal thesis of this article: given the vast spectrum of natural phenomena, from atoms to human brains, that operate via the EMI, we need seriously (...) to consider the EMI in formulating a viable natural theology. The encompassing properties of the EMI provide a unifying and cohesive influence heretofore neglected by the natural theology community. I intend here to stimulate more rigorous study of this approach. (shrink)

Codes of ethics exist in many, if not the majority, of all large U.S. companies today. But how the impact of these written codes affect managerial attitudes and behavior is still not clearly documented or explained. This study takes a step in that direction by proposing that attention should shift from the codes themselves as the sources of ethical behavior to the persons whose behavior is the focus of these codes. In particular, this study investigates the role of code familiarity (...) as a factor impacting the influence of an ethics code on manager behavior. Data collected from 286 executives from companies in the direct selling industry are used to test hypotheses (1) that the perceived usefulness of ethics codes is positively related to the degree of familiarity with the code, and (2) that ethical climate as assessed by managers is positively related to the code''s perceived usefulness. Both hypotheses are supported, and their implications and further research directions are discussed. (shrink)