I present a solution to the epistemological or characterisation problem of induction. In part I, Bayesian Confirmation Theory (BCT) is discussed as a good contender for such a solution but with a fundamental explanatory gap (along with other well discussed problems); useful assigned probabilities like priors require substantive degrees of belief about the world. I assert that one does not have such substantive information about the world. Consequently, an explanation is needed for how one can be licensed to act as (...) if one has substantive information about the world when one does not. I sketch the outlines of a solution in part I, showing how it differs from others, with full details to follow in subsequent parts. The solution is pragmatic in sentiment (though differs in specifics to arguments from, for example, William James); the conceptions we use to guide our actions are and should be at least partly determined by preferences. This is cashed out in a reformulation of decision theory motivated by a non-reductive formulation of hypotheses and logic. A distinction emerges between initial assumptions--that can be non-dogmatic--and effective assumptions that can simultaneously be substantive. An explanation is provided for the plausibility arguments used to explain assigned probabilities in BCT. -/- In subsequent parts, logic is constructed from principles independent of language and mind. In particular, propositions are defined to not have form. Probabilities are logical and uniquely determined by assumptions. The problems considered fatal to logical probabilities--Goodman's `grue' problem and the uniqueness of priors problem are dissolved due to the particular formulation of logic used. Other problems such as the zero-prior problem are also solved. -/- A universal theory of (non-linguistic) meaning is developed. Problems with counterfactual conditionals are solved by developing concepts of abstractions and corresponding pictures that make up hypotheses. Spaces of hypotheses and the version of Bayes' theorem that utilises them emerge from first principles. -/- Theoretical virtues for hypotheses emerge from the theory. Explanatory force is explicated. The significance of effective assumptions is partly determined by combinatoric factors relating to the structure of hypotheses. I conjecture that this is the origin of simplicity. (shrink)

Despite its theoretical importance, little is known about how semantic memory structure facilitates and constrains creative idea generation. We examine whether the semantic richness of a concept has both benefits and costs to creative idea generation. Specifically, we tested whether cue set size—an index of semantic richness reflecting the average number of elements associated with a given concept—impacts the quantity (fluency) and quality (originality) of responses generated during the Alternate Uses Task (AUT). Across four studies, we show that low-association, sparse, (...) AUT cues benefit originality at the cost of fluency compared to high-association, rich, AUT cues. Furthermore, we found an interaction with individual differences in fluid intelligence in the low-association AUT cues, suggesting that constraints of sparse semantic knowledge can be overcome with top-down intervention. Our findings indicate that semantic richness differentially impacts the quality and quantity of generated ideas, and that cognitive control processes can facilitate idea production when conceptual knowledge is limited. (shrink)

Le 13 novembre 2015, beaucoup d'acteurs politiques, médiatiques ou de témoins des attentats parisiens répétaient en boucle : " Nous sommes en guerre. " Cette expression ambigüe n'a pas permis de mieux comprendre ce qui s'était passé. Elle interroge d'autant plus si l'on considère que, durant les années 2000, l'on avait annoncé la fin de la guerre au profit de l'avènement d'" opérations de police " et d'" états de violence ". En s'attachant à restituer ce qui fut pensé sous (...) le nom de guerre à partir des écrits de Clausewitz, Mao, Schmitt et l'administration Bush, Catherine Hass nous montre que la guerre n'apparaît pas ou ne disparaît pas selon les périodes mais qu'elle change de mode selon la politique à l'oeuvre, redistribuant ses catégories - ami, ennemi, antagonisme, nation, révolution, terrorisme... Le pari de ce livre est que des pensées révolues de la guerre peuvent constituer une forme de recours pour réfléchir notre contemporain, à l'instar de la Syrie ou de Daech. Docteure en anthropologie politique, Catherine Hass est spécialisée dans l'étude du contemporain. Après avoir mené des enquêtes essentiellement sur les jeunes issus des quartiers populaires, ses recherches portent, depuis plus de dix ans, sur le nom de guerre et l'examen de quelques-unes de ses configurations politiques, actuelles comme révolues. (shrink)

Il concetto di atmosfera può essere inteso in due sensi diversi — da un lato come atmosfera terrestre, la cui composizione viene studiata con i metodi delle scienze naturali; dall’altro come fluido sentimentale-spaziale, capace di condizionare affettivamente gli uomini in determinate circostanze. L’atmosfera terrestre è oggetto delle scienze naturali, mentre le atmosfere affettive sono oggetto di una pluralità di discipline non-scientifiche eterogenee, sia dal punto di vista paradigmatico che...

Wenn ausgerechnet Pazifisten bei der Verfechtung ihrer Position aggressiv werden, so finden wir das besonders verstörend – jedenfalls verstörender als bei anderen Spannungen zwischen Theorie und Praxis. Woran liegt das? Meiner Ansicht nach kommen in diesem Fall drei Elemente zusammen, deren Mischung die pazifistische Position von innen bedroht: Während sich der hasserfüllte Pazifist schon beim Diskutieren schnell von negativen Emotionen fortreißen lässt, also alles andere als Willensstärke dokumentiert, verlangt er in seiner Theorie ein Höchstmaß an Willensstärke, und zwar gerade im (...) Umgang mit Emotionen. Dass er das nicht schafft, wirft nicht nur ein negatives Licht auf seine Person, sondern liefert Gründe gegen seine Theorie. Lektion: Der Pazifist ist gut beraten, vorbildlich mit seinen Emotionen umzugehen. (shrink)

The totality of extensional 1-ary connectives distinguishable in a logical framework allowing sequents with multiple or empty (alongside singleton) succedents form a lattice under a natural partial ordering relating one connective to another if all the inferential properties of the former are possessed by the latter. Here we give a complete description of that lattice; its Hasse diagram appears as Figure 1 in §2. Simple syntactic descriptions of the lattice elements are provided in §3; §§4 and 5 give some additional (...) remarks on matrix methods and on alternative terminology. Background: The size of this lattice was underestimated in [3]; some missing cases were noted in [4] in the course of correcting an example from [3] purporting to show the non-distributivity of the lattice. All the 'missing cases' (as well as those originally noted) are covered here. (The present discussion is self-contained.). (shrink)

In this study, we try to introduce the intellectual and literary personality of Temmâm Hassân and his place and importance in the modern Arabic literature, his works and translations, who was among the eminent personages of XX. century and an investigator, critic, translator and linguist. He was a prolific scholar, supplying a new countenance to the modern Arabic language in his nearly centennial life period.

In Working Virtue: Virtue Ethics and Contemporary Moral Problems, leading figures in the fields of virtue ethics and ethics come together to present the first ...

In my paper, I defend an interpretation according to which Aristotle thinks in Nicomachean Ethics (EN) that the rational aspect of soul is needed in discerning which ends of desire would be good. Many interpreters have traditionally supported this, ‘rationalist’ line of interpreting Aristotle’s theory of value cognition. The rationalist interpretation has, however, recently come under a novel challenge from Jessica Moss (2011, 2012), but has not yet received a defence. Moss attempts to resurrect now virtually abandoned ‘anti-rationalist’ interpretation, which (...) claims, in a contrast to the rationalist one, that discerning good ends may require no activity from the rational aspect, but only well-habituated non-rational desire. Moss’ interpretation appeals to certain Aristotle’s claims in De Anima (DA) 3, which, she thinks, show that non-rational phantasia suffices for discerning good ends if only accompanied with the habituated desire. Although her interpretation can successfully avoid some problems that earlier anti-rationalist interpretations faced with certain passages of EN, I also argue, however that it introduces some new problems, and attributes philosophically incoherent views about moral responsibility to Aristotle. Therefore I conclude that even after Moss’ improvements to the anti-rationalist interpretation, the rationalist interpretation remains overall more plausible. (shrink)

Mimesis as Make-Believe is important reading for everyone interested in the workings of representational art.

Baron d’Holbach was a critic of established religion, or a philosophe, in late 18 th -century France. His work is often perceived as less inventive than the work of other materialist philosophes, such as Helvétius and Diderot. However, I claim that d’Holbach makes an original, unjustly overlooked move in the criticism of religious moral teaching. According to the materialist philosophes, this teaching claims that true happiness is only possible in the afterlife. As an alternative, Helvétius and Diderot offer theories according (...) to which the experience of pleasure constitutes happiness, the end of all human desire. In contemporary terms, these theories would represent psychological hedonism. But, as Diderot himself admits, they have a problem in accounting for why people seem to naturally regard some pleasures as preferable to others. I argue that in response to this challenge, instead of accepting the psychological hedonism of his fellow materialists, d’Holbach shows how one can abstain from reducing happiness to pleasure and yet remain a materialist. (shrink)

Firm managers make ethical decisions regarding the form and quality of disclosure. Disclosure can have long-term implications for performance, earnings manipulation, and even fraud. We investigate the impact of venture capital (VC) backing on the quality and informativeness of disclosure controls and procedures for newly public companies. We find that these controls and procedures are stronger, as evidenced by fewer material weaknesses in internal control under Section 302 of the Sarbanes–Oxley Act, when companies are VC-backed. Moreover, these disclosures are informative (...) and are more likely to be followed by subsequent financial statement restatements than are disclosures made by non-VC-backed IPO companies. (shrink)

Autonomy was an important political concept in ancient Greece. Kant made it the ground of morality: only acting motivated by autonomous reason is moral. But he admits that reason does not have a power to motivate us: desires can always override it. Thus it seems that human reason is not autonomous. The principle of autonomy, however, is an intrinsic part of Kant’s “Copernican Revolution” and his rationalism about the grounding of morality. Questioning the former would lead to fideism or to (...) skepticism while rejecting the latter to reductionism. Neither course is less problematic for grounding morality than the principle of autonomy is. I suggest that Aristotle can help us to see how this dilemma can be avoided. Unlike Kant and many others, he does not seek to ground morality beyond our experience. The Aristotelian understanding of human beings as capable of evaluating one another’s actions with the language of purposefulness can explain which actions are moral without falling into the dilemma implied by the Kantian principle of autonomy. (shrink)

W niniejszym artykule analizuję koncepcję Arystotelesa dotyczącą wymagań epistemicznych koniecznych do identyfikacji czynów moralnie dobrych. W Etyce Nikomachejskiej, Arystoteles zdaje się twierdzić, że jesteśmy w stanie rozpoznawać takie czyny, nie mając wiedzy o tym, dlaczego są one dobre. Inne twierdzenia zawarte w tych dziele, nie pozwalają jednak na bezkrytyczne przyjęcie tej tezy. Zdaniem Johna McDowella, Arystoteles uważał, iż dobro etyczne czynu jest zależne od kontekstu. Gdyby tak było, by rozpoznać dany czyn jako dobry, musielibyśmy wiedzieć jakie cechy danej sytuacji czynią (...) go dobrym. Bronię tezy, że nawet jeśli dobro czynu byłoby zależne od kontekstu, Arystoteles nie uważałby znajomości tego kontekstu za jedyny sposób rozpoznania czynu jako dobry. By tego dowieść, sięgam do dorobku współczesnej filozofii. Realizm wewnętrzny Hilarego Putnama pozwala wyjaśnić w jaki sposób podmiot rozpoznaje egzemplarze należące do danego rodzaju naturalnego, bez znajomości definicji tego rodzaju naturalnego. David Charles pokazuje, że Arystoteles podziela podobny pogląd, choć nie uważa, że podmiot musi zakładać, iż istnieje definicja danego rodzaju. Twierdzę, że ten aspekt teorii Arystotelesa może być zastosowany także do identyfikacji czynów moralnie dobrych. Jednostka może rozpoznawać dobre czyny jako czyny konieczne do prowadzenia cnotliwego życia. Nie musi wiedzieć dlaczego określone czyny są dobre. Wystarczy, że ma wizję dobrego życia, którą – jak twierdzi Arystoteles – może rozwinąć poprzez naśladowanie tych, którzy mają „oko doświadczenia”. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

This article investigates the question why even the existence of “moral conscience” became regarded with serious doubts among radical eighteenth-century French philosophes La Mettrie, d’Holbach, Diderot, and Voltaire, from the vantage point of conceptual history. The philosophes’ stance of regarding moral conscience only as a name for certain acquired prejudices both fails to engage with the conception of moral conscience upheld by their theistic opponents and stands in a sharp contrast to the moral thought of Protestant reformation, which – less (...) than two centuries earlier – had elevated moral conscience to a position of an infallible moral authority. The article argues, however, that, in spite of the opposition between these two conceptions of conscience, they might be connected, and that the former might have even been a consequence of the latter. It will be shown that the pre-Reformation conception of moral conscience, crystallized in Aquinas, presents it being based on our natural attraction to “the human good”. However, as this conception was not created by medieval theologians, but was inherited from non-theistic ancient philosophy, in principle it would have been as compatible with the deistic and atheistic worldviews of the philosophes as the other ancient philosophical concepts, such as “the human good” and “human nature”, that the philosophes continued using in their original, teleological senses. Having presented a brief overview of the history of moral conscience, the article proceeds to show how the Protestant reformers removed the attraction to the human good from moral conscience while making its normative guidance infallible. The article will suggest that, due to the prevalence of this, exclusively theological, conception of moral conscience in the intellectual environment shaped by Protestantism, several British thinkers of the seventeenth century, including Hobbes, Locke, and Hume, who could not endorse the theological aspects of moral conscience, gradually reduced it into a mere acquired “sentiment”. As their philosophy was a major influence on the philosophes, the article concludes that the loss of a rational justification for moral conscience in the works of the British philosophers could have also been what motivated the philosophes to question moral conscience. (shrink)

Certain passages of Nicomachean Ethics seem to suggest a model of moral education that excludes those who have been misguided by their educators from being responsible for their character. I will argue, however, that this impression may result from misinterpreting the method of Aristotle’s moral educators. It is often thought, at least since Myles Burnyeat’s classic paper, ‘Aristotle on Learning to Be Good’1, that according to Aristotle, a moral educator should tell to moral students which actions are good so that (...) they could begin to practice performing them. I will show that this interpretation is both exegetically problematic, and the likely cause of the above, uncharitable impression. I will argue that it would be more justifiable to interpret Aristotle to be maintaining that the moral students should discover good actions themselves, though trial and error, and that the moral educator might only be needed to keep them away from acting too badly, as Howard Curzer has proposed2. Since in order to discover good actions on his own, a moral student needs to exercise moral discernment, he could be held responsible of the character that he will develop even if his moral educators were misguided him. I will suggest that Aristotle might think that what enables even morally misled people to become morally discerning learners is synesis–ability to identify good actions on the basis of other people’s opinions. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

This article argues that contrary to a received interpretation, Emanuel Swedenborg’s doctrine of correspondences, according to which each empirical reality has a corresponding spiritual reality, is closer to Spinozistic monism than Neoplatonic idealism. According to the former, there is only one substance: God, which we can cognize through its spir­itual and material aspects. According to the latter, the material world consists of substances that receive their form through participation in the ideas of the spiri­tual world. The article will show that (...) although some of Swedenborg’s claims can appear as expressing Neoplatonic idealism, his reading of the Bible as a guide for moral improvement, his rejection of the religious mysteries that cannot be rationally understood, his various examples of correspondences, his view that we can cognize God by studying the correspondences, and his definition of God as the only substance, make evident that he does not consider the spiritual realities ideas in the Neoplatonic sense. The article will interpret Swedenborg to think that the spiritual realities are learned concepts that enable us to describe and experience the world as having spiritual significance and thus acquire a fuller cognition of God. (shrink)

This paper examines a looming reproducibility crisis in the core of the hard sciences. Namely, it concentrates on molecular modeling and simulation (MMS), a family of methods that predict properties of substances through computing interactions on a molecular level and that is widely popular in physics, chemistry, materials science, and engineering. The paper argues that in order to make quantitative predictions, sophisticated models are needed which have to be evaluated with complex simulation procedures that amalgamate theoretical, technological, and social factors (...) – leading to problems with reproducibility. Thus, for methodological reasons, the predictive success causes a reproducibility problem. (shrink)

We claim that adjustable parameters play a crucial role in building and applying simulation models. We analyze that role and illustrate our findings using examples from equations of state in thermodynamics. In building simulation models, two types of experiments, namely, simulation and classical experiments, interact in a feedback loop, in which model parameters are adjusted. A critical discussion of how adjustable parameters function shows that they are boon and bane of simulation. They help to enlarge the scope of simulation far (...) beyond what can be determined by theoretical knowledge, but at the same time undercut the epistemic value of simulation models. (shrink)

This book examines the importance of the Enlightenment for understanding the secular outlook of contemporary Western societies. It shows the new ways of thinking about religion that emerged during the 17th and 18th centuries and have had a great impact on how we address problems related to religion in the public sphere today. Based on the assumption that political concepts are rooted in historical realities, this collection combines the perspective of political philosophy with the perspective of the history of ideas. (...) Does secularism imply that individuals are not free to manifest their beliefs in public? Is secularization the same as rejecting faith in the absolute? Can there be a universal rational core in every religion? Does freedom of expression always go hand in hand with freedom of conscience? Is secularism an invention of the predominantly Christian West, which cannot be applied in other contexts, specifically that of Muslim cultures? Answers to these and related questions are sought not only in current theories and debates in political philosophy, but also in the writings of Immanuel Kant, Benedict Spinoza, Thomas Hobbes, Anthony Collins, Adriaan Koerbagh, Abbé Claude Yvon, Giovanni Paolo Marana, and others. (shrink)

This book examines the importance of the Enlightenment for understanding the secular outlook of contemporary Western societies. It shows the new ways of thinking about religion that emerged during the 17th and 18th centuries and have had a great impact on how we address problems related to religion in the public sphere today. Based on the assumption that political concepts are rooted in historical realities, this collection combines the perspective of political philosophy with the perspective of the history of ideas. (...) Does secularism imply that individuals are not free to manifest their beliefs in public? Is secularization the same as rejecting faith in the absolute? Can there be a universal rational core in every religion? Does freedom of expression always go hand in hand with freedom of conscience? Is secularism an invention of the predominantly Christian West, which cannot be applied in other contexts, specifically that of Muslim cultures? Answers to these and related questions are sought not only in current theories and debates in political philosophy, but also in the writings of Immanuel Kant, Benedict Spinoza, Thomas Hobbes, Anthony Collins, Adriaan Koerbagh, Abbé Claude Yvon, Giovanni Paolo Marana, and others. -/- . (shrink)

Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

The English language has adopted the word Tardis for something that looks simple from the outside but is much more complicated when inspected from the inside. The word comes from a BBC science fiction series, in which the Tardis is a machine for traveling in time and space, that looks like a phone booth from the outside. This paper claims that simulation models are a Tardis in a way that calls into question their transferability. The argument is developed taking Molecular (...) Modeling and Simulation as an example. There, simulation models are force fields that describe the molecular interactions and that look like simple and highly modular mathematical expressions. To make them work, they contain parameters that are adjusted to match certain data. The role of these parameters and the way they are obtained is seriously under-appreciated. It is constitutive for the model and central for its applicability and performance. Hence, the model is more than it seems so that working with adjustable parameters deeply affects the ontology of simulation models. This is particularly crucial for the transferability of the models: the information on how a model was trained is like luggage the model must carry on its voyage. (shrink)

The work of French philosopher Maurice Merleau-Ponty touches on some of the most essential and vital concerns of the world today, yet his ideas are difficult and not widely understood. Lawrence Hass redresses this problem by offering an exceptionally clear, carefully argued, critical appreciation of Merleau-Ponty's philosophy. Hass provides insight into the philosophical methods and major concepts that characterize Merleau-Ponty's thought. Questions concerning the nature of phenomenology, perceptual experience, embodiment, intersubjectivity, expression, and philosophy of language are fully and (...) systematically discussed with reference to main currents and discussions in contemporary philosophy. The result is a refreshingly jargon-free invitation into Merleau-Ponty's important and transformational way of understanding human experience. (shrink)

It was proposed that the data from Monte Carlo statistical investigations be subjected to analysis of variance methods rather than the conventional techniques of tabling, graphing, and inspecting the data. Two examples in which analysis of variance methods were applied to published Monte Carlo studies were presented. It was suggested that balanced factorial designs should be used whenever possible in Monte Carlo studies so that analysis of variance methods would be directly applicable. Finally, three advantages of analysis of variance methods (...) over conventional techniques were described and analysis of variance methods were contrasted with a possible alternative analytical method, multiple regression analysis. (shrink)

A key objective of the law in the assessment of decision-making capacity in clinical settings is to allow clinicians and judges to avoid making value judgements about the reasons that patients use to refuse treatment. This paper advances two lines of argument in respect of this objective. The first is that authorities cannot rationally avoid significant evaluative judgements in the assessment of a patient’s own assessment of the facts of their case. Assessing reasoning is unavoidably value-laden. Yet the underlying motivation (...) behind clinicians’ and the law’s value-neutral aims, ie, the avoidance of undue paternalism, is worth preserving. That being so, the second line of argument will try to show that that underlying motivation is better served in a limited range of cases by embedding a ‘reversibility standard’ in the assessment process so that the patient can, if they wish, and in due course, bring about the consequences that they were prevented from realising as a result of a determination of incapacity. (shrink)