ZusammenfassungDie Zulässigkeit später Schwangerschaftsabbrüche nach Pränataldiagnostik wirft die Frage auf, ob die deutsche Rechtspraxis nicht widersprüchlich ist, die einerseits Ärzte dazu verpflichtet, zu früh und behindert geborene Kind zu behandeln, andererseits bei einer vorgeburtlich diagnostizierten Behinderung des Kindes aber den Abbruch einer Schwangerschaft bis zur Geburt zulässt. Der Beitrag geht der Frage nach, ob die Unterschiede, die im gesetzlichen Schutz des Lebens einerseits von ungeborenen und neugeborenen Kindern und anderseits von behinderten und nichtbehinderten Föten gemacht werden, aus ethischer Sicht verteidigt (...) werden können. Hierzu werden zunächst weltanschaulich liberale, konservative und vermittelnde Positionen in der Bioethik zum moralischen Status menschlicher Wesen diskutiert. Abschließend wird ein eigener Vorschlag vorgestellt, der von weiten Sorgepflichten der Schwangeren gegenüber ihrem ungeborenen Kind ausgeht und die außergewöhnliche Beziehung zwischen Frau und Kind in der Schwangerschaft berücksichtigt. Diese Argumentation zeigt, dass eine liberale Regelung des Schwangerschaftsabbruchs mit einer allgemeinen medizinischen Behandlungspflicht zu früh oder behindert geborener Kinder aus ethischer Sicht vereinbar ist. (shrink)

Die empirische Ethik sieht ihre eigene Aufgabe darin, soziale und kulturelle Aspekte der Medizin zu berücksichtigen. Damit trennt sie den wissenschaftlich kognitiven Aspekt der Medizin von kulturell normativen Aspekten, die einzig sozialwissenschaftlich zu erforschen wären. Wenn Medizin aber als gesellschaftliche Praxis begriffen wird, wird die saubere Trennung zwischen naturwissenschaftlicher Medizin, kulturell-normativen Aspekten und ethischer Reflexion durchbrochen. Wir schlagen vor, ethische Reflexion und empirische sozialwissenschaftliche Forschung in mehrstufiger Weise aufeinander zu beziehen. Den Sozialwissenschaften kommt dabei die Funktion einer ersten Reflexionsinstanz der (...) medizinischen Praxis zu, an die in einem zweiten Schritt die Medizinethik reflexiv anschließt und sich dabei wieder einer soziologischen Kritik stellen muss. (shrink)

ZusammenfassungDie empirische Ethik sieht ihre eigene Aufgabe darin, soziale und kulturelle Aspekte der Medizin zu berücksichtigen. Damit trennt sie den wissenschaftlich kognitiven Aspekt der Medizin von kulturell normativen Aspekten, die einzig sozialwissenschaftlich zu erforschen wären. Wenn Medizin aber als gesellschaftliche Praxis begriffen wird, wird die saubere Trennung zwischen naturwissenschaftlicher Medizin, kulturell-normativen Aspekten und ethischer Reflexion durchbrochen. Wir schlagen vor, ethische Reflexion und empirische sozialwissenschaftliche Forschung in mehrstufiger Weise aufeinander zu beziehen. Den Sozialwissenschaften kommt dabei die Funktion einer ersten Reflexionsinstanz der (...) medizinischen Praxis zu, an die in einem zweiten Schritt die Medizinethik reflexiv anschließt und sich dabei wieder einer soziologischen Kritik stellen muss. (shrink)

Zwischen Medizinethik und Behindertenbewegung besteht Uneinigkeit darüber, ob von einer Diskriminierung von behinderten Menschen durch biomedizinische Verfahren, wie der Pränatal- und der Präimplantationsdiagnostik, gesprochen werden kann. Dieser Konflikt beruht u. a. darauf, dass sich gesellschaftspolitische und ethische Argumente oft auf unterschiedlichen Ebenen bewegen. Während in der Ethik danach gefragt wird, ob durch die genannten Verfahren unmittelbar individuelle Rechte von Menschen mit Behinderungen verletzt werden, scheint es der Behindertenbewegung um die Verletzung des kollektiven Anspruches auf kulturelle Anerkennung zu gehen. Mit der (...) Unterscheidung verschiedener Anerkennungsverhältnisse in zwischenmenschlichen Beziehungen beabsichtigt der Beitrag, einen Rahmen für das Verständnis der Anliegen der Behindertenbewegung bereitzustellen. Daran anschließend wird eine Ethikkonzeption skizziert, die geeignet ist, die Argumente der Behindertenbewegung für eine konstruktive ethische Diskussion fruchtbar zu machen. (shrink)

ZusammenfassungDie Zulässigkeit später Schwangerschaftsabbrüche nach Pränataldiagnostik wirft die Frage auf, ob die deutsche Rechtspraxis nicht widersprüchlich ist, die einerseits Ärzte dazu verpflichtet, zu früh und behindert geborene Kind zu behandeln, andererseits bei einer vorgeburtlich diagnostizierten Behinderung des Kindes aber den Abbruch einer Schwangerschaft bis zur Geburt zulässt. Der Beitrag geht der Frage nach, ob die Unterschiede, die im gesetzlichen Schutz des Lebens einerseits von ungeborenen und neugeborenen Kindern und anderseits von behinderten und nichtbehinderten Föten gemacht werden, aus ethischer Sicht verteidigt (...) werden können. Hierzu werden zunächst weltanschaulich liberale, konservative und vermittelnde Positionen in der Bioethik zum moralischen Status menschlicher Wesen diskutiert. Abschließend wird ein eigener Vorschlag vorgestellt, der von weiten Sorgepflichten der Schwangeren gegenüber ihrem ungeborenen Kind ausgeht und die außergewöhnliche Beziehung zwischen Frau und Kind in der Schwangerschaft berücksichtigt. Diese Argumentation zeigt, dass eine liberale Regelung des Schwangerschaftsabbruchs mit einer allgemeinen medizinischen Behandlungspflicht zu früh oder behindert geborener Kinder aus ethischer Sicht vereinbar ist. (shrink)

Assembled here for the first time in English translation, Sigrid Weigel and Georgina Paul offer illuminating new insights into Benjamin's theory, combining impulses from post-structuralism, feminism, cultural anthropology and psychoanalysis.

Divergent evolution can explain how many proteins containing structurally similar domains, which perform a variety of related functions, have evolved from a relatively small number of modules or protein domains. However, it cannot explain how protein domains with similar, but distinguishable, functions and similar, but distinguishable, structures have evolved. Examples of this are the RNA‐binding proteins containing the RNA‐binding domain (RBD), and a newly established protein group, the cold‐shock domain (CSD) protein family. Both protein domains contain conserved RNP motifs on (...) similar single‐stranded nucleic acid‐binding surfaces. Apart from the RNP motifs, which have a similar function, the two families show little similarity in topology or amino acid sequence. This can be considered an interesting example of convergent evolution at the molecular level. Previously, a β‐sheet surface was found to interact with RNA in non‐homologous proteins from yeast, phage and man, revealing that this mode of RNA binding may be a widely recurring theme. (shrink)

Wie müssen wir zurückschauen, um Was sehen zu können und darüber unseren Blick für das Gegenwärtige und Kommende zu schärfen?0Die Beiträge des Bandes, der zu Ehren von Sigrid Schade erscheint, beziehen sich auf vielschichtige Diskursgeschichten an den Schnittstellen von Kunst-, Kultur- und Medienwissenschaften. Sie beleuchten künstlerische, kulturelle und soziale Praktiken und Ordnungen als Aushandlungsort komplexer Bedeutungs- und Beziehungsgefüge.

This article investigates a multiparty interaction in an accounting office by applying a multimodal approach to discourse. This approach allows the incorporation of all relevant communicative modes and is based on the following three notions: 1) the notion of mediated action; 2) the notion of modal density; and 3) the notion of a foreground– background continuum of attention/awareness. The article illustrates that a social actor in a multiparty interaction simultaneously co-constructs several higher-level actions with the various participants on different levels (...) of their attention/awareness. On a theoretical level, the article argues that traditional approaches to discourse analysis, with their unconditional focus on language as the primary mode, misconstrue the multiple higher-level actions that a social actor is engaged in simultaneously as dyadic or triadic interactions in quick succession. (shrink)

A semantics for interrogatives is presented which is based on Karttunen's theory, but in a flexible manner incorporates both weak and strong exhaustivity. The paper starts out by considering degree questions, which often require an answer picking out the maximal degree from a certain set. However, in some cases, depending on the semantic properties of the question predicate, reference to the minimal degree is required, or neither specifying the maximum nor the minimum is sufficient. What is needed is an operation (...) which defines the maximally informative answer on the basis of the Karttunen question denotation. Shifting attention to non-degree questions, two notions of answerhood are adopted from work by Heim. The first of these is weakly exhaustive and the second strongly exhaustive. The second notion of answerhood is proven to be equivalent to Groenendijk and Stokhof's interrogative semantics. On the basis of a wide range of empirical data showing that questions often are not interpreted exhaustively, it is argued that a fairly rich system of semantic objects associated with questions is needed to account for the various ways in which questions contribute to the semantics and pragmatics of the utterances in which they appear. (shrink)

An ‘Information Centre’ has recently been established by law which has the power to collect, collate and provide access to the medical information forall patients treated by the National Health Service in England, whether in hospitals or by General Practitioners. This so-called ‘care.data’ scheme has given rise to major and ongoing controversies. We will sketch the background of the scheme and look at the responses it has elicited from citizens and medical professionals. In Autumn 2013, NHS England set up a (...) care.data website where citizens could record their concerns regarding the collection of health-related data by the Information Centre. We have reviewed all the comments on this website up until June 2015. We have also analysed the readers’ comments on the coverage of the care.data scheme in one of the main national UK newspapers. When discussing the responses of citizens, we will make a distinction between the problems that citizens detect and the solutions they propose. The solutions that are being perceived as the most relevant ones can be summarized as follows: citizens wish to further the common good without being manipulated into doing it, while at the same time being safeguarded against various abuses. The issue of trust turns out to figure prominently. Our analysis of reactions to the scheme in no way pretends to be exhaustive, yet it provides various relevant insights into the concerns identified by citizens as well as medical professionals. These concerns, moreover, have a more general relevance in relation to other contexts of medical data-mining as well as biobank research. Our analysis also offers important pointers as to how those concerns might be addressed. (shrink)

The paper provides a semantic analysis of intervention effects in wh-questions. The interpretation component of the grammar derives uninterpretability, hence ungrammaticality, of the intervention data. In the system of compositional interpretation that I suggest, wh-phrases play the same role as focused phrases, introducing alternatives into the computation. Unlike focus, wh-phrases make no ordinary semantic contribution. An intervention effect occurs whenever a focus-sensitive operator other than the question operator tries to evaluate a constituent containing a wh-phrase. It is argued that this (...) approach can capture the universal as well as the crosslinguistically variable aspects of intervention effects, in a way that is superior to previous approaches. Further consequences concern other focus-related constructions: multiple focus data, NPI licensing, and alternative questions. (shrink)

More than a third of the world's population has no access to essential drugs. More than half of this group of people live in the poorest regions of Africa and Asia. Several factors determine the accessibility of drugs in developing countries. Hardly any medicines for tropical diseases are being developed, but even existing drugs are often not available to the patients who need them.One of the important determinants of access to drugs is the working of the patent system. This paper (...) first maps out some facts about the global patent regime that has emerged as a consequence of the conclusion of the WTO‐TRIPs Agreement in 1994. Attempts to construct a moral justification of the patent system have been based on three grounds: natural rights, distributive justice, and utilitarian arguments. This paper examines to what extent and on which grounds drug patents can be justified. The final section looks at the so‐called ‘Doha Declaration on the TRIPs Agreement and Public Health’, which was adopted by the WTO Ministerial Conference two years ago, recognising the primacy of public health over the interests of patent proprietors. (shrink)

Management of the renewable natural resources in Madagascar is gradually being transferred to the local communities, particularly that of forest resources. However, these local communities are struggling to assess the consequences of management plans that they themselves must develop and implement on ecologically, economically and socially sustainable grounds. In order to highlight key aspects of different management options beforehand, we have developed MIRANA, a computer model to simulate various scenarios of management plan implementation. MIRANA differs from other simulation models by (...) not only taking into account individual practices and economic exchanges, but also by accounting for the applicable regulations. These regulations are taken into consideration by means of a multiplicity of normative structures within a spatial context. The objective of this paper is to describe the representations of institutions, norms and territories proposed by MIRANA and to discuss these representations in relation to the state of the art in the field of normative multi-agent systems. (shrink)

Research regarding the drivers of acceptance of clinical decision support systems by physicians is still rather limited. The literature that does exist, however, tends to focus on problems regarding the user-friendliness of CDSS. We have performed a thematic analysis of 24 interviews with physicians concerning specific clinical case vignettes, in order to explore their underlying opinions and attitudes regarding the introduction of CDSS in clinical practice, to allow a more in-depth analysis of factors underlying acceptance of CDSS. We identified three (...) general themes from the results. First, ‘the perceived role of the AI’, including items referring to the tasks that may properly be assigned to the CDSS according to the respondents. Second, ‘the perceived role of the physician’, referring to the aspects of clinical practice that were seen as being fundamentally ‘human’ or non-automatable. Third, ‘concerns regarding AI’, including items referring to more general issues that were raised by the respondents regarding the introduction of CDSS in general and/or in clinical medicine in particular. Apart from the overall concerns expressed by the respondents regarding user-friendliness, we will explain how our results indicate that our respondents were primarily occupied by distinguishing between parts of their job that should be automated and aspects that should be kept in human hands. We refer to this distinction as ‘the division of clinical labor.’ This division is not based on knowledge regarding AI or medicine, but rather on which parts of a physician’s job were seen by the respondents as being central to who they are as physicians and as human beings. Often the respondents’ view that certain core parts of their job ought to be shielded from automation was closely linked to claims concerning the uniqueness of medicine as a domain. Finally, although almost all respondents claimed that they highly value their final responsibility, a closer investigation of this concept suggests that their view of ‘final responsibility’ was not that demanding after all. (shrink)

(1) a. Satoshi sent Thilo the Schw¨abische W¨orterbuch. b. Satoshi sent the Schw¨abische W¨orterbuch to Thilo. Many have entertained the notion that there is a rule that relates sentences such as these. This is suggested by the fact that it is possible to learn that a newly coined verb licenses one of them and automatically know that it licenses the other. Marantz (1984) argues for the existence of such a rule in this way, noting that once one has learned of (...) the new verb shin by exposure to (2a), the grammaticality of (2b) is also learned. (2) a. Thilo shinned the ball to Satoshi. b. Thilo shinned Satoshi the ball. This is explained if there is a rule that ties the double object frame together with the NP+PP frame, making it sufficient to know that a verb licenses one if it licenses the other. Frequently, the rule involved has been taken to be syntactic in nature. See, among many others, Fillmore (1965), Oehrle (1976), Baker (1988), and Larson (1988). The leading idea under this view is that the two frames are simply different surface manifestations of the same underlying structure. Typically, this approach posits that the NP+PP frame represents that underlying structure from which the double object frame is transformationally derived. There is evidence, however, that the two frames instead have different underlying structures, and are not related by transformation. This evidence, then. (shrink)

The role of physicians in armed conflict -- International humanitarian law -- International criminal law -- Customary status of international humanitarian law -- The relevant human rights norms applicable to the work of physicians in armed conflict -- The interpretation of the reference to medical ethics and generally accepted medical standards pursuant to the Vienna Convention on the Law of Treaties -- Medical ethics in international law -- A pluralistic approach to medical ethics -- The documents by the World Medical (...) Association (WMA) -- Conclusion, recommendations and outlook. (shrink)

The last decade has seen a new wave of interest in philosophical and theoretical circles in the writings of Walter Benjamin. In _Body-and Image-Space_ Sigrid Weigel, one of Germany's leading feminist theorists and a renowned commentator on the work of Walter Benjamin, argues that the reception of his work has so far overlooked a crucial aspect of his thought - his use of images. Weigel shows that it is precisely his practice of thinking in images that holds the key (...) to understanding the full complexity, richness and topicality of Benjamin's theory. (shrink)

This paper proposes that elementary reciprocal sentences have four semantic readings: a strongly reciprocal interpretation, a weakly reciprocal interpretation, a situation-based weakly reciprocal reading, and a collective reading. Interpretational possibilities of reciprocal sentences that have been discussed in the literature are identified as one of these four. A compositional semantic analysis of all of these readings is provided in which the reciprocal expression is uniformly represented as 'the other ones among them' (recasting Heim, Lasnik and May 1991a, b). A reciprocal (...) sentence is thus a special kind of relational plural. Interpretational variability comes about by the same mechanisms of plural predication at work in relational plurals: pluralization operators, LF operations like QR, and addition of contextual information. (shrink)

In this paper I argue for a restriction on certain types of LF movement, which I call ‘wh-related LF movement’. Evidence comes from a number of wh-in-situ constructions in German, such as the scope-marking construction and multiple questions. For semantic reasons, the in situ element in those constructions has to move at LF to either a position reserved for wh-phrases, or even higher up in the structure. The restriction (the Minimal Quantified Structure Constraint, MQSC) is that an intervening quantified expression (...) blocks this movement. In the case of every, the MQSC leads to an unambiguously distributive interpretation of the question. In the case of all other intervening operators, including negation, it leads to ungrammaticality. (shrink)

We expand on Della Croce’s ambition to interpret “epistemic injustice” as a specification of non-maleficence in the use of the influential four-principle framework. This is an alluring line of thought for conceptual, moral, and heuristic reasons. Although it is commendable, Della Croce’s attempt remains tentative. So does our critique of it. Yet, we take on the challenge to critically address two interrelated points. First, we broaden the analysis to include deliberations about hermeneutical injustice. We argue that, if due consideration of (...) epistemic injustice is to require more than negative ethical obligations in medicine, dimensions of hermeneutical injustice should be explored as an avenue to arrive at such positive duties. Second, and relatedly, we argue that this may encompass moral responsibilities beyond the individual level, that is: positive obligations to take action on a structural level. Building on Dotson’s concept of “contributory injustice” and Scheman’s concept of “perceptual autonomy,” we suggest that the virtues of testimonial and hermeneutical justice may provide additional content not only to negative prohibitions of action (i.e. non-maleficence) but also to positive requirements of action, like respecting patient autonomy. (shrink)

Since the adoption of the WTO-TRIPS Agreement in 1994, there has been significant controversy over the impact of pharmaceutical patent protection on the access to medicines in the developing world. In addition to the market exclusivity provided by patents, the pharmaceutical industry has also sought to further extend their monopolies by advocating the need for additional ‘regulatory’ protection for new medicines, known as data exclusivity. Data exclusivity limits the use of clinical trial data that need to be submitted to the (...) regulatory authorities before a new drug can enter the market. For a specified period, generic competitors cannot apply for regulatory approval for equivalent drugs relying on the originator's data. As a consequence, data exclusivity lengthens the monopoly for the original drug, impairing the availability of generic drugs. This article illustrates how the pharmaceutical industry has convinced the US and the EU to impose data exclusivity on their trade partners, many of them developing countries. The key arguments formulated by the pharmaceutical industry in favor of adopting data exclusivity and their underlying ethical assumptions are described in this article, analyzed, and found to be unconvincing. Contrary to industry's arguments, it is unlikely that data exclusivity will promote innovation, especially in developing countries. Moreover, the industry's appeal to a property rights claim over clinical test data and the idea that data exclusivity can prevent the generic competitors from ‘free-riding’ encounters some important problems: Neither legitimize excluding all others. (shrink)

This paper investigates the semantics of adverbials like ‘page by page’ and ‘stone upon stone’. An analysis is developed in which sentences containing such adverbials have a pluractional semantics; that is, pluralization affects simultaneously the event- and the individual-argument slot of a predicate. Sternefeld's system of plural operators is used and extended for this purpose. The adverbial constrains the relation that is pluralized and makes visible a higher plural operator. In the case of ‘page by page’-type adverbials, this is a (...) fairly standard operator that leads to a simple divisional interpretation. In the case of ‘stone upon stone’-type adverbials, the operator has a stronger semantics that leads to a sequence interpretation. The generality of our theory permits straightforward extension to data like ‘she ran and ran’ and ‘she climbed higher and higher’, among others. Finally we propose that inclusive alternative ordering reciprocals have a pluractional sequence interpretation as well. (shrink)

Actin performs structural as well as motor‐like functions in eukaryotic cells. Orthologues of actin have also been identified in bacteria, where they perform an essential function during cell growth. Bacterial actins are implicated in the maintenance of rod‐shaped cell morphology, and appear to form a cytoskeletal structure, localising as helical filaments underneath the cell membrane. Recently, a plasmid‐borne actin orthologue has been shown to perform a mitotic‐like function during segregation of a plasmid, and chromosomally encoded actin proteins were found to (...) play an important role in chromosome segregation. Based on the findings that actin filaments are dynamic structures in two bacterial species, we propose that actins perform motor functions rather than a purely structural role in bacteria. We suggest that an intracellular motor exists in bacteria that could be derived from an ancestral actin motor that was present in cells early in evolution. BioEssays 26:1209–1216, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

An extensive body of research documents that women experience a motherhood penalty at work whereas men experience a fatherhood premium. Yet much of this work presupposes that employers are aware of a worker’s parental status. Given the different consequences that parenthood has on outcomes such as pay and promotions, it is conceivable that men and women may deploy their status as parents differently when interacting with employers. Drawing on in-depth interviews with a racially diverse sample, this article examines how mothers (...) and fathers working in the service sector use their parental status when negotiating work and child care responsibilities. Mothers, particularly black mothers, were less likely to openly discuss their children at work. In some cases, women purposefully concealed from their employers the fact that they were mothers or found other ways of signaling their commitment to their jobs. Fathers, on the other hand, were more likely to discuss their children with their employers and overwhelmingly characterized their managers as understanding of their parenting obligations. Together, these findings help us understand how mothers and fathers navigate the consequences of parenthood in the workplace and add nuance to previous studies of motherhood penalties and fatherhood premiums. (shrink)

The semantic literature takes degree operators like the comparative, but also measure phrases, the equative, the superlative and so on, to be quantifiers over degrees. This is well motivated by their semantic contribution, but leads one to expect far more scope interaction than is actually observed. This paper proposes an alternative-semantic analysis of certain degree constructions, in particular constructions with little and other negative antonyms. Restrictions on scope can then be explained as intervention effects.

Considéré de nos jours comme l’un des principaux représentants de la phénoménologie expérimentale, le psychologue Albert Michotte n’a adopté que sur le tard le terme de « phénoménologie expérimentale » pour qualifier sa démarche. Dans cet article, j’étudie l’usage qu’il fait de cette dénomination, les implications de ce choix ainsi que l’interprétation qu’il en a donnée. Je montre, notamment, comment une discussion entre Michotte et le traducteur anglais de son livre, Tim R. Miles, a été importante pour déterminer l’orientation de (...) la seule présentation explicite que Michotte a publiée de sa phénoménologie expérimentale. L’étude des différents rôles que ce terme a été amené à jouer dans l’œuvre de Michotte montre également les problèmes soulevés par la communication entre différentes disciplines et écoles psychologiques dans lesquelles ce concept a été à la fois employé et débattu : cette communication demandait un véritable travail de traduction. (shrink)