CRISPR-Cas9 genome editing can and has altered human genomes, bringing bioethical debates about this capability to the forefront of philosophical and policy considerations. Here, I consider the underexplored implications of CRISPR-Cas9 gene drives for heritable human genome editing. Modification gene drives applied to heritable human genome editing would introduce a novel form of involuntary eugenic practice that I term guerrilla eugenics. Once introduced into a genome, stealth genetic editing by a gene drive genetic element would occur each subsequent generation irrespective (...) of whether reproductive partners consent to it and irrespective of whether the genetic change confers any benefit. By overriding the ability to ‘opt in’ to genome editing, gene drives compromise the autonomy of carrier individuals and their reproductive partners to choose to use or avoid genome editing and impose additional burdens on those who hope to ‘opt out’ of further genome editing. High incidence of an initially rare gene drive in small human communities could occur within 200 years, with evolutionary fixation globally in a timeframe that is thousands of times sooner than achievable by non-drive germline editing. Following any introduction of heritable gene drives into human genomes, practices intended for surveillance or reversal also create fundamental ethical problems. Current policy guidelines do not comment explicitly on gene drives in humans. These considerations motivate an explicit moratorium as being warranted on gene drive development in heritable human genome editing. (shrink)

It is tempting to invoke organismal selection as perpetually optimizing the function of any given gene. However, natural selection can drive genic functional change without improvement of biochemical activity, even to the extinction of gene activity. Detrimental mutations can creep in owing to linkage with other selectively favored loci. Selection can promote functional degradation, irrespective of genetic drift, when adaptation occurs by loss of gene function. Even stabilizing selection on a trait can lead to divergence of the underlying molecular constituents. (...) Selfish genetic elements can also proliferate independent of any functional benefits to the host genome. Here we review the logic and evidence for these diverse processes acting in genome evolution. This collection of distinct evolutionary phenomena – while operating through easily understandable mechanisms – all contribute to the seemingly counterintuitive notion that maintenance or improvement of a gene's biochemical function sometimes do not determine its evolutionary fate. (shrink)

Recent research has filled many gaps about Caenorhabditis natural history, simultaneously exposing how much remains to be discovered. This awareness now provides means of connecting ecological and evolutionary theory with diverse biological patterns within and among species in terms of adaptation, sexual selection, breeding systems, speciation, and other phenomena. Moreover, the heralded laboratory tractability of C. elegans, and Caenorhabditis species generally, provides a powerful case study for experimental hypothesis testing about evolutionary and ecological processes to levels of detail unparalleled by (...) most study systems. Here, I synthesize pertinent theory with what we know and suspect about Caenorhabditis natural history for salient features of biodiversity, phenotypes, population dynamics, and interactions within and between species. I identify topics of pressing concern to advance Caenorhabditis biology and to study general evolutionary processes, including the key opportunities to tackle problems in dispersal dynamics, competition, and the dimensionality of niche space. (shrink)

“Metapolitics” is an ambiguous term. Recent philosophers have claimed the concept for neo-conservative, even right-wing agendas, while others have employed it to signal radical discontent with politics altogether. Beginning with Peter Viereck’s characterization of Nazi ideology as “Meta-Politics,” this essay works its way back from an “irrational,” “volkish,” and supposedly “conservative” concept to another use of “Metapolitics” as found in Martin Buber and Hermann Cohen that was rooted in a liberal tradition of the Enlightenment—especially in August Schlözer and Saul Ascher. (...) Both, Buber and Cohen, linked “metapolitical politics” to prophetic and theopolitical sensibilities. As such, the prophetic motif of turning loomed large at the center of their respective philosophies of nationalism. But it was a theme that also connected a wide range of thinkers, including Hans Kohn and Leo Baeck, and which emerged as a Leitmotiv of cultural and spiritual Zionism as well as of the modern Renaissance of Jewish culture. Drawing on Moritz Lazarus, the essay argues that the recurring trope of turning helped establish a paradoxical nationalism founded not upon self-empowerment and political othering but on self-criticism. Concluding with a brief excursion on Abraham Joshua Heschel’s prophetic politics in the Civil Rights Movement, the essay gestures towards the possibility of nationalism as collective introspection and self-reformation. (shrink)

Franz Rosenzweig’s Star of Redemption culminates in an aesthetic configuration of simultaneous presences: world, man, God, creation, revelation, and redemption are viewed in a metahistorical side-by-side, connected by the “factualizing power of the And.” But the idea of simultaneity, which is central to Rosenzweig’s configurative thinking, belongs to the historical imagination as much as it belongs to the theological “breaking through the shackles of time.” Rosenzweig’s “and” belongs to both a tradition of cosmic-aesthetic historicism and the philosophical reconstitution of time (...) as a simultaneous perception. In the co-presence of all historical moments, history’s hidden Gestalt, which only a people that is at once old and young can envision, connects the “and” of history with what Hegel considered history’s end—its ultimate self-recognition. Eternity, then, means neither flight from, nor resistance to, history’s naked fact, but the recognition of history’s Gestalt as an image that “does not tolerate epochs.”. (shrink)

Ḳitsur Ḥovat ha-levavot me-Rabenu Asher mi-Lunil -- Ḳitsur Ḥovat ha-levavot mi-sefer Tsedah la-derekh -- Ḳitsur Ḥovat ha-levavot ʻAśarah hilulim -- Ḳitsur Ḥovat ha-levavot Margaliyot ṭovot.

In recent times there have been increasing efforts at reinterpreting core CSR theories such as stakeholder theory with new perspectives as well as applying them to different contexts away from its Western masculinist connotations. This work seeks to add to these efforts by exploring the impacts that the African philosophical worldview of Afro-communitarianism has on small business stakeholder relationships. Specifically it discusses the kinds of relationships that owner/managers of small businesses, in adherence to Afro-communitarianism, maintain with their families, employees, local (...) communities and competitors- all key stakeholders. The contention is that such ethics demand more extensive ethical responsibilities from owner/managers of small businesses than owner/managers motivated by traditional stakeholder theory with its Western masculinist undertones. It is hoped that this effort will add significant perspectives to stakeholder theory as well as having implications for both small and large business practice. (shrink)

Extreme conditions like savantism, autism or synaesthesia, which have a neurological 2AH, UK basis, challenge the idea that other minds are similar to our own. In this paper we report a single case study of a man in whom all three of these conditions co-occur. We suggest, on the basis of this single case, that when savantism and synaesthesia co- occur, it is worthwhile testing for an undiagnosed Autism Spectrum Condition (ASC). This is because savantism has an established association with (...) ASC, and the combination of ASC with synaesthesia may increase the likelihood of savantism. The implications of these conditions for philosophy of mind are introduced. (shrink)

Philosophy Lab: An Experiential Approach to Conceptual Analysis gives students the skills and strategies needed to do philosophical work in the Analytic tradition. They are presented with a step-by-step method for performing a preliminary conceptual analysis and practice examples to apply the method to standard philosophical problems. Students are introduced to the work of great thinkers including Descartes, Hobbes, Locke, Wittgenstein, and Ryle. These works are complemented by contemporary empirical findings concerning perception, desire, emotion, moral intuition, and other basic elements (...) of explicit intentional cognition. Each chapter features primary source material, commentary, and activity instructions. The activities are designed to allow students to experience each mode of cognition in relative isolation, and then to see how they combine and interrelate in more complex contexts. Finally, students use the template model of conceptual analysis to explore the material. They identify and isolate the concept to be analyzed, determine whether it is simple or complex, and if complex, identify the constituent parts of the concept. Specific topics covered include causal power, sex and marriage, compassion, ambition, justice, and death. Through presentation and modeling the book not only enables student to do conceptual analysis with precision, it helps them understand and interpret philosophical issues. Philosophy Lab is a comprehensive, carefully designed text for first courses in philosophy. It may be used with first-year undergraduate students, advanced high-school students, or adult learners. Asher Walden holds a Ph.D. in philosophy and religion from Drew University. Dr. Walden is currently an adjunct lecturer at the University of Massachusetts, Dartmouth. (shrink)

The volume contributes to the ongoing nanoethics debate in four topical areas. The first part tackles questions of what could be called ‘meta-nanoethics’. Its focus lies on basic concepts and the issue of what - if anything - is truly novel and special about the new field of nanoethics or its subject matter. The second part of this volume presents a selection of interesting perspectives on some of the opportunities and challenges of nanotechnology. Part three takes a more in depth (...) look at one of the most pressing current concerns: how to deal with the risks and uncertainties surrounding nanotechnology in a responsible manner. In its fourth and final part the volume touches on issues of public debate and policy. (shrink)

Recently there has been a renewed interest in the ethical value of literature. However, how exactly does literature contribute to our ethical understanding? In Literature, Ethics, and the Emotions, Kenneth Asher argues that literary scholars should locate this question in the long and various history of moral philosophy. On the basis of his own reading of this history, Asher contends for the centrality of emotions in our ethical lives and shows how literature - novels, poetry, and drama - (...) can each contribute to crucial emotional understanding. Individual chapters on T. S. Eliot, D. H. Lawrence, Virginia Woolf, and George Bernard Shaw give detailed analyses of how this contribution takes shape even in modernist authors who try to reconfigure the very nature of the self. (shrink)

Jay Asher’s novel Thirteen Reasons Why and its Netflix adaptation have enjoyed widespread popularity. While they draw needed attention to issues like bullying and teen estrangement, they may have an unintended effect: they mislead about the etiology of suicide and even glamorize it to a degree. The medical literature has shown that suicide is almost always the result of psychiatric disorder, not provocative stress, in much the same way an asthmatic crisis is primarily the result of an underlying medical (...) condition, not an allergic stimulus. Both the novel and Netflix series ignore this premise and even belittle the idea. Thus, while the story has artistic merits, it also has the potential to be destructive if accessed by young readers and viewers seeking guidance. Approximately ten percent of teens suffer from depression, and suicide recently surpassed homicide as the second-leading cause of death among persons ages ten to twenty-four in the United States. A more balanced view addressing these misconceptions is provided for teens, parents, and mental health professionals. (shrink)

Antes de qualquer coisa, o leitor do presente artigo encontrará uma grande preocupação de David Asher em transmitir o pensamento filosófico de Schopenhauer para o leitor britânico da época (1871), isso fica claro, pois esse empreendimento por vezes levou o autor a fazer citações ultra extensas de Schopenhauer (das quais ele mesmo traduzia da língua alemã para o inglês). Nessas longas citações/traduções que o autor faz do filósofo, tratei de copiá-las da tradução brasileira de Jair Barboza d’O mundo como (...) vontade e como representação. Sempre especifico essas cópias em notas, por isso, meu trabalho foi de fazer uma tradução parcial: traduzir o próprio Asher e não o texto de Schopenhauer traduzido por ele. Outro ponto muitíssimo importante a ser levado em consideração é que o presente texto foi comprovadamente lido pelo próprio Charles Darwin, tal como devidamente mostro na nota de rodapé número 16. (shrink)

La célébration du cinquantième anniversaire de la fin de la Seconde Guerre mondiale et de l’ouverture des camps donne depuis quelques années l’occasion de revisiter une histoire juive douloureuse et loin d’être dépassionnée. De nombreux déportés, l’âge venu, écrivent leurs témoignages, toujours poignants, et qui éclairent les faits avec la brutalité que donne l’expérience personnelle. Quelques-uns de ces témoignages retiennent particulièrement l’attention par ce qu’ils nous font comprendre de...

La célébration du cinquantième anniversaire de la fin de la Seconde Guerre mondiale et de l’ouverture des camps donne depuis quelques années l’occasion de revisiter une histoire juive douloureuse et loin d’être dépassionnée. De nombreux déportés, l’âge venu, écrivent leurs témoignages, toujours poignants, et qui éclairent les faits avec la brutalité que donne l’expérience personnelle. Quelques-uns de ces témoignages retiennent particulièrement l’attention par ce qu’ils nous font comprendre de...

Animal welfare science and ecology are both generally concerned with the lives of animals, however they differ in their objectives and scope; the former studies the welfare of animals considered ‘domestic’ and under the domain of humans, while the latter studies wild animals with respect to ecological processes. Each of these approaches addresses certain aspects of the lives of animals living in the world though neither, we argue, tells us important information about the welfare of wild animals. This paper argues (...) for the development of a new scientific discipline ‘welfare biology’ to address these issues and more, given the deficiencies of pre-existing life science disciplines to research the subject. Welfare biology is the study of the welfare of all living beings who have a welfare, with a value orientation toward promoting that welfare, regardless of the beings’ situation or relationship to humans and our activities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Butler on Subjectivity and Authorship: Reflections on Doing Philosophy in the First PersonAsher WaldenWhat drew me to theology a number of years ago was that it was the most personal kind of philosophy, to the extent that it deals with the most important issues of one’s own “personal” life. It used the tools of the philosophical tradition to address questions that the philosophers—especially those in the University of Chicago’s (...) analytically oriented environment—seemed not to want to ask; at least, not when I was an undergraduate there some years ago. My engagement with philosophy has always been about personal questions, and in the past I tended to eschew the political realm as being at best external to the more essential business of philosophy. But the questions I have been asking lately are rather different from the ones that concerned me back when I was still in Chicago. Largely due to the birth of my son two years ago, questions that before were only secondhand—questions about education, democracy, and debt—are now very personal and very, very important to me. I am perhaps a latecomer to the position that, as the saying goes, “The personal is the political.” But being a convert, like the earliest Christian Apologists, may afford me an opportunity and motivation to argue the position all the more earnestly.The way I have sought to incorporate these different questions and perspectives in my theologizing has primarily been through engagement with the Confucian philosophical tradition. The Confucian tradition is, in large measure, a series of reflections on the individual’s utter embeddedness in familial, sociopolitical, environmental, and sacred structures and forces. The tradition has its own resources for expressing and navigating this embeddedness, but what has become interesting to me is that the requisite resources are being developed independently, and perhaps more forcefully, within the realm of postmodern and postcolonial theory. Indeed, these newer articulations may [End Page 55] well be vital for present-day Confucian thinkers to consider in reformulating and re-presenting their own commitments and traditions in the current era.The questions posed to and for the current paper are, first, how does the religiously committed philosopher (or theologian, in a loose sense of the term) consciously incorporate political and economic considerations into her theological research and discursive product; and second, to what extent and in what ways is it necessary for her also to include and address her own personal life/history into the same. Naturally, these are questions which religious thinkers will ask and answer anew for themselves, and repeatedly. My own engagement with Judith Butler in the current paper will merely provide, I hope, one possible model for such an account of how the personal and the political may function in theological discourse. Generally, the model given here suggests that such considerations are not external add-ons to the more essential “hard-core” theologizing of the doctrines of God and Christology. It is not a matter of (first) theory and (then) application. Rather, theological discourse is one place where ethical subjectivity is attained, if provisionally, through conscientious and critical engagement with both one’s religious tradition and the sociopolitical-economic structures in which those traditions are practiced, and where one’s own place within those structures is both questioned and created.In her recent work Giving an Account of Oneself, Judith Butler continues her project of deconstructing the metaphysics of the substantive self, begun in her deservedly noted early work, Gender Trouble. In particular, she argues that the subject comes into being through processes and in contexts that, while not completely determinative of one’s subjectivity, do limit one’s ability to give a complete account of oneself, one’s actions and motivations. She asks the important question of whether this opacity of the conditions of one’s coming into being limits the possibility of taking responsibility, or being held responsible, for one’s actions. She ultimately finds, with Foucault, that selfhood is itself an ethical process, one occasioned and in large part constituted by the call, and subsequent attempt, to give an account.The question which drives Butler’s essay is, generally, if the subject comes... (shrink)

This paper draws upon Hannah Arendt's idea of the 'right to have rights' to critique the current protection gap faced by refugees today. While refugees are protected from refoulement once they make it to the jurisdiction or territory of a state, they face an ever-increasing array of non-entrée policies designed to stymie access to state territory. Without being able to enter a state capable of securing their claims to safety and dignity, refugees cannot achieve the rights which ought to be (...) afforded to them under international law. Drawing upon both legal theory and political philosophy, this paper argues that refugees today, just as the stateless in Arendt’s time, must be afforded the ‘right to have rights’, understood as a right to enter state territory. (shrink)

This book explores the problem of moral metaphysics through investigations of four pivotal philosophers. It uses the contemporary idea of moral sentimentalism as a comparative category to explore the problems and challenges inherent in the project of moral metaphysics.

The study of the feeling of knowing may have implications for some of the metatheoretical issues concerning consciousness and control. Assuming a distinction between information-based and experience-based metacognitive judgments, it is argued that the sheer phenomenological experience of knowing (''noetic feeling'') occupies a unique role in mediating between implicit-automatic processes, on the one hand, and explicit-controlled processes, on the other. Rather than reflecting direct access to memory traces, noetic feelings are based on inferential heuristics that operate implicitly and unintentionally. Once (...) such heuristics give rise to a conscious feeling that feeling can then affect controlled action. Examination of the cues that affect noetic feelings suggest that not only do these feelings inform controlled action, but they are also informed by feedback from the outcome of that action. (shrink)

A substantial guide providing an overview of both physicalism and metaphysical naturalism, reviewing both questions of formulation and justification for both doctrines. Includes a diagnostic strategy for understanding talk of naturalism as a metaphysical thesis.