Effectiveness is a key criterion in assessing the justification of antibiotic resistance interventions. Depending on an intervention’s effectiveness, burdens and costs will be more or less justified, which is especially important for large scale population-level interventions with high running costs and pronounced risks to individuals in terms of wellbeing, integrity and autonomy. In this paper, we assess the case of routine hospital screening for multi-drug-resistant Gram-negative bacteria (MDRGN) from this perspective. Utilizing a comparison to screening programs for Methicillin-Resistant Staphylococcus aureus (...) (MRSA) we argue that current screening programmes for MDRGN in low endemic settings should be reconsidered, as its effectiveness is in doubt, while general downsides to screening programs remain. To accomplish justifiable antibiotic stewardship, MDRGN screening should not be viewed as a separate measure, but rather as part of a comprehensive approach. The program should be redesigned to focus on those at risk of developing symptomatic infections with MDRGN rather than merely detecting those colonised. (shrink)

We argue that Wittgenstein’s philosophical perspective on Gödel’s most famous theorem is even more radical than has commonly been assumed. Wittgenstein shows in detail that there is no way that the Gödelian construct of a string of signs could be assigned a useful function within (ordinary) mathematics. — The focus is on Appendix III to Part I of Remarks on the Foundations of Mathematics. The present reading highlights the exceptional importance of this particular set of remarks and, more specifically, emphasises (...) its refined composition and rigorous internal structure. (shrink)

The book demonstrates for the first time that transculturality – the mixed constitution of cultures – is by no means only a characteristic of the present, but has de facto determined the composition of cultures since time immemorial. This is demonstated using examples from the arts across all cultures and continents.

This book is about the interrelationship between nature, semiosis, metarepresentation and (self-)consciousness, and the role played by metarepresentation in ...

Concentrating upon applications that are most relevant to modern physics, this valuable book surveys variational principles and examines their relationship to dynamics and quantum theory. Stressing the history and theory of these mathematical concepts rather than the mechanics, the authors provide many insights into the development of quantum mechanics and present much hard-to-find material in a remarkably lucid, compact form. After summarizing the historical background from Pythagoras to Francis Bacon, Professors Yourgrau and Mandelstram cover Fermat's principle of least time, the (...) principle of least action of Maupertuis, development of this principle by Euler and Lagrange, and the equations of Lagrange and Hamilton. Equipped by this thorough preparation to treat variational principles in general, they proceed to derive Hamilton's principle, the Hamilton-Jacobi equation, and Hamilton's canonical equations. An investigation of electrodynamics in Hamiltonian form covers next, followed by a resume of variational principles in classical dynamics. The authors then launch into an analysis of their most significant topics: the relation between variational principles and wave mechanics, and the principles of Feynman and Schwinger in quantum mechanics. Two concluding chapters extend the discussion to hydrodynamics and natural philosophy. Professional physicists, mathematicians, and advanced students with a strong mathematical background will find this stimulating volume invaluable reading. Extremely popular in its hardcover edition, this volume will find even wider appreciation in its first fine inexpensive paperbound edition. (shrink)

Source domain verification has not received as much attention as criteria for metaphor identification in the study of conceptual metaphor. In this paper, we provide a replicable approach to source...

Probabilistic reasoning is heavily investigated in decision research. Violations of probability theory have been demonstrated numerously, for instance, the tendency to overestimate the joint probab...

We provide a finite axiomatization of the consequence , i.e. of the set of common sequential rules for and . Moreover, we show that has no proper non-trivial strengthenings other than and . A similar result is true for , but not, e.g., for +.

We provide a finite axiomatization of the consequence $\vdash ^{\wedge}\cap \vdash ^{\vee}$ , i.e. of the set of common sequential rules for $\wedge $ and $\vee $ . Moreover, we show that $\vdash ^{\wedge}\cap \vdash ^{\vee}$ has no proper non-trivial strengthenings other than $\vdash ^{\wedge}$ and $\vdash ^{\vee}$ . A similar result is true for $\vdash ^{\leftrightarrow}\cap \vdash ^{\rightarrow}$ , but not, e.g., for $\vdash ^{\leftrightarrow}\cap \vdash ^{+}$.

Aristotle's Categories can easily seem to be a statement of a naïve, pre-philosophical ontology, centered around ordinary items. Wolfgang-Rainer Mann argues that the treatise, in fact, presents a revolutionary metaphysical picture, one Aristotle arrives at by (implicitly) criticizing Plato and Plato's strange counterparts, the "Late-Learners" of the Sophist. As Mann shows, the Categories reflects Aristotle's discovery that ordinary items are things (objects with properties). Put most starkly, Mann contends that there were no things before Aristotle. The author's argument consists (...) of two main elements. First, a careful investigation of Plato which aims to make sense of the odd-sounding suggestion that things do not show up as things in his ontology. Secondly, an exposition of the theoretical apparatus Aristotle introduces in the Categories--an exposition which shows how Plato's and the Late-Learners' metaphysical pictures cannot help but seem inadequate in light of that apparatus. In doing so, Mann reveals that Aristotle's conception of things--now so engrained in Western thought as to seem a natural expression of common sense--was really a hard-won philosophical achievement. Clear, subtle, and rigorously argued, The Discovery of Things will reshape our understanding of some of Aristotle's--and Plato's--most basic ideas. (shrink)