Results for 'organelle identity'

993 found
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  1.  6
    Controlling contacts—Molecular mechanisms to regulate organelle membrane tethering.Suzan Kors, Smija M. Kurian, Joseph L. Costello & Michael Schrader - 2022 - Bioessays 44 (11):2200151.
    In recent years, membrane contact sites (MCS), which mediate interactions between virtually all subcellular organelles, have been extensively characterized and shown to be essential for intracellular communication. In this review essay, we focus on an emerging topic: the regulation of MCS. Focusing on the tether proteins themselves, we discuss some of the known mechanisms which can control organelle tethering events and identify apparent common regulatory hubs, such as the VAP interface at the endoplasmic reticulum (ER). We also highlight several (...)
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  2.  21
    Changing phosphoinositides “on the fly”: how trafficking vesicles avoid an identity crisis.Roberto J. Botelho - 2009 - Bioessays 31 (10):1127-1136.
    Joining an antagonistic phosphoinositide (PtdInsP) kinase and phosphatase into a single protein complex may regulate rapid and local PtdInsP changes. This may be important for processes such as membrane fission that require a specific PtdInsP and that are innately local and rapid. Such a complex could couple vesicle formation, with erasing of the identity of the donor organelle from the vesicle prior to its fusion with target organelles, thus preventing organelle identity intermixing. Coordinating signals are postulated (...)
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  3.  19
    Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles.Wei Li, Michael E. Rusiniak, Sreenivasulu Chintala, Rashi Gautam, Edward K. Novak & Richard T. Swank - 2004 - Bioessays 26 (6):616-628.
    In the mouse, at least 16 genes regulate vesicle trafficking to specialized lysosome‐related organelles, including platelet dense granules and melanosomes. Fourteen of these genes have been identified by positional cloning. All 16 mouse mutants are models for the genetically heterogeneous human disease, Hermansky–Pudlak Syndrome (HPS). Five HPS genes encode known vesicle trafficking proteins. Nine genes are novel, are found only in higher eukaryotes and encode members of three protein complexes termed BLOCs (Biogenesis of Lysosome‐related Organelles Complexes). Mutations in murine HPS (...)
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  4.  38
    An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity.Toni Radanović, John Reinhard, Stephanie Ballweg, Kristina Pesek & Robert Ernst - 2018 - Bioessays 40 (5):1700250.
    The biological membranes of eukaryotic cells harbor sensitive surveillance systems to establish, sense, and maintain characteristic physicochemical properties that ultimately define organelle identity. They are fundamentally important for membrane homeostasis and play active roles in cellular signaling, protein sorting, and the formation of vesicular carriers. Here, we compare the molecular mechanisms of Mga2 and Ire1, two sensors involved in the regulation of fatty acid desaturation and the response to unfolded proteins and lipid bilayer stress in order to identify (...)
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  5. Chapter Ten Agents of Change: Theology, Culture and Identity Politics Ibrahim Abraham.Identity Politics - 2007 - In Julie Connolly, Michael Leach & Lucas Walsh (eds.), Recognition in politics: theory, policy and practice. Newcastle-upon-Tyne: Cambridge Scholars Press. pp. 175.
     
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  6. Suresh Chandra.Identity Scepticism & Interrupted Existence - 1991 - In Ramakant A. Sinari (ed.), Concept of Man in Philosophy. Indian Institute of Advanced Study, Shimla in Association with B.R.. pp. 36.
  7.  15
    Paul Sawyer.Identity As Calling, Martin Luther & King On War - 2006 - In Linda Alcoff (ed.), Identity Politics Reconsidered. Palgrave-Macmillan.
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  8. Kurt W. Schmidt.Stabilizing or Changing Identity? The Ethical - 2002 - In Julia Lai Po-Wah Tao (ed.), Cross-Cultural Perspectives on the (Im) Possibility of Global Bioethics. Kluwer Academic.
     
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  9. Gerald A. Sanders and James H.-y. Tai.Immediate Dominance & Identity Deletion - 1972 - Foundations of Language 8:161.
     
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  10. Robert Nozick.I. Personal Identity Through Time - 1991 - In Daniel Kolak & R. Martin (eds.), Self and Identity: Contemporary Philosophical Issues. Macmillan.
  11. Barbara Christian.Feminist Identity Politics - 2006 - In Elizabeth Hackett & Sally Anne Haslanger (eds.), Theorizing Feminisms: A Reader. Oxford University Press.
     
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  12. Mari Matsuda.On Identity Politics - 2006 - In Elizabeth Hackett & Sally Anne Haslanger (eds.), Theorizing Feminisms: A Reader. Oxford University Press.
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  13. The jazz solo as ritual: conforming to the conventions of innovation.Roscoe C. Scarborough505 0 $A. Iii Experience Of Music: Stratification & Identity : - 2013 - In Sara Horsfall, Jan-Martijn Meij & Meghan D. Probstfield (eds.), Music sociology: examining the role of music in social life. Boulder, CO: Paradigm Publishers.
     
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  14. Books Available List.J. M. Beach, Gerald Grant, Vicki Gunther, James McGowan, Kate Donegan, Michael S. Merry, Jeffery Ayala Milligan & Identity Citizenship - 2011 - Educational Studies: A Jrnl of the American Educ. Studies Assoc 47 (3).
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  15.  50
    Problems of multi-species organisms: endosymbionts to holobionts.David C. Queller & Joan E. Strassmann - 2016 - Biology and Philosophy 31 (6):855-873.
    The organism is one of the fundamental concepts of biology and has been at the center of many discussions about biological individuality, yet what exactly it is can be confusing. The definition that we find generally useful is that an organism is a unit in which all the subunits have evolved to be highly cooperative, with very little conflict. We focus on how often organisms evolve from two or more formerly independent organisms. Two canonical transitions of this type—replicators clustered in (...)
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  16. Identity and necessity.Saul A. Kripke - 1971 - In Milton Karl Munitz (ed.), Identity and individuation. New York,: New York University Press. pp. 135-164.
    are synthetic a priori judgements possible?" In both cases, i~thas usually been t'aken for granted in fife one case by Kant that synthetic a priori judgements were possible, and in the other case in contemporary,'d-". philosophical literature that contingent statements of identity are ppss. ible. I do not intend to deal with the Kantian question except to mention:ssj~".
     
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  17.  40
    Organelle size control systems: From cell geometry to organelle‐directed medicine.Wallace F. Marshall - 2012 - Bioessays 34 (9):721-724.
    Graphical AbstractOrganelles are reaction vessels containing metabolic pathways. As in a chemical factory, the size of the reaction vessels limits the rate of product formation. Organelle size is tuned to metabolic needs, hence reprogramming organelle size could be a novel therapeutic strategy as well as a new tool for metabolic engineering.
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  18. Personal identity and persisting as many.Sara Weaver & John Turri - 2018 - In Tania Lombrozo, Joshua Knobe & Shaun Nichols (eds.), Oxford Studies in Experimental Philosophy, volume 2. Oxford, England: Oxford University Press. pp. 213-242.
    Many philosophers hypothesize that our concept of personal identity is partly constituted by the one-person-one-place rule, which states that a person can only be in one place at a time. This hypothesis has been assumed by the most influential contemporary work on personal identity. In this paper, we report a series of studies testing whether the hypothesis is true. In these studies, people consistently judged that the same person existed in two different places at the same time. This (...)
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  19. Personal Identity and Self-Regarding Choice in Medical Ethics.Lucie White - 2020 - In Michael Kühler & Veselin L. Mitrović (eds.), Theories of the Self and Autonomy in Medical Ethics. Springer. pp. 31-47.
    When talking about personal identity in the context of medical ethics, ethicists tend to borrow haphazardly from different philosophical notions of personal identity, or to abjure these abstract metaphysical concerns as having nothing to do with practical questions in medical ethics. In fact, however, part of the moral authority for respecting a patient’s self-regarding decisions can only be made sense of if we make certain assumptions that are central to a particular, psychological picture of personal identity, namely, (...)
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  20.  20
    Synthetic cells and organelles: compartmentalization strategies.Renée Roodbeen & Jan C. M. van Hest - 2009 - Bioessays 31 (12):1299-1308.
    The recent development of RNA replicating protocells and capsules that enclose complex biosynthetic cascade reactions are encouraging signs that we are gradually getting better at mastering the complexity of biological systems. The road to truly cellular compartments is still very long, but concrete progress is being made. Compartmentalization is a crucial natural methodology to enable control over biological processes occurring within the living cell. In fact, compartmentalization has been considered by some theories to be instrumental in the creation of life. (...)
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  21. Plant organelles.C. Jackson, A. L. Moore & E. Reid - 1979 - Method. Surv. Biochem 9:1-12.
     
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  22.  7
    Short‐range inversions: Rethinking organelle genome stability.Samuel Tremblay-Belzile, Étienne Lepage, Éric Zampini & Normand Brisson - 2015 - Bioessays 37 (10):1086-1094.
    In the organelles of plants and mammals, recent evidence suggests that genomic instability stems in large part from template switching events taking place during DNA replication. Although more than one mechanism may be responsible for this, some similarities exist between the different proposed models. These can be separated into two main categories, depending on whether they involve a single‐strand‐switching or a reciprocal‐strand‐switching event. Single‐strand‐switching events lead to intermediates containing Y junctions, whereas reciprocal‐strand‐switching creates Holliday junctions. Common features in all the (...)
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  23. Identity and Identities.Bernard Williams - 1995 - In H. Harris (ed.), Identity. Oxford University Press. pp. 1-11.
     
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  24.  28
    Why are most organelle genomes transmitted maternally?Stephan Greiner, Johanna Sobanski & Ralph Bock - 2015 - Bioessays 37 (1):80-94.
    Why the DNA‐containing organelles, chloroplasts, and mitochondria, are inherited maternally is a long standing and unsolved question. However, recent years have seen a paradigm shift, in that the absoluteness of uniparental inheritance is increasingly questioned. Here, we review the field and propose a unifying model for organelle inheritance. We argue that the predominance of the maternal mode is a result of higher mutational load in the paternal gamete. Uniparental inheritance evolved from relaxed organelle inheritance patterns because it avoids (...)
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  25.  13
    The Drosophila fusome, organelle biogenesis and germ cell differentiation: If you build it….Dennis McKearin - 1997 - Bioessays 19 (2):147-152.
    From stem cells to oocyte, Drosophila germ cells undergo a short, defined lineage. Molecular genetic analyses of a collection of female sterile mutations have indicated that a germ cell‐specific organelle called the fusome has a central role at several steps in this lineage. The fusome grows from a prominent spherical organelle to an elongated and branched structure that connects all mitotic sisters in a germ cell syncytium. The organelle is assembled from proteins normally found in the membrane (...)
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  26. Human Identity and Bioethics.David DeGrazia - 2005 - New York: Cambridge University Press.
    When philosophers address personal identity, they usually explore numerical identity: what are the criteria for a person's continuing existence? When non-philosophers address personal identity, they often have in mind narrative identity: Which characteristics of a particular person are salient to her self-conception? This book develops accounts of both senses of identity, arguing that both are normatively important, and is unique in its exploration of a range of issues in bioethics through the lens of identity. (...)
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  27.  56
    Neurodegeneration and identity.Nina Strohminger & Shaun Nichols - 2015 - Psychological Science 26 (9):1469– 1479.
    There is a widespread notion, both within the sciences and among the general public, that mental deterioration can rob individuals of their identity. Yet there have been no systematic investigations of what types of cognitive damage lead people to appear to no longer be themselves. We measured perceived identity change in patients with three kinds of neurodegenerative disease: frontotemporal dementia, Alzheimer’s disease, and amyotrophic lateral sclerosis. Structural equation models revealed that injury to the moral faculty plays the primary (...)
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  28.  32
    Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While.Michael G. Hanna, Jennifer L. Peotter, E. B. Frankel & Anjon Audhya - 2018 - Bioessays 40 (7):1800004.
    Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum‐Golgi intermediate compartment (ERGIC). These membranous vesicular‐tubular clusters are found tightly juxtaposed to ER subdomains that are competent for the production of COPII‐coated transport carriers. In contrast to many unicellular systems, metazoan COPII carriers largely transit just a few hundred nanometers to the ERGIC, prior to COPI‐dependent transport on to the cis‐Golgi. The mechanisms underlying formation and (...)
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  29.  17
    High‐throughput localization of organelle proteins by mass spectrometry: a quantum leap for cell biology.Denise J. L. Tan & Alfonso Martinez Arias - 2006 - Bioessays 28 (8):780-784.
    Cells are the fundamental building blocks of organisms and their organization holds the key to our understanding of the processes that control Development and Physiology as well as the mechanisms that underlie disease. Traditional methods of analysis of subcellular structure have relied on the purification of organelles and the painstaking biochemical description of their components. The arrival of high‐throughput genomic and, more significantly, proteomic technologies has opened hereto unforeseen possibilities for this task. Recently two reports(1,2) show how much can be (...)
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  30. Building narrative identity: Episodic value and its identity-forming structure within personal and social contexts.Huiyuhl Yi - 2020 - Human Affairs 30 (2):281-292.
    In this essay, I develop the concept of episodic value, which describes a form of value connected to a particular object or individual expressed and delivered through a narrative. Narrative can bestow special kinds of value on objects, as exemplified by auction articles or museum collections. To clarify the nature of episodic value, I show how the notion of episodic value fundamentally differs from the traditional axiological picture. I extend my discussion of episodic value to argue that the notion of (...)
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  31. Personal identity in multicultural constitutional democracies.H. P. P. Lotter - 1998 - South African Journal of Philosophy 17 (3):179-198.
    Awareness of, and respect for differences of gender, race, religion, language, and culture have liberated many oppressed groups from the hegemony of white, Western males. However, respect for previously denigrated collective identities should not be allowed to confine individuals to identities constructed around one main component used for political mobilisation, or to identities that depend on a priority of properties that are not optional, like race, gender, and language. In this article I want to sketch an approach for accommodating different (...)
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  32. Identity Syntax.Roger Wertheimer - 1999 - In Tom Rockmore (ed.), The Proceedings of the Twentieth World Congress of Philosophy. Philosophy Document Center. pp. 171-186.
    Like '&', '=' is no term; it represents no extrasentential property. It marks an atomic, nonpredicative, declarative structure, sentences true solely by codesignation. Identity (its necessity and total reflexivity, its substitution rule, its metaphysical vacuity) is the objectual face of codesignation. The syntax demands pure reference, without predicative import for the asserted fact. 'Twain is Clemens' is about Twain, but nothing is predicated of him. Its informational value is in its 'metailed' semantic content: the fact of codesignation (that 'Twain' (...)
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  33. ""Identity and its Vicissitudes: Hegel's" Logic of Essence" as a Theory of Ideology'.Slavoj Zizek - 1994 - In Ernesto Laclau (ed.), The making of political identities. New York: Verso. pp. 40--75.
  34. Personal Identity.David Shoemaker & Kevin P. Tobia - 2022 - In Manuel Vargas & John Doris (eds.), The Oxford Handbook of Moral Psychology. Oxford, U.K.: Oxford University Press.
    Our aim in this entry is to articulate the state of the art in the moral psychology of personal identity. We begin by discussing the major philosophical theories of personal identity, including their shortcomings. We then turn to recent psychological work on personal identity and the self, investigations that often illuminate our person-related normative concerns. We conclude by discussing the implications of this psychological work for some contemporary philosophical theories and suggesting fruitful areas for future work on (...)
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  35. Identity and Psychoanalysis: Silent, Intimate and Unconscious Conflicts in the Formation of Adolescence.Camila Incau - 2024 - Revista Guairacá de Filosofia 40 (1).
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  36. Addiction, Identity, Morality.Brian D. Earp, Joshua August Skorburg, Jim A. C. Everett & Julian Savulescu - 2019 - AJOB Empirical Bioethics 10 (2):136-153.
    Background: Recent literature on addiction and judgments about the characteristics of agents has focused on the implications of adopting a ‘brain disease’ versus ‘moral weakness’ model of addiction. Typically, such judgments have to do with what capacities an agent has (e.g., the ability to abstain from substance use). Much less work, however, has been conducted on the relationship between addiction and judgments about an agent’s identity, including whether or to what extent an individual is seen as the same person (...)
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  37.  48
    Trans‐splicing of organelle introns – a detour to continuous RNAs.Stephanie Glanz & Ulrich Kück - 2009 - Bioessays 31 (9):921-934.
    In eukaryotes, RNA trans‐splicing is an important RNA‐processing form for the end‐to‐end ligation of primary transcripts that are derived from separately transcribed exons. So far, three different categories of RNA trans‐splicing have been found in organisms as diverse as algae to man. Here, we review one of these categories: the trans‐splicing of discontinuous group II introns, which occurs in chloroplasts and mitochondria of lower eukaryotes and plants. Trans‐spliced exons can be predicted from DNA sequences derived from a large number of (...)
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  38. Identity in physics: a historical, philosophical, and formal analysis.Steven French & Decio Krause - 2006 - New York: Oxford University Press. Edited by Decio Krause.
    Steven French and Decio Krause examine the metaphysical foundations of quantum physics. They draw together historical, logical, and philosophical perspectives on the fundamental nature of quantum particles and offer new insights on a range of important issues. Focusing on the concepts of identity and individuality, the authors explore two alternative metaphysical views; according to one, quantum particles are no different from books, tables, and people in this respect; according to the other, they most certainly are. Each view comes with (...)
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  39. Identity and Discrimination.Timothy Williamson (ed.) - 1990 - Cambridge, Mass., USA: Wiley-Blackwell.
    _Identity and Discrimination_, originally published in 1990 and the first book by respected philosopher Timothy Williamson, is now reissued and updated with the inclusion of significant new material. Williamson here proposes an original and rigorous theory linking identity, a relation central to metaphysics, and indiscriminability, a relation central to epistemology.__ Updated and reissued edition of Williamson’s first publication, with the inclusion of significant new material Argues for an original cognitive account of the relation between identity and discrimination that (...)
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  40. Composition as Identity, Modal Parts, and Mereological Essentialism.Meg Wallace - 2014 - In A. J. Cotnoir & Donald L. M. Baxter (eds.), Composition as Identity. Oxford, UK: pp. 111-129.
    Some claim that Composition as Identity (CI) entails Mereological Essentialism (ME). If this is right, then we have an effective modus tollens against CI: ME is clearly false, so CI is, too. Rather than deny the conditional, I will argue that a CI theorist should embrace ME. I endorse a theory of modal parts such that ordinary objects are spatially, temporally, and modally extended. Accepting modal parts is certainly beneficial to CI theorists, but it also provides elegant solutions to (...)
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  41.  29
    Essays for David Wiggins: identity, truth, and value.David Wiggins, Sabina Lovibond & Stephen G. Williams (eds.) - 1996 - Cambridge: Blackwell.
    A collection of 14 essays honoring the life and work of Oxford philosopher Wiggins touching on topics from ancient philosophy to ethics, metaphysics and the theory of meaning. The contributing scholars debate many of the seminal issues of Wiggins' work, including the determinancy of distinctness, relative identity, naturalism in ethics, logic and truth in moral judgments, and the practical wisdom of Aristotle. The collection uniquely features replies by Wiggins to each of the papers. Annotation copyright by Book News, Inc., (...)
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  42.  3
    Novel secretory organelles of parasite origin ‐ at the center of host‐parasite interaction.Viktor Bekić & Nicole Kilian - 2023 - Bioessays 45 (9):2200241.
    Reorganization of cell organelle‐deprived host red blood cells by the apicomplexan malaria parasite Plasmodium falciparum enables their cytoadherence to endothelial cells that line the microvasculature. This increases the time red blood cells infected with mature developmental stages remain within selected organs such as the brain to avoid the spleen passage, which can lead to severe complications and cumulate in patient death. The Maurer's clefts are a novel secretory organelle of parasite origin established by the parasite in the cytoplasm (...)
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  43.  93
    Identity and difference.Martin Heidegger - 1969 - New York,: Harper & Row. Edited by Martin Heidegger.
    Identity and Difference consists of English translations and the original German versions of two little-known lectures given in 1957 by Martin Heidegger, "The Principle of Identity" and "The Onto-theo-logical Constitution of Metaphysics.
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  44. Personal identity.Sydney Shoemaker - 1984 - Oxford, England: Blackwell. Edited by Richard Swinburne.
    What does it mean to say that this person at this time is 'the same' as that person at an earlier time? If the brain is damaged or the memory lost, how far does a person's identity continue? In this book two eminent philosophers develop very different approaches to the problem.
  45.  14
    Regulation of organelle transport: Lessons from color change in fish.Leah T. Haimo & Catherine D. Thaler - 1994 - Bioessays 16 (10):727-733.
    Organelles transported along microtubules are normally moved to precise locations within cells. For example, synaptic vesiceles are transported to the neruronal synapse, the Golgi apparatus is generally found in a perinuclear location, and the membranes of the endoplasmic reticulum are actively extended to the cell periphery. The correct positioning of these organelles depends on microtubules and microtubule motors. Melanophores provide an extreme example of organized organelle transport. These cells are specialized to transport pigment granules, which are coordinately moved towards (...)
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  46.  58
    Constitutional identity.Gary J. Jacobsohn - 2010 - Cambridge, Mass.: Harvard University Press.
    The conundrum of the unconstitutional constitution -- The quest for a compelling unity -- The permeability of constitutional borders -- The sounds of silence : militant and acquiescent constitutionalism -- "The first page of the constitution" : family, state, and identity.
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  47. Relative identity.Nicholas Griffin - 1977 - Oxford: Clarendon Press.
    The author attacks the view that identity, Like largeness, Is a relative relation. The primary advocate of the view that identity is relative is p.T. Geach. It is argued that geach has not shown that the failure of the identity of indiscernibles principle, As a truth of logic, Forces us to stop taking indiscernibility within particular formal theories or languages as a sufficient condition for identity. The author also argues that the whole notion of relative (...), As explicated by geach, Is very probably incoherent. (shrink)
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  48.  14
    Identity Economics: How Our Identities Shape Our Work, Wages, and Well-Being.George A. Akerlof & Rachel E. Kranton - 2010 - Princeton University Press.
    Identity Economics provides an important and compelling new way to understand human behavior, revealing how our identities--and not just economic incentives--influence our decisions. In 1995, economist Rachel Kranton wrote future Nobel Prize-winner George Akerlof a letter insisting that his most recent paper was wrong. Identity, she argued, was the missing element that would help to explain why people--facing the same economic circumstances--would make different choices. This was the beginning of a fourteen-year collaboration--and of Identity Economics. The authors (...)
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  49. Personal Identity and Uploading.Mark Walker - 2011 - Journal of Evolution and Technology 22 (1):37-52.
    Objections to uploading may be parsed into substrate issues, dealing with the computer platform of upload and personal identity. This paper argues that the personal identity issues of uploading are no more or less challenging than those of bodily transfer often discussed in the philosophical literature. It is argued that what is important in personal identity involves both token and type identity. While uploading does not preserve token identity, it does save type identity; and (...)
     
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  50.  58
    How do endosymbionts become organelles? Understanding early events in plastid evolution.Debashish Bhattacharya, John M. Archibald, Andreas Pm Weber & Adrian Reyes‐Prieto - 2007 - Bioessays 29 (12):1239-1246.
    What factors drove the transformation of the cyanobacterial progenitor of plastids (e.g. chloroplasts) from endosymbiont to bona fide organelle? This question lies at the heart of organelle genesis because, whereas intracellular endosymbionts are widespread in both unicellular and multicellular eukaryotes (e.g. rhizobial bacteria, Chlorella cells in ciliates, Buchnera in aphids), only two canonical eukaryotic organelles of endosymbiotic origin are recognized, the plastids of algae and plants and the mitochondrion. Emerging data on (1) the discovery of non‐canonical plastid protein (...)
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