En 2015 empieza una epidemia causada por el virus del zika en Brasil, siendo luego asociada a problemas teratógenos congénitos. A partir de la sospecha de esta relación, surgen, en dos vertientes, artículos defendiendo el aborto: presentándolo como uno de los tratamientos para las mujeres embarazadas; utilizando la crisis sanitaria y la confusión de la opinión pública como una estrategia para despenalizar el aborto. Las dos vías son injustas al exigir que los recursos ya escasos fuesen destinados al (...) aborto y no a la prevención, tratamiento y cuidados necesarios a los afectados. Se concluye que los datos científicos, en si mismos, son acordes a la inmoralidad del aborto, siendo justamente la falta de rigor científico y/o las cuestiones ideológicas los que lo promueven. (shrink)

Estudio desde las distintas perspectivas de comprensión de las políticas de vigilancia y control social de la vida al enfocar la actual pandemia. Se enfatiza que todas esas políticas se aplican hoy mediante las TIC, extendiendo el dominio digital sobre el mundo offline y transformando la pandemia en tecnopandemia. Así resultan todas ellas, biopolítica, teoría de la excepción y psicopolítica, conceptualmente superadas por la tecnopolítica. La tecnopolítica es la forma político-social de la vida onlife, la práctica de un poder infodémico, (...) que utiliza tecno-personas, que no son ni individuos ni tampoco sujetos políticos, para controlar y someter la vida offlife. (shrink)

La infección por el virus del papiloma humano (VPH) constituye la causa necesaria, aunque no suficiente, de la enfermedad de transmisión sexual más frecuente en el mundo, responsable del 4,5 % de todos los cánceres en ambos sexos. La vacunación frente al VPH, con niveles de eficacia y seguridad similares en ambos sexos, está dirigida básicamente a mujeres, para reducir la incidencia de infección y sus consecuencias, como el cáncer de cérvix. La transmisibilidad del virus en ambos sexos (...) y la inmunidad colectiva que proporciona la vacunación universal hace que su extensión al sexo masculino constituya una cuestión no solo de salud pública, sino también un dilema bioético relacionado con la protección de la salud y la equitativa distribución de los recursos. Este trabajo aborda el análisis bioético de la extensión de la vacunación contra VPH a ambos sexos. (shrink)

This paper argues that Zika virus infection has its ethical implications beyond the reproductive health of women. It claims that Zika virus infection like public health emergency exposes the underlying health determinants and health status of women. Therefore, ethical mitigation of Zika like public health emergencies should consider these underlying health determinants and health status of women. For, undermining and overlooking these underlying determinants and health status of women, during the public health emergencies, enhance the (...) health inequities. The recent Zika virus infection in Brazil has triggered different ethics consultation and has prompted to outline ethical recommendations. However, the recommendations have either focused on the reproductive health of women or on the core strategies of public health emergency. Considering this as a gap in perspective to prepare for Zika like public health emergencies, this paper argues that it is the underlying holistic health of women, precisely, health capability, which should be given due ethical consideration. Finally, the paper concludes highlighting the fact that focusing on the holistic health of the women during Zika like public health emergencies and beyond can bring in long-term benefits for global health equity. (shrink)

As the Zika virus pandemic continues to bring worry and fear to health officials and medical scientists, Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) have recommended that residents of the Zika-infected countries, e.g., Brazil, and those who have traveled to the area should delay having babies which may involve artificial contraceptive, particularly condom. This preventive policy, however, is seemingly at odds with the Roman Catholic Church’s position on the contraceptive. As least since (...) the promulgation of Paul VI’s 1968 encyclical, Humanae Vitae, the Church has explicitly condemned artificial birth control as intrinsic evil. However, the current pontiff, Pope Francis, during his recent visit to Latin America, remarked that the use of artificial contraception may not be in contradiction to the teaching of Humanae Vitae while drawing a parallel between the current Zika Crisis and the 1960’s Belgian Congo Nun Controversy. The pope mentioned that the traditional ethical principle of the lesser of two evils may be the doctrine that justified the exceptions. The authors of this paper attempt to expand the theological rationale of the pope’s suggestion. In so doing, the authors rely on casuistical reasoning as an analytic tool that compares the Belgian Congo Nun case and the given Zika case, and suggest that the former is highly similar to, if not the same as, the latter in terms of normative moral feature. That is, in both cases the use of artificial contraception is theologically justified in reference to the criteria that the doctrine of the lesser of two evils requires. The authors wish that the paper would provide a solid theological-ethical ground based on which condom-use as the most immediate and effective preventive measure can be recommended in numerous Catholic hospitals as well as among Catholic communities in the world, particularly the most Zika-affected and largest Catholic community in the world, Brazil – 123 million present Brazilian citizens are reported to be Roman Catholic. (shrink)

Herbert, Dilinie The Zika virus has dominated the news media and captured the attention of the international community. Epidemic disease has become the mainstay of public health emergencies in our recent past with Ebola virus in West Africa and now Zika virus in Latin America. An unexpected and troubling feature of this current outbreak is the high incidence of birth defects and neurological health complications. As scientists investigate a possible causal link, health authorities as well (...) as Catholic Church leaders are involved in communicating how women and the wider community should make decisions about their health, reproduction and pregnancy. A morally appropriate, culturally sensitive and socially inclusive approach to managing the immanent risk should be the priority. (shrink)

There currently is sufficient scientific evidence directly linking acquisition, exposure and prevalence of the human papillomavirus to cervical cancer. The article addresses HPV in women by taking NaProTechnology into account, which makes it posible to combine scientific evidence with ethical approaches. It looks at both the biological aspect of sexuality and the ability to become a person within one’s sexual nucleus. There is an analysis of sex education programs based on preventive health and on the anthropology of sexuality, and supported (...) by family institutions, that have demonstrated better acceptance in dealing with the risk of sexually transmitted diseases, including HPV infection. (shrink)

There is limited guidance on how to assess the ethical acceptability of research risks that extend beyond research participants to third parties (or “research bystanders”). Community or stakeholder engagement has been proposed as one way to address potential harms to community members, including bystanders. Despite widespread agreement on the importance of community engagement in biomedical research, this umbrella term includes many different goals and approaches, agreement on which is ethically required or recommended for a particular context. We analyse the case (...) of a potential Zika virus human challenge trial to assess whether and how community engagement can help promote the ethical acceptability of research posing risks to bystanders. We conclude that, in addition to having intrinsic value, community engagement can improve the identification of bystander risks, effective approaches to minimizing them, and transparency about bystander risks for host communities. (shrink)

No contexto da realização de megaeventos esportivos no Brasil, este artigo tem como objetivo refletir sobre as práticas de agendamento das Olimpíadas Rio 2016 em relação à problemática do zika vírus pela Folha de S. Paulo e pela Zero Hora. O método utilizado é a análise de conteúdo, de Laurence Bardin. A amostra compreende o mês de fevereiro de 2016. Foram localizadas 19 matérias na Folha e três matérias em Zero Hora. A partir disso, trabalhamos sobre a defasagem noticiosa (...) entre esses veículos de comunicação. Os resultados indicam que o agendamento de cada veículo está vinculado aos fluxos da informação em cada plataforma midiática. Na Folha, há uma cobertura intensiva e difusa, enquanto em Zero Hora o agendamento é seletivo e concentrado. (shrink)

Zika virus infection in a pregnant woman may cause severe brain malformations and other birth defects in her child, and women living in or traveling to areas where it is endemic are urged to postpone pregnancy. Do the dangers posed by microcephaly justify the use of contraceptives under the principle of double effect? The author discusses ambiguities in Humanae vitae n. 14 and the claim that the use of contraceptives was approved by Pope Paul VI for nuns at (...) risk of rape, and uses the principle of double effect to show that the answer to this question is no: the use of the anovulant pill by married couples for the purpose of preventing conception of a microcephalic child cannot be licit. (shrink)

Much of the fear and uncertainty around Zika epidemics stem from potential association between Zika virus complications on infected pregnant women and risk of their babies being born with microcephaly and other neurological abnormalities. However, much remains unknown about its mode of transmission, diagnosis and long-term pathogenesis. Worries of these unknowns necessitate the need for effective and efficient psychosocial programs and medical-legal strategies to alleviate and mitigate ZIKV related burdens. In this light, local and global efforts in (...) maintaining fundamental health principles of moral, medical and legal decision-making policies, and interventions to preserve and promote individual and collectiveHuman Rights, autonomy, protection of the most vulnerable, equity, dignity, integrity and beneficence that should not be confused and relegated by compassionate humanitarian assistance and support. This paper explores the potential medical and ethical-legal implications of ZIKV epidemics emergency response packages and strategies alongside optimizing reproductive and mental health policies, programs and best practice measures. Further long-term cross-borders operational research is required in elucidating Zika-related population-based epidemiology, ethical-medical and societal implications in guiding evidence-based local and global ZIKV maternal-child health complications related approaches and interventions. Core programs and interventions including future Zika safe and effective vaccines for global Zika immunization program in most vulnerable and affected countries and worldwide should be prioritized. (shrink)

Much of the fear and uncertainty around Zika epidemics stem from potential association between Zika virus complications on infected pregnant women and risk of their babies being born with microcephaly and other neurological abnormalities. However, much remains unknown about its mode of transmission, diagnosis and long-term pathogenesis. Worries of these unknowns necessitate the need for effective and efficient psychosocial programs and medical-legal strategies to alleviate and mitigate ZIKV related burdens. In this light, local and global efforts in (...) maintaining fundamental health principles of moral, medical and legal decision-making policies, and interventions to preserve and promote individual and collectiveHuman Rights, autonomy, protection of the most vulnerable, equity, dignity, integrity and beneficence that should not be confused and relegated by compassionate humanitarian assistance and support. This paper explores the potential medical and ethical-legal implications of ZIKV epidemics emergency response packages and strategies alongside optimizing reproductive and mental health policies, programs and best practice measures. Further long-term cross-borders operational research is required in elucidating Zika-related population-based epidemiology, ethical-medical and societal implications in guiding evidence-based local and global ZIKV maternal-child health complications related approaches and interventions. Core programs and interventions including future Zika safe and effective vaccines for global Zika immunization program in most vulnerable and affected countries and worldwide should be prioritized. (shrink)

Zika infection in pregnant women is associated with an elevated probability of giving birth to a child with microcephaly and multiple other disabilities. Public health messaging on Zika prevention has predominantly targeted women who know they are pregnant or intend to become pregnant, but not teenage females for whom unintended pregnancy is more likely. Vulnerabilities among this population to reproductive risks associated with Zika are further amplified by restrictive abortion laws in several Zika-impacted states. Key to (...) prevention is enhanced, targeted public health messaging centered on teens nationally and particularly in certain high-risk regions. (shrink)

Introducción: El embarazo, aborto, las infecciones de transmisión sexual incluido el Virus de Inmuno Deficiencia Humana, se han convertido en problemas sanitarios de mayor vulnerabilidad en jóvenes. Objetivo: Describir las conductas de riesgo y prevalencia de problemas sexuales y reproductivos de estudiantes universitarios. Método: Investigación descriptiva, el universo estuvo constituido por alumnos de dos grupos de segundo semestre; el grupo de estudio conformado por la totalidad de estudiantes de la Facultad de Salud Pública ; y el control seleccionado mediante (...) una muestra aleatoria de estudiantes del resto de las facultades, se realizó esta selección con el propósito de valorar la homogeneidad de las variables entre los grupos. Resultados: Existe homogeneidad en la mayoría de conductas de riesgo y problemas sexuales en los grupos, en consecuencia estas variables no están influenciadas por la pertenencia a la Facultad de Salud Pública. Se evidencian conductas de riesgo como: inicio temprano de relaciones sexuales, múltiples parejas, infidelidad, relaciones sexuales ligadas al consumo de sustancias, dificultades con el uso de métodos anticonceptivos o de protección; se encontró prevalencia de problemas como: experiencia de embarazos, la mayoría no planeados, abortos inducidos y presencia de infecciones de transmisión sexual. Conclusiones: Existe vulnerabilidad en la salud sexual y reproductiva de los jóvenes universitarios independientemente de la formación que reciben, por tanto, emerge la necesidad de buscar alternativas integrales de promoción, prevención y educación sexual integral. Introduction: Pregnancy, abortion, sexually transmitted infections including Human Immunodeficiency Virus, have become a health problem of more vulnerable in young people. Objective: To describe risk behaviors and prevalence of sexual and reproductive problems of university. Method: Descriptive study, the universe consisted of students from two groups of second semester; the study group is conformed by students of the Public Health Faculty ; and control selected by a random sample of students from other faculties, in order to assess the homogeneity of the variables between groups. Results: Homogeneity exists in most risk behaviors and sexual problems in groups, therefore these variables are not influenced by membership in the Public Health Faculty. Risk behaviors as evidence: early initiation of sexual activity, multiple partners, infidelity, sexual relationship linked to substance consumption, which prevails alcohol, together with the non-use or inappropriate use of contraception or protection; experience of pregnancy, most unplanned, induced abortions and the presence of sexually transmitted infections: prevalence of problems as found. Conclusions: There is vulnerability in sexual and reproductive health of young students regardless of their training, thus emerges the need to find alternatives comprehensive promotion, prevention and comprehensive sex education. (shrink)

The teratogenicity of the Zika virus was considered established in 2016, and is an interesting case because three different sets of causal criteria were used to assess teratogenicity. This paper appeals to the thesis of Russo and Williamson (2007) to devise an epistemological framework that can be used to compare and evaluate sets of causal criteria. The framework can also be used to decide when enough criteria are satisfied to establish causality. Arguably, the three sets of causal criteria (...) considered here offer only a rudimentary assessment of mechanistic studies, and some suggestions are made as to alternative ways to establish causality. (shrink)

Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation (...) of post‐transcriptional RNA editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

The rapidly increasing number of cases of Zika virus and limited understanding of its congenital sequelae (e.g., microcephaly) led to stories of fear and uncertainty across social media and other mass communication networks. In this study, we used techniques generic to netnography, a form of ethnography, using Internet‐based computer‐mediated communications as a source of data to understand the experience and perceptions of families with infants diagnosed with Zika‐related microcephaly. We screened 27 YouTube™ videos published online between October (...) 2015 and July 2016, during which the Zika epidemic started, peaked, and declined. We identified three themes: (a) experiencing the news of a diagnosis of Zika‐associated microcephaly; (b) experiencing feelings and expectations of the ‘imperfect’ child; and (c) seeking to understand microcephaly to care for the child. We found that families experienced distressing feelings of shock, sadness, hopelessness, and pain, while dealing with emerging and sometimes conflicting information being transmitted by news outlets, uncertainty about the child's health, and healthcare providers’ lack of clarity to guide the family members. The ‘unknown’ factor of ZIKA was an additional stressful factor in the experience of the families. (shrink)

This paper suggests that the focus on abortion legalization in the aftermath of the Zika outbreak is distracting for policy and lawmakers from what needs to be done to address the outbreak effectively. Meeting basic health needs, together with research and development conducive to a vaccine or treatment for the Zika virus should be priorities.

The asymmetric distribution of lipids, maintained by flippases/floppases and scramblases, plays a pivotal role in various physiologic processes. Scramblases are proteins that move phospholipids between the leaflets of the lipid bilayer of the cellular membrane in an energy‐independent manner. Recent studies have indicated that viral infection is closely related to cellular lipid distribution. The level and distribution of phosphatidylserine (PtdSer) in cells have been demonstrated to be critical regulators of viral infections. Previous studies have supported that the infection of human (...) immunodeficiency virus (HIV), Zika virus, Ebola virus (EBOV), influenza virus, and dengue fever virus require the externalization of phospholipids mediated by scramblases, which are also involved in the pathogenicity of the pandemic severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). In this review, we review the relationship of scramblases with viruses and the potential viral effector proteins that might utilize host scramblases. (shrink)

Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation, with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting (...) the PAHO ethics guidance and the role of ethics in emergency responses, before turning to ethical issues that are yet to be resolved. Zika raises traditional bioethical issues related to reproduction, prenatal diagnosis of serious malformations and unjust disparities in health outcomes. But the epidemic has also highlighted important issues of growing interest in public health ethics, such as the international spread of infectious disease; the central importance of reproductive healthcare in preventing maternal and neonatal morbidity and mortality; diagnostic and reporting biases; vector control and the links between vectors, climate change, and disparities in the global burden of disease. Finally, there are controversies regarding Zika vaccine research and eventual deployment. Zika virus was a neglected disease for over 50 years before the outbreak in Brazil. As it continues to spread, public health agencies should promote gender equity and disease control efforts in Latin America, while preparing for the possibility of a global epidemic. (shrink)

El estudio de los virus ha experimentado una gran transformación en las primeras décadas del siglo XXI. El descubrimiento de los virus gigantes ha hecho que la distinción entre algunos tipos de virus y de bacterias sea cada vez más difusa, lo que obliga a replantearse el estatus epistemológico y ontológico de estas entidades biológicas. Tanto la visión clásica de los virus por parte de la Biología, como las definiciones generales que las autoridades sanitarias, y las (...) definiciones realizadas por virólogos y microbiólogos necesitan ser revisadas para dar cabida a los conocimientos actuales sobre los virus, o más concretamente, sobre los procesos virales. En este proceso de nuevos descubrimientos aparecen nuevos términos, como virión, viroide, virobiota, viroma y virocélula que deben ser tenidos en cuenta e integrados en un nuevo marco ontológico y epistemológico general. Aunque aún estamos lejos de conseguir una definición generalmente aceptada que permita diferenciar nítidamente a los virus de otras entidades biológicas similares, al final del artículo se presenta una definición tentativa, que trata de evitar las limitaciones que presentaban las definiciones anteriores. (shrink)

Existe una guerra cultural que pretende la destrucción de Occidente utilizando como caballo de Troya el enemigo interno del “virus cultural posmoderno”. Se analiza el origen complejo de dicho virus, con más de una cepa, sin descartar la posibilidad de que fuera diseñado en un laboratorio. Apelando a acabar con las verdades fuertes, el “pensamiento culturalmente correcto”impone su propia verdad fuerte sin buscar acuerdo ni síntesis con quien piensa diferente. Se examinan sus principales variantes que se caracterizan por (...) la ausencia de límites y un exceso de contradicciones que producen el aumento de la polaridad, la confusión y la fragilidad. Para contrarrestar todo ello, el artículo plantea algunas posibles vacunas en torno a la idea de un renacimiento cultural y un nuevo equilibrio entre modernidad y tradición. (shrink)

Los principales patógenos víricos que podemos ad­quirir ingiriendo alimentos contaminados son los norovirus, el virus de la hepatitis A y el virus de la hepatitis E que se propagan principalmente a través de la vía fecal oral. En los últimos años, la incidencia de brotes de transmisión alimentaria causados por estos patógenos ha experimentado un aumento considerable, en parte debido al comercio globalizado y a los cambios en los hábitos de consumo. Las matrices alimentarias que mayor riesgo representan (...) para el consumidor son los moluscos bivalvos, ve­getales de IV gama, frutas tipo baya y platos listos para comer. Actualmente las técnicas moleculares son las más habituales para la detección de estos patógenos en alimentos, aunque toda­vía existen dudas acerca del significado de la presencia de estos genomas víricos en términos de seguridad alimentaria. La infec­tividad de estos patógenos en alimentos viene también determi­nada por su elevada persistencia ambiental y por su resistencia a los tratamientos aplicados para la conservación de los alimentos. (shrink)

Es mi intención como Editor recién estrenado de los Anales de la Cátedra Francisco Suárez hacer lo posible para que la revista siga siendo un foro de referencia en la reflexión filosófica sobre los problemas que plantea la organización política de la convivencia social. Han sido precisamente esa determinación y ese criterio los que han inspirado la elección del tema al que está dedicada la Sección Monográfica de este número: el populismo.Hasta hace relativamente poco, el populismo parecía un fenómeno singular (...) hasta la extravagancia, geográficamente remoto e ideológicamente tan extremo que lo normal era decretar su irrelevancia práctica. Sin embargo, tras la gran recesión iniciada en 2008, hemos asistido a una asombrosa irrupción populista. El populismo se ha manifestado de un modo especialmente intenso allí donde, en cierto sentido, era endémico; se ha extendido, con mayor o menor ímpetu y con distintas máscaras, por todos los rincones de Europa, hasta poner en peligro la continuidad del proyecto de integración europeo; y, como colofón, ha terminado afectando a países teóricamente vacunados frente al virus populista y considerados auténticas luminarias democráticas, como es el caso de los Estados Unidos y de Gran Bretaña, que han terminado sucumbiendo a los cantos de sirena populistas. Todas esas circunstancias justificaban, por sí solas, una indagación filosófica sobre el fenómeno populista. (shrink)

El presente ensayo toma como punto de partida varios artículos de opinión con el propósito de reflexionar sobre varias cuestiones que han surgido a raíz de la crisis sanitaria, económica y social del COVID-19. La pandemia ha puesto de relieve distintos asuntos trascendentales de nuestra sociedad: la desigualdad, el uso de la tecnología, la percepción de la realidad, el lenguaje, la solidaridad o los servicios públicos.

Resumen Slavoj Zizek, afirmó que el coronavirus implicó la irrupción de lo real lacaniano en tanto imposible al saber y a lo simbólico, agujereó a la ciencia, la ideología y conmovió los cimientos del sistema global. El virus destrozó certezas ideológicas e identificaciones, cambió la escena del mundo y produjo en la subjetividad una desestabilización fantasmática de las fijaciones neoliberales sedimentadas en la cultura. Arriesgamos la hipótesis de que el coronavirus está llamado a funcionar como el significante que marca (...) un límite y nombra el fin de la época neoliberal. Palabras clave Coronavirus – neoliberalismo – real - ideología.Slavoj Zizek stated that the coronavirus involves the irruption of the Lacanian real as the impossible to know and into the symbolic. The coronavirus has pierced through science and ideology and has broken the foundations of the global system. The virus has destroyed ideological certainties and identifications, changed the world scene and produced a fantasmatic destabilization of a fixated neoliberal subjectivity sedimented in culture. We support the hypothesis that the coronavirus has come to work as a signifier which marks a limit and names the end of the neoliberal era. Keywords Coronavirus - neoliberalism - the real - ideology. (shrink)

Los estudiantes de las instituciones educativas de educación básica y media en Colombia y en el mundo, se tuvieron que enfrentar a nuevas realidades y situaciones de su proceso académico, debido a la crisis sanitaria del 2020 por el virus COVID 19, que impidió que alrededor de 1370 millones de estudiantes no asistan a la escuela en condiciones tradicionales de educación, en Latinoamérica más de 156 millones de niños y jóvenes, según la UNESCO y en Colombia más de 9,4 (...) millones de niños de educación inicial, básica y media según cifras del MEN Colombia. (shrink)

Este artículo examina las medidas adoptadas por el Gobierno de Colombia para atender las necesidades de la población diagnosticada con coinfección de los virus de inmunodeficiencia humana (VIH) y de hepatitis C (VHC), inclusive las personas privadas de la libertad, y de esa manera garantizar su derecho fundamental a la salud. Para verificar tales acciones, se realiza una revisión de las guías elaboradas por el Ministerio de Salud y Protección Social y la Cuenta de Alto Costo, en las que (...) se aborda el panorama de estas enfermedades, así como los mecanismos legales para acceder al tratamiento. Los hallazgos indican que, si bien el Sistema de Salud en Colombia no es excelente, lo cierto es que se evidenció la gestión de los últimos gobiernos para implementar una política de prevención de tales enfermedades, así como, para destinar mayores recursos públicos que permitan una adecuada satisfacción de las necesidades sanitarias de este grupo vulnerable. (shrink)

Based on the most recent metanalysis on the efficacy and safety of the human papilloma virus (HPV) vaccine, thevicissitudes in the gynecological, ethical, and bioethical fields are explored. A review of the bibliography on thesubject is made. As one of the justifications for the vaccine is the prevention of endocervical cancer, viable alter-natives for its early detection and treatment are shown and discussed. Some ethical limitations that this vaccinehas shown are analyzed. It is concluded that there is a need (...) to rethink the management of certain diseases withvaccines, achieve greater transparency in the pharmaceutical industry, resizing evidence-based medicine, anddesign educational strategies that promote behaviors that are in accordance with the nature of human sexuality -/- . (shrink)

El propósito central de este artículo consiste en realizar un análisis de la pandemia actual, intentando situar estratos básicos del fenómeno, y particularmente el modo como se estructura su mundo y los vínculos de coexistencia entre los individuos, tomando como hilo conductor un elemento que la analítica existencial heideggeriana destaca como característico del modo de apertura del hombre al mundo: el temple anímico o la disposición afectiva. Para situar este elemento y buscar una orientación para nuestra indagación, analizaremos el relato (...) de Tucídides acerca de la peste que asoló a Atenas a finales del siglo V a. C. Partiendo de las indicaciones que extraeremos de Tucídides nos encaminaremos hacia el campo de la analítica existencial para descubrir a partir de su enfoque el modo como se definen las relaciones mundanas en conexión con el temple anímico del miedo. Nos interesa mostrar cómo este temple anímico motiva una especial transformación del sentido del virus responsable de la pandemia actual, transformación que nos lleva a considerar su carácter mutualista, lo cual remitirá en última instancia y de manera retroactiva a una mejor determinación del modo de ser de la existencia humana, como esencialmente vinculada al otro, como co-existencia. (shrink)

El suicidio es una problemática grave de salud pública en México y en el mundo. La Organización Mundial de la Salud señala que cada año mueren por este medio aproximadamente 800 mil personas. De origen multifactorial, los factores de riesgo del suicidio incluyen elementos biológicos, psicológicos, sociales y culturales y, sobre todo, los trastornos mentales y las crisis de vida. Precisamente en estos dos ámbitos es donde se inserta el impacto que la pandemia del Covid-19 ha tenido en la población (...) general, en quienes han dado positivo a este virus y en el personal sanitario. Pese a que aún es pronto para reconocer con seguridad la huella profunda de la pandemia en diferentes ámbitos y, en particular, en la muerte autoprovocada, es indudable que la crisis sanitaria ha develado la imperiosa necesidad de reflexionar sobre la solidaridad, el principio de sociabilidad, subsidiariedad y la vulnerabilidad del ser humano. (shrink)

La pandemia derivada de la enfermedad por coronavirus 2019 (Covid-19) a inicios del 2020 tomó por sorpresa al mundo. A medida que el virus se expandía, varios gobiernos decidieron adoptar diferentes medidas encaminadas a limitar el número de contagios. Dichas medidas representan nuevas restricciones para algunos derechos fundamentales, varios de ellos, con una garantía ya con consolidada a través de los años. Esto fue el caso de la libertad de reunión en el ordenamiento constitucional alemán. La libertad de reunión (...) tiene un lugar importante dentro del orden objetivo de valores de la Ley Fundamental de Bonn. Sin embargo, esta libertad se vio limitada por reglamentos encaminados a proteger la vida e integridad de los individuos. En este trabajo se analizará una sentencia del Tribunal Constitucional, en la cual se puede observar los efectos de las medidas contra la enfermedad por Covid-19 en la protección de los derechos fundamentales. (shrink)

A partir de los años 90 la industria del salmón despega poniendo a Chile en el segundo lugar de exportación mundial. La instalación de las salmoneras en la isla de Chiloé ha desatado procesos de transformación económica, social y cultural importantes entre los que destaca el incremento de la participación femenina en el trabajo. El 2008 se produce la crisis de la industria salmonera por la presencia del virus ISA, lo que ha implicado cesantía y quiebre de empresas pequeñas. (...) En este artículo analizaremos como en la comuna de Quellón el auge y la crisis de la industria salmonera han puesto en juego elementos donde tradición y modernidad se expresan en las identidades de trabajadores /as de la industria salmonera que en 20 años han sido protagonistas de cambios profundos a nivel personal y colectivo. (shrink)

The Covid-19 pandemic has resulted in disruption of work and other social activities of so many people. Some were forced to stay at home and many decided to stay at home for fear of being infected with the virus. This phenomenon brought different reactions and even mental stress to many people. However, there were people who turned this kind of tragedy into creative work. This paper discusses the experiences and insights of known plant lovers in Digos City, Davao del (...) Sur Philippines. Digos City is one of the heavily affected places during the series of earthquakes that jolted Davao del Sur last year. While people are still recovering, COVID-19 added an additional burden to the residents. In this paper, we argue that their decision to focus on gardening was not only to fight boredom and to divert their attention during lockdown but this was their way of maintaining their well-being by participating in the on-going work of creation and recreation and to rise from the tragedy. We further argue that it might be good that this creative work will go beyond home gardening and beyond pots and slowly extend to creative work for environmental protection and preservation through more active engagements into reforestation activities. (shrink)

Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

For many viruses, RNA is the holder of genetic information and serves as the template for both replication and translation. While host and viral proteins play important roles in viral decision‐making, the extent to which viral RNA (vRNA) actively participates in translation and replication might be surprising. Here, the focus is on flaviviruses, which include common human scourges such as dengue, West Nile, and Zika viruses, from an RNA‐centric viewpoint. In reviewing more recent findings, an attempt is made to (...) fill knowledge gaps and revisit some canonical views of vRNA structures involved in replication. In particular, alternative views are offered on the nature of the flaviviral promoter and genome cyclization, and the feasibility of refining in vitro‐derived models with modern RNA probing and sequencing methods is pointed out. By tracing vRNA structures from translation through encapsidation, a dynamic molecule closely involved in the self‐regulation of viral replication is revealed. (shrink)

This article addresses an important, overlooked regulatory challenge during global health emergencies. It provides novel insights into how, and why, best practice can support decision makers in interpreting and implementing key guidance on conducting research during GHEs. The ability to conduct research before, during and after such events is crucial. The recent West-African Ebola outbreaks and the Zika virus have highlighted considerable room for improvement in meeting the imperative to research and rapidly develop effective therapies. A means of (...) effectively capturing these experiences and folding them into future decision-making is lacking; the need for effective practical translational measures remains. The challenge for the research community lies in extracting meaningful action-guiding content from pre-existing guidelines—which draw upon practical examples of guidelines ‘in action’—that assist in determining how to act in a particular situation. Insights are provided into the role of best practice as a means to do so; such examples can provide invaluable support to decision makers in interpreting high-level guidance; overarching guidelines retain their necessary level of generality and flexibility, whilst corresponding best practice examples—which incorporate important lessons learned—illustrate how such guidelines can be interpreted at a practical level. (shrink)

DISEASE X is the codename given by the World Health Organisation to a pathogen currently unknown to science that could cause havoc to humankind. Emerging infections are sending us multiple warnings that another Disease X is looming. We've had SARS in 2002, H5N1 bird flu in 2004, H1N1 'swine flu' in 2009, MERS in 2012, Ebola in 2014, Zika in 2015 and now COVID-19. These events are not freak events, but are happening continually, and at an increasing cadence. Written (...) by a long-standing ex-Reuters global health and science correspondent, DISEASE X will use privileged access to the body leading international efforts to control viruses, the Coalition for Epidemic Preparedness Innovations (CEPI), and its CEO, Dr Richard Hatchett. CEPI seed-funded three successful COVID vaccines, including Astra-Zeneca and Moderna. DISEASE X will explore the emergence of the novel coronavirus and the crisis it caused, analysing the responses of global health organisations and experts, including the WHO, national governments such as Britain, China and the USA, COVAX, the global vaccine allocation facility, pharmaceutical companies, and leading research scientists. Weaving in insights from the likes of Bill Gates, Sir Jeremy Farrar, Dr Anthony Fauci and Sir Patrick Vallance, the book will explain how the world's public health scientists are embarking on a 100 Days Mission to snuff out future threats before they become deadly pandemics. This is the inside story written for the public. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:PrefaceScott Paeth and Kevin CarnahanThis issue of the Journal of the Society of Christian Ethics is organized around the theme of structural evil. Each of the essays deals with some dimension of the problem of how we can conceive of evil beyond the question of simple human volition, and understand it as embedded in the institutions and cultural assumptions that we often take for granted as societal givens.Cristina Traina's (...) presidential address, "This Is the Year," takes as its starting point the aftermath of the 2016 US presidential election, arguing that it exposes the way in which liberal narratives of progress have failed to address the deeply embedded structural evil within American society. She argues that this political moment provides an opportunity for liberals to engage in a critical self-examination with respect to their complicity in these structures by embracing a form of "utopian praxis."Ryan Darr's essay considers the intersection of structural evil and individual responsibility, arguing, on the one hand, for a distinction between sin and moral wrongdoing and, on the other, for an approach to both concepts that is social in form. Esther Reed's essay, meanwhile, offers an analysis of responsibility in light of the question of structural evil, using the theology of Dietrich Bonhoeffer to aid in understanding the connection between individual responsibility and distant harm.David Cloutier continues the examination of the tension between individual agency and structural evil in his critique of the "neo-Franciscan" and "Junian" approaches to issues of violence and racism, arguing that a "critical realist" approach to structural evil provides greater resources for Christian ethics.Elizabeth Sweeny Block offers a different approach to the question in her consideration of the role of conscience in grappling with crises on a global scale, such as climate change and the Zika virus. She contrasts the "reflexive conscience" predominant in Christian ethics with a model of "engaged conscience," which may provide a better approach to large-scale structural evil and its consequences.Stewart Clem uses Thomas Aquinas's conception of virtue to understand the problems inherent in striving for moral clarity in a "post-truth" context. In [End Page vii] light of Harry Frankfurt's philosophical analysis of the concept of "bullshit," he argues that Christian ethics needs to develop a way of speaking about truth as a virtue in order to respond to the structural problem of truth indifference in contemporary political discourse.Looking at the problem from a different perspective, Christopher Jones and Conor Kelly examine the sin of sloth from a structural point of view. Critiquing individualist conceptions of the idea, they make the case for retrieving the classical definition of sloth as a vice against charity and consider how sloth can be overcome through a reinvigoration of forms of civic virtue.Another dimension of structural evil is considered by Ryan Newson in his examination of the role that Confederate monuments play in the American South. For many, they stand as a symbol of the glorification of evil that should be removed, but Newson suggests that there may be reasons to keep at least some of these monuments as reminders of the failure of justice and the judgment of God.Wonchul Shin and Elizabeth Bounds consider these questions from the perspective of how "ordinary" experiences of moral harm need to be analyzed as dimensions of structural evil, and they call for an examination of structural responsibility and the ethics of repair as a means of addressing these questions.Finally, Willa Swenson-Lengyel looks at the connection between structural evil and environmental ethics, arguing that the "moral paralysis" often experienced in light of the ecological crisis exposes certain forms of privilege that need to be addressed from the perspective of Christian ethics. In many ways, she argues, privileged inaction can be a manifestation of "works righteousness" that can be addressed through a Lutheran conception of the doctrine of justification.________This year the JSCE is retiring the demographic survey that has been used since 2008 and adopting a new demographic survey. With the transition comes an apt time for reflection on what the data from the last nine years show.The first piece of data to... (shrink)

In recent years, CRISPR-Cas9 has become one of the simplest and most cost-effective genetic engineering techniques among scientists and researchers aiming to alter genes in organisms. As Zika came to the fore as a global health crisis, many suggested the use of CRISPR-Cas9 gene drives in mosquitoes as a possible means to prevent the transmission of the virus without the need to subject humans to risky experimental treatments. This paper suggests that using gene drives or other forms of (...) genome editing in nonhumans (like mosquitos) for the purposes of disease prevention raises important issues about informed consent. Additionally, it examines the consequences this line of inquiry could have for the use of gene drives as a tool in public health and suggests that the guidance offered by informed consent protocols could help the scientific community deploy gene drives in a way that ensures that ongoing research is consistent with our ethical priorities. (shrink)

Bradford Hill (1965) highlighted nine aspects of the complex evidential situation a medical researcher faces when determining whether a causal relation exists between a disease and various conditions associated with it. These aspects are widely cited in the literature on epidemiological inference as justifying an inference to a causal claim, but the epistemological basis of the Hill aspects is not understood. We offer an explanatory coherentist interpretation, explicated by Thagard's ECHO model of explanatory coherence. The ECHO model captures the complexity (...) of epidemiological inference and provides a tractable model for inferring disease causation. We apply this model to three cases: the inference of a causal connection between the Zika virus and birth defects, the classic inference that smoking causes cancer, and John Snow’s inference about the cause of cholera. (shrink)