Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation of post‐transcriptional RNA (...) editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

Rips et al.'s proposition cannot account for the facts that (1) a historical look at the word number systems suggests that the concept of natural numbers has been progressively elaborated; (2) people from cultures without an elaborate counting system do not master the concept of natural numbers; (3) children take time to master natural numbers; and (4) the competing advantage of the postulated math schema in the natural selection process is not obvious.

Developmental dyscalculia (DD) is a pervasive difficulty affecting number processing and arithmetic. It is encountered in around 6% of school-aged children. While previous studies have mainly focused on general cognitive functions, the present paper aims to further investigate the hypothesis of a specific numerical deficit in dyscalculia. The performance of 10- and 11-year-old children with DD characterised by a weakness in arithmetic facts retrieval and age-matched control children was compared on various number comparison tasks. Participants were asked to compare a (...) quantity presented in either a symbolic (Arabic numerals, number words, canonical dots patterns) or a nonsymbolic format (noncanonical dots patterns, and random sticks patterns) to the reference quantity 5. DD children showed a greater numerical distance effect than control children, irrespective of the number format. This favours a deficit in the specialised cognitive system underlying the processing of number magnitude in children with DD. Results are discussed in terms of access and representation deficit hypotheses. (shrink)

L'ouvrage nous offre un exposé minutieux de la Poétique de Gaston Bachelard, qui nous mène à un dialogue imaginaire où María Noel Lapoujade exprime ses propres points de vue dérivés de sa Philosophie de l'imagination, des images et des imaginaires et donne ainsi les fondements de sa notion originale d'Homo imaginans. La lecture de cet ouvrage original et fondé nous conduit à un scénario peuplé de résonances inédites de la pensée de Bachelard.

Max Weber a, dans sa Sociologie de la musique, souligné l'importance de l'invention de la notation sur lignes par Guy d'Arezzo (c. 990-1035). Cet article retrace les débuts de la notation musicale. Si Guy d'Arezzo propose un système de lignes pour que chaque note ait toujours la même place, il met encore sur ces lignes les neumes inventés avant lui. Les premiers notateurs avaient cherché à noter avec précision les nuances rythmiques et ornementales des mélodies ; mais ces subtiles indications (...) disparurent peu à peu de la notation, traduisant un infléchissement de la tradition, qui contribua à orienter la musique occidentale vers des voies que ne connurent pas d'autres musiques de tradition orale. (shrink)

This article is aimed at introducing a French discourse analysis model, e.g. the ‘star model’, initiated by the LAA team led by Robert Vion in Aix-en-Provence, to English-speaking researchers. It will be argued that language activity is multi-dimensional and can be traced at various heterogeneous levels of speech productions belonging to macro as well as micro orders. Speakers achieve different varieties of positioning which result in negotiating an interactional space within a pre-given situation. The model is precisely designed to offer (...) a unified and comprehensive view of such heterogeneous phenomena in constant interconnection. In this study, we also intend to illustrate our approach through the analysis of two different corpora. Speakers’ strategies under extreme conditions will be analysed; the various sequences used were taken from a special corpus which we were asked to study as part of a national research programme. In order to illustrate interactional space shifts, we will also use the transcript of a meeting which took place between a patient and a medical investigator in a hospital in Marseilles. (shrink)

_Youth in Education_ explores the multiple, interrelated social contexts that young people inhabit and navigate, and how educational institutions cope with increasing ethnic, cultural and ideological diversity. Schools, families and communities represent important settings in which young people must make successful transitions to adulthood, and the classroom often becomes a battleground in which these contexts and values interact. With contributions from the UK, Belgium, Germany and Canada, the chapters in this book explore rich examples from Europe and North America to (...) suggest strategies that can help to counter negative perceptions, processes of stigmatization and disengagement, instead prioritising peer support and cooperative learning to give pupils a renewed sense of worth. This book takes the growing ethno-cultural diversity in education systems to heart and studies the various related educational processes from a multidisciplinary and multi-method approach. It aims to offer more insight into underlying mechanisms that are often implicit, but can be important factors that positively or negatively influence educational trajectories and outcomes. It is essential reading for researchers, academics and postgraduate students in the fields of education, sociology, higher education, policy and politics, and social and cultural geography. (shrink)

French end-of-life law aims at protecting patients from unreasonable treatments, but has been used to force caregivers to prolong treatments deemed unreasonable. We describe six cases (five intensi...

Ce livre présente cinq entretiens avec des philosophes pionniers dans le champ de la bioéthique francophone, Anne Fagot-Largeault et Jean-Yves Goff i (France), Gilbert Hottois et Jean-Noël Missa (Belgique) et Marie-Hélène Parizeau (Québec), cinq personnalités de renom, connues pour leur trajectoire exceptionnelle. Les entretiens menés avec ces auteurs au sujet de leurs oeuvres, de leurs expériences dans des comités de bioéthique et des différents débats soulevés ces dernières années nous permettent de connaître leur travail, mais aussi de faire une (...) incursion dans le développement fulgurant de la bio-médecine et des biotechnologies des cinquante dernières années. Les conséquences de ces applications, les problèmes éthiques générés, les jugements favorables et défavorables à l'égard des changements sociaux qui se sont produits et le bouleversement d'idées qui s'en est suivi, sont autant d'aspects abordés dans ces entretiens. L'utilisation du langage courant exige un effort de synthèse important; aussi ces entretiens sous la forme d'une conversation, offrent-ils au lecteur une large vision panoramique, rigoureuse et concise de l'évolution de la bioéthique francophone. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Noël Carroll THE PARADOX OFJUNK FICTION Perhaps on your way to some academic conference, if you had no papers to grade, you stopped in die airport gift shop for something to read on the plane. You saw racks of novels authored by die likes of Mary Higgins Clark, Michael Crichton, John Grisham, Danielle Steele, Sidney Sheldon, Stephen King, Sue Grafton, Elmore Leonard, Sara Paretsky, Tom Clancy, and so on. (...) These are the kinds of novels that, when you lend them to friends, you don't care, unless you live in Bowling Green, Ohio, whether you ever get them back. They are mass, popular fictions. In another era, they would have been called pulp fictions. Following Thomas Roberts,1 I will call diem junk fictions, under which rubric I will also include things like Harlequin romances; sci-fi, horror, and mystery magazines; comic books; and broadcast narratives on either the radio or TV, as well as commercial movies. There are a number of interesting philosophical questions diat we may ask aboutjunk fiction. We could, for example, attempt to characterize its essential features. However, for the present, I will assume that the preceding examples are enough to provide you with a rough-andready notion of what I am calling junk fiction, and I will attempt to explore anotiier feature of the phenomenon, viz., what I call the paradox ofjunk fiction. Thejunk fictions that I have in mind are all narratives. Indeed, dieir story dimension is die most important thing about diem. Stephen King, for instance, makes diis point by saying that he is primarily a story teller rather than a writer. Junk fictions aspire to be page-turners—the blurb on the cover of Stillwatch by Mary Higgins Clark says that it is "designed to be read at breatiitaking speed"—and what motivates turning die page so quickly is our interest in what happens next. We do not dawdle Philosophy and Literature, © 1994, 18: 225-241 226Philosophy and Literature over Clark's diction as we might over Updike's nor do we savor die complexity of her sentence structure, as we do widi Virginia Woolfs. Radier, we read for story. Moreover, junk fictions are die sort of narratives that commentators are wont to call formulaic. That is, junk fictions generally belong to well-entrenched genres, which diemselves are typified by tiieir possession of an extremely limited repertoire of story-types. For example, as John Cawelti has pointed out, one such recurring Western narrative is diat of the recendy pacifist gunfighter, like Shane, who is forced by circumstances to take up his pistols again, widi altogedier devastating effect.2 Junk fictions tell diese generic stories again and again with minor variations. Sometimes diese variations may be quite clever and unexpected. Agatiia Christie was the master of this; she was able to use the conventions of the mystery genre in order to "hide" her murderers. In TheMurderofRogerAckroyd, she "secrets" the murderer in the personage of the narrator; in Ten Little Indians, die murderer is a "dead man"; while in Murder on the Orient Express, all the suspects did it. In each of these cases, Christie's brilliance hinges upon her playing (and preying) upon conventional expectations. Neverdieless, even diese surprising variations require a well-established background of narrative forms. That is, in order to appreciate diese variations, die reader must in some sense know die standard story already. And with junk fiction, it is generally fair to say that in some sense, the reader—or, at least, the reader who has read around in die genre before—knows in rough oudine how die story is likely to go. Readers and/or viewers of Jurassic Park surmised, once die dinosaur enclosures were described, diat in fairly short order die dinosaurs would trample them down and go on the rampage—after all we had already seen or read The Lost World, King Kong, and their progeny. So, junk fictions are formulaic. They rehearse certain narrative formats again and again. And, furthermore, in some very general sense, the audience already knows die story in question. But this knowledge on die part of die audience provokes a question, specifically, why if the reader, viewer or listener already... (shrink)

Phonological Knowledge addresses central questions in the foundations of phonology and locates them within their larger linguistic and philosophical context. Phonology is a discipline grounded in observable facts, but like any discipline it rests on conceptual assumptions. This book investigates the nature, status, and acquisition of phonological knowledge: it enquires into the conceptual and empirical foundations of phonology, and considers the relation of phonology to the theory of language and other capacities of mind. The authors address a wide range of (...) interrelated questions, the most central of which is this: is phonological knowledge different from linguistic knowledge in general? They offer responses to this question from a variety of perspectives, each of which has consequences for how phonology and language are conceived. Each also involves a host of further questions concerning the modularity of mind and of language; whether phonology should be included in the language faculty; the nature-convention debate; the content of phonological elements and its relation to phonetic substance; the implications of sign languages for phonology; whether functional and variationist considerations are relevant in phonology; how phonological knowledge arises; and, not least, the data and methods appropriate for phonological inquiry. Phonological Knowledge is an important contribution to the most fundamental issues in phonology and the understanding of language. It will interest researchers in and advanced students of phonology, linguistic theory, and philosophy of language.In addition to the editors, the authors are Mary Beckman, Silvain Bromberger, Jennifer Fitzpatrick, Paul Foulkes, Mark Hale, Morris Hallé, John Harris, Harry van der Hulst, Robert Ladd, G. Lindsey, Scott Myers, Janet Pierrehumbert, Charles Reiss, Shelley Velleman, Marilyn Vihman, and Linda Wheeldon.By relating foundational questions of phonology to their larger linguistic, cognitive, and philosophical contexts this book will generate interest not only among phonologists and their advanced students, but also among all those concerned to understand the forms and functions of language. (shrink)

Supramolecular chemistry, at the interface between chemistry, physics and biology, is a research domain which has grown considerably in the last 40 years. Jean-Marie Lehn was the first to lay its foundations and formalise its concepts, in a seminal article published in 1978. This work earned him the 1987 Nobel Prize for Chemistry, which he shared with Charles J. Pedersen and Donald J. Cram. The development of SMC has led to the creation of a dedicated institute and a new (...) building on the university campus. In this chapter, the emergence of supramolecular chemistry as a paradigm and research speciality at the University of Strasbourg is reconstructed with a focus on Lehn’s central role in this process, proposing a three-period chronology based on Mullins’ sequential model. It is furthermore argued that the creation of a physical space, with particular architecture and functions, has also played a key role in consolidating what is now called the “Strasbourg’s chemistry”. The disciplinary character of SMC is discussed in reference to the concept of “new disciplinarity” put forward by Marcovich and Shinn :582–6062011, Toward a new dimension: exploring the nanoscale. Oxford University Press, Oxford, 2014). (shrink)

« Ma Chérie, ceci n'est pas censé être un journal, et il se peut même que ça ne te parvienne jamais, mais j'aime penser à toi en train de le lire, page après page, un jour dans les années à venir, après que je serai partie. J'aimerais t'entendre rire en regardant ces photos de moi. Je suis seule dans ma cabane ce soir et fatiguée ». Avertissement ou défi, ceci est la première lettre écrite par Calamity Jane à sa fille (...) le 25 septembre 1877. Une vingtaine d'autres lettres suivront, de fa.. (shrink)

« Ma Chérie, ceci n'est pas censé être un journal, et il se peut même que ça ne te parvienne jamais, mais j'aime penser à toi en train de le lire, page après page, un jour dans les années à venir, après que je serai partie. J'aimerais t'entendre rire en regardant ces photos de moi. Je suis seule dans ma cabane ce soir et fatiguée ». Avertissement ou défi, ceci est la première lettre écrite par Calamity Jane à sa fille (...) le 25 septembre 1877. Une vingtaine d'autres lettres suivront, de fa... (shrink)

Amidst the many voices clamoring to interpret the environmental crisis, some of the most important are the voices of religious traditions. Long before modernity's industrialism began the rape of Earth, premodern religious and philosophical traditions mediated to untold generations the wisdom of living as a part of nature. These traditions can illuminate and empower wiser ways of postmodern living. The original writings of Worldviews and Ecology creatively present and interpret worldviews of major religious and philosophical traditions on how humans can (...) live more sustainably on a fragile planet. Contributors include Charlene Spretnak, Larry Rasmussen, Noel Brown, Jay McDaniel, Tu Wei-Ming, Thomas Berry, David Ray Griffin, J. Baird Callicott, Eric Katz, Roger E. Timm, Robert A. White, Christopher Key Chapple, Brian Swimme, Brian Brown, Michael Tobias, Ralph Metzner, George Sessions, and Mary Evelyn Tucker and John Grim. Insights from traditions as diverse as Jain, Jewish, ecofeminist, deep ecology, Christian, Hindu, Bahai, and Whiteheadian will interest all who seek an honest analysis of what religious and philosophical traditions have to say to a modernity whose consciousness and conscience seems tragically narrow, the source of attitudes that imperil the biosphere. (shrink)

The essays in this volume discuss the life and work of French philosopher Gaston Bachelard, exploring the context of his thought, the relationship between his work on science and on poetry, and his approach to language. Contents: include: 1. "Bachelard in the Context of a Century of Philosophy of Science," by Colin Smith; 2. "Gaston Bachelard: Phenomenologist of Modern Science," by Alfons Grieder; 3. "Gaston Bachelard and Ferdinand Gonseth: Philosophers of Scientific Dialectics," by Henri Lauener; 4. "Science and Poetry in (...) the Ontology of Human Freedom: Bachelard's Account of the Poetic and the Scientific Imagination," by Noel Parker; 5. "Bachelard and the Refusal of Metaphor," by Jean-Claude Margolin; 6. "The Place of Alchemy in Bachelard's Oneiric Criticism," by John G. Clark; "Unfixing the Subject: Gaston Bachelard and Reading," by Mary McAllester. Co-published with the Center for Advanced Research in Phenomenology. (shrink)

Dernier ouvrage en date de l'excellente série dirigée par Michel Marie de l'Université de Paris III, le livre de Noël Burch et de Geneviève Sellier marque à bien des égards un moment important dans la recherche sur le cinéma en France. Bien que le cinéma de cette période trouble et troublée de l'histoire contemporaine ait déjà été traitée par d'autres (voir Jacques Siclier et François Garçon par exemple), l'approche méthodologique adoptée par les auteurs renouvelle radicalement le disc..

Dernier ouvrage en date de l'excellente série dirigée par Michel Marie de l'Université de Paris III, le livre de Noël Burch et de Geneviève Sellier marque à bien des égards un moment important dans la recherche sur le cinéma en France. Bien que le cinéma de cette période trouble et troublée de l'histoire contemporaine ait déjà été traitée par d'autres (voir Jacques Siclier et François Garçon par exemple), l'approche méthodologique adoptée par les auteurs renouvelle radicalement le disc...

Understanding Ethics introduces the frameworks of moral philosophy to analyse contemporary moral issues and perennial human dilemmas.While the early chapters ...

These essays are the fruit of many years' research by one of the world's leading Hobbes scholars. Noel Malcolm offers not only succinct introductions to Hobbes 's life and thought, but also path-breaking studies of many different aspects of his political philosophy, his scientific and religious theories, his relations with his contemporaries, the sources of his ideas, the printing history of his works, and his influence on European thought.

This book critically interrogates the work of David Harvey, one of the world’s most influential geographers, and one of its best known Marxists. Considers the entire range of Harvey’s oeuvre, from the nature of urbanism to environmental issues. Written by contributors from across the human sciences, operating with a range of critical theories. Focuses on key themes in Harvey’s work. Contains a consolidated bibliography of Harvey’s writings.

The principles that AN INSTANCE OF A CLASS IS THE CLASS and A CLASS IS AN INSTANCE OF ITSELF allow for the so called LAWS OF THOUGHTIDENTITY - WHAT IS, IS.CONTRADICTION - NOTHING BOTH IS and IS NOT.EXCLUDED MIDDLE - EVERYTHING IS or IS NOT.and allow us to adopt a bivalent system. Everything essential for primary logic is provided.Though this is not the place to discuss it, it should be noted that the development of general logic with its current theories (...) of class, identity and natural numbers could take a very different course from the one it currently pursues.Human thought would have had to evolve to a high level of development before any systematic attempt to analyse it could have been made. It seems it was in the floruit of the Greek civilisation that this attempt was first made. The issues in this paper were of prime concern to those ancient thinkers and their achievements were considerable. Since those times further developments have occurred, many of which they would not have dreamed, but to this day there are still great issues that have not been resolved. The state of the art leaves much to be desired and it is my hope that this paper will contribute to its progress.If the ideas in this paper are true, then it seems we have come across the very origins of human rationality. (shrink)