In this book of essays, he argues that morality cannot be defined solely by rational and universal principles; instead, a major place must be found for changing and conflicting ideals, values peculiar to specific times and cultures.

Proposed changes to the Common Rule are proffered to save almost 7,000 reviews annually and consequently vast amounts of investigator and IRB-member time. However, the proposed changes have been subject to criticism. While some have lauded the changes as being imperfect, but nevertheless as improvements, others have contended that ‘neither the scientific community nor the public can be confident that improved practices will emerge from the regulatory changes mandated by the NPRM.’ In the present article, I discuss an important aspect (...) that has been overlooked: the question of whether benefits will emerge is demonstrably empirical, yet data upon which to draw conclusions are conspicuous by their absence. This is thrown into sharp relief when we consider the current environment in which health research is increasingly focused on providing evidence of need or benefit, where there is greater emphasis on evidence-based practice, and when we have the nascent field of implementation science. (shrink)

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

Scientific developments take place in a socio-political context but scientists often ignore the ways their innovations will be both interpreted by the media and used by policy makers. In the rush to neuroscientific discovery important questions are overlooked, such as the ways: (1) the brain, environment and behavior are related; (2) biological changes are mediated by social organization; (3) institutional bias in the application of technical procedures ignores race, class and gender dimensions of society; (4) knowledge is used to the (...) advantage of the powerful; and (5) its applications may reinforce existing structures of power that pose ethical questions about distributive justice. The case of crime, deception and functional Magnetic Resonance Imaging (fMRI) shows the complexity, and the political and ethical challenges that confront those who seek to use neuroscience to explain the etiology of crime, and who base policy on its findings. An ethically grounded neuroscience needs to take account of existing structures of power and difference, and to develop a public neuropolitical consciousness that ensures that those subject to risk by the application of science and technology are participants in the decision-making processes involving the implementation of policies that affect them. (shrink)

In this article the author is concerned with the justification of the knowledge of other minds by virtue of statements of other people's feelings based upon inductive arguments of any ordinary pattern as being inferences from the observed to the unobserved of a familiar and accepted form. The author argues that they are not logically peculiar or invalid, When considered as inductive arguments. The author also proposes that solipsism is a linguistically absurd thesis, While at the same time stopping to (...) explain why it is a thesis which tempts those who confuse epistemological distinctions with logical distinctions. (staff). (shrink)

When and where did consciousness emerge in the course of evolution? Did it happen as recently as the past million years, for example concomitant with language or tool making in humans or primates? Or did consciousness arrive somewhat earlier, with the advent of mammalian neocortex 200 million years ago (Eccles, 1992)? At the other extreme, is primitive consciousness a property of even simple unicellular organisms of several billion years ago (e.g. as suggested by Margulis and Sagan, 1995)? Or did consciousness (...) appear at some intermediate point, and if so, where and why? Whenever it first occurred, did consciousness alter the course of evolution? (shrink)

feelings (brainstem, limbic system). The best scientific synchrony and consciousness.21,27 Anesthesiology, V 105, No 2, Aug 2006.

Newborn bloodspot screening programs are some of the longest running population screening programs internationally. Debate continues regarding the need for parents to give consent to having their child screened. Little attention has been paid to how meanings of consent-related terminology vary among stakeholders and the implications of this for practice. We undertook semi-structured interviews with parents, healthcare professionals and policy decision makers in two Canadian provinces. Conceptions of consent-related terms revolved around seven factors within two broad domains, decision-making and information (...) attainment. Decision-making comprised: parent decision authority; voluntariness; parent engagement with decision-making; and the process of enacting choice. Information ascertainment comprised: professional responsibilities ; parent responsibilities; and the need for discussion and understanding prior to a decision. Our findings indicate that consent-related terms are variously understood, with substantive implications for practice. We suggest that consent procedures should be explained descriptively, regardless of approach, so there are clear indications of what is expected of parents and healthcare professionals. Support systems are required both to meet the educational needs of parents and families and to support healthcare professionals in delivering information in a manner in keeping with parent needs. (shrink)

Freedom of mind.--Subjunctive conditionals.--Multiply general sentences.--Dispositions.--Fallacies in moral philosophy.--Ethics: A defense of Aristotle.--Ryle's the Concept of mind.--The analogy of feeling.--On referring and intending.--Feeling and expression.--Disposition and memory.--Spinoza and the idea of freedom.--A kind of materialism.--Sincerity and single-mindedness.

In the 1960’s and 1970’s there was a brief flourishing of practical and group phenomenological work, spurred by a renewed intention towards the things themselves. Despite a growing turn to phenomenology across the Humanities since the 1990’s, there is still much more written about phenomenology than phenomenology performed. This essay sketches a brief history of group phenomenological methods which have sought to remedy this situation and outlines a project nearing completion at the Department of Performance Studies at the University of (...) Sydney, Australia, using a small group of trained phenomenological researchers to study the phenomenon of being in audiences. (shrink)

Quantum aspects of brain activity and the role of consciousness. Proceedings of the National ... Casti, JL 1996. Confronting science's logical limits. ...

In the Democratic Republic of Congo, only an estimated 2% of all AIDS patients have access to treatment. As AIDS treatment access is scaled‐up in the coming years, difficult rationing decisions will have to be made concerning who will come to gain access to this scarce medical resource. This article focuses on the position, expressed by representatives of Médecins sans Frontières (MSF), that the practice of AIDS treatment access rationing is fundamentally unethical because it conflicts with the ideal of universal (...) treatment access and the human right to health. The conclusion is that MSF's position lacks coherence, has negative practical implications, and is unfair to governments struggling to increase patient's access to AIDS treatment in unfavorable circumstances. (shrink)

Of the nature and origin of the mind, by B. de Spinoza.--Spinoza and the theory of organism, by H. Jonas.--Man a machine, and The natural history of the soul, by J. O. de la Mettrie.--On the first ground of the distinction of regions in space, and What is orientation in thinking? by I. Kant.--Soul and body, by J. Dewey.--The philosophical concept of a human body, by D. C. Long.--Are persons bodies? By B. A. O. Williams.--Lived body, environment, and ego, by (...) M. Scheler.--Metaphysical journal, and A metaphysical diary, by G. Marcel.--The body, by J.-P. Sartre.--The spatiality of the lived body and motility, by M. Merleau-Ponty.--Anthropodology: man a-foot, by R. M. Griffith.--Man and his body, by H. Plügge.--The nobility of sight: a study in the phenomenology of the senses, by H. Jonas.--Born to see, bound to behold: reflections on the function of upright posture in the esthetic attitude, by E. W. Straus.--Selected reading (p. [363]-367). (shrink)

Popular songs are ubiquitous in the lives of school-age children, but the construction of traditional school music curricula does not always provide an adequate framework for studying them. In particular, the salience of words qua lyrics is an inescapable feature of popular songs, and recognizing the musical properties of those lyrics opens for study an important dimension of the real-world music that students of all ages engage so readily. Rather than treating song lyrics as separate from the music, I here (...) attempt to establish that lyrics can be treated as musical entities, as demonstrated in scholarship from popular music theorists and musicologists that highlights the musical properties of song lyrics and the musicianship of those who write them. Then, I argue that existing school curricula could do more to give lyrics their musical due, which would not only enhance the teaching and learning of popular songwriting itself, but also may expand notions of what counts as music more broadly, with benefits for school music curricula overall, perhaps especially in the domains of choral and general music. (shrink)

Anesthetic gas molecules are recognized to act by van der Waals (London dispersion) forces in hydrophobic pockets of select brain proteins to ablate consciousness. Enigmatic features of consciousness have defied conventional neurophysiological exp lanations and prompted suggestions for supplemental occurrence of macroscopic quantum coherent states and quantum computation in the brain. Are these feasible? During conscious (non-anesthetic) conditions, endogenous Van der Waals London dispersion forces occur among non-polar amino acid groups in hydrophobic pockets of neural proteins and help regulate their (...) conformation/function. London forces are weak instantaneous couplings between pairs of electron induced dipoles (e.g. between adjacent non-polar amino acid groups), and are quantum mechanical effects capable of supporting quantum superposition/computation and macroscopic quantum coherence. Quantum effects mediated by endogenous London forces in hydrophobic pockets of select neural proteins may be necessary for consciousness. The mechanism of anesthetics may be to inhibit (by exogenous London forces) the necessary quantum states. (shrink)

This article explores Augustine’s response to the Pelagians who claimed that if one truly desired to be sinless, one could be. The standard scholarly view, as articulated by Gerald Bonner, was that Augustine’s thought during the Pelagian controversy did not change over time. However, Augustine’s thoughts on sinlessness changed over a very brief period of time. He initially admits the possibility that, through grace, some may not have sinned ; he later retracts this view, only to assert in De gestis (...) Pelagii that he unsure. Finally, he returns to his original position. (shrink)

This article will exploreJerome's understanding of sinlessness and will argue that he saw himself just as opposed toAugustine as toPelagius. I begin by exposing Jerome's context in thePelagianControversy. I then expose his understanding of sinlessness. Next, I turn to his arguments inEp.133 and the first two books of hisDialogi contraPelagianos. In book three of that text, we notice a change in his arguments which indicates that Jerome is no longer arguing only againstPelagius; he now disagrees withAugustine as well. I then (...) examine a variety of issues besides sinlessness in the third book of theDialogithat reveal thatJerome disagreed withAugustine on multiple topics, showing that his opposition toAugustine's position on sinlessness was not exceptional. Finally I turn to statements byJerome that seem to indicate a positive appreciation for theBishop ofHippo, but which on closer inspection are seen to contain latent criticisms. (shrink)

From antiquity to the present the ability of clinicians to assure confidentiality has been a cornerstone of practice. Though the expectations and emphases of the various ethical codes and laws concerning confidentiality have evolved over time, it has always been the practitioner’s responsibility to observe them. The use of computers for the generation and storing of individual medical records is a significant change from our current paper-based records. That change makes the security of records a technological problem generally outside the (...) realm of physician knowledge or control. Researchers and vendors first began developing electronic health records (EHRs) in the late 1960s to 1980s. “Peripherals” were .. (shrink)

This book brings together two experienced educators from the fields of teacher education and arts education. The authors Richmond, a photographer, and Snowber, a dancer and poet, see aesthetic education as aiming to extend creativity, appreciation of the arts and nature, and the sensuous qualities of everyday life, to gain a more intimate understanding of the self and the world. They include poetic, narrative, philosophical, and artistic ways of writing to support a more embodied and holistic aesthetics. Landscapes of Aesthetic (...) Education has significance for educators, scholars, students, and artists, and for all who would like to explore the connections between the arts, aesthetics, and transformation. (shrink)

Scholars have highlighted various issues and approaches on which to focus attention within the emerging field of cross-cultural political thought. Developing a responsible methodological approach to non-Western traditions is of particular significance, given the growing importance of such traditions, the danger of cultural reductionism and the undue imposition of Western terms and categories during the comparative process. Consequently, this article argues for a historical approach to Brahmanical-Hindu political thought that examines distinctions between genres, concepts, terms and categories, including how these (...) distinctions influence the historical meaning of political ideas. To illustrate my argument, a revised interpretation of the Sanskrit word mtsyanyya -- which had been unfortunately translated into the familiar phrase 'state of nature' -- both clarifies our understanding of Brahmanical political thought and displays how existing comparisons 'domesticate' important differences between European and Brahmanical political ideas. Such analysis exposes a culturally reductive interpretive process operating within existing comparative scholarship. (shrink)

Between March and June 2008, a group of fifteen Performance Studies and Communications students at Monash University in Melbourne, Australia undertook a course on comedy based on a series of six lectures by Agnes Heller in which she outlined ideas from her book, Immortal Comedy. Subsequently, the students attended a number of comedy shows and other events to perform practical group phenomenological research with an aim to activate the ground opened by Heller’s theories through description of actual comic phenomena. The (...) outcomes—theoretical, experiential and, most surprisingly, pedagogical—were remarkable in their demonstration of the efficacy of group phenomenology as a method of intertwined practice, research and learning. (shrink)

The political thought of Mohandas K. Gandhi has been increasingly used as a paradigmatic example of hybrid political thought that developed out of a cross-cultural dialogue of eastern and western influences. With a novel unpacking of this hybridity, this article focuses on the conceptual influences that Gandhi explicitly stressed in his autobiography and other writings, particularly the works of Leo Tolstoy and the Bhagavad Gītā. This new tracing of influence in the development of Gandhi’s thought alters the substantive thrust of (...) Gandhi’s thought away from more familiar quasi-liberal interpretations and towards a far more substantive bhakti or devotional understanding of politics. The analysis reveals a conception of politics that is not pragmatic in its use of non-violence, but instead points to a devotional focus on cultivating the self (ātman), ultimately dissolving the public/private distinction that many readings of Gandhi’s thought depend upon. (shrink)

Since the rediscovery of the ancient Indian political thinker Kautilya and his Arthaśāstra in the early twentieth century, scholars have argued for similarities between his political thinking and Machiavelli’s, especially on the topic of realism. Employing a new analytic approach to reexamine their political thought, I locate unidentified tensions and overlaps between Machiavelli’s secular ethic, which pulls towards autonomous standards, and Kautilya’s political-theological ethic, which follows traditional brahmanical beliefs. In the first part of the essay, I challenge existing interpretations of (...) Kautilya’s thought and clarify a coherent political theology in the Arthaśāstra. The second part critically assesses their realist positions using the concepts of flexibility and legitimacy. While I explain how the Machiavellian position poses justifiable objections to the apparent repression and self-defeating nature of brahmanical realism, I also argue that the Kautilyan position raises important questions concerning both the flexibility and inflexibility of a secular realist position. (shrink)