BackgroundUmbilical cord banks are a central component, as umbilical cord tissue providers, in both medical treatment and scientific research with stem cells. But, whereas the creation of umbilical cord banks is seen as successful practice, it is perceived as a risky style of play by others. This article examines and discusses the ethical, medical and legal considerations that arise from the operation of umbilical cord banks in Mexico.DiscussionA number of experts have stated that the use of umbilical cord goes beyond (...) the mere utilization of human tissues for the purpose of treatment. This tissue is also used in research studies: genetic studies, studies to evaluate the effectiveness of new antibiotics, studies to identify new proteins, etc. Meanwhile, others claim that the law and other norms for the functioning of cord banks are not consistent and are poorly defined. Some of these critics point out that the confidentiality of donor information is handled differently in different places. The fact that private cord banks offer their services as "biological insurance" in order to obtain informed consent by promising the parents that the tissue that will be stored insures the health of their child in the future raises the issue of whether the consent is freely given or given under coercion. Another consideration that must be made in relation to privately owned cord banks has to do with the ownership of the stored umbilical cord.SummaryConflicts between moral principles and economic interests (non-moral principles) cause dilemmas in the clinical practice of umbilical cord blood storage and use especially in privately owned banks. This article presents a reflection and some of the guidelines that must be followed by umbilical cord banks in order to deal with these conflicts. This reflection is based on the fundamental notions of ethics and public health and seeks to be a contribution towards the improvement of umbilical cord banks' performance. (shrink)

Fluid neural networks can be used as a theoretical framework for a wide range of complex systems as social insects. In this article we show that collective logical gates can be built in such a way that complex computation can be possible by means of the interplay between local interactions and the collective creation of a global field. This is exemplified by a NOR gate. Some general implications for ant societies are outlined. ©.

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

El objetivo de este trabajo es analizar los ejemplos que se dan en las obras tradicionales del denominado καί estructural con el fin de determinar sus características desde una perspectiva más actual. Este es uno de los tipos de καί adverbial que se distinguen, pero, como veremos, se trata de una categoría compleja en la que, sobre la base de su aparición en una oración subordinada, se han mezclado al menos tres usos más o menos habituales de καί adverbial: aditivo, (...) identificativo y corresponsivo. The aim of this paper is to analyse the examples of the so-called structural καί from a modern perspective. The examples are taken from the traditional grammars, in which this adverbial use of καί is usually distinguished. As it will be shown, this is in fact a complex category, established on the basis of its appearance in a subordinate clause and including three quite common uses of adverbial καί: additive, identificational and corresponsive. (shrink)

En esta entrevista se formularon preguntas al magíster Iván Martínez, docente universitario destacado por sus conocimientos especializados en infraestructuras de redes y por sus múltiples participaciones en eventos académicos. Los interrogantes que se le plantearon se basaron en sus recientes enfoques de estudio, como el empleo de la herramienta informática de Microsoft Azure. En la conversación se llega a comprender cuál es su utilidad y cómo esta puede servir al usuario en distintos ámbitos, como el laboral. Por otro lado, el (...) ingeniero de Sistemas concluye con el modo en que sus saberes son transferidos a sus alumnos con mucha prerrogativa. (shrink)

The increasing application of artificial intelligence (AI) to healthcare raises both hope and ethical concerns. Some advanced machine learning methods provide accurate clinical predictions at the expense of a significant lack of explainability. Alex John London has defended that accuracy is a more important value than explainability in AI medicine. In this article, we locate the trade-off between accurate performance and explainable algorithms in the context of distributive justice. We acknowledge that accuracy is cardinal from outcome-oriented justice because it helps (...) to maximize patients’ benefits and optimizes limited resources. However, we claim that the opaqueness of the algorithmic black box and its absence of explainability threatens core commitments of procedural fairness such as accountability, avoidance of bias, and transparency. To illustrate this, we discuss liver transplantation as a case of critical medical resources in which the lack of explainability in AI-based allocation algorithms is procedurally unfair. Finally, we provide a number of ethical recommendations for when considering the use of unexplainable algorithms in the distribution of health-related resources. (shrink)

Alba María Laredo Delgado y Darío Méndez Salcedo Facultad de Psicología, Universidad de Granada, España La comunicación entre dos personas … Read More →.

'This book is a masterpiece of theoretical thought. It anticipates the actual achievements of much of what we now call sociolinguistics.

Privacy loss is one of the primary issues associated with the use of social media or social network sites. These sites operate by collecting and sharing data from users to obtain economic revenue. As a solution, it is recommended that users be informed about safe online practices and that they should behave accordingly. However, this does not usually happen, which makes privacy regulations ineffective. We argue that a top-down, control-focused approach to privacy, such as that found in the European Commission’s (...) recent General Data Protection Regulation, does not capture the way online practices unfold and fails to prevent privacy issues. Instead, we frame privacy using the concept of the “logic of care,” an approach that promotes a situated analysis of online practices and of the diverse actors involved (users, companies, regulators, etc.). This shift favors the creation of safer interactions on social network sites instead of restrictive regulations. (shrink)

Things and Their Place in Theories Our talk of external things, our very notion of things, is just a conceptual apparatus that helps us to foresee and ...

Las nociones de vida y biología adquieren distintos sentidos en la teoría de las generaciones o se expresan en distintas oposiciones según se sitúen en el campo político, filosófico o científico. Este artículo afronta estas dimensiones prestando especial atención al peculiar estilo de Ortega, en particular a las reiteradas metáforas biologicistas, asumiendo que son inseparables del contenido teórico presente en sus obras. Este estilo puede ser un instrumento muy apropiado para articular la relación de los campos entre sí y con (...) la biografía de Ortega, teniendo en cuenta su heterodoxa apuesta filosófica. (shrink)

The influence of age and formal education on the development of moral reasoning in a Spanish sample of students was assessed by using a Spanish translation of Rest's Defining Issues Test. Our results support the hypothesis that moral development is highly related to both variables in our cultural context, although more so with formal education than with age.

En este artículo se estudian 25 fragmentos inéditos que forman parte de 19 inscripciones árabes conservadas en el Museo Provincial de Almería. Todas ellas son de Almería, sin que conste el lugar exacto de procedencia, salvo en dos casos. La mayoría, en concreto trece inscripciones, son de carácter funerario; dos son conmemorativas o fundacionales; y el resto, cuatro, son decorativas. Su cronología va desde el segundo cuarto del siglo X al XII, predominando las de época almorávide, que es la época (...) de mayor desarrollo económico de la ciudad. (shrink)

Este artículo es una aproximación al estudio de la relación de los filósofos de la generación del 14 con la universidad. Para ello, se especificará, en primer lugar, qué se entiende por “generación del 14”. Después se analizará la situación de la Filosofía en la Universidad, desde la Restauración hasta la II República, a través de las sucesivas reformas en los planes de estudio, los procesos de selección del profesorado y su relación con el campo político. El estudio de las (...) trayectorias de algunos filósofos permitirá precisar cuál era la norma filosófica generacional y su relación con otras formas contemporáneas de práctica filosófica. Por último, se propondrá un modelo de interpretación para organizar las diversas formas de intervención política que protagonizaron los filósofos de esta generación. (shrink)

The writings and speeches of the Mexican president Andrés Manuel López Obrador (2018-2024) have been characterized by a constant reference to a teleological history. Using Karl Löwith’s proposals, I analyse the president’s liberal-progressive idea of history and I propose that in this respect he has followed a certain speculative philosophy of history, which I call philosophy of Trans-Historic-History.