The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al.1 investigated beta‐cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta‐cell replication was the only source for new beta cells without contributions from stem cells or other non‐beta cells. This underlines the capacity for (...) beta‐cell self‐renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas. BioEssays 26:1156–1159, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The live outdoor webcam seems inseparable from the mid-1990s’ popular proliferation of the Internet. Combining a well-known medium, i.e. the photograph, with a new one, i.e. the Internet, the live outdoor webcam seems in the rear-view mirror to have contributed significantly to the popular perception of the Internet as a globally distended and thus “geographical” medium. Moreover, due to its role in the NASA Triana mission, the never-realised flagship of the Clinton–Gore administration’s Digital Earth project, the live webcam seemed to (...) play an important part in the construction of what leading geographers coined a “virtual geography”—the geography of the Internet, and the networked geography—that sought to establish itself as a new field of study during the late 1990s. In order to substantiate for this interpretation, I would like in the first part of this article to identify a number of basic characteristics of the outdoor webcam and, in the second, to analyse and discuss two papers written by leading scholars in the field; papers which have been important in the assessment of the impact of the Internet and geographical information systems (GIS) before the scientific community as well as policy makers within technological innovation and the public sector. (shrink)

In a letter of 1932, Karl Popper described _Die beiden Grundprobleme der Erkenntnistheorie – The Two Fundamental Problems of the Theory of Knowledge_ – as ‘…a child of crises, above all of …the crisis of physics.’ Finally available in English, it is a major contribution to the philosophy of science, epistemology and twentieth century philosophy generally. The two fundamental problems of knowledge that lie at the centre of the book are the problem of induction, that although we are able to (...) observe only a limited number of particular events, science nevertheless advances unrestricted universal statements; and the problem of demarcation, which asks for a separating line between empirical science and non-science. Popper seeks to solve these two basic problems with his celebrated theory of falsifiability, arguing that the inferences made in science are not inductive but deductive; science does not start with observations and proceed to generalise them but with problems, which it attacks with bold conjectures. _The Two Fundamental Problems of the Theory of Knowledge_ is essential reading for anyone interested in Karl Popper, in the history and philosophy of science, and in the methods and theories of science itself. (shrink)

Existing accounts of Foucault’s archaeological methodology have not (a) contextualized the concept properly within the intellectual field of its emergence and (b) explained why it is called ‘archaeology’ and not simply ‘history’. Foucault contributed to the field of ‘history of systems of thought’ in France around 1960 by broadening its scope from the study of scientific and philosophical systems into systems of ‘knowledge’ in a wider sense. For Foucault, the term ‘archaeology’ provided a response to new methodological questions arising from (...) this initiative. Archaeological methodology had already been developed into a distinct comparative approach for the study of linguistic and cultural systems, notably by Dumézil. Foucault redevised archaeological methodology for the post-Hegelian tradition of studying ‘problems’ prevalent in the history of systems of thought. The article thus furnishes the groundwork for a ‘sociological archaeology’ or ‘problem analysis’ that is not particularly dependent on Foucault as a social theorist of power. (shrink)

In this article Troels Norager discusses the subject of sacrifice in the context of Kierkegaard's Works of Love and Fear and Trembling. The first section argues that contrary to contemporary attempts to turn Kierkegaard into a phenomenologist of love, Kierkegaard should be regarded as a radical Christian thinker who (partly for biographical reasons) deliberately emphasized the necessity of being willing to sacrifice one's most precious love object. The second part deals with Abraham's dilemma in Genesis 22 and argues, critically (...) surveying the intriguing interpretation proposed by Ingolf Dalferth, that no credible solution to this deeply troubling story is to be found. In the final section the author ponders the contemporary significance of Abraham's sacrifice and briefly points to insights from eminent political philosophers like Rawls and Habermas. This leads to the conclusion that theology should finally be taking leave of Abraham by rejecting Abraham as the 'Father of faith' and as a paradigm to be emulated. Instead, theologians and philosophers of religion are called upon to embrace our post-secular modernity without surrendering to the demands of authoritarian religion. (shrink)

This second volume in the series "Studies in Hellenistic Civilization", published for the Danish Research Council for the Humanities, offers a comprehensive analysis of the Stoic theory of Oikeiosis.

At the top of his ethical system Aristotle placed, as the supreme value, eudai- monia (happiness). But what does this really mean? ...

From Stoicism to Platonism describes the change in philosophy from around 100 BCE, when monistic Stoicism was the strongest dogmatic school in philosophy, to around 100 CE, when dualistic Platonism began to gain the upper hand - with huge consequences for all later Western philosophy and for Christianity. It is distinguished by querying traditional categories like 'eclecticism' and 'harmonization' as means of describing the period. Instead, it highlights different strategies of 'appropriation' of one school's doctrines by philosophers from the other (...) school, with all philosophers being highly conscious of their own identity. The book also sets out to break down the traditional boundaries between, on the one hand, the study of Greco-Roman philosophy in the period and, on the other hand, that of contemporary Hellenistic Jewish and early Christian writings with a philosophical profile. In these ways, the book opens up an immensely fruitful period in the history of philosophy. (shrink)

In a letter of 1932, Karl Popper described Die beiden Grundprobleme der Erkenntnistheorie – _The Two Fundamental Problems of the Theory of Knowledge_ – as ‘…a child of crises, above all of …the crisis of physics.’ Finally available in English, it is a major contribution to the philosophy of science, epistemology and twentieth century philosophy generally. The two fundamental problems of knowledge that lie at the centre of the book are the problem of induction, that although we are able to (...) observe only a limited number of particular events, science nevertheless advances unrestricted universal statements; and the problem of demarcation, which asks for a separating line between empirical science and non-science. Popper seeks to solve these two basic problems with his celebrated theory of falsifiability, arguing that the inferences made in science are not inductive but deductive; science does not start with observations and proceed to generalise them but with problems, which it attacks with bold conjectures. _The Two Fundamental Problems of the Theory of Knowledge_ is essential reading for anyone interested in Karl Popper, in the history and philosophy of science, and in the methods and theories of science itself. (shrink)

In a letter of 1932, Karl Popper described Die beiden Grundprobleme der Erkenntnistheorie – _The Two Fundamental Problems of the Theory of Knowledge_ – as ‘…a child of crises, above all of …the crisis of physics.’ Finally available in English, it is a major contribution to the philosophy of science, epistemology and twentieth century philosophy generally. The two fundamental problems of knowledge that lie at the centre of the book are the problem of induction, that although we are able to (...) observe only a limited number of particular events, science nevertheless advances unrestricted universal statements; and the problem of demarcation, which asks for a separating line between empirical science and non-science. Popper seeks to solve these two basic problems with his celebrated theory of falsifiability, arguing that the inferences made in science are not inductive but deductive; science does not start with observations and proceed to generalise them but with problems, which it attacks with bold conjectures. _The Two Fundamental Problems of the Theory of Knowledge_ is essential reading for anyone interested in Karl Popper, in the history and philosophy of science, and in the methods and theories of science itself. (shrink)

This book presents an innovative challenge to the traditional reading of Paul. Troels Engberg-Pedersen argues that the usual, mainly cognitive and metaphorical ways of understanding central Pauline concepts must be supplemented by a literal understanding that directly reflects Paul's materialist cosmology.

John and Philosophy: A New Reading of the Fourth Gospel offers a Stoic reading of the Fourth Gospel, especially its cosmology, epistemology, and ethics. It works through the gospel in narrative sequence providing a 'philosophical narrative reading'. In each section of the gospel Troels Engberg-Pedersen raises discusses philosophical questions. He compares John with Paul and Mark to offer a new reading of the transmitted text of the Fourth Gospel. Of these two profiles, the narrative one is strongly influenced by (...) the literary critical paradigm. Moreover, by attending carefully to a number of narratological features, one may come to see that the transmitted text in fact hangs together much more coherently than scholarship has been willing to see. The other profile is specifically philosophical. Scholarship has been well aware that the Fourth Gospel has what one might call a philosophical dimension. Engberg-Pedersen shows that throughout the Gospel contemporary Stoicism, works better to illuminate the text. This pertains to the basic cosmology that is reflected in the text, to the epistemology that underlies a central theme in it regarding different types of belief in Jesus, to the ethics that is introduced fairly late in the text when Jesus describes how the disciples should live once he has himself gone away from them, and more. (shrink)

Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients ( n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD (...) signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated ( r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN). (shrink)

These photographs, essays, drawings, and original texts document the rich agit-art legacy of the Situationist International, a group of European artists and writers who emerged from such avant-garde movements as COBRA, Lettrisme, and the Imaginary Bauhaus and from the breakup of surrealism to launch a strategy of art as cultural critique.