Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these (...) appear necessary to enable appropriate scarce resource allocation according to societal values. (shrink)

Central to Kuhn's notion of incommensurability are the ideas of meaning variance and lexicon, and the impossibility of translation of terms across different theories. Such a notion of incommensurability is based on a particular understanding of what a scientific language is. In this paper we first attempt to understand this notion of scientific language in the context of incommensurability. We consider the consequences of the essential multisemiotic character of scientific theories and show how this leads to even a single theory (...) being potentially 'internally incommensurable'. We then discuss Kuhn's lexicon-based approach to incommensurability and the problems associated with it. Finally we argue that this approach by Kuhn has interesting overlaps with the problem of meaning associated with multisemiosis, particularly the challenge of understanding the process of symbolization in scientific theories. (shrink)

The papers collected in this volume, although dealing with several different themes, congeal around a debate about the ways and extent of the dominance of linear time and progressive history and the concomitant delineation of the nation in Chinese and Japanese historiography.

Encyclopedic dictionary of philosophy; includes brief biographies of prominent philosophers.

A comparative study of wonder in South Asian religions.

In this paper I argue that although the Confucian idea of 'minben' is not synonymous with democracy, some its tenets are conducive to the promotion of a regime in which citizens are politically and economically empowered. In particular, I focus on the way that Confucius, Mencius and Jia Yi stress that government should meet the basic needs of its people. Material well-being is an important precondition of democracy that is often overlooked in contemporary discussions of Chinese government, which usually focus (...) on negative rights or the authoritarian state. (shrink)

Devant les désordres du monde d’aujourd’hui, il existe au sein du confucianisme chinois un courant qui tente, dans les termes traditionnels du tianxia, « tous sous le ciel », d’esquisser les contours d’un nouvel ordre du monde et d’un horizon soutenable pour l’avenir. En le rapportant aux perspectives marxistes, cet article s’efforce de dégager ses motifs essentiels et de décrypter les termes du débat auquel il donne lieu. Quels enseignements parvient-il à dégager de cette philosophie millénaire? Est-il à comprendre comme (...) une alternative au marxisme? Ou bien serait-il capable de se repenser autour d’une critique de l’impérialisme? L’article interroge en ce sens un auteur contemporain significatif, Zhao Tingyang. (shrink)

Eukaryotic genomes are packaged into nucleosomal chromatin, and genomic activity requires the precise localization of transcription factors, histone modifications and nucleosomes. Classic work described the progressive reassembly and maturation of bulk chromatin behind replication forks. More recent proteomics has detailed the molecular machines that accompany the replicative polymerase to promote rapid histone deposition onto the newly replicated DNA. However, localized chromatin features are transiently obliterated by DNA replication every S phase of the cell cycle. Genomic strategies now observe the rebuilding (...) of locus‐specific chromatin features, and reveal surprising delays in transcription factor binding behind replication forks. This implies that transient chromatin disorganization during replication is a central juncture for targeted transcription factor binding within genomes. We propose that transient occlusion of regulatory elements by disorganized nucleosomes during chromatin maturation enforces specificity of factor binding. (shrink)

The Sai Baba movement, one of the most widespread and popular modern South Asian religious movements, owes its origin to a saint, Sai Baba of Shirdi (d.1918), who was probably born around 1838. Through his successor, Sathya Sai Baba (b. 1926), the movement has become a transnational phenomenon in the late twentieth century and has also expanded the main centers of its charisma, including today Shirdi town in the Indian state of Maharashtra and Puttaparthi town in the neighboring state of (...) Andhra Pradesh. While most of the available literature is hagiographical in nature, some aspects of the movement have been studied - the figures of Shirdi Sai Baba and Sathya Sai Baba, the middle-class constituency of the Sathya Sai Baba movement, role of miracles, and the pedagogical role of movement, for instance. These studies are part of a growing interest in new religious and reformist movements in South Asia in the past century, their impacts on civil society and its institutions, and their relationships to the nation-state. (shrink)

Hegel's Eurocentrism has become something of an elephant in the room, too obvious to merit discussion. The secondary literature on Hegel often concedes that many of Hegel's comments about the Orient are misguided and uninformed, and then declares that such remarks are of no consequence to his philosophy. However, recently, some scholars have contended that Hegel's view of freedom is fundamentally connected to his negative vision of the Orient and Africa. For example, Alison Stone asserts that Hegel's idea of freedom (...) is premised on his Eurocentrism and colonialism. Drawing on Peter Sahota's essay on Hegel and Hinduism, she argues that Hegel's idea of freedom as liberation from nature tends to exclude non-Western conceptions of freedom. If Stone's contention is true, there would be no way to, as she puts it, save Hegel from himself. I argue that we can move some way towards rescuing Hegel by noting how scholars from modern Asia incorporated some of Hegel's ideas to struggle against Eurocentrism. This essay will read Hegel's comments on the Orient in light of his larger philosophy and then examine how Japanese scholars, specifically Okakura Tenshin (1863–1913) construct what could be called a Hegel-inspired defense of the concept of Asia or the Orient. I claim that if one understands the excesses of Western life to be linked to a vision of freedom based merely on self-interest and pleasure, when scholars and activists from Asia question Western culture, they actually follow Hegel's insights. Okakura, who studied Hegel in college, rethought Asia as overcoming the abstract individualist freedom of the West and replacing it a more holistic, and partially, Hegelian form of freedom. (shrink)

Spirituality-at-work is a new movement in the United States that links spirituality with business. It seeks to usher in a values-based environment wherein individuals can experience meaning and purpose in life by functioning holistically—as physical, intellectual, emotional and spiritual beings. Several examples are cited of companies actively working towards achieving such a climate, and their success in meeting social as well as fiscal responsibilities. The paper traces some of the undercurrents that have led to this new movement—rightsizing, labour force shortages, (...) entry of women, concerns for ecology and human collectivity, society's renewed interest in religion, and new thinking on the essence of leadership. The paper concludes with an examination of the likely future of the movement. (shrink)

The concept of avidyā or ignorance is central to the Advaita Vedāntic position of Śȧnkara. The post-Śaṅkara Advaitins wrote sub-commentaries on the original texts of Śaṅkara with the intention of strengthening his views. Over the passage of time the views of these sub-commentators of Śaṅkara came to be regarded as representing the doctrine of Advaita particularly with regard to the concept of avidyā. Swami Satchidanandendra Saraswati, a scholar-monk of Holenarsipur, challenged the accepted tradition through the publication of his work Mūlāvidyānirāsaḥ, (...) particularly with regard to the avidyādoctrine. It was his contention that the post-Śaṅkara commentators brought their own innovations particularly on the nature of avidyā. This was the idea of mūlāvidyā or ‘root ignorance’, a positive entity which is the material cause of the phenomenal world. Saraswati argues that such an idea of mūlāvidyā is not to be found in the bhāṣyas (commentaries) of Śaṅkara and is foisted upon Śaṅkara. This paper attempts to show that although Śaṅkara may not have explicitly favoured such a view of mūlāvidyā, his lack of clarity on the nature of avidyā left enough scope for the post-Śaṅkara commentators to take such a position on avidyā. (shrink)

The various forms of accounting practice have a long history. However, the focus of historical accounting scholarship examining premodern times has tended to be the genesis of double-entry book-keeping techniques. In particular, very few scholars have examined influences on the adoption of management accounting techniques in the ancient periods of India’s long history. We respond to this lacuna by examining management accounting at an organizational level within an ancient and economically successful society, namely the Mauryan period. The aim is to (...) explore management accounting practices implicated in the enforcement of economic and ethical behavior in the daily lives of Mauryan organizational actors. Drawing on a translation of original records in the form of a collection of texts known as the Arthasastra, this paper explores the intended uses of management accounting and, in particular, controls to persuade organizational actors to adapt the values and norms of wealth generation within the boundaries of socially acceptable roles. Our contribution is to highlight the society-oriented role of management accounting within Mauryan organizations. (shrink)

Introduction : Zhang Taiyan and Chinese modernity -- Zhang's critique of Kang Youwei : anti-Manchuism, the national essence, and revolution -- Buddhist epistemology and modern self-identity : Zhang Taiyan's "On establishing religion" -- Transfiguring modern temporality : Zhang Taiyan's critique of evolutionary history -- Daoist equalization against the universal principle : Zhang Taiyan's critique of late Qing political theory -- Conclusion : Zhang Taiyan, Lu Xun and Wang Hui : the politics of imagining a better future.

Bacteria use trans‐translation to rescue stalled ribosomes and target incomplete proteins for proteolysis. Despite similarities between tRNAs and transfer‐messenger RNA (tmRNA), the key molecule for trans‐translation, new structural and biochemical data show important differences between translation and trans‐translation at most steps of the pathways. tmRNA and its binding partner, SmpB, bind in the A site of the ribosome but do not trigger the same movements of nucleotides in the rRNA that are required for codon recognition by tRNA. tmRNA‐SmpB moves from (...) the A site to the P site of the ribosome without subunit rotation to generate hybrid states, and moves from the P site to a site outside the ribosome instead of to the E site. During catalysis, transpeptidation to tmRNA appears to require the ribosomal protein bL27, which is dispensable for translation, suggesting that this protein may be conserved in bacteria due to trans‐translation. These differences provide insights into the fundamental nature of trans‐translation, and provide targets for new antibiotics that may have decrease cross‐reactivity with eukaryotic ribosomes. (shrink)

This article describes how the COVID-19 pandemic has forced the higher education institutes in developing nations like India to relook at pedagogical approaches. Due to government imposing nationwide lockdown, higher educational institutes were quickly adopting to imbibe online learning medium. This research takes a qualitative thematic analytical approach to explore the facilitators and challenges to online learning from the perspectives of both learners and educators in higher education institutes. We have specifically explored the ethical and social concerns related to online (...) learning and the possible solution for the same. (shrink)

Description: This monograph intends to highlight Professor P.T. Raju's contribution to Indian philosophy in general and Advaita in particular. Raju is regarded as one of the architects and disseminators of Indian philosophy in the contemporary philosophical scene. This work covers a wide range of philosophical issues discussed by Raju in his writings concerning the nature of Indian philosophy, Comparative philosophy, and Advaita. His corpus of writings exhibits the richness of Indian philosophy, culture and heritage. His approach to Indian philosophy is (...) an eye opener to those who look down upon it as a form of religious occultism and mysticism. Raju vindicates that there is as much metaphysics, epistemology and logic in Indian philosophy as it is found in its Western counterpart. His commitment to Advaita is not a blind one. He is fully convinced that the arguments advanced by the Advaitins in support of their position are not dogmatic but logical in their nature. Raju critically examines other systems of philosophy, both Eastern and Western, from the standpoint of Advaita. (shrink)