Parkinsonism (PD) is a neurodegenerative disorder of the brain resulting in dopamine deficiency caused by the progressive death of dopaminergic neurons. PD is characterized by a combination of rigidity, poverty of movement, tremor and postural instability. Selegiline is a selective and irreversible propargylamine type B monoamine oxidase (MAO‐B) inhibitor. This drug, which inhibits dopamine metabolism, has been effectively used in the treatment of PD. However, its therapeutic effects are compromised by its many neurotoxic metabolites. To circumvent this obstacle, a novel (...) MAO‐B inhibitor, rasagiline, was developed. Paradoxically, the neuroprotective mechanism of propargylamines in different neuronal models appears to be independent of MAO‐B inhibition. Recent investigations into the neuroprotective mechanism of propargylamines indicate that glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), MAO‐B and/or other unknown proteins may represent pivotal proteins in the survival of the injured neurons. Delineation of the mechanism(s) involved in the neuroprotective effects exerted by MAO‐B inhibitors may provide the key to preventive novel therapeutic modalities. BioEssays 26:80–90, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

Photographers John Shimon and Julie Lindemann use antique cameras, modern lens technology, artificial light, and contemporary pop culture to create portraits of the people in their native state amidst backyards, living rooms, parking lots, and the landscape of Wisconsin. These recent photographs are juxtaposed with portraits from the Milwaukee Art Museum’s permanent collections, including daguerreotype portraits, ambrotypes, and tintypes of anonymous people taken by nineteenth-century photographers, as well with photographs by such well-known artists as Alfred Stieglitz, Sally Mann, Larry (...) Clark, Walker Evans, Nan Goldin, Eugene von Beuenchenhein, and Francis Ford. The pairings of new and old illustrate the legacy of portraiture and the significance of “posing” before the lens, and each image is enriched by its proximity to another, unmasking sitter, photographer, and viewer. Unmasked & Anonymous: Shimon & Lindemann Consider Portraiture includes more than sixty color and black-and-white photographs plus essays by Shimon, Lindemann, and Milwaukee Art Museum curator Lisa Hostetler. (shrink)

Central to contemporary cognitive science is the notion that mental processes involve computations defined over internal representations. This view stands in sharp contrast to the to visual perception and cognition, whose most prominent proponent has been J.J. Gibson. In the direct theory, perception does not involve computations of any sort; it is the result of the direct pickup of available information. The publication of Gibson's recent book (Gibson 1979) offers an opportunity to examine his approach, and, more generally, to contrast (...) the theory of direct perception with the computational/representational view. In the first part of the present article (Sections 2direct perceptioncase study”: the problem of perceiving the three-dimensional shape of moving objects is examined. This problem, which has been extensively studied within the immediate perception framework, serves to illustrate some of the inherent shortcomings of that approach. Finally, in Section 5, an attempt is made to place the theory of direct perception in perspective by embedding it in a more comprehensive framework. (shrink)

This article aims to reveal aspects of the relation between the image and the victim in Georges Bataille’s writing, certainly as this applies to writings on art, but more particularly as it applies to Bataille’s relation to the victim of torture in the photographs of Chinese lingchi punishment, which entails physical dismemberment. It will be shown that Bataille does not have a ‘media specific’ approach to the image but reflects Sartre’s notion of the image. Critiques of Bataille’s relation to the (...) lingchi photos will be addressed, so as to clarify what is at stake in the relation between image and victim. (shrink)

_Fifty Key Contemporary Thinkers_ surveys the most important figures who have influenced post-war thought. The reader is guided through structuralism, semiotics, post-Marxism and Annales history, on to modernity and postmodernity. With its comprehensive biographical and bibliographical information, this book provides a vital reference work of the last fifty years.

The problem of representing the spatial structure of images, which arises in visual object processing, is commonly described using terminology borrowed from propositional theories of cognition, notably, the concept of compositionality. The classical propositional stance mandates representations composed of symbols, which stand for atomic or composite entities and enter into arbitrarily nested relationships. We argue that the main desiderata of a representational system—productivity and systematicity—can (indeed, for a number of reasons, should) be achieved without recourse to the classical, proposition‐like compositionality. (...) We show how this can be done, by describing a systematic and productive model of the representation of visual structure, which relies on static rather than dynamic binding and uses coarsely coded rather than atomic shape primitives. (shrink)

Fifty Key Contemporary Thinkers surveys the most important figures who have influenced post-war thought. The reader is guided through structuralism, semiotics, post-Marxism and Annales history, on to modernity and postmodernity. With its comprehensive biographical and bibliographical information, this book provides a vital reference work of the last fifty years.

Review of: How Photography Changed Philosophy, Daniel Rubinstein (2023) New York and Abingdon: Routledge, 122 pp., ISBN 978-0-36769-422-7, h/bk, GBP 130.00.

Human rights are in crisis today. Everywhere one looks, there is violence, deprivation, and oppression, which human rights norms seem powerless to prevent. This book investigates the roots of the current crisis through the thought of Italian philosopher, Giorgio Agamben. Human rights theory and practice must come to grips with key problems identified by Agamben "e; the violence of the sovereign state of exception and the reduction of humanity to 'bare' life. Any renewal of human rights today must involve breaking (...) decisively with the traditional coordinates of Western political thought and instead affirm a new understanding of life and political action. (shrink)

Intelligent systems are faced with the problem of securing a principled (ideally, veridical) relationship between the world and its internal representation. I propose a unified approach to visual representation, addressing both the needs of superordinate and basic-level categorization and of identification of specific instances of familiar categories. According to the proposed theory, a shape is represented by its similarity to a number of reference shapes, measured in a high-dimensional space of elementary features. This amounts to embedding the stimulus in a (...) low-dimensional proximal shape space. That space turns out to support representation of distal shape similarities which is veridical in the sense of Shepard's (1968) notion of second-order isomorphism (i.e., correspondence between distal and proximal similarities among shapes, rather than between distal shapes and their proximal representations). Furthermore, a general expression for similarity between two stimuli, based on comparisons to reference shapes, can be used to derive models of perceived similarity ranging from continuous, symmetric, and hierarchical, as in the multidimensional scaling models (Shepard, 1980), to discrete and non-hierarchical, as in the general contrast models (Tversky, 1977; Shepard and Arabie, 1979). (shrink)

Mohandas K. Gandhi (1869–1948)’s relationship with the Jews is explored in this article. The history of this relationship can be divided into two different periods. The first begins during his formative years in South Africa from 1893 to 1914, and the second, during his political activism in India thereafter. The article points out that Gandhi’s close Jewish associates in South Africa, although coming primarily from a Theosophist background, considered their support of Gandhi and his struggle to represent their core Jewish (...) values. Still, Gandhi’s close Jewish supporters did not successfully influence Gandhi regarding Zionism. In retrospect, Gandhi’s objection to Zionism enormously impacted the Indian Congress Party’s position regarding Palestine. The article notes that although Gandhi opposed political Zionism, he supported Zionism as a spiritual movement that could be best realized “within.” Somewhat surprising and little-known fact was a desire on Gandhi’s part to mediate between the Arabs and the Jews in direct talks. Gandhi hoped the Zionist leaders would respond positively to his offer to mediate so that he could advance his teachings of nonviolence while also claiming to represent the Indian Muslims. The article discusses Gandhi’s call to German and European Jews to resist the Nazi regime by adopting Satyagraha, the consequent rift with Jewry that followed, and his silence after the Holocaust. Finally, the article also briefly explores B. R. Ambedkar (1891–1956)’s views on the Jews and the Indian pariahs. (shrink)

Society's problems cannot be alleviated via mere policy interventions, whether individual- or system-level, when the system is the problem. To bring about true and lasting change to the better, we must replace the present global political-economic system – oligarchic capitalism backed by the power of the state – with one that would let the people take charge of their lives.

This article examines the issues surrounding transcendence, the Other and base materialism in relation to Georges Bataille’s heterology and Emmanuel Levinas’s notion of the face of the Other as infinity and transcendence. The article concludes that there is no facet of human existence – including work and the economy – which is not touched by transcendence, and that the idea that there are societies based in subsistence and in nothing but a ‘struggle for existence’ is a prejudice of modernity.

Thought: A Journal of Philosophy, EarlyView.

Taking a largely thematic approach, this reflection aims to demonstrate the richness of Julia Kristeva’s theoretical work in relation to questions of justice and injustice. Injustice becomes primary because a definition of justice continues to be open to debate, whereas injustice as incarnate in the scapegoat as depicted by René Girard is far less so, if at all. Through her analyses of the work of Mallarmé and the Paris of the Dreyfus affair, Céline and abjection and anti-Semitism, the ‘need to (...) believe’ as a key component of subjectivity, the foreigner as the other in ourselves, Dostoyevsky and forgiveness, a vista is opened up onto injustice and how it might be combatted. (shrink)

Review of: Photography from the Turin Shroud to the Turing Machine, Yanai Toister (2020)Bristol and Chicago, IL: Intellect, p/bk, 215 pp.,ISBN 978-1-78938-156-6, p/bk, £37.

The strangeness of modern physics has sparked several popular books--such as The Tao of Physics--that explore its affinity with Eastern mysticism. But the founders of quantum mechanics were educated in the classical traditions of Western civilization and Western philosophy. In Nature Loves to Hide, physicist Shimon Malin takes readers on a fascinating tour of quantum theory--one that turns to Western philosophical thought to clarify this strange yet inescapable explanation of reality. Malin translates quantum mechanics into plain English, explaining its (...) origins and workings against the backdrop of the famous debate between Niels Bohr and the skeptical Albert Einstein. Then he moves on to build a philosophical framework that can account for the quantum nature of reality. He shows, for instance, how Platonic and Neoplatonic thought resonates with quantum theory. He draws out the linkage between the concepts of Neoplatonism and the more recent process philosophy of Alfred North Whitehead. The universe, Whitehead wrote, is an organic whole, composed not of lifeless objects, but "elementary experiences." Beginning with Whitehead's insight, Malin shows how this concept of "throbs of experience" expresses quantum reality, with its subatomic uncertainties, its constituents that are waves and also particles, its emphasis on acts of measurement. Once any educated person could explain the universe as a vast Newtonian web of cause and effect, but since quantum theory, reality again appears to be richer and more mysterious than we had thought. Writing with broad humanistic insight and deep knowledge of science, and using delightful conversations with fictional astronauts Peter and Julie to explain more difficult concepts, Shimon Malin offers a profound new understanding of the nature of reality--one that shows a deep continuity with aspects of our Western philosophical tradition going back 2500 years, and that feels more deeply satisfying, and truer, than the clockwork universe of Newton. (shrink)

La primera parte de este libro expone la idea o teoría de las Leyes Noájicas, desde perspectivas espirituales, filosóficas, psicológicas, sociales y políticas. Varios de sus contenidos ya han sido presentados a líderes, incluidos estadistas internacionales (cuyas cartas se incluyen aquí), que han respondido con ánimo a su estudio y difusión. La segunda parte del libro presenta la conducta o práctica concreta de las Leyes Noájicas. Esta tarea precisa procede de una extensa investigación acerca de la Tradición del comentario sobre (...) la Revelación en el Sinaí, de la cual forman parte las Leyes de Noé (que ya anteriormente eran el pacto moral de la humanidad, pero que fueron reexpresadas con autoridad en el Sinaí). La forma en que las Leyes de Noé con sus detalles estructuran la conducta ética de los principales dominios de la existencia humana se establece claramente para el lector general; y con extensas notas a pie de página y referencias para aquellos que buscan profundizar el estudio. (shrink)

This article analyses the biochemical object of tnf inhibitors from the perspective of living with an autoimmune disease. The author tries to tease out how the concept of immune inhibition is used in tandem with the biochemical object of tnf inhibitors to dominate in defining and narrating what health and disease, normal and pathological, cure and healing can mean in the context of autoimmune bodies. Specifically, and within the ‘pathological’ framework of autoimmune diseases, the pharmacological treatment of tnf inhibition is (...) designed to suppress the ‘overly’ active immune system, thus acting as a negative or suppressing biochemical agent aimed at putting the ‘malfunctioning’ immune system back in balance. As can be seen in the current conjuncture, tnf inhibitors officially —and governmentally— place those taking them in a risk group, as they 'lower' their overall bodily immunity and make them more vulnerable to infectious diseases, while stabilizing their patho-logical, ‘over’-immune uninhibited condition. Part personal narrative of being diagnosed with an autoimmune condition, part speculative autoimmune theory inspired by such a diagnosis, the article ultimately calls for a different form of embodiment that is neither negative nor affirmative, and yet is resistant even to itself. (shrink)

The editors welcome letters from readers, although we cannot guarantee that all will be published. To ensure timeliness, correspondents must respond to an article within seven weeks, and not exceed two double‐spaced pages. Letters become the property of the editors and may be edited and shortened at our discretion.

This article is a further philosophical engagement with the human-animal relation. The argument presented is that neither animals nor humans can be reduced to a biological essence characterised as ‘bare life,’ but live according to the call of a way of life. Heidegger’s thinking on the polis in terms of the animal-human relation is addressed in order to show how he reduces animality to a biological sub-stratum, while the human becomes the privileged bearer of the word. Heidegger’s deep-seated humanism is (...) thus exposed, as is that of Bataille. The latter’s Hegelian stance on animality and humanity is revealed as the embodiment of the dialectic of necessity and freedom. The article is a critique of the view that freedom and transcendence can only be arrived after so-called basic biological needs (the needs of ‘bare life,’ or necessity) have been satisfied. (shrink)

We prove that the strong polarized relation $\left( {\mu _\mu ^ + } \right) \to \left( {\mu _\mu ^ + } \right)_2^{1.1}$ is consistent with ZFC, for a singular ì which is a limit of measurable cardinals.

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts from (...) about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

Suppose $D$ is an ultrafilter on $\kappa$ and $\lambda^\kappa = \lambda$. We prove that if ${\bf B}_i$ is a Boolean algebra for every $i.

We deal here with colorings of the pair , when μ is a strong limit and singular cardinal. We show that there exists a coloring c with no refinement. It follows that the properties of colorings of when μ is singular differ in an essential way from the case of regular μ.

Arbib, Érdi, and Szentágothai's book should be a required reading for any serious student of the brain. The scope and the accessibility of its presentation of the neurobiological data (especially the functional anatomy of select parts of the central nervous system) more than make up for the peculiarities of the theoretical stance it adopts.

A theory of representation is incomplete if it states “representations areX” whereXcan be symbols, cell assemblies, functional states, or the flock of birds fromTheaetetus, without explaining the nature of the link between the universe ofXs and the world. Amit's thesis, equating representations with reverberations in Hebbian cell assemblies, will only be considered a solution to the problem of representation when it is complemented by a theory of how a reverberation in the brain can be a representation of anything.

Short essays that touch many topics-anxiety, consciousness, death, happiness, morality, stupidity, & truth-that make the case for realism & help set expectations with regard to the human condition.

Representational systems need to use symbols as internal stand-ins for distal quantities and events. Barsalou's ideas go a long way towards making the symbol system theory of representation more appealing, by delegating one critical part of the representational burden to image-like entities. The target article, however, leaves the other critical component of any symbol system theory underspecified. We point out that the binding problem can be alleviated if a perceptual symbol system is made to rely on image-like entities not only (...) for grounding the constituent symbols, but also for composing these into structures. (shrink)