Parkinsonism (PD) is a neurodegenerative disorder of the brain resulting in dopamine deficiency caused by the progressive death of dopaminergic neurons. PD is characterized by a combination of rigidity, poverty of movement, tremor and postural instability. Selegiline is a selective and irreversible propargylamine type B monoamine oxidase (MAO‐B) inhibitor. This drug, which inhibits dopamine metabolism, has been effectively used in the treatment of PD. However, its therapeutic effects are compromised by its many neurotoxic metabolites. To circumvent this obstacle, a novel (...) MAO‐B inhibitor, rasagiline, was developed. Paradoxically, the neuroprotective mechanism of propargylamines in different neuronal models appears to be independent of MAO‐B inhibition. Recent investigations into the neuroprotective mechanism of propargylamines indicate that glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), MAO‐B and/or other unknown proteins may represent pivotal proteins in the survival of the injured neurons. Delineation of the mechanism(s) involved in the neuroprotective effects exerted by MAO‐B inhibitors may provide the key to preventive novel therapeutic modalities. BioEssays 26:80–90, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

Photographers John Shimon and Julie Lindemann use antique cameras, modern lens technology, artificial light, and contemporary pop culture to create portraits of the people in their native state amidst backyards, living rooms, parking lots, and the landscape of Wisconsin. These recent photographs are juxtaposed with portraits from the Milwaukee Art Museum’s permanent collections, including daguerreotype portraits, ambrotypes, and tintypes of anonymous people taken by nineteenth-century photographers, as well with photographs by such well-known artists as Alfred Stieglitz, Sally Mann, Larry (...) Clark, Walker Evans, Nan Goldin, Eugene von Beuenchenhein, and Francis Ford. The pairings of new and old illustrate the legacy of portraiture and the significance of “posing” before the lens, and each image is enriched by its proximity to another, unmasking sitter, photographer, and viewer. Unmasked & Anonymous: Shimon & Lindemann Consider Portraiture includes more than sixty color and black-and-white photographs plus essays by Shimon, Lindemann, and Milwaukee Art Museum curator Lisa Hostetler. (shrink)

Central to contemporary cognitive science is the notion that mental processes involve computations defined over internal representations. This view stands in sharp contrast to the to visual perception and cognition, whose most prominent proponent has been J.J. Gibson. In the direct theory, perception does not involve computations of any sort; it is the result of the direct pickup of available information. The publication of Gibson's recent book (Gibson 1979) offers an opportunity to examine his approach, and, more generally, to contrast (...) the theory of direct perception with the computational/representational view. In the first part of the present article (Sections 2direct perceptioncase study”: the problem of perceiving the three-dimensional shape of moving objects is examined. This problem, which has been extensively studied within the immediate perception framework, serves to illustrate some of the inherent shortcomings of that approach. Finally, in Section 5, an attempt is made to place the theory of direct perception in perspective by embedding it in a more comprehensive framework. (shrink)

La primera parte de este libro expone la idea o teoría de las Leyes Noájicas, desde perspectivas espirituales, filosóficas, psicológicas, sociales y políticas. Varios de sus contenidos ya han sido presentados a líderes, incluidos estadistas internacionales (cuyas cartas se incluyen aquí), que han respondido con ánimo a su estudio y difusión. La segunda parte del libro presenta la conducta o práctica concreta de las Leyes Noájicas. Esta tarea precisa procede de una extensa investigación acerca de la Tradición del comentario sobre (...) la Revelación en el Sinaí, de la cual forman parte las Leyes de Noé (que ya anteriormente eran el pacto moral de la humanidad, pero que fueron reexpresadas con autoridad en el Sinaí). La forma en que las Leyes de Noé con sus detalles estructuran la conducta ética de los principales dominios de la existencia humana se establece claramente para el lector general; y con extensas notas a pie de página y referencias para aquellos que buscan profundizar el estudio. (shrink)

The strangeness of modern physics has sparked several popular books--such as The Tao of Physics--that explore its affinity with Eastern mysticism. But the founders of quantum mechanics were educated in the classical traditions of Western civilization and Western philosophy. In Nature Loves to Hide, physicist Shimon Malin takes readers on a fascinating tour of quantum theory--one that turns to Western philosophical thought to clarify this strange yet inescapable explanation of reality. Malin translates quantum mechanics into plain English, explaining its (...) origins and workings against the backdrop of the famous debate between Niels Bohr and the skeptical Albert Einstein. Then he moves on to build a philosophical framework that can account for the quantum nature of reality. He shows, for instance, how Platonic and Neoplatonic thought resonates with quantum theory. He draws out the linkage between the concepts of Neoplatonism and the more recent process philosophy of Alfred North Whitehead. The universe, Whitehead wrote, is an organic whole, composed not of lifeless objects, but "elementary experiences." Beginning with Whitehead's insight, Malin shows how this concept of "throbs of experience" expresses quantum reality, with its subatomic uncertainties, its constituents that are waves and also particles, its emphasis on acts of measurement. Once any educated person could explain the universe as a vast Newtonian web of cause and effect, but since quantum theory, reality again appears to be richer and more mysterious than we had thought. Writing with broad humanistic insight and deep knowledge of science, and using delightful conversations with fictional astronauts Peter and Julie to explain more difficult concepts, Shimon Malin offers a profound new understanding of the nature of reality--one that shows a deep continuity with aspects of our Western philosophical tradition going back 2500 years, and that feels more deeply satisfying, and truer, than the clockwork universe of Newton. (shrink)

Human rights are in crisis today. Everywhere one looks, there is violence, deprivation, and oppression, which human rights norms seem powerless to prevent. This book investigates the roots of the current crisis through the thought of Italian philosopher, Giorgio Agamben. Human rights theory and practice must come to grips with key problems identified by Agamben "e; the violence of the sovereign state of exception and the reduction of humanity to 'bare' life. Any renewal of human rights today must involve breaking (...) decisively with the traditional coordinates of Western political thought and instead affirm a new understanding of life and political action. (shrink)

An infinite cardinal λ is Magidor if and only if. It is known that if λ is Magidor then for some, and the first such α is denoted by. In this paper we try to understand some of the properties of. We prove that can be the successor of a supercompact cardinal, when λ is a Magidor cardinal. From this result we obtain the consistency of being a successor of a singular cardinal with uncountable cofinality.

After beginning by situating the author's (possible) relation to Derrida's expression, ‘democracy to come’, the article proceeds from the position that Derrida's phrase is to be understood as part of a political intervention. Indeed, the inseparability of democracy and deconstruction confirms this. After setting out some of the pertinent features of ‘democracy to come’ – seen, in part, in the General Will – the notion of political community in the thought of Hannah Arendt is brought into question, if not deconstructed. (...) Political community as presented by Arendt is seen to limit the inclusiveness of democracy. In the final section, the article suggests that Agamben's critique of the very structure of the nation-state opens the way for a renewal of the notion of the human in the ‘community to come’. (shrink)

The recent essay by Schuklenk and Smalling opposing respect for physicians’ conscientious objections to providing patients with medical services that are legally permitted in liberal democracies is based on several erroneous assumptions. Acting in this manner would have serious harmful effects on the ethos of medicine and of bioethics. A much more nuanced and balanced position is critical in order to respect physicians’ conscience with minimal damage to patients’ rights.

Review of: How Photography Changed Philosophy, Daniel Rubinstein (2023) New York and Abingdon: Routledge, 122 pp., ISBN 978-0-36769-422-7, h/bk, GBP 130.00.

Mohandas K. Gandhi (1869–1948)’s relationship with the Jews is explored in this article. The history of this relationship can be divided into two different periods. The first begins during his formative years in South Africa from 1893 to 1914, and the second, during his political activism in India thereafter. The article points out that Gandhi’s close Jewish associates in South Africa, although coming primarily from a Theosophist background, considered their support of Gandhi and his struggle to represent their core Jewish (...) values. Still, Gandhi’s close Jewish supporters did not successfully influence Gandhi regarding Zionism. In retrospect, Gandhi’s objection to Zionism enormously impacted the Indian Congress Party’s position regarding Palestine. The article notes that although Gandhi opposed political Zionism, he supported Zionism as a spiritual movement that could be best realized “within.” Somewhat surprising and little-known fact was a desire on Gandhi’s part to mediate between the Arabs and the Jews in direct talks. Gandhi hoped the Zionist leaders would respond positively to his offer to mediate so that he could advance his teachings of nonviolence while also claiming to represent the Indian Muslims. The article discusses Gandhi’s call to German and European Jews to resist the Nazi regime by adopting Satyagraha, the consequent rift with Jewry that followed, and his silence after the Holocaust. Finally, the article also briefly explores B. R. Ambedkar (1891–1956)’s views on the Jews and the Indian pariahs. (shrink)

It is proposed to conceive of representation as an emergent phenomenon that is supervenient on patterns of activity of coarsely tuned and highly redundant feature detectors. The computational underpinnings of the outlined concept of representation are (1) the properties of collections of overlapping graded receptive fields, as in the biological perceptual systems that exhibit hyperacuity-level performance, and (2) the sufficiency of a set of proximal distances between stimulus representations for the recovery of the corresponding distal contrasts between stimuli, as in (...) multidimensional scaling. The present preliminary study appears to indicate that this concept of representation is computationally viable, and is compatible with psychological and neurobiological data. (shrink)

We deal here with colorings of the pair , when μ is a strong limit and singular cardinal. We show that there exists a coloring c with no refinement. It follows that the properties of colorings of when μ is singular differ in an essential way from the case of regular μ.

Taking a largely thematic approach, this reflection aims to demonstrate the richness of Julia Kristeva’s theoretical work in relation to questions of justice and injustice. Injustice becomes primary because a definition of justice continues to be open to debate, whereas injustice as incarnate in the scapegoat as depicted by René Girard is far less so, if at all. Through her analyses of the work of Mallarmé and the Paris of the Dreyfus affair, Céline and abjection and anti-Semitism, the ‘need to (...) believe’ as a key component of subjectivity, the foreigner as the other in ourselves, Dostoyevsky and forgiveness, a vista is opened up onto injustice and how it might be combatted. (shrink)

Fifty Key Contemporary Thinkers surveys the most important figures who have influenced post-war thought. The reader is guided through structuralism, semiotics, post-Marxism and Annales history, on to modernity and postmodernity. With its comprehensive biographical and bibliographical information, this book provides a vital reference work of the last fifty years.

This innovative introductory text not only clearly explains Kristeva's most difficult ideas, but also provides new insights into her work.

We prove that the strong polarized relation $\left( {\mu _\mu ^ + } \right) \to \left( {\mu _\mu ^ + } \right)_2^{1.1}$ is consistent with ZFC, for a singular ì which is a limit of measurable cardinals.

Lasnik’s review of the Minimalist program in syntax [1] offers cognitive scientists help in navigating some of the arcana of the current theoretical thinking in transformational generative grammar. One may observe, however, that this journey is more like a taxi ride gone bad than a free tour: it is the driver who decides on the itinerary, and questioning his choice may get you kicked out. Meanwhile, the meter in the cab of the generative theory of grammar is running, and has (...) been since the publication of Chomsky’s Syntactic Structures in 1957. The fare that it ran up is none the less daunting for the detours made in his Aspects of Theory of Syntax in 1965, Government and Binding in 1981, and now The Minimalist Program, in 1995. Paraphrasing Winston Churchill, it seems like never in the field of cognitive science was so much owed by so many of us to so few. For most of us in the cognitive sciences this situation will appear quite benign, if we realize that it is the generative linguists who should by rights be paying this bill. The reason for that is simple and is well known in the philosophy of science: putting forward a theory is like taking out a loan, to be repayed by gleaning an empirical basis for it; theories that fail to do so are declared bankrupt. In the sciences of the mind, this maxim translates into the need to demonstrate the psychological, and, eventually, the neurobiological, reality of the theoretical constructs. Many examples of this process can be found in the study of human vision, where, as in language, direct observation of the underlying mechanisms is difficult; for instance, the concept of multiple parallel spatial frequency channels, introduced in the late 1960s, was completely vindicated by purely behavioral means over the following decade; see, e.g., [2]. In linguistics, the nature of the requisite evidence is well described by Townsend and Bever: “What do we test today if we want to explore the behavioral implications of syntax?. (shrink)

Society's problems cannot be alleviated via mere policy interventions, whether individual- or system-level, when the system is the problem. To bring about true and lasting change to the better, we must replace the present global political-economic system – oligarchic capitalism backed by the power of the state – with one that would let the people take charge of their lives.

We characterize the situation of having at least $^{+}$-many normal ultrafilters on a measurable cardinal $\kappa$. We also show that if $\kappa$ is a compact cardinal, then $\kappa$ carries $^{+}$-many $\kappa$-complete ultrafilters, each of which extends the club filter on $\kappa$.

A few years ago, a Yemenite patient came to Maimonides Hospital in Brooklyn. The friendly, diminutive gentleman apologized for visiting the clinic in the first place because, as he explained, he was a devotee of Maimonides and invariably used the medical treatments recommended by him rather than current Western medicine. But for this patient’s problem, Maimonides had prescribed garlic. The patient told his doctor that if he ingested garlic, his wife would refuse contact with him. So, having no alternative, he (...) came to our clinic for consultation and to see if there were any other appropriate treatments.Moses Maimonides was one the most important Jewish scholars of all times. A popular folk saying.. (shrink)

This article is a further philosophical engagement with the human-animal relation. The argument presented is that neither animals nor humans can be reduced to a biological essence characterised as ‘bare life,’ but live according to the call of a way of life. Heidegger’s thinking on the polis in terms of the animal-human relation is addressed in order to show how he reduces animality to a biological sub-stratum, while the human becomes the privileged bearer of the word. Heidegger’s deep-seated humanism is (...) thus exposed, as is that of Bataille. The latter’s Hegelian stance on animality and humanity is revealed as the embodiment of the dialectic of necessity and freedom. The article is a critique of the view that freedom and transcendence can only be arrived after so-called basic biological needs have been satisfied. (shrink)

_Fifty Key Contemporary Thinkers_ surveys the most important figures who have influenced post-war thought. The reader is guided through structuralism, semiotics, post-Marxism and Annales history, on to modernity and postmodernity. With its comprehensive biographical and bibliographical information, this book provides a vital reference work of the last fifty years.

The problem of representing the spatial structure of images, which arises in visual object processing, is commonly described using terminology borrowed from propositional theories of cognition, notably, the concept of compositionality. The classical propositional stance mandates representations composed of symbols, which stand for atomic or composite entities and enter into arbitrarily nested relationships. We argue that the main desiderata of a representational system — productivity and systematicity — can (indeed, for a number of reasons, should) be achieved without recourse to (...) the classical, proposition-like compositionality. We show how this can be done, by describing a systematic and productive model of the representation of visual structure, which relies on static rather than dynamic binding and uses coarsely coded rather than atomic shape primitives. (shrink)

The problem of representing the spatial structure of images, which arises in visual object processing, is commonly described using terminology borrowed from propositional theories of cognition, notably, the concept of compositionality. The classical propositional stance mandates representations composed of symbols, which stand for atomic or composite entities and enter into arbitrarily nested relationships. We argue that the main desiderata of a representational system—productivity and systematicity—can (indeed, for a number of reasons, should) be achieved without recourse to the classical, proposition‐like compositionality. (...) We show how this can be done, by describing a systematic and productive model of the representation of visual structure, which relies on static rather than dynamic binding and uses coarsely coded rather than atomic shape primitives. (shrink)

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts from (...) about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

This article analyses the biochemical object of tnf inhibitors from the perspective of living with an autoimmune disease. The author tries to tease out how the concept of immune inhibition is used in tandem with the biochemical object of tnf inhibitors to dominate in defining and narrating what health and disease, normal and pathological, cure and healing can mean in the context of autoimmune bodies. Specifically, and within the ‘pathological’ framework of autoimmune diseases, the pharmacological treatment of tnf inhibition is (...) designed to suppress the ‘overly’ active immune system, thus acting as a negative or suppressing biochemical agent aimed at putting the ‘malfunctioning’ immune system back in balance. As can be seen in the current conjuncture, tnf inhibitors officially —and governmentally— place those taking them in a risk group, as they 'lower' their overall bodily immunity and make them more vulnerable to infectious diseases, while stabilizing their patho-logical, ‘over’-immune uninhibited condition. Part personal narrative of being diagnosed with an autoimmune condition, part speculative autoimmune theory inspired by such a diagnosis, the article ultimately calls for a different form of embodiment that is neither negative nor affirmative, and yet is resistant even to itself. (shrink)

Short essays that touch many topics-anxiety, consciousness, death, happiness, morality, stupidity, & truth-that make the case for realism & help set expectations with regard to the human condition.

We show that the character spectrum Spχ may include any prescribed set of regular cardinals between λ and 2λ.

We study the structural rainbow Ramsey theory at uncountable cardinals. Compared to the usual rainbow Ramsey theory, the variation focuses on finding a rainbow subset that not only is of a certain cardinality but also satisfies certain structural constraints, such as being stationary or closed in its supremum. In the process of dealing with cardinals greater than ω1, we uncover some connections between versions of Chang's Conjectures and instances of rainbow Ramsey partition relations, addressing a question raised in [18].