Biomedical research is so important that there is a positive moral obligation to pursue it and to participate in itScience is under attack. In Europe, America, and Australasia in particular, scientists are objects of suspicion and are on the defensive.i“Frankenstein science”5–8 is a phrase never far from the lips of those who take exception to some aspect of science or indeed some supposed abuse by scientists. We should not, however, forget the powerful obligation there is to undertake, support, and (...) participate in scientific research, particularly biomedical research, and the powerful moral imperative that underpins these obligations. Now it is more imperative than ever to articulate and explain these obligations and to do so is the subject and the object of this paper.Let me present the question in its starkest form: is there a moral obligation to undertake, support and even to participate in serious scientific research? If there is, does that obligation require not only that beneficial research be undertaken but also that “we”, as individuals and “we” as societies be willing to support and even participate in research where necessary?Thus far the overwhelming answer given to this question has been “no”, and research has almost universally been treated with suspicion and even hostility by the vast majority of all those concerned with the ethics and regulation of research. The so called “precautionary approach”9 sums up this attitude, requiring dangers to be considered more likely and more serious than benefits, and assuming that no sane person would or should participate in research unless they had a pressing personal reason for so doing, or unless they were motivated by a totally impersonal altruism. International agreements and protocols—for example, the Declaration of Helsinki10 and the CIOMS Guidelines11—have been directed principally at …. (shrink)

This essay analyzes the concept of public trust in science and offers some guidance for ethicists, scientists, and policymakers who use this idea defend ethical rules or policies pertaining to the conduct of research. While the notion that public trusts science makes sense in the abstract, it may not be sufficiently focused to support the various rules and policies that authors have tried to derive from it, because the public is not a uniform body with a common set of (...) interests. Well-focused arguments that use public trust to support rules or policies for the conduct of research should specify (a) which public is being referred to (e.g. the general public or a specific public, such as a particular community or group); (b) what this public expects from scientists; (c) how the rule or policy will ensure that these expectations are met; and (d) why is it important to meet these expectations. (shrink)

I argue that the title question needs to be taken seriously because there are important questions about how the scientific agenda should be set. Natural answers to the question – declarations of the proper autonomy of science or expressions of faith in market forces – are found inadequate. Instead, I propose a form of democracy with respect to scientific research that will avoid the obvious dangers of a tyranny of ignorance. I conclude with some modest proposals about (...) how the ideal of a democratic science might be implemented and with a response to common objections. (shrink)

Original research is of course what scientists are expected to do. Therefore the research project is in many ways the unit of science in the making: it is the center of the professional life of the individual scientist and his coworkers. It is also the means towards the culmination of their specific activities: the original publication they hope to contribute to the scientific literature. The scientific project should therefore be of central interest to all the students (...) of science, particularly the philosophers and sociologists of science. We shall focus on the preliminary evaluation of research projects—the specific task of referees—and will emphasize the problem of their scientificity—the chief concern of scientific gatekeepers. In the past such an examination aimed only at protecting the taxpayer from swindlers and incompetent amateurs, such as the inventors of continuous motion artifacts. In recent times a similar issue has resurfaced with regard to some of the most prestigious and most handsomely funded projects, namely work on string theory and many-worlds cosmology. Indeed, some of their faithful have claimed that these theories are so elegant, and so full of high-grade mathematics, that they should be exempted from empirical tests. This claim provoked the spirited rebuttal of the well-known cosmologists Ellis and Silk, which the present paper is intended to reinforce. Indeed, we shall try to show why empirical testability is necessary though insufficient for a piece of work to qualify as scientific. Finally, the present paper may also be regarded as an indirect contribution to the current debate over the reliability of quantitative indicators of scientific worth, such as the h-index of scientific productivity. But we shall touch only tangentially on the sociological, political, and economics of research teams: our focus will be the acquisition of new scientific knowledge. (shrink)

With the recent rise of the philosophy of scientific practices, SSK (Sociology of Scientific Knowledge), and feminist approaches to the philosophy of science, a new perspective is gradually coming into being, holding that the starting point for scientific research is opportunity. Opportunistic features in solar neutrino experiments, Opportunistic features of complexity studies emerging from economics, and the measurement of insects’ flight can prove the above perspective from different angels. It is important and significant to determine whether (...) the starting point for scientific research is opportunity, a problem, or an observation. (shrink)

Continuously from the 1940s, Michael Polanyi comments on topics that have resonated later since the 1960s in the works of his fellow theorists of science, philosophers of natural sciences, and epistemologists. First part of this article provides a brief reconstruction of Polanyi’s concept of „personal knowledge“ which focuses mainly on the interconnection of the individual level of scientific research with its social dimension. My aim is to evaluate the potential of this concept for the interpretation of research (...) fields where sciences are in close contact with other disciplines. I am convinced that Polanyi’s original approach to the problem of reality should be read as an advocacy of diversity of thought. In my interpretation, Polanyi carries out some form of philosophical therapy of science and its self-concept, which, like the whole of Western society, has undergone dramatic changes over the last century. (shrink)

With the recent rise of the philosophy of scientific practices, SSK (Sociology of Scientific Knowledge), and feminist approaches to the philosophy of science, a new perspective is gradually coming into being, holding that the starting point for scientific research is opportunity. Opportunistic features in solar neutrino experiments, Opportunistic features of complexity studies emerging from economics, and the measurement of insects' flight can prove the above perspective from different angels. It is important and significant to determine whether (...) the starting point for scientific research is opportunity, a problem, or an observation. /// 近年来由于科学实践哲学的兴起，以及 SSK 和女性主义科学哲学研究的兴起， 科学研究始于机会的观点正在悄然形成之中。太阳中微子实验、复杂性研究和昆虫 飞行测量等案例都从不同角度证明了 "科学研究始于机会" 的观点。区别科学研究 "始于机会"、"始于问题" 和 "始于观察" 这三种观点，是重要而且有意义的。. (shrink)

In ‘Scientific Research and Moral Rectitude’ Robert Hoffman defends the scientific community against critics who maintain that ‘the researcher's claim to freedom of inquiry should be upheld only if his discovery does not adversely affect mankind….’ He uses two arguments in his defence, both of which purport to show that this sort of criticism is logically misconceived.

Lakatos’s methodology of scientific research programmes centres around series of theories, with little regard to the role of models in theory construction. Modifying it to incorporate model-groups, clusters of developmental models that are intended to become new theories, provides a description of the model dynamics within the search for physics beyond the standard model. At the moment, there is no evidence for BSM physics, despite a concerted search effort especially focused around the standard model account of electroweak symmetry (...) breaking. Using the framework provided by Lakatosian research programmes, we can capture the way the periphery of a model-group changes as the available parameter space shrinks, while its central tenets remain untouched by unfavourable experimental findings. By way of motivation, I provide two case studies of model-groups that offer alternative mechanisms for electroweak symmetry breaking: supersymmetry and composite-Higgs models. Both of these model-groups are under pressure from the discovery of the Higgs boson, yet they have both been active research projects in the years after the Higgs discovery. However, a proper assessment of the progress of an ongoing research programme is impossible through a purely Lakatosian lens, so I propose replacing it with Laudan’s problem-solving account, which provides ongoing assessment, while offering normative guidance concerning the pursuit-worthiness of research programmes. My incorporation of model-groups into Lakatosian research programmes captures the developments of two attempts to expand our physical description of the world, and Laudan’s problem-solving rationality allows us to assess their pursuit-worthiness. (shrink)

In his recent work exploring the role of science in democratic societies Kitcher claims that scientists ought to have a prominent role in setting the agenda for and limits to research. Against the backdrop of the claim that the proper limits of scientific inquiry is John Stuart Mill’s Harm Principle , he identifies the limits of inquiry as the point where the outcomes of research could cause harm to already vulnerable populations. Nonetheless, Kitcher argues against explicit limitations (...) on unscrupulous research on the grounds that restrictions would exacerbate underlying social problems. I show that Kitcher’s argument in favor of dissuading inquiry through conventional standards is problematic and falls prey to the same critique he offers in opposition to official bans. I expand the conversation of limiting scientific research by recognizing that the actions that count as ‘science’ are located in the space between ‘thinking’ and ‘doing’. In this space, we often attempt to balance freedom of research, as scientific speech, against the disparate impact citizens might experience in light of such research. I end by exploring if such disparate impact justifies limiting research, within the context of the United States, under Title VII of the Civil Rights Act of 1964 or under international human rights standards more generally. (shrink)

An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences. In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent (...) explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility—the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized. When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993. (shrink)

Imre Lakatos' philosophical and scientific papers are published here in two volumes. Volume I brings together his very influential but scattered papers on the philosophy of the physical sciences, and includes one important unpublished essay on the effect of Newton's scientific achievement. Volume II presents his work on the philosophy of mathematics (much of it unpublished), together with some critical essays on contemporary philosophers of science and some famous polemical writings on political and educational issues. Imre Lakatos had (...) an influence out of all proportion to the length of his philosophical career. This collection exhibits and confirms the originality, range and the essential unity of his work. It demonstrates too the force and spirit he brought to every issue with which he engaged, from his most abstract mathematical work to his passionate 'Letter to the director of the LSE'. Lakatos' ideas are now the focus of widespread and increasing interest, and these volumes should make possible for the first time their study as a whole and their proper assessment. (shrink)

This article examines the question of how can museum professionals and the interested public resolve the competing claims of traditional ownership and continuing scientific research in relation to museum collections.

Frauds and misconduct have been common in the history of science. Recent events connected to the COVID-19 pandemic have highlighted how the risks and consequences of this are no longer acceptable. Two papers, addressing the treatment of COVID-19, have been published in two of the most prestigious medical journals; the authors declared to have analysed electronic health records from a private corporation, which apparently collected data of tens of thousands of patients, coming from hundreds of hospitals. Both papers have been (...) retracted a few weeks later. When such events happen, the confidence of the population in scientific research is likely to be weakened. This paper highlights how the current system endangers the reliability of scientific research, and the very foundations of the trust system on which modern healthcare is based. Having shed light on the dangers of a system without appropriate monitoring, the proposed analysis suggests to strengthen the existing journal policies and improve the research process using new technologies supporting control activities by public authorities. Among these solutions, we mention the promising aspects of the blockchain technology which seems a promising solution to avoid the repetition of the mistakes linked to the recent and past history of research. (shrink)

Modern science, whose methodologies give special privilege to using decontextualizing strategies and downplay the role of context-sensitive strategies, have been extraordinarily successful in producing knowledge whose applications have transformed the shape of the lifeworld. Nevertheless, I argue that how the mainstream of the modern scientific tradition interprets the nature and objectives of science is incoherent; and that today there are two competing interpretations of scientific activities that are coherent and that maintain continuity with the success of the tradition: (...) "commercially-oriented technoscience" and "multi-strategy research" . The greater part of this article is devoted to discussing what is involved in MS, by pointing to its positive research program in three areas , and its critical stance towards the innovations of CT, especially insofar as it makes use of the Precautionary Principle. In this way important dimensions of the agenda of science and technology for social justice, democratic participation and sustainability become clear. (shrink)

Chapter discussing what it takes for an activity to be an instance of scientific research.

In this paper, we empirically explore some manifestations of norms for the conduct of science. We focus on scientific research ethics and report survey results from 606 scientists who received funding in 1993 and 1994 from the Division of Molecular and Cellular Biology of the Biology Directorate of the National Science Foundation. We also report results for 91 administrators charged with overseeing research integrity at the scientists’ research institutions. Both groups of respondents were presented with a (...) set of scenarios, designed by fractional factorial methods, describing different kinds of scientific conduct that in the eyes of some would likely be unethical. Respondents then were asked to evaluate each of these scenarios for how unethical the behavior might be and what kinds of sanctions might be appropriate. We use the responses to consider the nature of consensus around norms related to the practice of science and in particular, similarities and differences between scientists and science administrators. Implications for policy are also discussed. (shrink)

This article gives a personal perception of the author, of what scientific research means. Citing examples from the lives of all time greats like Newton, Kelvin and Maxwell he stresses the agonies of thinking up new ideas, the urge for creativity and the pleasure one derives from the process when it is completed. He then narrates instances from his own life that proved inspirational towards his research career. In his early studenthood, his parents and maternal uncle had (...) widened his intellectual horizons while in later life his interaction with Fred Hoyle made him take up research challenges away from the beaten path. He concludes that taking up an anti-Establishment stand in research can create many logistical difficulties, but the rewards of success are all the more pleasing. (shrink)

A persistent puzzle for philosophers of science is the well-documented appeal made by scientists to their aesthetic emotions in the course of scientific research. Emotions are usually viewed as irremediably subjective, and thus of no epistemological interest. Yet, by denying an epistemic role for scientists’ emotional dispositions, philosophers find themselves in the awkward position of ignoring phenomena which scientists themselves often insist are of importance. This paper suggests a possible solution to this puzzle by challenging the wholesale identification (...) of emotion with subjectivity. The proposed method is a naturalistic and externalist one, calling for empirical investigation into the intersubjective processes by which scientists’ emotional dispositions become refined and attuned to specific objects of attention. The proposal is developed through a critical discussion of Michael Polanyi’s theory of scientific passions, as well as plant geneticist Barbara McClintock’s celebrated “feeling for the organism.”. (shrink)

We live in a world in which scientific expertise and its epistemic authority become more important. On the other hand, the financial interests in research, which could potentially corrupt science, are increasing. Due to these two tendencies, a concern for the integrity of scientific research becomes increasingly vital. This concern is, however, hollow if we do not have a clear account of research integrity. Therefore, it is important that we explicate this concept. Following Rudolf Carnap’s (...) characterization of the task of explication, this means that we should develop a concept that is (1) similar to our common sense notion of research integrity, (2) exact, (3) fruitful, and (4) as simple as possible. Since existing concepts do not meet these four requirements, we develop a new concept in this article. We describe a concept of epistemic integrity that is based on the property of deceptiveness, and argue that this concept does meet Carnap’s four requirements of explication. To illustrate and support our claims we use several examples from scientific practice, mainly from biomedical research. (shrink)

When interests and preferences of researchers or their sponsors cause bias in experimental design, data interpretation or dissemination of research results, we normally think of it as an epistemic shortcoming. But as a result of the debate on science and values, the idea that all extra-scientific influences on research could be singled out and separated from pure science is now widely believed to be an illusion. I argue that nonetheless, there are cases in which research is (...) rightfully regarded as epistemologically deficient due to the influence of preferences on its outcomes. I present examples from biomedical research and offer an analysis in terms of social epistemology. (shrink)

In the modern world, science and technology touch our lives every day, and if they are to serve the public interest it is more important than ever that society discusses the way in which scientific research is performed, funded, organized and reported. Science for Survival provides an accessible and readable examination of the ways in which society interacts with science and the means by which political and other leaders use and misuse science and engineering. Case studies, such as (...) the handling of 'mad cow disease' and the internet revolution, reveal both how mistakes are often made in handling science and technology, and also how good practice can contribute to the public interest. Each of the first eight chapters of Science for Survival is focused on an issue of public debate – such as the environment, unemployment, defence, pensions, or transport policy – and uses recent examples and historical parallels to demonstrate different aspects of the relationship between science and the rest of society. The final chapter examines some of the ways in which society can discuss science, technology and engineering in order to maximise mutual understanding between scientists and non-scientists. Science for Survival is written for anyone who cares about the public interest in twenty-first century society, and about how science and technology can be used to serve the public good. (shrink)

Book reviewedJames F. Keenan, Catholic Ethicists on HIV/AIDS Prevention.

Extending and expanding Geiger and Feller’s analysis of increasing dispersion in R&D expenditures during the 1980s, the paper analyzes publication and citation counts as well as R&D expenditures for 194 top producers using Web of Science data. We find high and stable levels of inequality in the 1990s and 2000s, combined with robust growth both in the system and on individual campuses, considerable opportunities for short-range mobility and very limited opportunities for long-range mobility. Initial investments in research, private control, (...) and the capacity of wealthy institutions to attract productive faculty are associated with high levels of scientific output. New entrants to the system and those that leave the system are both clustered near the bottom of the hierarchy. (shrink)

Decapod crustaceans are faceless animals with five pairs of legs, an external skeleton and multiple nerve centres rather than a single brain. They include common seafood species such as crayfish, crabs, lobsters, prawns and shrimp. These characteristics make them difficult to empathise with and consequently legal protection of decapods ranges from strong, through circumstantial to non-existent. Whether they are capable of experiencing pain depends on definitions and the requirement for absolute proof of an inherently subjective psychological experience. Yet like other (...) animals, decapods fulfil neuroanatomical, pharmacological and behavioural criteria that are consistent with a pain response. Whether they experience stress, harm and distress is less controversial because these conditions are more measurable than the pain response. To balance animal welfare concerns with scientific merit whilst providing confidence for the growing public awareness of crustacean welfare, use of decapod crustaceans in research should require ethical review. (shrink)

Papers on nanotechnology in the Scientific Electronic Library Online database were studied bibliometrically. The terms ‘nanotechnology’, ‘nanoparticle’, ‘graphene’, ‘fullerene’, ‘nanotube’ and ‘quantum dot’ were used for the search in their singular and plural forms in three languages, and a total of 1205 papers were selected for the study to assess the frequency rates of the study variables. The results of the study are presented in this article focusing on gender differences.

Summary Pluralism and monism are the two current views concerning scientific research and language understanding. Between them there is a third, intermediate, view. We take a procedural methodology of science as exemplified in the work of L. Tondl, and procedural linguistics , as exemplified in the work of B. Harrison, to be representative of this third possibility. Procedures are cognitive, linguistic, and physical processes which, through their hierarchical interconnections can generate fruitful mechanisms . These mechanisms are sensitive to (...) context and operate in heuristic and algorithmic ways. Their similar logical structure points towards a profound unified basis for scientific and linguistic activities, thus providing an interesting bridge between what is achieved by a little child talking to his parents, and a creative scientist struggling to interpret the results of his experiments. (shrink)

Openness is one of the most important principles in scientifi c inquiry, but there are many good reasons for maintaining secrecy in research, ranging from the desire to protect priority, credit, and intellectual property, to the need to safeguard the privacy of research participants or minimize threats to national or international security. This article examines the clash between openness and secrecy in science in light of some recent developments in information technology, business, and politics, and makes some practical (...) suggestions for resolving confl icts between openness and secrecy. (shrink)

We live in a world in which scientific expertise and its epistemic authority become more important. On the other hand, the financial interests in research, which could potentially corrupt science, are increasing. Due to these two tendencies, a concern for the integrity of scientific research becomes increasingly vital. This concern is, however, hollow if we do not have a clear account of research integrity. Therefore, it is important that we explicate this concept. Following Rudolf Carnap’s (...) characterization of the task of explication, this means that we should develop a concept that is similar to our common sense notion of research integrity, exact, fruitful, and as simple as possible. Since existing concepts do not meet these four requirements, we develop a new concept in this article. We describe a concept of epistemic integrity that is based on the property of deceptiveness, and argue that this concept does meet Carnap’s four requirements of explication. To illustrate and support our claims we use several examples from scientific practice, mainly from biomedical research. (shrink)

This article examines conflicts of interest in the context of scientific research related to regulation or litigation. The article defines conflicts of interest, considers how conflicts of interest can impact research, and discusses different strategies for dealing with conflicts of interest. While it is not realistic to expect that scientific research related to regulation or litigation will ever be free from conflicts of interest, society should consider taking some practical steps to minimize the impact of (...) these conflicts, such as requiring full disclosure of information required for independent evaluation of research, prohibiting financial relationships between regulatory agencies and the companies they regulate, and banning payments to expert witnesses for specific research results, testimony or legal outcomes. (shrink)

Efficient knowledge sharing is an important support for the continuous innovation and sustainable development of scientific research teams. However, in realistic management situations, the knowledge sharing of scientific research teams always appears to be unsustainable, and the reasons for this are the subject of considerable debate. In this study, an attempt was made to explore the interactive mechanism of knowledge hiding behaviors in scientific research teams between individual and collective knowledge hiding behaviors and its (...) impact on knowledge sharing by adopting grounded theory to comprehensively understand this situation. The results show that knowledge hiding behavior in the scientific research team is a two-phase interactive process and is capable of affecting sustainable knowledge sharing by reducing the supply of knowledge, creating a poor knowledge sharing atmosphere, and forming an interpersonal distrust relationship. This research may provide a strong basis for a deeper understanding of the interaction mechanism of knowledge hiding behavior and its impact on knowledge sharing. (shrink)

From the arguments I have presented, I hope it is clear that the distinction between basic and applied research is tenuous. Certain areas of research and methods may be favoured over others because of intrinsic biases, which are predictive of the type of application possible. Believing in the neutrality of pure knowledge is like wearing blinders: scientists need not be too concerned about the way in which the knowledge they generate is used. In my own case, this belief (...) led to my participation in a system of agriculture to which I do not subscribe. Scientists should be willing to take responsibility for how they function in the system as a whole. Given the social structure of science, it is difficult for basic researchers to see their connections with the larger issues, much less to control them. Perhaps new ways of constructing knowledge-generating societies will be necessary in order to encourage individual responsibility. (shrink)