Drosophila melanogaster is often considered to lack genomic 5‐methylcytosine (m5C), an opinion reinforced by two whole genome bisulfite‐sequencing studies that failed to find m5C. New evidence, however, indicates that genomic methylation is indeed present in the fly, albeit in small quantities and in unusual patterns. At embryonic stage 5, m5C occurs in short strand‐specific regions that cover ∼1% of the genome, at tissue levels suggesting a distribution restricted to a subset of nuclei. Its function is not obvious, but methylation in (...) subsets of nuclei would obscure functional associations since transcript levels and epigenetic modifications are assayed in whole embryos. Surprisingly, Mt2, the fly's only candidate DNA methyltransferase, is not necessary for the observed methylation. Full evaluation of the functions of genome methylation in Drosophila must await discovery and experimental inactivation of the DNA methyltransferase, as well as a better understanding of the pattern and developmental regulation of genomic m5C. (shrink)

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artifacts—manufactured objects worth commissioning, collecting, and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, (...) colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades.” Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records. (shrink)

第5回東京大学南原繁記念出版賞受賞作。徳川日本の思想家らが構想した、美しく「人に接」わるための制度とその実践を鋭利に分析。思想史、文学史、文化史研究の新たな地平。.

This book provides a systematic exposition of mathematical economics, presenting and surveying existing theories and showing ways in which they can be extended. One of its strongest features is that it emphasises the unifying structure of economic theory in such a way as to provide the reader with the technical tools and methodological approaches necessary for undertaking original research. The author offers explanations and discussion at an accessible and intuitive level providing illustrative examples. He begins the work at an elementary (...) level and progessively takes the reader to the frontier of current research. This second edition brings the reader fully up to date with recent research in the field. (shrink)

教科書には絶対に載らない真実の数々―かの米国総司令官の初仕事は、日本に慰安婦を供出させることだった!「週刊新潮」連載の超辛口名物コラム。傑作選、第八弾。.

Dienes & Perner's analysis provides a clear theoretical justification for using a demonstration of volitional control as a criterion for conscious awareness. However, in memory tasks, the converse does not hold: A phenomenological awareness of a memory episode can arise involuntarily, even when the task does not require retrieval of the episode. The varying amounts of volitional retrieval required by different memory tasks need to be recognized.

Images in the service of scientific knowledge (broadly construed) in early modern Europe have received much scholarly attention in recent years. Given that this was a period where there was a large...

In lieu of an abstract, here is a brief excerpt of the content:Leonhart Fuchs on the Importance of PicturesSachiko KusukawaIf not for the attractive plant with overhanging flute-like flowers that was named after him, Leonhart Fuchs (1501–66) is best known today as one of the pioneers of accurate representations of plants in histories of scientific illustrations.1 The pictures in Fuchs’s Remarkable Commentaries on the History of Plants (1542) have been appreciated usually for their “naturalistic” features (i.e., pictures drawn from observing (...) a plant specimen), as well as for their tendency to discard individual blemishes and portray a universal or ideal “type” of a plant where several varieties of species could be incorporated into one bush, or where various stages of the same plant may be depicted in one figure.2 On the other hand no historian of botany who has examined the text these pictures accompanied has found that such qualities as observation from nature or a sense of “ideal type” contributed to Fuchs’s theoretical understanding of [End Page 403] plants: he lacked any sense of the family genera or Linnean classification, for he had simply adopted an alphabetical ordering.3Fuchs himself considered his pictures remarkable—as he was at pains to point out—and he believed his pictures were absolutely crucial for his commentary on plants. My immediate aim in this paper, therefore, is to offer an interpretation of Fuchs’s Remarkable Commentaries on the History of Plants which does not split the work into artistically positive and botanically negative elements. As I shall argue, the uniqueness and so the controversial nature of Fuchs’s enterprise lies in the kind of argument and procedure he believed to be valid for an academic study of plants. More generally, I hope to use this reassessment of Fuchs’s work to show how pictures could be as controversial as texts and how the uses of texts and pictures together form past acts which require historical explanation. Click for larger view View full resolutionFigure 1.The Artists. Leonhart Fuchs, De historia stirpium, 1542, verso of last folio page. Reproduced by permission of the Syndics of Cambridge University Library.In 1542 Fuchs published his Remarkable Commentaries on the History of Plants Belaboured with Great Expense and Vigilance with More than Five Hundred Live Images of Plants Attached. It begins with a picture of Fuchs, the author, at the age of forty-one and ends with that of the artists (fig. 1). Although the division of labor depicted here seems to have been a standard one for printing illustrated books in this period,4 it is unusual that we know their names. Albrecht Meyer did the drawings from life, Heinrich Füllmaurer transferred the drawings to woodblocks, and Veit Rudolf Speckle cut those woodblocks.5 Fuchs was proud of one of the artists in particular: “the woodcutter [sculptor] Veit Rudolf Speckle, by far the best in Strasbourg, excellently imitated the admirable industry of painters: he has so skilfully expressed the outlines of each picture by carving [sculpendo] that he seems to compete with the painter for glory and victory.”6 A comparison between the painter and the sculptor had been a favorite topic in the Renaissance genre of paragone—Leonardo da Vinci, Galileo, Castiglione, and Michaelangelo composed treatises on it—where the [End Page 404] relative merits of various mimetic arts were discussed.7 Fuchs’s comment on Speckle is more nuanced, however, than a polite competition between the arts over their mimetic skills: Fuchs announces that Speckle is worthy of praise in producing a picture—normally the domain of the painter (pictor)—with the specialized skill of carving of the cutter (sculptor). This is surely an appreciation of the particular skill involved in producing replicable pictures for printed books, just as Erasmus had, a generation earlier, acknowledged in Albrecht Dürer’s prowess at engraving the potential for reproducibility in a print culture.8 Indeed, of the artists involved in printing, it was the woodcutter who could expect to be paid most in this period—nearly fifteen times more than the artist who originally drew the pictures.9 Click for larger view View full resolutionFigure 2.Atriplex. Theodore Dorsten, Botanicon, 1540, fol. 35r. Reproduced... (shrink)

This is an important volume of seventeen essays that historicizes observation as a practice, concept and ideal. It belongs to the historiographical tradition of scrutinizing central aspects of the scientific enterprise such as experiments and objectivity that once appeared too self-evident to be probed. The challenge of historicizing such a significant idea is that it has to be a collective enterprise.The volume starts with three essays that provide a chronological survey of the period from 500 to 1800. Katherine Park, covering (...) the period from 500 to 1500, explains how observation for Cicero and Pliny had nothing to do with experiment or systematic investigation, but rather was a collective and largely anonymous process, associated with originary phrases of natural knowledge of a distant past and intelligible even by the illiterate. It was the basis for conjectural knowledge that lacked causal explanation. Observation of celestial events occurred from time to time, but in the context o .. (shrink)

This paper examines the inter-relationship between image, text and object in the Codex Kentmanus, which is one of the earliest records of the plants in the botanical garden at Padua, studied by Johannes Kentmann . The manuscript shows that “observation” for Kentmann involved a gradual process of assimilating knowledge from other physicians, apothecaries, and books in order to make the plants which were originally encountered at a specific time and place into a more generalised object of study for learned physicians.

Philip Melanchthon, humanist and colleague of Martin Luther, is best known for his educational reforms, for which he earned the title Praeceptor Germaniae. His most influential form of philosophical writing was the academic oration, and this volume, first published in 1999, presents a large and wide-ranging selection of his orations and textbook prefaces translated into English. They set out his views on the distinction between faith and reason, the role of philosophy in education, moral philosophy, natural philosophy, astronomy and astrology, (...) and the importance of philosophy to a true Christian, as well as his views on Classical philosophical authorities such as Plato and Aristotle and on contemporaries such as Erasmus and Luther. Powerfully influential in their time, inspiring many Protestant students to study philosophy, mathematics and natural philosophy, they illuminate the relationship between Renaissance and Reformation thought. (shrink)

ABSTRACT In volume two of his work Democracy in America, Alexis de Tocqueville argued that religion could guarantee individual liberties against the tyranny of the majority. However, in volume one of this work, Tocqueville presented a conventional ‘civil religion’ as a phenomenon that was identical to or subsumed by American social mores or opinions. Thus, the following questions are raised: How can such a religion represent a brake on potential tyranny? How can genuine religion be distinguished from common opinion? Consequently, (...) understanding Tocqueville’s approach to religion remains a major problem. This article demonstrates that in the second volume of Democracy in America, Tocqueville suggested a different type of civil religion, one that has a transcendent authority that distinguishes it from public opinion but that, nevertheless, facilitates intellectual liberty. It also shows how Tocqueville resolved the dilemmas of authority and liberty in the civil religion, by focusing on, with his observations of American Christianity, his reading of Blaise Pascal’s works regarding religious authority and human reason, in which Pascal exhorted human beings to willingly recognise the limits of reason. (shrink)

Este artigo pretende fazer uma breve apresentação do platonismo não-realista de Abelardo através da solução dada na Logica Ingredientibus à célebre “querela dos universais”.

Islamic Thought and the Art of Translation honors two of the most beloved and productive scholars in the field of Islamic Studies, Professors William Chittick and Sachiko Murata. For the past five decades, and in over 40 books (monographs, editions, translations, edited volumes) and more than 300 articles, Professors Chittick and Murata have presented us with philologically astute and analytically sound expositions of the pre-modern Islamic intellectual tradition, particularly in the areas of Sufism and philosophy. They have done so (...) primarily by zeroing in on the technical vocabularies of these disciplines (in Arabic, Persian, and Chinese), demonstrating just how important the functions of philology and cross-cultural translation are when studying pre-modern cultures and civilizations. (shrink)

In this paper, I discuss a drawing that substituted for an engraving in a copy of Philosophical Transactions once owned by Thomas Kirke (1650–1706, FRS 1693). I suggest that prints allowed Kirke to train his eye as well as his hand. His case is useful for raising further questions about visual representations in early modern science.

Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome structure. Together with associated proteins and RNAs, these nucleosomes are organized three‐dimensionally in the cell as chromatin. Emerging evidence demonstrates that chromatin consists of rather irregular and variable nucleosome arrangements without the regular fiber structure and that its dynamic behavior plays a critical role in regulating various genome functions. Single‐nucleosome imaging is a promising method to investigate chromatin behavior in living cells. It reveals local chromatin motion, which reflects (...) chromatin organization not observed in chemically fixed cells. The motion data is like a gold mine. Data analyses from many aspects bring us more and more information that contributes to better understanding of genome functions. In this review article, we describe imaging of single‐nucleosomes and their tracked behavior through oblique illumination microscopy. We also discuss applications of this technique, especially in elucidating nucleolar organization in living cells. (shrink)

We agree with Frost that the variety of orthographies in the world's languages complicates the task of Frost suggests that orthographic processing must therefore differ between orthographies. We suggest that the same basic orthographic processes are applied to all languages. Where languages differ is in what the reader must do with the results of orthographic processing.

啓蒙思想の系譜を繙き、理性の力を問い直す。古代ギリシアから、ホッブズ、カント、フランクフルト学派を経て最新の議論まで。啓蒙を巡る問題意識の変遷を追う論考集。.

This paper examines the inter-relationship between image, text and object in the Codex Kentmanus, which is one of the earliest records of the plants in the botanical garden at Padua, studied by Johannes Kentmann . The manuscript shows that “observation” for Kentmann involved a gradual process of assimilating knowledge from other physicians, apothecaries, and books in order to make the plants which were originally encountered at a specific time and place into a more generalised object of study for learned physicians.

The four papers in this volume arise out of a research project, “Making Visible: The visual and graphic practices of the early Royal Society,” funded by the Arts and Humanities Research Council of the United Kingdom.1 The project sought to understand how visual resources and practices contributed to, and shaped the development and dissemination of scientific knowledge in the first fifty years of the Royal Society. The Royal Society, as an early institution dedicated to promoting natural knowledge, has received substantial (...) scholarly attention from historians of science, aided by a rich administrative archive that has been preserved virtually unbroken since its foundation.2 Because modern cataloguing of manuscripts... (shrink)