Since its inception as an international requirement to protect patients and healthy volunteers taking part in medical research, informed consent has become the primary consideration in research ethics. Despite the ubiquity of consent, however, scholars have begun to question its adequacy for contemporary biomedical research. This book explores this issue, reviewing the application of consent to genetic research, clinical trials, and research involving vulnerable populations. For example, in genetic research, information obtained from an autonomous research participant may have significant bearing (...) on the interests of family members who have not consented to the study. This casts doubt on the adequacy of consent for such studies. This book also questions the assumptions that informed consent is essential and that it satisfactorily protects the principle of individual autonomy. It reviews recent empirical studies that challenge the possibility of truly informed consent and highlights the extent to which consent is governed by social norms and expectations. It also investigates how consent might be of secondary importance in some circumstances, for example when a research project appears to protect a public or community interest. (shrink)

By questioning the modern categories of Plato and Platonism, this book offers new ways of reading the Platonic dialogues and the many traditions that resonate ...

ABSTRACT In this article, we discuss the potential of Virtual Reality (VR) technologies for the creation and adaptation of stories aimed at children and young adult, focusing on the specificities of their usage protocols. We begin by introducing narratives in VR and their connection to the field of children and young adult literature. Subsequently, 360º videos targeted at children and young people are presented, along with the reading and engagement protocols that arise from their peculiarities. Starting from the field of (...) Cinematic Virtual Reality (CVR), we discuss about the main challenges posed by this medium for the enjoyment of immersive works, based on the analysis of the work Invasion!, produced by the Baobab studio. Thus, we conclude that both the production and reception of narratives in Virtual Reality presuppose the management of the viewer’s vision and attentional focus, considering the reading protocols already learned and naturalized through other media. (shrink)

With this paper I intend to rehabilitate the status of orality as medium of the public use of reason in the normative Kantian sense. As a first step, I reconstruct the reasons why Kant rejects the spoken word and designates the written word as the sole medium of public reasoning. As a second step, I argue for the possibility of employing the spoken word as medium of public reasoning while remaining within the normative framework of Kant’s concept of the public (...) use of reason. (shrink)

The aim of my paper is to investigate Gorgias’ argument against motion, which is found in his Peri tou mē ontos and preserved only in MXG 980a1˗8. I tried to shed new light both on this specific reflection and on the reliability of Pseudo-Aristotle’s version. By exploring the so called “change argument” and the “argument from divisibility", I focused on the particular strategy used by the Sophist in his synthetikē apodeixis, which should be investigated in relation to the dispute between (...) monistic and pluralistic ontology. In this regard, the puzzle from “divisibility everywhere” and its connection with the void as not-being can provide new elements to grasp the philosophical background in which the Sophist moves. On the one hand, Gorgias’ argument against motion is part of a broader dispute on the divisibility/indivisibility of being; on the other, his original elaboration of this puzzle seems to be perfectly understandable within the controversy between Eleatics and Atomists, and coherent with the argumentative style of the Sophist. (shrink)

A review of the literature indicates that linear models are frequently used in situations in which decisions are made on the basis of multiple codable inputs. These models are sometimes used normatively to aid the decision maker, as a contrast with the decision maker in the clinical vs statistical controversy, to represent the decision maker "paramorphically" and to "bootstrap" the decision maker by replacing him with his representation. Examination of the contexts in which linear models have been successfully employed indicates (...) that the contexts have the following structural characteristics in common: each input variable has a conditionally monotone relationship with the output; there is error of measurement; and deviations from optimal weighting do not make much practical difference. These characteristics ensure the success of linear models, which are so appropriate in such contexts that random linear models may perform quite well. 4 examples involving the prediction of such codable output variables as GPA and psychiatric diagnosis are analyzed in detail. In all 4 examples, random linear models yield predictions that are superior to those of human judges. (shrink)

The term research subject has traditionally been the preferred term in professional guidelines and academic literature to describe a patient or an individual taking part in biomedical research. In recent years, however, there has been a steady shift away from the use of the term 'research subject' in favour of 'research participant' when referring to individuals who take part by providing data to various kinds of biomedical and epidemiological research. This article critically examines this shift, reflecting on the different meanings (...) evoked by the terms 'subject' and 'participant', as well as examining recent examples of patient activism in research. It concludes by suggesting that the wholesale unreflective adoption of the term 'participant' is inappropriate and provides instead a guide on how to determine the circumstances in which the terms subject, participant and activist should legitimately be used. (shrink)

Concern about the ethics of clinical drug trials research on patients and healthy volunteers has been the subject of significant ethical analysis and policy development—protocols are reviewed by Research Ethics Committees and subjects are protected by informed consent procedures. More recently attention has begun to be focused on DNA banking for clinical and pharmacogenetics research. It is, however, surprising how little attention has been paid to the commercial nature of such research, or the unique issues that present when subjects are (...) asked to consent to the storage of biological samples. Our contention is that in the context of pharmacogenetic add-on studies to clinical drug trials, the doctrine of informed consent fails to cover the broader range of social and ethical issues. Applying a sociological perspective, we foreground issues of patient/subject participation or ‘work’, the ambiguity of research subject altruism, and the divided loyalties facing many physicians conducting clinical research. By demonstrating the complexity of patient and physician involvement in clinical drug trials, we argue for more comprehensive ethical review and oversight that moves beyond reliance on informed consent to incorporate understandings of the social, political and cultural elements that underpin the diversity of ethical issues arising in the research context. (shrink)

I examine recent debates in the philosophy of biology over the determinism or indeterminism of the evolutionary process, focusing on two papers in particular: Glymour 2001 and Stamos 2001. I argue that neither of these papers succeeds in making the case for the indeterminism of the evolutionary process, and suggest that what is needed is a detailed analysis of the causal processes at every level from the quantum mechanical to the evolutionary.

The latter half of the twentieth century has been marked by debates in evolutionary biology over the relative significance of natural selection and random drift: the so-called “neutralist/selectionist” debates. Yet John Beatty has argued that it is difficult, if not impossible, to distinguish the concept of random drift from the concept of natural selection, a claim that has been accepted by many philosophers of biology. If this claim is correct, then the neutralist/selectionist debates seem at best futile, and at worst, (...) meaningless. I reexamine the issues that Beatty raises, and argue that random drift and natural selection, conceived as processes, can be distinguished from one another. (shrink)

The goal of this paper is to explore the presuppositionality of factive verbs, with special emphasis on the verbs know and regret. The hypothesis put forward here is that the factivity related to know and the factivity related to regret are two different phenomena, as the former is a semantic implication that is licensed by the conventional meaning of know, while the latter is a purely pragmatic phenomenon that arises conversationally. More specifically, it is argued that know is factive in (...) the sense that it both entails and presupposes p, while regret is factive in the sense that it only presupposes p. In a recent article, Hazlett, 497–522, 2010) shows with authentic examples how know is used non-factively in ordinary language, and he observes in these examples, as he says, “a threat to Factivity.” I argue that non-factive uses of factive verbs, such as know and regret, far from being a threat to factivity, show that, on the one hand, know is ambiguous between a factive and a non-factive sense; on the other hand, in the case of regret, the presupposition of factivity has to be intended as a merely pragmatic implication which can be suspended by the speaker herself. (shrink)

In this paper I argue against the commonly received view that Kripke's formal Possible World Semantics (PWS) reflects the adoption of a metaphysical interpretation of the modal operators. I consider in detail Kripke's three main innovations vis-à-vis Carnap's PWS: a new view of the worlds, variable domains of quantification, and the adoption of a notion of universal validity. I argue that all these changes are driven by the natural technical development of the model theory and its related notion of validity: (...) they are dictated by merely formal considerations, not interpretive concerns. I conclude that Kripke's model theoretic semantics does not induce a metaphysical reading of necessity, and is formally adequate independently of the specific interpretation of the modal operators. (shrink)

In this paper, I reconstruct Quine’s arguments against quantified modal logic, from the early 1940’s to the early 1960’s. Quine’s concerns were not technical. Quine was looking for a coherent interpretation of quantified-in English modal sentences. I argue that Quine’s main thesis is that the intended objectual interpretation of the quantifiers is incompatible with any semantic reading of the modal operators, for example as expressing analytic necessity, unless the entities in the domain of quantification are intensions, i.e. definitional entities. The (...) difficulty is that it makes no sense to say of an ordinary object that it bears a property necessarily or contingently when the necessity or contingency in question is analytic. However, starting in 1960, Quine claims that quantified-in modal sentences can be coherently interpreted only as essentialist predications. When we say about an object that it necessarily F ’s, we can only coherently mean that it essentially F ’s. In the paper, I argue that adequately qualified the thesis is plausible. Two important qualifications are needed. The first is the assumption that satisfaction is an irreducibly predicative notion, making any explication of satisfaction in terms of truth inadequate. The second is the ontological rejection of purely semantic, i.e. merely definitional, entities. With these qualifications in place, Quine’s rejection of the combination of objectual quantifiers and semantic modalities can be upheld. In this way, we vindicate a qualified version of Quine’s conjecture that quantified modal logic is committed to essentialism. (shrink)

In this paper, I examine Ruth Barcan Marcus's early formal work on modal systems and the deduction theorem, both for the material and the strict conditional. Marcus proved that the deduction theorem for the material conditional does not hold for system S2 but holds for S4. This last result is at odds with the recent claim that without proper restrictions the deduction theorem fails also for S4. I explain where the contrast stems from. For the strict conditional, Marcus proved the (...) deduction theorem for S4 though restricted to arguments with necessary premises. I discuss Marcus's result and analyze her philosophical position on the significance of the deduction theorem for modal systems designed to express the notion of deducibility. (shrink)

This paper centers on Takashi Yagisawa’s book Worlds and Individuals, Possible and Otherwise (Oxford: 2010), which provides a novel and systematic analysis of modality and time. I consider the overall structure of Yagisawa’s treatment of modality and time, and discuss in detail the following three topics: (i) Possible worlds as modal indices, (ii) Trans-world identity, (iii) The claim that existence, unlike reality, is relative. My main conclusion is that Yagisawa's view of modality is driven by a strong primitivism, leading to (...) the endorsement of possibility, actuality, and presentness, but also possible worlds and times, as irreducible. The resulting view is saddled with the typical problems of primitivism on the one hand, and modal realism on the other. I criticize the view that existence is relative. (shrink)

According to a common misconception, Kant rejects rhetoric as worthy of no respect and neglects popularity as a dispensable accessory. Two recent publications on the communicative dimension of Kant’s conception and practice of philosophy represent a very solid rebuttal of such criticism. The books in question are Kant’s Philosophy of Communication by G. L. Ercolini and A linguagem em Kant. A linguagem de Kant edited by Monique Hulshof and Ubirajara Rancan de Azevedo Marques, especially in light of the long chapter (...) “Kant e a Questão da Popularidade e da Linguagem da Filosofia” by Leonel Ribeiro dos Santos (pp. 17- 69). What Ercolini’s monograph and Santos’ chapter have in common, is that they both argue that Kant does indeed value and practice both rhetoric and popularity. However, they differ from each other in that Ercolini lets Kant’s reflection on popularity derive from occasional factors, while Santos locates its origin at the heart of Kant’s critical project. In order fully to appreciate their novelty, these two contributions call for an overview of the state of research on the subject of Kant’s conception of rhetoric. Thus, before closely examining them, I will briefly outline the relevant scholarship by dividing it into the three classes of those who interpret Kant (a) as a skillful rhetorician, (b) as dismissive of rhetoric, and finally (c) as according rhetoric a moral function. (shrink)

Biologists and philosophers have been extremely pessimistic about the possibility of demonstrating random drift in nature, particularly when it comes to distinguishing random drift from natural selection. However, examination of a historical case-Maxime Lamotte's study of natural populations of the land snail, Cepaea nemoralis in the 1950s - shows that while some pessimism is warranted, it has been overstated. Indeed, by describing a unique signature for drift and showing that this signature obtained in the populations under study, Lamotte was able (...) to make a good case for a significant role for drift. It may be difficult to disentangle the causes of drift and selection acting in a population, but it is not impossible. (shrink)

“Modal logic was conceived in sin: the sin of confusing use and mention.” So quips Quine. The stigma stuck with modal logic for a while. But by the mid-sixties, a whole cluster of mathematically elegant interpretations of modal logic became available. All are natural extensions of the classical Tarskian semantics of predicate logic. By the mid-seventies, Quine’s criticisms seemed obsolete. Today, we teach the model theory of modal logic as a matter of course. Quine’s “interpretive problem” is just forgotten. The (...) purpose of my dissertation is to revamp Quine’s thesis: the very foundations of modal logic—simple propositional modal logic, even before quantifiers are added—are shaky. Quine holds that the natural interpretation of the operator “necessarily” is in terms of a full-blooded metaphysical notion of real necessity. Such a notion, Quine conjectures, is committed to the “metaphysical jungle of Aristotelian essentialism”. Hence, the intended interpretation is to be rejected. Thus Quine: so much the worse for real necessity. An alternative comes to mind: a meta-level, formal rather than real, semantic interpretation of the operator of necessity. In the late forties, Carnap developed this line of interpretation which culminates in the aforementioned model theory (“Kripke’s possible world semantics”) in the sixties. On this basis a formal interpretation is introduced: it grounds necessity in the notion of model theoretic validity. As pointed by friends of the formal interpretation (Marcus, Parsons and Kaplan), no invidious essentialist claim is verified. But have Quine’s concerns been answered? Yes and no. Technical problems regarding quantification across modal operators, substitutivity, matters of scope, and the basis of cross-world identification have indeed been solved. However, no real interpretation of “necessarily” has been provided. I argue that the seeds of such an interpretation are present in Kripke’s philosophical discussion of de re necessities in Naming and Necessity. It is not model theoretic, and it does not reduce necessity to some non-modal notion, just as Quine predicted. Even more in his vein, the real interpretation is (i) metaphysically, grounded indeed in essentialist theses, and (ii) epistemologically, forced to give up Kant’s ideal that all necessities are known a priori. (shrink)

This book explores the intimate connections, conflicts and discontinuities between religion and philosophy in the Platonic and Neoplatonic traditions from Antiquity to the early Medieval period. It presents a broader comparative view of Platonism by examining the strong Platonist resonances among different philosophical/religious traditions, primarily Jewish, Christian, Islamic and Hindu, and suggests many new ways of thinking about the relation between these two fields or disciplines that have in modern times become such distinct and, at times, entirely separate domains.

The aim of the present paper is to investigate the connection between ancient medicine and sophistry at the end of 5th century B.C. Beginning with analyses of some passages from the De vetere medicina, De natura hominis and De arte, the article identifies many similarities between these treatises, on the one hand, and the sophistic doctrines, on the other: these concern primarily perceptual/intellectual knowledge and the interaction between reality, knowledge and language. Among the Sophists, Gorgias was particularly followed and imitated, (...) as he was admired not only for his tremendous rhetorical skills, but also for his philosophically significant work On not being, which probably influenced various discussions in the Hippocratic treatises. However, if Gorgias argues in favor of language as dynastēs megas, the authors of VM, NH and De arte consider knowledge to be far more relevant and reliable than logos. These Hippocratic treatises criticize the philosophical thesis and the resulting kind of reductionism. Above all they defend the supremacy of medicine over any other art. By using the same argumentative and rhetorical strategies that were employed by Gorgias, these treatises reverse the thought of those Sophists who exalted only the technē tōn logōn. (shrink)

This article argues that Ralph Waldo Emerson employs metempsychosis (reincarnation or the transmigration of the soul into successive bodies) as a figurative template for human consciousness. Mapping various traditions from Hinduism, Pythagoreanism, Platonism, and Neoplatonism onto the vastness of the geological and biological records, Emerson translates metaphysics for modernity: he depicts the soul's journey through the chronological sequence of history as a poetic process that culminates in a tenuous form of self-knowledge.

Phenomenological description can be interpreted as an explicitation of experience as it is lived. However, there are at least two ways in which the explicitation of experience can be realised: the first is associated with an epistemic model, the second to an ontological model. The first is based on a principle of manifestation, the second on a principle of disposition. The aim of this paper is to show that only the second model, the ontological one, is able to account for (...) the concept of movement understood not as mere displacement but as change. In order to do this, however, it is necessary to introduce a notion that classical phenomenology – starting from the well-known Brentanian definition – considers to be oxymoronic: the notion of physical intentionality. (shrink)

Human genetic engineering may soon be possible. The gathering debate about this prospect already threatens to become mired in irresolvable disagreement. After surveying the scientific and technological developments that have brought us to this pass, _The Ethics of Genetic Engineering_ focuses on the ethical and policy debate, noting the deep divide that separates proponents and opponents. The book locates the source of this divide in differing framing assumptions: reductionist pluralist on one side, holist communitarian on the other. The book argues (...) that we must bridge this divide, drawing on the resources from both encampments, if we are to understand and cope with the distinctive problems posed by genetic engineering. These problems, termed "fractious problems," are novel, complex, ethically fraught, unavoidably of public concern, and unavoidably divisive. Berry examines three prominent ethical and political theories – utilitarianism, Kantianism, and virtue ethics – to consider their competency in bridging the divide and addressing these fractious problems. The book concludes that virtue ethics can best guide parental decision making and that a new policymaking approach sketched here, a "navigational approach," can best guide policymaking. These approaches enable us to gain a rich understanding of the problems posed and to craft resolutions adequate to their challenges. (shrink)

When philosophers of physics explore the nature of chance, they usually look to quantum mechanics. When philosophers of biology explore the nature of chance, they usually look to microevolutionary phenomena, such as mutation or random drift. What has been largely overlooked is the role of chance in macroevolution. The stochastic models of paleobiology employ conceptions of chance that are similar to those at the microevolutionary level, yet different from the conceptions of chance often associated with quantum mechanics and Laplacean determinism.

Current corporate systems risk generating inequality among workers, insofar as they concentrate only on economic results by favoring, through the incentive and award system, only what can be seen, produced, and measured. As such, these systems are unable to recognize workers’ agapic behaviors – similar to the ones considered in organizational citizenship behavior literature – that cannot be quantified, i.e. workers’ generosity, humanity, kindness, compassion, help for others and mercy. Although these types of behaviors may appear unproductive or irrational, they (...) create symbols of belonging to the company and social cohesion. This article claims that beyond focusing on reward systems, companies should recognize agapic behaviors to increase workers’ intrinsic motivation. These behavioral attitudes allow fraternal relationships -as conceived in the Civil Economy tradition- to arise within organizations; moreover, they contribute to advancing new managerial practical implications in the humanistic management field. (shrink)

A myth exists that Jews can embrace the cultural components of Judaism without appreciating the legal aspects of the Jewish tradition. This myth suggests that law and culture are independent of one another. In reality, however, much of Jewish culture has a basis in Jewish law. Similarly, Jewish law produces Jewish culture. Roberta Rosenthal Kwall develops and applies a cultural analysis paradigm to the Jewish tradition that departs from the understanding of Jewish law solely as the embodiment of Divine (...) command. (shrink)

Recent discussions in the philosophy of biology have brought into question some fundamental assumptions regarding evolutionary processes, natural selection in particular. Some authors argue that natural selection is nothing but a population-level, statistical consequence of lower-level events (Matthen and Ariew [2002]; Walsh et al. [2002]). On this view, natural selection itself does not involve forces. Other authors reject this purely statistical, population-level account for an individual-level, causal account of natural selection (Bouchard and Rosenberg [2004]). I argue that each of these (...) positions is right in one way, but wrong in another; natural selection indeed takes place at the level of populations, but it is a causal process nonetheless. (shrink)