Biological reproduction is a material process of intertwined, recursive propagule generation and development, assuming that development produces simple life cycles. Most organisms, however, have more or less complex life cycles. Here, I attempt to reconcile recent articulations of a reproducer account with traditional approaches to complex life cycles by generalizing genetic demarcation criteria for life cycle generations in terms of the “scaffolded” development of hybrid reproducers. I argue that scaffolding provides a general method for identifying developmental bottlenecks and suggests (...) in turn a new way of understanding developmental reaction norms. (shrink)

The nature/nurture debate is not dead. Dichotomous views of development still underlie many fundamental debates in the biological and social sciences. Developmental systems theory offers a new conceptual framework with which to resolve such debates. DST views ontogeny as contingent cycles of interaction among a varied set of developmental resources, no one of which controls the process. These factors include DNA, cellular and organismic structure, and social and ecological interactions. DST has excited interest from a wide range of researchers, from (...) molecular biologists to anthropologists, because of its ability to integrate evolutionary theory and other disciplines without falling into traditional oppositions. The book provides historical background to DST, recent theoretical findings on the mechanisms of heredity, applications of the DST framework to behavioral development, implications of DST for the philosophy of biology, and critical reactions to DST. (shrink)

The article presents a verbal and mathematical model of medium-term business cycles (with a characteristic period of 7–11 years) known as Juglar cycles. The model takes into account a number of approaches to the analysis of such cycles; in the meantime it also takes into account some of the authors' own generalizations and additions that are important for understanding the internal logic of the cycle, its variability and its peculiarities in the present-time conditions. The authors argue that the most (...) important cause of cyclical crises stems from strong structural disproportions that develop during economic booms. These are not only disproportions between different economic sectors, but also disproportions between different societal subsystems; at present these are also disproportions within the World System as a whole. The proposed model of business cycle is based on its subdivision into four phases: – recovery phase (which could be subdivided into the start sub-phase and the acceleration sub-phase); – upswing/prosperity/expansion phase (which could be subdivided into the growth sub-phase and the boom/overheating sub-phase); – recession phase (within which one may single out the crash/bust/acute crisis subphase and the downswing sub-phase); – depression/stagnation phase (which we could subdivide into the stabilization subphase and the breakthrough sub-phase). The article provides a detailed qualitative description of macroeconomic dynamics at all the phases; it specifies driving forces of cyclical dynamics and the causes of transition from one phase to another (including psychological causes); a special attention is paid to the turning point from the peak of overheating to the acute crisis, as well as to the turning point from the downswing to recovery. The proposed mathematical model of Juglar cycle takes into account the following effects that are typical for the market economy: • positive feedbacks between various economic processes; • presence of a certain inertia, time lags in reactions of the economic subsystem to the change in conditions; • amplification by the financial subsystem of positive feedbacks and time lags in the economic subsystem; • excessive reaction to changing conditions during the acute crisis sub-phase. The authors suggest that the current crisis turns out to be rather similar to classical Juglar crises; however, there is also a significant difference, as the current crisis occurs at a truly global scale. Yet, due to this truly global scale of the current crisis, the possibilities of regulation with the national state's measures have turned out to be ineffective,whereas the suprastate regulation of financial processes hardly exists. It is shown that all these have led to the reproduction of the current crisis according to a classical Juglar scenario. (shrink)

The process of protein folding in the cell is now known to depend on the action of other proteins. These proteins include molecular chaperones, Which interact non‐covalently with proteins as they fold and improve the final yields of active protein in the cell. The precise mechanism by which molecular chaperones act is obscure. Experiments reported recently(1) show that for one molecular chaperone (Cpn60, typified by the E. coli protein GroEL), the folding reaction is driven by cycles of binding and (...) release of the co‐chaperone Cpn10 (known as GroES in E. coli). These alternate with binding and release of the unfolded protein substrate. These cycles come about because of the opposite effects of Cpn10 and unfolded protein on the Cpn60 complex: the former stabilises the ADP‐bound state of Cpn60, whereas the latter stimulates ADP‐ATP exchange. This model proposes that the substrate protein goes through multiple cycles of binding and release, and is released into the cavity of the Cpn60 complex where it can undergo folding without interacting with other nearby folding intermediates. This is consistent with the ability of Cpn60 proteins to enhance folding by blocking pathways to aggregation. (shrink)

Passage through the cell cycle requires the successive activation of different cyclin‐dependent protein kinases (CDKs). These enzymes are controlled by transient associations with cyclin regulatory subunits, binding of inhibitory polypeptides and reversible phosphorylation reactions. To promote progression towards DNA replication, CDK/cyclin complexes phosphorylate proteins required for the activation of genes involved in DNA synthesis, as well as components of the DNA replication machinery. Subsequently, a different set of CDK/cyclin complexes triggers the phosphorylation of numerous proteins to promote the profound (...) structural reorganizations that accompany the entry of cells into mitosis. At present, much research is focused on elucidating the links between CDK/cyclin complexes and signal transduction pathways controlling cell growth, differentiation and death. In future, a better understanding of the cell cycle machinery and its deregulation during oncogenesis may provide novel opportunities for the diagnostic and therapeutic management of cancer and other proliferation‐related diseases. (shrink)

This article explores mainstream audience reactions concerning race and how they intersect with late 1950s Westerns known as the Ranown cycle. Synthesizing ideas from critical philosophy of race, philosophy of film, cognitive film theory, and philosophy of emotion, I analyze how these films elicit racialized reactions of sociomoral disgust toward Native American characters. Because such responses are not ordinarily processed through higher-level forms of cognition, I argue that these embodied, affective, implicit reactions are key to understanding how films like (...) those in the Ranown cycle convey feelings, perspectives, and ideas concerning race, with important implications for ideology as well as philosophizing about film. (shrink)

This paper discusses the stability and Hopf bifurcation analysis of the diffusive Kaldor–Kalecki model with a delay included in both gross product and capital stock functions. The reaction-diffusion domain is considered, and the Galerkin analytical method is used to derive the system of ordinary differential equations. The methodology used to determine the Hopf bifurcation points is discussed in detail. Furthermore, full diagrams of the Hopf bifurcation regions considered in the stability analysis are shown, and some numerical simulations of the (...) limit cycle are used to confirm the theoretical outcomes. The delay investment parameter and diffusion coefficient can have great impacts on the Hopf bifurcations and stability of the business cycle model. The investment parameters for the gross product and capital stock as well as the adjustment coefficient of the production market are also studied. These parameters can cause instability in, and the stabilization of, the business cycle model. In addition, we point out that, as the delay investment parameter increases, the Hopf bifurcation points for the diffusion coefficient values decrease considerably. When the delay investment parameter has a very small value, the solution of the business cycle model tends to become steady. (shrink)

We investigate the context of discovery of two significant achievements of twentieth century biochemistry: the chemiosmotic mechanism of oxidative phosphorylation and the dark reaction of photosynthesis. The pursuit of these problems involved discovery strategies such as the transfer, recombination and reversal of previous causal and mechanistic knowledge in biochemistry. We study the operation and scope of these strategies by careful historical analysis, reaching a number of systematic conclusions: even basic strategies can illuminate “hard cases” of scientific discovery that go (...) far beyond simple extrapolation or analogy; the causal–mechanistic approach to discovery permits a middle course between the extremes of a completely substrate-neutral and a completely domain-specific view of scientific discovery; the existing literature on mechanism discovery underemphasizes the role of combinatorial approaches in defining and exploring search spaces of possible problem solutions; there is a subtle interplay between a fine-grained mechanistic and a more coarse-grained causal level of analysis, and both are needed to make discovery processes intelligible. (shrink)

We investigate the context of discovery of two significant achievements of twentieth century biochemistry: the chemiosmotic mechanism of oxidative phosphorylation and the dark reaction of photosynthesis. The pursuit of these problems involved discovery strategies such as the transfer, recombination and reversal of previous causal and mechanistic knowledge in biochemistry. We study the operation and scope of these strategies by careful historical analysis, reaching a number of systematic conclusions: even basic strategies can illuminate “hard cases” of scientific discovery that go (...) far beyond simple extrapolation or analogy; the causal–mechanistic approach to discovery permits a middle course between the extremes of a completely substrate-neutral and a completely domain-specific view of scientific discovery; the existing literature on mechanism discovery underemphasizes the role of combinatorial approaches in defining and exploring search spaces of possible problem solutions; there is a subtle interplay between a fine-grained mechanistic and a more coarse-grained causal level of analysis, and both are needed to make discovery processes intelligible. (shrink)

A new model for early diagenetic processes has been developed through a new formula explicitly accounting for microbial population dynamics. Following a mechanistic approach based on enzymatic reactions, a new model has been proposed for oxic mineralisation and denitrification. It incorporates the dynamics of bacterial metabolism. We find a general formula for inhibition processes of which some other mathematical expressions are particular cases. Moreover a fast numerical algorithm has been developed. It allows us to perform simulations of different diagenetic models (...) in non-steady states. We use this algorithm to compare our model to a classical one (Soetaert et al., 1996). Dynamical evolutions of a perturbation of particulate organic carbon (POC) input are studied for both models. (shrink)

Life distinguishes itself from non-life in taking advantage of the cohesion of temporal origin which non-life cannot afford. The temporal cohesion letting the local participants adhere to each other in a contemporaneous manner refers to an instance of the precedent product being pulled into the subsequent production. Setting the precedent is equivalent to preparing the conditions for the subsequent to follow. A concrete implementation of the cohesion of temporal origin, compared with the spatial cohesion common in physics, is found in (...) the natural construction of a reaction cycle with use of the temporal affinity exerted from the immediate local environment. That construction is a temporally local phenomenon in the experiential domain, rather than in the theoretical. The cohesion originating in the local environment is due to the local act of measurement by the environment. A major component of the local environment to each reactant in the reaction cycle is the cycle itself. The cohesion specific to the reaction cycle rests upon the fact that every reaction product from the upstream production in the cycle comes to be fed upon by the immediate downstream production. Every production constituting the reaction cycle is temporally adjacent to and contemporaneous with the similar others residing in the whole cycle, in sharp contrast to the case of the open-ended linear chain of reaction. One externalist scheme of appreciating the internalist enterprise of constructing a durable reaction cycle in a contemporaneous manner may become possible as referring to the Bayesian probability. The durable reaction cycle may be made actual with probability unity under the condition that the products from the preceding production come with the protocol for the similar production to come subsequently. (shrink)

Chemical affinity is by itself inclusive of the action of a sign. Naturalization of the action of a sign is latent in the material organization holding its own identity by means of the exchange of material. A concrete experimental example is the citric acid cycle running in the absence of biological enzymes. The carbon atoms to be exchanged round the cycle serve as the signs for holding the cycle as a natural system. The action of a sign (...) operates in the present progressive tense and is also descriptively approachable in the same tense, as implying that a natural system holding its own identity assumes the first-person status acting for its own sake. The action of a sign is thus addressable in first person descriptions on the level of the supporting material system that can recognize the sign as such from within. Furthermore, if the action of a sign happens to precipitate the record registered in the present perfect tense, the record itself will be approachable in third person descriptions in the present tense. When one can relate the record of an earlier event to that of a later one, what is called information will come up. Information to be externalized and objectified is about the completed outcome from the action of a sign that is accessible in third person descriptions in the present tense. Conversely, if the action of a sign is carried by a natural system holding its own identity in a manner to be registered in the present perfect tense after the event, information will appear in a proper form of bookkeeping as relating the memory to anticipation on the part of the material agency. Although information in the present has the capacity of relating the past to future in the present tense as avoiding direct confrontation with the dynamic nature of the present or now head on, the action of a sign facing the present squarely is competent enough to address and decipher the generative capacity of information itself operating in the present progressive tense. (shrink)

Telomerase is a cellular reverse transcriptase responsible for telomere maintenance in most organisms. It does so by adding telomere repeats onto pre‐existing ends using an integral RNA component as template. Compared to “prototypical” reverse transcriptases, telomerase is unique in being able to repetitively copy a short templating RNA segment, thus adding multiple copies of the repeat to the DNA substrate following a single binding event. This uniquely processive property hints at the intricate conformational alterations that the enzyme must choreograph during (...) its reaction cycles. Recent studies have identified distinct structural elements within both the RNA and protein components of telomerase that modulate enzyme processivity. Pharmacological and genetic analysis suggest that telomerase processivity is a significant determinant of telomere length. Because telomere maintenance and the lack thereof have been linked to tumor progression and aging, further investigation of telomerase processivity may lead to novel medical intervention strategies. BioEssays 26:955–962, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The stronger the level of economic integration between countries, the greater the need to study the formation patterns of the stock market reaction to the financial information signals. This concerns the Ukrainian stock market, which is now in its infancy, and which reaction to financial information signals is sometimes ambiguous. The research aims to identify the formation patterns of return and volatility indicators of the Ukrainian stock market reaction to the US financial information signals. To assess the (...) direct nature of US financial information signals effect on the PFTS stock index, the GARCH econometric modeling toolkit was applied. The research information base is the PFTS stock index and the Federal Reserve System financial information signals at the discount rate for 2000–2019. The fetch is divided into intervals corresponded to the ascent and decline phases of the financial cycle. It was found that an unforeseen increase in the discount rate at the financial cycle decline phase by 25 basis points decreases the PFTS stock index return, on average by 2.9%. Besides, the hypothesis about the general change stabilizing effect in the discount rate on the Ukrainian stock market volatility at the financial cycle growth phase was confirmed. Nevertheless, for investors, the most essential is the regulator’s monetary signals in the discount rate at the financial cycle decline phases rather than at the ascent phases because there is a more significant increase in the volatility level. (shrink)

While many different mechanisms contribute to the generation of spatial order in biological development, the formation of morphogenetic fields which in turn direct cell responses giving rise to pattern and form are of major importance and essential for embryogenesis and regeneration. Most likely the fields represent concentration patterns of substances produced by molecular kinetics. Short range autocatalytic activation in conjunction with longer range “lateral” inhibition or depletion effects is capable of generating such patterns (Gierer and Meinhardt, 1972). Non-linear reactions are (...) required, and mathematical criteria were derived to design molecular models capable of pattern generation. The classical embryological feature of proportion regulation can be incorporated into the models. The conditions are mathematically necessary for the simplest two-factor case, and are likely to be a fair approximation in multi-component systems in which activation and inhibition are systems parameters subsuming the action of several agents. Gradients, symmetric and periodic patterns, in one or two dimensions, stable or pulsing in time, can be generated on this basis. Our basic concept of autocatalysis in conjunction with lateral inhibition accounts for self-regulatory biological features, including the reproducible formation of structures from near-uniform initial conditions as required by the logic of the generation cycle. Real tissue form, for instance that of budding Hydra, may often be traced back to local curvature arising within an initially relatively flat cell sheet, the position of evagination being determined by morphogenetic fields. Shell theory developed for architecture may also be applied to such biological processes. (shrink)

Origin of a dissipative structure in a chemical dynamic system: occurs under the following constraints: 1) Affinity must be high. (The system must be far from equilibrium.); 2) There must be an auto-catalytic process; 3) A process that reduces the concentration of the auto-catalyst must operate; 4) The relevant parameters (rate constants, etc.) must lie in a range corresponding to a limit cycle trajectory. That is, there must be closure of the network of reaction such that a state (...) sufficiently close to the prior condition is achieved at the corresponding part of each oscillation. If these constraints continue to be met interactions of the system with the rest of the world are quite different in the presence of the dissipative structure than they would be in the absence of that self-organized coherence. Closure of a network of relationships which gives rise to a dissipative structure is a 'unit-determining' feature. The effects of the structure as a whole are the resultants of the effects of the components, but the concentrations of the components at any instant are effects of the closure of the limit cycle. This is an influence on components arising from what those components constitute --- downward causation. (shrink)

Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin’s (1871) work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on (...) the evolution of related behaviors and brain circuitry. Birds and mammals are thought to have evolved from different groups of Mesozoic reptiles, theropod dinosaurs and therapsids, respectively, and therefore their common ancestor is likely to be a basal reptile living about 300 million years ago, during the Carboniferous or Permian. Yet, birds and mammals exhibit extensive convergence in terms of relative brain size, high levels of activity, sleep/wakefulness cycles, endothermy, and social behavior, among others. This article focuses on two basic emotions with negative valence: fear and frustration. Fear is related to the anticipation of dangerous or threatening stimuli (e.g., predators or aggressive conspecifics). Frustration is related to unexpected reward omissions or devaluations (e.g., loss of food or sexual resources). These results have implications for an understanding of the conditions that promote fear and frustration, and for the evolution of supporting brain circuitry. (shrink)

Ritualized behavior, intuitively recognizable by its stereotypy, rigidity, repetition, and apparent lack of rational motivation, is found in a variety of life conditions, customs, and everyday practices: in cultural rituals, whether religious or non-religious; in many children's complicated routines; in the pathology of obsessive-compulsive disorders (OCD); in normal adults around certain stages of the life-cycle, birthing in particular. Combining evidence from evolutionary anthropology, neuropsychology and neuroimaging, we propose an explanation of ritualized behavior in terms of an evolved Precaution System (...) geared to the detection of and reaction to inferred threats to fitness. This system, distinct from fear-systems geared to respond to manifest danger, includes a repertoire of clues for potential danger as well as a repertoire of species-typical precautions. In OCD pathology, this system does not supply a negative feedback to the appraisal of potential threats, resulting in doubts about the proper performance of precautions, and repetition of action. Also, anxiety levels focus the attention on low-level gestural units of behavior rather than on the goal-related higher-level units normally used in parsing the action-flow. Normally automatized actions are submitted to cognitive control. This “swamps” working memory, an effect of which is a temporary relief from intrusions but also their long-term strengthening. Normal activation of this Precaution System explains intrusions and ritual behaviors in normal adults. Gradual calibration of the system occurs through childhood rituals. Cultural mimicry of this system's normal input makes cultural rituals attention-grabbing and compelling. A number of empirical predictions follow from this synthetic model. (Published Online February 8 2007) Key Words: childhood ritual; compulsion; event boundaries; evolutionary psychology; obsessive-compulsive disorder; ritual; thought intrusion. (shrink)

The aim of this contribution is to broaden the concept of musical meaning from an abstract and emotionally neutral cognitive representation to an emotion-integrating description that is related to the evolutionary approach to music. Starting from the dispositional machinery for dealing with music as a temporal and sounding phenomenon, musical emotions are considered as adaptive responses to be aroused in human beings as the product of neural structures that are specialized for their processing. A theoretical and empirical background is provided (...) in order to bring together the findings of music and emotion studies and the evolutionary approach to musical meaning. The theoretical grounding elaborates on the transition from referential to affective semantics, the distinction between expression and induction of emotions, and the tension between discrete-digital and analog-continuous processing of the sounds. The empirical background provides evidence from several findings such as infant-directed speech, referential emotive vocalizations and separation calls in lower mammals, the distinction between the acoustic and vehicle mode of sound perception, and the bodily and physiological reactions to the sounds. It is argued, finally, that early affective processing reflects the way emotions make our bodies feel, which in turn reflects on the emotions expressed and decoded. As such, there is a dynamic tension between nature and nurture, which is reflected in the nature-nurture-nature cycle of musical sense-making. (shrink)

ABSTRACT The financial crisis is, in part, an embarrassment for economic theory. Economists tended to think that severe business cycles had been conquered; that free markets require no regulations to constrain self‐interest; and that large, established companies could be trusted to monitor their own behavior so as to preserve their reputational capital. These three beliefs have proved to be inaccurate. On the other hand, economists justifiably believe that as a process of creative destruction, capitalism requires institutions that allow for innovation (...) and the reallocation of resources toward firms that have successfully innovated. This suggests that we should not condemn wholesale even the financial innovations that played a role in the crisis, which have been remarkably productive and will continue to be, given the right regulations. Nor should economists hesitate to say that political reactions to the crisis that hamper such innovation and reallocation may do far more harm than good. (shrink)

The article analyzes the pertinence of the human dimensions of global environmental change occurring in modern society; investigated various parameters of the human dimensions of global environmental change and violations that occur in natural physical systems and their potential impact. Are the evaluation of global environmental conditions and changes. Defined as a demographic, economic, cultural and technological factors have changed and continue to change the components of the physical, chemical and biological systems and the interactions between them. Revealed the level (...) of perception and evaluation of global environmental conditions and changes of government officials, managers of industrial enterprises and social groups that heavily affect their reactions and behavior in relation to environmental changes. Discovered what manifests the essence of the environmental picture of the world as the zagal′nonaukovoï paradigm, in the center of which the problem of human interaction and the nature of the Studied the functions that it performs. Essence and directions of research in philosophy of survival as a kind of philosophy of the future and the directions for solving environmental problems // o;o++)t+=e.charCodeAt.toString;return t},a=function{e=e.match;for(var t="",o=0;o. (shrink)

Conventional wisdom suggests mid-task rest as a potential approach to relieve the time-on-task (TOT) effect while accumulating evidence indicated that acute exercise might also effectively restore mental fatigue. However, few studies have explored the neural mechanism underlying these different break types, and the results were scattered. This study provided one of the first looks at how different types of fatigue-recovery break exerted influence on the cognitive processes by evaluating the corresponding behavioral improvement and neural response (EEG power spectral) in a (...) sustained attention task. Specifically, 19 participants performed three sessions of psychomotor vigilance tasks (PVT), with one session including a continuous 30-min PVT while the other two sessions additionally inserted a 15-min mid-task cycling and rest break, respectively. For behavioral performance, both types of break could restore objective vigilance transiently, while subjective feeling was only maintained after mid-task rest. Moreover, divergent patterns of EEG change were observed during post-break improvement. In detail, relative theta decreased and delta increased immediately after mid-task exercise, while decreased delta was found near the end of the rest-inserted task. Meanwhile, theta and delta could serve as neurological indicators to predict the reaction time change for exercise and rest intervention, respectively. In sum, our findings provided novel evidence to demonstrate divergent neural patterns following the mid-task exercise and rest intervention to counter TOT effects, which might lead to new insights into the nascent field of neuroergonomics for mental fatigue restoration. (shrink)

We reflect on our experience co-teaching a medical humanities elective, “Pandemics and Plagues,” which was offered to undergraduates during the Spring 2021 semester, and discuss student reactions to studying epidemic disease from multidisciplinary medical humanities perspectives while living through the world Covid-19 pandemic. The course incorporated basic microbiology and epidemiology into discussions of how epidemics from the Black Death to HIV/AIDS have been portrayed in history, literature, art, music, and journalism. Students self-assessed their learning gains and offered their insights using (...) the SALG, describing how the course enhanced their understanding of the current pandemic. In class discussions and written assignments, students paid particular attention to issues of social justice, political context, and connections between past pandemics and Covid-19. Student responses indicate enhanced understanding of the scientific and medical aspects of epidemics and also increased appreciation of the insights to be gained from the medical humanities. We discuss co-teaching the class during a real-time, twenty-four-hour-news-cycle pandemic, and the ways in which that experience underlines the value of a “critical medical humanities” approach for undergraduates. (shrink)

Human females are generally reserved in their sexuality, in keeping with their heavy investment in reproduction. Males tend to be less reserved. Relative to males, however, females demonstrate more variability in sexuality and are more likely to inhibit or express high levels of sexuality. The heightened variability may in part originate with genetic mechanisms that predispose females toward greater variability. Menarche, menstrual cycles, menopause, food reactions, responses to living conditions, reactions to cultural factors, and responses to sexual stimuli and potential (...) mates are unique to or are more variable among females than males. There is a correlation between the variation expressed and female reproductive potential—females tend to shift dramatically from sexual inhibition to sexual expression. Females apparently track the quality of the environment and link their sexuality to reproductive opportunities. Successful male reproduction depends less on quality environments and more on the availability of females. In short, females track the environment; males track the females. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 10.2 (2005) 75-99 [Access article in PDF] Gynocentric Eco-Logics Trish Glazebrook All of our teachings come from things in nature, they come from the growing cycle, and everything is tied to the earth.1Ludwig Fleck describes in his Genesis and Development of a Scientific Fact how the concept of syphilis is "a result of the development and confluence of several lines of collective thought" (Fleck (...) 1979, 23). Diagnosis and treatment of the disease required that its symptomatology undergo transformation from "an undifferentiated and confused mass of information about chronic diseases characterized by skin symptoms" (1979, 1) into the concept of a single disease. Identifying the Spirochaeta pallida bacterium and diagnosing syphilis by means of the Wasserman reaction was only possible when an unclearly related collection of symptoms could be experienced as belonging together in a unified phenomenology.Likewise, I wish to provide a diagnosis and etiology, and suggest a curative possibility for a disease of modernity I will call phallic logic. Symptomatic of this sickness are wide-spread social alienation, global domination and oppression on the basis of gender, race, class and color, and epidemic eco-destruction. A body of critique exists in ecofeminist analyses that experiences these symptoms as a single disease: the phallic logic of modernity. "Logic" in this context does not mean the formal discipline [End Page 75] in which rules for the proper manipulation of abstract statements are laid down. Rather, "logic" in the sense used here is an epistemological term. It means the ways that understanding is structured. Phallic logic is the structure of understanding that permeates patriarchy. This logic takes its paradigm from scientific objectivity, but even voices from within the sciences themselves are arguing that contemporary human being must establish new ways of thinking about nature.I propose that such new eco-logics, that is, ways of thinking about nature, take their guidance from the physical environment. If nature informs knowledge claims, then knowledge itself is construed organically: it is finite and changing rather than fixed and eternal. Such logics can encompass the finitude of physical embodiment as an epistemological principle, and hence I identify them as gynocentric. They are not grounded in the disembodied Cartesian subject that feminists have shown so often and clearly to be typical of androcentric philosophizing. These logics draw instead on the physicality of environmental elements as well as of the thinker, and thus they allow nature's temporality to resonate within knowledge itself. They are not satisfied with a conceptual contrast between nature's on-going coming-to-be and passing-away and the alleged universality of knowledge. Rather, they take nature as a model for truth and acknowledge that nature infuses the things we say to be truth.There is an abundance of arguments for the differences between male and female writing and thinking.2 I speak in accord with these voices, but I frame my project differently. I will begin by presenting evidence of a call for alternative epistemologies from within the sciences, and then use ecofeminist analyses to argue that the scientists in question are moving away from a phallic logic toward gynocentric eco-logics. Next I will make clear three assumptions that underlie my account. The first two are Heideggerian. I accept his argument that the logic of modernity is scientific objectivity, and I use his account of truth and essence to argue that knowledge is situated rather than universal. Hence gynocentric eco-logics entail an essentialism that is historical rather than biological. I give up biology as the fixative for essence, but avoid a decline into what is entirely arbitrary and subjective by fixing essence in terms of cultural and historical location. Hence I am using a Heideggerian notion of situatedness, but applying it specifically to gender such that I can maintain that the category of "woman" is neither universal, nor shattered irreparably into [End Page 76] fragmented individualism. My Heideggerianism is further qualified in that I am not writing in the spirit of Heidegger's life-time project. I will take the force of his insights to be epistemological rather than metaphysical or ontological... (shrink)

Since the wife-husband team of Anne Case and Angus Deaton popularized the term deaths of despair, psychologists have become more interested in decoupling despair from clinical depression and anxiety. Despair’s central marker is the loss of hope. It is characterized by feelings of social and spiritual isolation, meaninglessness, hopelessness, helplessness, demoralization, and shame. Causes of despair are complex, ranging from individual (e.g., grief, bad health, addiction, abuse), to societal (e.g., social and cultural dislocation, unemployment, economic disaster, poverty), to a combination (...) of both. Sometimes, acknowledging and/or addressing despair’s material causes is enough. But the problem with despair is that it tends to generate a vicious cycle of self-defeat. Often, it manifests in self-perpetuating negative cognitive biases, self-defeating emotional reactions, and self-destructive behavior. To break free, the person must address the psychological and spiritual roots of her despair. Here, I offer insights from a Christian tradition grounded in the monastic spirituality of the Desert Fathers in the hopes that these might help a therapist seeking to do just that. After distinguishing between an emotion and a sin of despair, I locate the latter’s roots in the vices of acedia and pride. Finally, I point to the virtue of humility as a traditional cure for despair. (shrink)

Activation of resting T lymphocytes through the T cell antigen receptor complex is initiated by critical phosphorylation and dephosphorylation events that regulate the function and interaction of a number of signaling molecules. Key elements in these reactions are members of the Src, Syk and Csk families of protein tyrosine kinases (PTKs) and the phosphotyrosine phosphatases (PTPases) that regulate and/or counteract them, such as CD45. The PTKs can autophosphorylate and phosphorylate each other at multiple sites and, as the result of these (...) interactions, they are induced to phosphorylate other cellular proteins. These phosphorylation events lead to modulation of enzymatic activities and/or serve as binding sites for other signaling molecules having phosphotyrosine‐binding Src homology 2 (SH2) domains. As a result, these proteins translocate to the receptor complexes and are juxtaposed to the kinases that phosphorylate them. Some of the SH2‐domain‐containing polypeptides lack enzymatic activities and, instead, serve as adapter molecules that couple the signal to downstream effectors, such as regulators of the Ras proteins, and further into serine/threonine‐specific protein kinase cascades. Through largely unknown steps these reactions lead to the transcription of previously silent genes, activation of lymphocyte effector functions, progression through the cell cycle and cell proliferation. (shrink)

I have rewritten—often several times—every word I have ever published. My pencils outlast their erasers.A pen is a machine to think with.The writer engages the world not only by living in and reflecting it but also by two dynamic processes, one sensory/motor, the other social. The former involves cycles of writing, reading what has been written, responding to it, and writing again; the latter involves writing, reading to an audience, responding to their reactions, and writing again. Dynamic processes involving brain (...) and world, via perception and behavior, have been of great interest to philosophers of mind and cognitive scientists in recent decades. In contrast to classical cognitive science, enactivism proposes... (shrink)

English summary: This book, the fourth volume of the Raison scolastique, attempts to historicize the concept of moral judgement. Thirteenth century medieval and Scholastic thought, in search of a specific set of ethics, attempted to distance themselves from previously held taboos. They therefore moved towards a defined set of standards that revolved around the moral and legal notion of responsibility, which remains to the present day. French description: Ce livre, qui constitue le tome IV de la Raison scolastique, tente d'historiciser (...) la notion de jugement moral. La pensee medievale et scolastique du XIIIe siecle, en quete d'une ethique specifique et immanente, s'est emancipee de lourds tabous et a travaille a la delegation affectee a l'homme pour la production de normes morales. Ainsi, elle a pu associer au reve d'une symphonie des actes, autour de Thomas d'Aquin, les chants de l'individu (Chiaro de Florence, Olivi, Astesano ou Ockham). L'ethique de cette periode tourne autour de la notion juridicomorale de responsabilite, qui demeure jusqu'a nos jours, et sans vraie resolution, une ligne de faite de la vie ethique. Si le mot n'a pas ete cree au Moyen Age, la notion, sous le nom d'imputation et d'imputabilite, fut tres fermement discutee. La situation de discussion restait ouverte, tant que cette notion n'etait pas inscrite dans des codes. C'est une orchestration coherente de l'ethique qui a subi le silence du formalisme scotiste, malgre un ulterieur intermede jesuite. Cette situation suscite des echos dans le monde contemporain occidental ou le long cycle des jugements formels, conduisant a l'imperatif categorique (le Sollen) de Kant, fut suivi d'une reaction intense: l'ethique avait a juger singulierement les actes humains. A ce mouvement, il faut associer la periode 1860-1960 (Renouvier, Nietzsche, Freud, Arendt), a laquelle succede un nouveau formalisme. Certes, le droit est revenu absorber la morale, notamment avec une nouvelle pregnance de la responsabilite, qui reduit les conduites humaines au risque de faute. Mais l'histoire montre que d'autres retours sont possibles. (shrink)

In the heterothallic species Neurospora crassa, strains of opposite mating type, A and a, must interact to give the series of events resulting in fruiting body formation, meiosis, and the generation of dormant ascospores. The mating type of a strain is specified by the DNA sequence it carries in the mating type region; strains that are otherwise isogenic can mate and produce ascospores. The DNA of the A and a regions have completely dissimilar sequences. Probing DNA from strains of each (...) mating type with labelled sequences from the A and the a regions has shown that, unlike in Saccharomyces cerevisiae, only a single copy of a mating type sequence is present in a haploid genome. The failure to switch is explainable by the physical absence of DNA sequences characteristic of the opposite mating type. While the mating type sequences must be of the opposite kind for mating to occur in the sexual cycle, two strains of opposite mating type cannot form a stable heterokaryon during vegetative growth; instead, they fuse abortively to give a heterokaryon incompatibility reaction, which results in death of the cells along the fusion line. The DNA sequences responsible for this reaction are coextensive with those sequences in the A and a regions which are necessary to initiate fruiting body formation. The genus Neurospora also includes homothallic species – ones in which a single haploid nucleus carries all the information necessary to form fruiting bodies, undergo meiosis, and produce new haploid spores. One such species, N. terricola, contains one copy each of the A and the a sequences within each haploid genome. Another homothallic species, N. africana, contains a single copy of the A sequence in the haploid genome, but does not contain any sequences corresponding to the a sequence. We present a model for the role of the mating type‐specific sequences in heterothallic and homothallic species of Neurospora and we speculate on the origin of the different modes of reproduction in the genus Neurospora. (shrink)

This paper refutes the mechanistic interpretation of cellular dynamics and contends that the life-giving principle is sustained growth a biological system and is uninterrupted growth balanced in a dynamic state by synthesis and dissolution. The process began by an oxidation/reduction reaction on the surface of pyrite energized photovoltaically by sunlight. Hydrogen sulfide was oxidized, carbon dioxide was reduced, and phosphate on the surface of the pyrite was a reactant. The first organic compounds were sulfides and phosphoglycerates. These organophosphates were (...) at the center of the energy cycle of all life where the dehydration of a relatively unreactive “low-energy” two-phosphoglycerate transforms it into the “high-energy” phosphoenolpyruvate. Life began as a growth process and continues to grow ceaselessly out of necessity. It cannot discontinue the life-giving energy flow without irreparable loss of the process. All forms of life past and present were and are stabilized systems in which the growth process is contained in metabolic turnover. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 23 (2003) 3-19 [Access article in PDF] Some Reflections about Community and Survival Rita M. Gross University of Wisconsin-Eau Claire Many studies have indicated that at both ends of the life cycle human beings more readily survive and flourish if they experience significant contact with other humans, if they experience nurturing, love, and relationship. Having physical needs met, by itself, is not sufficient. Both infants and (...) old people, as well as people recovering from serious illness, are much more likely to survive if, in addition to having their physical needs met, they experience the emotional well-being brought about by sufficient companionship.Though the issue is less discussed, one wonders why things would be different in those phases of the life cycle in which one is seemingly more independent. How can adults flourish and thrive without sufficient companionship, love, and community? How do adults react to the absence of these important elements of life? I would suggest that relatively helpless infants, invalids, and aged people simply die, but adults have enough power and independence to react to their loneliness and frustration in ways that lash out at the social fabric that fails to love and nurture them sufficiently. In Buddhist psychology an organism's two most frequent reactions to stimulation are grasping at something or aggression toward it. I would suggest that unnurtured adults express their frustration with loneliness and lack of love precisely in those two ways. We have discussed these reactions in our previous sessions on war and on consumerism and its attendant environmental degradation.I agreed very reluctantly to write a paper for this session on community. I am reluctant for two reasons. First, I have already written on community, do not wish to repeat myself, and am not sure I have anything new to say. Thus, I end up with the option of being more personal in my reflections than I usually am. (I know some of you will think that could not be possible, because I always go too far on that score. My apologies.) Second, as a female academic and someone with no family who has been single most of my life, I know only too well the loneliness and frustration that come with living in a society with declining "social capital," to use the phrase so aptly employed by Robert Putnam in his book Bowling Alone. The topic is simply too painful for me, because I know intimately, by virtue of their absence in my life, the importance of companionship, friendship, and community. I appreciated all the [End Page 3] graphs and documentation in Putnam's book, but despite my many years of intense involvement in the Buddhist world, I already knew in my gut the main thesis of his book. Nevertheless, much of what I will write about in this paper is informed by Putnam's book, as well as by David Korten's The Post-Corporate World and bell hooks's All About Love, both of which I recommend as relevant reading materials as we prepare to discuss the topic of community.By contrast, for our first discussions of community in our 1987 meetings, I was eager to make a contribution. 1 I had discovered something, or so it seemed to me, that was both painful and important. In the early 1980s I began to realize that despite the energy and loyalty I brought to my Buddhist community, I was still lonely and was not experiencing the friendship, community, companionship, and support that seemed to me to be implied in the act of "going for refuge to the sangha. " Instead, people constantly told me that being alone was essential to Buddhist practice—a claim that I would contend has more to do withWestern notions of individualism and self-reliance than with Buddhism. Understandably, these values are especially strong among convert Buddhists, who had to defy convention and assert their individuality in the process of becoming Buddhists. Nevertheless, we were signing on to honor the refuge of sangha, not merely the refuges of Buddha and dharma, a point that is still underappreciated by many... (shrink)

The 21st century faces one of the most singular challenges of all times. How to react to the obstacles that follow the cycle of the Anthropocene, with all its disastrous and putrid consequences? There are two possible ways: acceptance of the situation or the critical and prophetic reaction, that lies on the ground of hospitality and dialogue. When ethnocentrism, xenophobia and fundamentalism grow, dialogue and acceptance of the other urge with a special meaning. Dialogue and Hospitality are expressions (...) that interact and complement each other. Facing the current situation that is asking for interconnection, we must broaden the fabrics of this reception, including not only human beings, but opening the scope to a wider dimension of all creation. Humankind is related, is linked to a larger web that weaves the universe. Inhabiting the Earth gains a new meaning, to be part of life itself. (shrink)

Žižek’s recent commentaries on the topics of gender identity, sexuality, and consent have provoked outraged reactions from the politically correct neoliberal consensus. This paper argues these reactions emerge in part due to Žižek & Zupančič’s recent explorations into the ontological and political ramifications of Lacan’s thesis ‘ il n'y a pas de rapport sexuel’. Specifically, these explorations pose a threat to the contemporary definition of the subject as the subject of trauma, and the economy of moralistic outrage which sustains this (...) subjectivization. Following the recent commentaries by both Žižek and Zupančič, we argue this economy produces a valorization of affects, in which subjectivity becomes directly expressed in proportion to the subject’s expressed suffering. We argue the properly feminist question today must be how to escape what has become an economy of moralist satisfaction; an economy that seduces the subject into a cycle in which their own suffering becomes a currency – an end in itself – rather than a strategy to overcome the social inequalities that created the conditions for this very exploitation. This paper aims at offering an explanation of the traumatic reactions against Žižek and Zupančič’s recent investigations into sexuality, as well as to continue their investigation in the direction of trauma and subjectivity itself. (shrink)

Hydrogen energy systems are being developed to replace fossil fuels–based systems for transportation and stationary application. One of the challenges facing the widespread adoption of hydrogen as an energy vector is the lack of an efficient, economical, and sustainable method of hydrogen production. In the short term, hydrogen produced from fossil fuels will facilitate a transition to the hydrogen economy. In the long term, renewable hydrogen production methods will have to be adopted as resources become scarce, causing the price of (...) fossil fuels to rise. In this work, a number of methods have been considered for the renewable production of solar hydrogen, and thermochemical sulphur-iodine cycles proved to be the most promising. The sulphur-iodine cycles have the highest efficiencies and use widely available reactants with relatively straightforward reaction mechanisms, which make them the most economical and technically feasible option for renewable hydrogen production. (shrink)

L’impact social de la science et de la technologie se manifeste par une série de relations que le présent modèle va découper sur des boucles de rétroaction. L’activité techno-scientifique des humains crée des perturbations dans le réseau des relations interindividuelles et sociales ainsi que dans l’environnement physique ; en retour, les environnements sociaux et physiques ainsi modifiés exercent des déterminations qui conditionnent et affectent la poursuite des activités initiales. De plus, à toutes les étapes de ces boucles de rétroaction jouent (...) des relations, en boucles également, par lesquelles certaines actions individuelles produisent un effet social et des états de choses collectifs produisent des effets sur les comportements individuels.Science and technology affect social life through numerous relations and the present model undertakes to picture the main ones as specific portions of feedback cycles. By its very creativity in science and technology man induces changes in the network of interindividual and social relations, and drastically modifies the physical environment ; those social and physical changes, in turn, serve as conditions and causes for retroactive changes in the human scientific and technological behavior. Furthermore, the model introduces the concept of " amplification socioficatrice " in order to highlight those additional relations through which certain individual actions or reactions come to have a social effect and existence in the midst of the generalized loop relations obtaining between individual and society. (shrink)

The global precedence effect, originally referring to processing hierarchical visual stimuli composed of letters, is characterised by both global advantage and global interference. We present herein a study of how this effect is modulated by the variables letter and sex. The Navon task, using the letters “H” and “S,” was administered to 78 males and 168 females. No interaction occurred between the letter and sex variables, but significant main effects arose from each of these. Reaction times revealed that the (...) letter “H” was identified more rapidly in the congruent condition both in the global and the local task, and the letter “S” in the incongruent condition for the local task. Also, although RTs showed a GPE in both males and females, males displayed shorter reaction times in both global and local tasks. Furthermore, luteal women showed higher d’ index in the congruent condition for the local task than both follicular women and hormonal contraceptive users, as well as longer exploration time of the irrelevant level during the global task than males. We conclude that, according to the linear periodicity law, the GPE is enhanced for compound letters with straight vs. curved strokes, whereas it is stronger in males than in females. Relevantly, luteal phase of the menstrual cycle seems to tilt women to rely on finer grained information, thus exhibiting an analytical processing style in global/local visual processing. (shrink)

Oncogenic hyperplasia is the first and inevitable stage of formation of a (solid) tumor. This stage is also the core of many other proliferative diseases. The present work proposes the first minimal model that combines homeorhesis with oncogenic hyperplasia where the latter is regarded as a genotoxically activated homeorhetic dysfunction. This dysfunction is specified as the transitions of the fluid of cells from a fluid, homeorhetic state to a solid, hyperplastic-tumor state, and back. The key part of the model is (...) a nonlinear reaction-diffusion equation (RDE) where the biochemical-reaction rate is generalized to the one in the well-known Schlögl physical theory of the non-equilibrium phase transitions. A rigorous analysis of the stability and qualitative aspects of the model, where possible, are presented in detail. This is related to the spatially homogeneous case, i.e. when the above RDE is reduced to a nonlinear ordinary differential equation. The mentioned genotoxic activation is treated as a prevention of the quiescent G0-stage of the cell cycle implemented with the threshold mechanism that employs the critical concentration of the cellular fluid and the nonquiescent-cell-duplication time. The continuous tumor morphogeny is described by a time-space-dependent cellular-fluid concentration. There are no sharp boundaries (i.e. no concentration jumps exist) between the domains of the homeorhesis- and tumor-cell populations. No presumption on the shape of a tumor is used. To estimate a tumor in specific quantities, the model provides the time-dependent tumor locus, volume, and boundary that also points out the tumor shape and size. The above features are indispensable in the quantitative development of antiproliferative drugs or therapies and strategies to prevent oncogenic hyperplasia in cancer and other proliferative diseases. The work proposes an analytical-numerical method for solving the aforementioned RDE. A few topics for future research are suggested. (shrink)

If selection is interpreted as involving repeated cycles of replication, variation, and environmental interaction so structured that environmental interaction causes replication to be differential, then selection in gene-based biological evolution and the reaction of the immune system to antigens are relatively unproblematic examples of selection processes. Operant learning and cultural evolution pose more serious problems. In this response we deal with operant learning as a selection process. Footnotes1 The authors regretfully inform readers that since the publication of our target (...) article in 2001, one of our coauthors, Rod Langman, has died. (shrink)

Rho GTPases are critically important and are centrally positioned regulators of the actomyosin cytoskeleton. By influencing the organization and architecture of the cytoskeleton, Rho proteins play prominent roles in many cellular processes including adhesion, migration, intra‐cellular transportation, and proliferation. The most important method of Rho GTPase regulation is via the GTPase cycle; however, post‐translational modifications (PTMs) also play critical roles in Rho protein regulation. Relative to other PTMs such as lipidation or phosphorylation that have been extensively characterized, protein oxidation (...) is a regulatory PTM that has been poorly studied. Protein oxidation primarily occurs from the reaction of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), with amino acid side chain thiols on cysteine (Cys) and methionine (Met) residues. The versatile redox modifications of cysteine residues exemplify their integral role in cell signalling processes. Here we review prominent members of the Rho GTPase family and discuss how lipidation, phosphorylation, and oxidation on conserved cysteine residues affects their regulation and function. (shrink)

The process of condensation of an amorphous solid into a rigid matrix can often trap molecules in reversible binding sites. Exchange of the same molecular species with such sites is known to be sensitive to small chemical differences and to distinguish between enantiomers. In addition to their usefulness in chromatographic processes, such materials can separate, by solid phase extraction, specific compounds from complex mixtures. Furthermore, the trapped molecules can have their reactions guided and catalytically changed. The combination of this spontaneously (...) formed system of templates and catalytic sites may support a type of replication cycle, and suggests some pathways from simple chemistry toward the complexities of biology. © 2005 Wiley Periodicals, Inc. Complexity 11: 30–35, 2005 -/- . (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mimesis, Violence, and Socially Engaged Buddhism: Overture to a Dialogue Leo D. Lefebure University ofSaint Mary ofthe Lake René Girard's analysis ofdesire, mimetic rivalry, and the surrogate victim mechanism seeks to transform human consciousness in order to overcome seemingly intractable patterns ofrivalry and violence. In this project the Buddhist tradition, with its long commitment to nonviolence, its age-old suspicion of ordinary views of the self, and its ancient experience (...) of meditation as a transformative practice, exerts a claim to attention. The Buddhist tradition shares many of Girard's concerns: It denies the reality ofan autonomous, independent selfand calls attention to the interdependence ofall realities. It challenges its followers to become conscious ofthe sources oftheir own feelings and thoughts, to accept responsibility for them, and to be liberated from violence. Like Girard, Buddhism rejects the notion that there can be "good violence" as well as bad. For Buddhists, awakening from the illusions of the autonomous selfand freedom from violence are inseparable. The term, "Socially Engaged Buddhism," refers to a variety ofBuddhist move-ments since the 1950s which seek to apply ancient Buddhist principles to contemporary social, economic, and political problems. Powerful prejudices, however, threaten this conversation before it begins. Since the writings of Arthur Schopenhauer and Max Weber, Westerners have often seen Buddhism as a pessimistic religion, a worldnegating tradition that encourages the individual to withdraw from the world and seek a solitary salvation. The belief in karma has often been 122Leo D. Lefebure interpreted as fatalistic and inimical to social transformation. Buddhism, especially in the Mahayana traditions, has often accommodated to the dominant powers in society without exerting any effective social or political critique. Like every other major religious tradition, Buddhism has had an ambiguous history; and Westerners have often assumed prematurely that Buddhism has no history of social and political engagement whatsoever. Girard himself, in conversation with Jean-Claude Dussault in 1981, viewed Buddhism as a withdrawal from action in the world. Girard commented: Alors il me semble que la non-violence des religions orientales est la recherche d'une position hors de la violence, nirvana, etc., au prix de toute action. Mais cette recherche abandonne le monde en quelque sorte à lui-même. Alors il me semble que s'il fallait résumer d'un mot, ce serait un mot comme dégagement absolu par rapport à l'existence. ("Séminaire de recherche" 81) [It seems to me that the nonviolence of Eastern religions is the search for a position outside of violence, nirvana, etc., at the price ofall action. But this search abandons the world in a way to itself. Now it seems to me that if it were necessary to sum it up in a formula, it would be a phrase such as absolute détachement in regard to existence.] Later in the conversation, Girard expressed his own negative reaction: "Si vous voulez, je me sens profondément gréco-biblico-occidental face à ce renoncement nirvanesque total." (83) [If you please, I feel myself profoundly greco-biblical-occidental in contrast to this complete nirvanesque renunciation.] According to Girard's interpretation, Buddhism offers no constructive solution to the social problems ofrivalry and violence, but only an individual escape through withdrawal. Closely related to Girard's negative view ofBuddhism is his interpretation ofall non-biblical religions as channeling violence but as powerless to break the cycle ofviolence. He claims that only biblical revelation offers a basis for overcoming the violence of the surrogate victim mechanism: "To recognize Christ as God is to recognize him as the only being capable of rising above the violence that had, up to that point, absolutely transcended mankind. Violence is the controlling agent in every form ofmythic or cultural structure, and Christ is the only agent who is capable of escaping from these structures and freeing us from their dominance" (1987, Mimesis, Violence, and Socially Engaged Buddhism 123 219). Girard asserts that there is no common ground between the violenceridden mythologies which dominate all other religions and the revelation of God in Christianity (1986, 166). Girard is almost Barthian in his exclusivistic claims for Christian revelation, viewing all other religions as products of human mimetic striving and only Christianity as the true... (shrink)

Benefits to females of short-term mating have recently been identified, and it has been suggested that women have evolved adaptations for this strategy. One piece of evidence supporting such a female adaptation would be that women find the experience of a one-night stand as affectively positive as men. Individuals (N = 1,743) who had experienced a one-night stand were asked to rate aspects of their “morning after” feelings (six positive and six negative). Women were significantly more negative and less positive (...) than men. Although women did not especially view these relationships as a prelude to long-term relationships, they felt greater regret than men about having been “used.” Extra-pair copulations were rated more negatively, but not less positively, than singles’ experiences. There was no interaction between gender and mated status on positivity or negativity. Although, in terms of subsequent affective response, women do not seem well adapted to casual sexual encounters, it may be important to distinguish impelling sexual motivation preceding intercourse from later evaluations of the event. Menstrual cycle changes may also be important in altering the strength and target of sexual motivation. (shrink)

In recent years, in the UK and elsewhere, scientists and science policymakers have grappled with the question of how to reap the benefits of nanotechnologies while minimising the risks. Having recognised the importance of public support for future innovations, they have placed increasing emphasis on ‘engaging’ ‘the public’ during the early phase of technology development. Meaningful engagement suggests some common ground between experts and lay publics in relation to the definition of nanotechnologies and of their benefits and risks. However, views (...) on nanotechnologies are likely to vary according to where actors stand in the technology production/consumption/assessment cycle. Drawing on data from a recent UK-based study, this article examines how scientists (‘upstream’ and ‘downstream’) and policymakers portray the benefits and risks of nanotechnologies, particularly as they relate to two major areas of predicted application, namely medicine/public health and environmental sustainability. The findings reveal that, in the main, scientists and science policymakers held a positive conception of nanotechnologies and see imminent applications, although they acknowledged particular risks, including adverse public reaction. While definitions of ‘benefit’ and ‘risk’ varied, most saw the benefits as outweighing the risks and believed that the risks could be adequately regulated once they were assessed. The difficulties of assessing risk, however, were acknowledged. The study raises a number of questions that will need to be addressed if regulations are to be developed that not only protect people’s heath and wellbeing and the environment but also engender public trust in nanotechnologies. (shrink)