Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Researchers have identified how in some rapidly developing countries, road and aviation transportation CO2 emissions are rising faster (over time) when compared to the experiences of the USA at similar levels of economic development. While suggestive of how experiences of the rapidly developing Asia are different from those of the developed world these studies have used only one developed country for comparison, the USA, arguably a special case when it comes to transportation. To address this point this research compares the (...) road transportation CO2 experiences of rapidly developing Asian economies (Hong Kong, Japan, Malaysia, Singapore, South Korea, Taiwan and Thailand) with the USA and six other developed economies (Australia, France, the Netherlands, Italy, Sweden and the United Kingdom). The findings confirm previous results, to wit, Asian economies demonstrate faster annual growth of CO2 emissions in comparison to the experiences of the developed world. (shrink)

Sustainability reporting and assurance of sustainability reports have been used by organizations in an attempt to provide accountability to their stakeholders. A better understanding of current practices is important to provide a base for comparative and trend analyses. This paper aims to consolidate and provide information on sustainability reporting, assurance of sustainability reports and types of assurance providers. Another aim of this paper is to provide a descriptive analysis of these practices for a global sample, comparing results with previous studies, (...) and suggesting opportunities for future research. To accomplish these objectives, a literature review was performed, an analysis of the organizations included in the Fortune Global 500 2010 was completed, and results were presented and consolidated by country. These results demonstrate that all organizations analysed provided some type of information in relation to their social or environmental performance in their official website. The percentage of organizations issuing a sustainability report has been increasing in the last few years. However, the percentage of organizations assuring their sustainability report has stagnated. Types of assurance engagements include those performed by accountants and non-accountants, and new practices have emerged, namely the “mixed approach” and the “stakeholder or specialist review”. The analysis also shows that the practices of issuing sustainability reports and having them assured have become a world-wide phenomenon, occurring in developed, and emerging economies around the world. (shrink)

Most patients suffering from progressive dementia have thoughts, emotions, perspectives, and perceptions of a world of experience. Decisions about life‐sustaining treatment should incorporate a principled approach to evaluating what life is like for these patients.

Emotion influences parameters of goal-directed whole-body movements in several ways. For instance, previous research has shown that approaching (moving toward) pleasant stimuli is easier compared to approaching unpleasant stimuli. However, some studies found that when emotional pictures are viewed for a longer time, approaching unpleasant stimuli may in fact be facilitated. The effect of viewing duration may have modulated whole-body approach movement in previous research but this has not been investigated to date. In the current study, participants initiated a step (...) forward after viewing neutral, high-arousal pleasant and high-arousal unpleasant stimuli. The viewing duration of the stimuli was set to seven different durations, varying from 100 to 4000 ms. Valence and arousal scores were collected for all stimuli. The results indicate that both viewing duration and the arousal of the stimuli influence kinematic parameters in forward gait initiation. Specifically, longer viewing duration, compared to shorter viewing duration, (a) diminished the step length and peak velocity in both neutral and emotional stimuli, (b) increased reaction time in neutral stimuli and, (c) decreased reaction time in pleasant and unpleasant stimuli. Strikingly, no differences were found between high-arousal pleasant and high-arousal unpleasant stimuli. In other words, the valence of the stimuli did not influence kinematic parameters of forward step initiation. Instead the arousal level (neutral: low; pleasant and unpleasant: high) explained the variance found in the results. The kinematics of forward gait initiation seemed to be reflected in the subjective arousal scores, but not the valence scores. So it seems arousal affects forward gait initiation parameters more strongly than valence. In addition, longer viewing duration seemed to cause diminished alertness, affecting GI parameters. These results shed new light on the prevailing theoretical interpretations regarding approach motivation in the literature, which warrants further examination in future research. (shrink)

This book, based on the prestigious Oxford Amnesty Lecture series, focuses on human rights abuses, and the ways in which they are interpreted. The collection includes contributions by Tzvetan Todorov, Michael Ignatieff, Peter Singer, Gitta Sereny, Susan Sontag, and Eva Hoffman, with commentaries on their essays by Niall Fergusson, Timothy Garton Ash, John Broome, Hermione Lee and others.

In het huidige Israël lijkt zelfs hoop op een oplossing van het conflict met Palestina een onderdeel van dat conflict. Maar wat vermag de poëzie?

The nonrandom distribution of fears is not as clearly related to phylogenetically survival relevance as preparedness theory seems to imply. Although delayed extinction reflects some of the best human evidence for preparedness, even this phenomenon is not as robust as it once seemed to be. Apart from the evidence reviewed by Davey, recent studies from our laboratory provide further evidence for an expectancy bias model of selective associations.

Acknowledgments 1. Culture Is Essential 2. Culture Exists 3. Culture Evolves 4. Culture Is an Adaptation 5. Culture Is Maladaptive 6. Culture and Genes Coevolve 7. Nothing about Culture Makes Sense except in the Light of Evolution.

Alan C. LoveDarwinian calisthenicsAn athlete engages in calisthenics as part of basic training and as a preliminary to more advanced or intense activity. Whether it is stretching, lunges, crunches, or push-ups, routine calisthenics provide a baseline of strength and flexibility that prevent a variety of injuries that might otherwise be incurred. Peter Bowler has spent 40 years doing Darwinian calisthenics, researching and writing on the development of evolutionary ideas with special attention to Darwin and subsequent filiations among scientists exploring (...) evolution . Therefore, we would expect that when Bowler engages in a counterfactual history—imagining a world without Darwin—he is able to avoid historical injury and generate novel insights. My assessment is that the results are mixed. Before we can see why, it is necessary to walk briskly through the main contours of his argument.Bowler begins with an apologia for a counterfactual appr .. (shrink)

This paper investigates the tenability of wavefunction realism, according to which the quantum mechanical wavefunction is not just a convenient predictive tool, but is a real entity figuring in physical explanations of our measurement results. An apparent difficulty with this position is that the wavefunction exists in a many-dimensional configuration space, whereas the world appears to us to be three-dimensional. I consider the arguments that have been given for and against the tenability of wavefunction realism, and note that both the (...) proponents and the opponents assume that quantum mechanical configuration space is many-dimensional in exactly the same sense in which classical space is three-dimensional. I argue that this assumption is mistaken, and that configuration space can be taken as three-dimensional in a relevant sense. I conclude that wavefunction realism is far less problematic than it has been taken to be. Introduction Non-separability The instantaneous solution The dynamical solution Invariance What is configuration space, anyway? Conclusion. (shrink)

Putnam and Laudan separately argue that the falsity of past scientific theories gives us reason to doubt the truth of current theories. Their arguments have been highly influential, and have generated a significant literature over the past couple of decades. Most of this literature attempts to defend scientific realism by attacking the historical evidence on which the premises of the relevant argument are based. However, I argue that both Putnam's and Laudan's arguments are fallacious, and hence attacking their premises is (...) unnecessary. The paper concludes with a discussion of the further historical evidence that would be required if the pessimistic induction is to present a serious threat to scientific realism. (shrink)

In quantum mechanics it is usually assumed that mutually exclusives states of affairs must be represented by orthogonal vectors. Recent attempts to solve the measurement problem, most notably the GRW theory, require the relaxation of this assumption. It is shown that a consequence of relaxing this assumption is that arithmatic does not apply to ordinary macroscopic objects. It is argued that such a radical move is unwarranted given the current state of understanding of the foundations of quantum mechanics.

Metaphysicians should pay attention to quantum mechanics. Why? Not because it provides definitive answers to many metaphysical questions-the theory itself is remarkably silent on the nature of the physical world, and the various interpretations of the theory on offer present conflicting ontological pictures. Rather, quantum mechanics is essential to the metaphysician because it reshapes standard metaphysical debates and opens up unforeseen new metaphysical possibilities. Even if quantum mechanics provides few clear answers, there are good reasons to think that any adequate (...) understanding of the quantum world will result in a radical reshaping of our classical world-view in some way or other. Whatever the world is like at the atomic scale, it is almost certainly not the swarm of particles pushed around by forces that is often presupposed. This book guides readers through the theory of quantum mechanics and its implications for metaphysics in a clear and accessible way. The theory and its various interpretations are presented with a minimum of technicality. The consequences of these interpretations for metaphysical debates concerning realism, indeterminacy, causation, determinism, holism, and individuality are explored in detail, stressing the novel form that the debates take given the empirical facts in the quantum domain. While quantum mechanics may not deliver unconditional pronouncements on these issues, the range of possibilities consistent with our knowledge of the empirical world is relatively small-and each possibility is metaphysically revisionary in some way. This book will appeal to researchers, students, and anybody else interested in how science informs our world-view. (shrink)

The main difficulty facing no-collapse theories of quantum mechanics in the Everettian tradition concerns the role of probability within a theory in which every possible outcome of a measurement actually occurs. The problem is two-fold: First, what do probability claims mean within such a theory? Second, what ensures that the probabilities attached to measurement outcomes match those of standard quantum mechanics? Deutsch has recently proposed a decision-theoretic solution to the second problem, according to which agents are rationally required to weight (...) the outcomes of measurements according to the standard quantum-mechanical probability measure. I show that this argument admits counterexamples, and hence fails to establish the standard probability weighting as a rational requirement. (shrink)

It has long been recognized that a local hidden variable theory of quantum mechanics can in principle be constructed, provided one is willing to countenance pre-measurement correlations between the properties of measured systems and measuring devices. However, this ‘conspiratorial’ approach is typically dismissed out of hand. In this article I examine the justification for dismissing conspiracy theories of quantum mechanics. I consider the existing arguments against such theories, and find them to be less than conclusive. I suggest a more powerful (...) argument against the leading strategy for constructing a conspiracy theory. Finally, I outline two alternative strategies for constructing conspiracy theories, both of which are immune to these arguments, but require one to either modify or reject the common cause principle. Introduction The incompleteness of quantum mechanics Hidden variables Hidden mechanism conspiracy theories Existing arguments against hidden mechanisms A new argument against hidden mechanisms Backwards-causal conspiracy theories Acausal conspiracy theories Conclusion. (shrink)

I examine recent arguments based on functionalism that claim to show that Bohm's theory fails to solve the measurement problem, or if it does so, it is only because it reduces to a form of the many-worlds theory. While these arguments reveal some interesting features of Bohm's theory, I contend that they do not undermine the distinctive Bohmian solution to the measurement problem. ‡I would like to thank Harvey Brown, Martin Thomson-Jones, and David Wallace for helpful discussions. †To contact the (...) author, please write to: Department of Philosophy, University of Miami, P.O. Box 248054, Coral Gables, FL 33124–4670; e-mail: [email protected]. (shrink)

This article provides an overview of the philosophical literature on the GRW theory of quantum mechanics, and argues for a particular position regarding that literature. Much of the literature is ontological; it attempts to defend a conception of what the world is like according to the GRW theory against perceived competitors. I argue that there is no real debate here, since these supposedly conflicting positions are better regarded as alternative and compatible ways of describing the world of the GRW theory.

There is a recurring line of argument in the literature to the effect that Bohm's theory fails to solve the measurement problem. I show that this argument fails in all its variants. Hence Bohm's theory, whatever its drawbacks, at least succeeds in solving the measurement problem. I briefly discuss a similar argument that has been raised against the GRW theory.

A few years ago, I argued that according to spontaneous collapse theories of quantum mechanics, arithmetic applies to macroscopic objects only as an approximation. Several authors have written articles defending spontaneous collapse theories against this charge, including Bassi and Ghirardi, Clifton and Monton, and now Frigg. The arguments of these authors are all different and all ingenious, but in the end I think that none of them succeeds, for reasons I elaborate here. I suggest a fourth line of response, based (...) on an analogy with epistemic paradoxes, which I think is the best way to defend spontaneous collapse theories, and which leaves my main thesis intact. (shrink)

Spontaneous collapse theories of quantum mechanics require an interpretation if their claim to solve the measurement problem is to be vindicated. The most straightforward interpretation rule, the fuzzy link, generates a violation of common sense known as the counting anomaly. Recently, a consensus has developed that the mass density link provides an appropriate interpretation of spontaneous collapse theories that avoids the counting anomaly. In this paper, I argue that the mass density link violates common sense in just as striking a (...) way as the fuzzy link, and hence should not be regarded as a problem-free alternative to the fuzzy link. Hence advocates of spontaneous collapse theories must accept some violation of common sense, although this is not necessarily fatal to their project. (shrink)

Philosophy and Phenomenological Research, EarlyView.

It is widely acknowledged that the link between quantum language and ordinary language must be "fuzzier" than the traditional eigenstate-eigenvalue link. In the context of spontaneous-collapse theories, Albert and Loewer argue that the form of this fuzzy link is a matter of convention, and can be freely chosen to minimize anomalies for those theories. I defend the position that the form of the link is empirical, and could be such as to render collapse theories idle. This means that defenders of (...) spontaneous-collapse theories must gamble that the actual form of the link renders such theories tenable. (shrink)

I argued that anyone who adopts the Everettian approach to the foundations of quantum mechanics must also accept the (unpopular) ‘halfer’ solution to the Sleeping Beauty puzzle. Papineau and Durà-Vilà have responded with an argument that it is perfectly cogent both to be an Everettian and to accept the (popular) ‘thirder’ solution to Sleeping Beauty. Here I attempt to rebut their argument, and to clarify my original position.

I argue that the Doomsday argument fails because it fails to take into account the lesson of the Sleeping Beauty puzzle.

A major problem facing no-collapse interpretations of quantum mechanics in the tradition of Everett is how to understand the probabilistic axiom of quantum mechanics (the Born rule) in the context of a deterministic theory in which every outcome of a measurement occurs. Deutsch claims to derive a decision-theoretic analogue of the Born rule from the non-probabilistic part of quantum mechanics and some non-probabilistic axioms of classical decision theory, and hence concludes that no probabilistic axiom is needed. I argue that Deutsch’s (...) derivation begs the question. (shrink)

Epistemic defeat is standardly understood in either evidentialist or responsibilist terms. The seminal treatment of defeat is an evidentialist one, due to John Pollock, who famously distinguishes between undercutting and rebutting defeaters. More recently, an orthogonal distinction due to Jennifer Lackey has become widely endorsed, between so-called doxastic (or psychological) and normative defeaters. We think that neither doxastic nor normative defeaters, as Lackey understands them, exist. Both of Lackey’s categories of defeat derive from implausible assumptions about epistemic responsibility. Although Pollock’s (...) evidentialist view is superior, the evidentialism per se can be purged from it, leaving a general structure of defeat that can be incorporated in a reliabilist theory that is neither evidentialist nor responsibilist in any way. (shrink)

Proper functionalism explicates epistemic warrant in terms of the function and normal functioning of the belief-forming process. There are two standard substantive views of the sources of functions in the literature in epistemology: God (intelligent design) or Mother Nature (evolution by natural selection). Both appear to confront the Swampman objection: couldn’t there be a mind with warranted beliefs neither designed by God nor the product of evolution by natural selection? Is there another substantive view that avoids the Swampman objection? There (...) are two. The first is the generalized selected-effects theory of functions. The second is the organizational theory of functions. Both, however, require some history to assign functions, for both are etiological theories of functions: past effects help explain current function. Swampman can then acquire functions, perhaps soon after creation, though he has none at the moment of inception. (shrink)

The Doomsday Argument and the Simulation Argument share certain structural features, and hence are often discussed together. Both are cases where reflecting on one’s location among a set of possibilities yields a counter-intuitive conclusion—in the first case that the end of humankind is closer than you initially thought, and in the second case that it is more likely than you initially thought that you are living in a computer simulation. Indeed, the two arguments do have some structural similarities. But there (...) are also significant disanalogies between the two arguments, and I argue that these disanalogies mean that the Simulation Argument succeeds and the Doomsday Argument fails. (shrink)

The main problem with the many‐worlds theory is that it is not clear how the notion of probability should be understood in a theory in which every possible outcome of a measurement actually occurs. In this paper, I argue for the following theses concerning the many‐worlds theory: If probability can be applied at all to measurement outcomes, it must function as a measure of an agent’s self‐location uncertainty. Such probabilities typically violate reflection. Many‐worlds branching does not have sufficient structure to (...) admit self‐location probabilities. Decision‐theoretic arguments do not solve this problem. †To contact the author, please write to: Department of Philosophy, University of Miami, P.O. Box 248054, Coral Gables, FL 33124‐4670; e‐mail: [email protected]. (shrink)

Propositionalism explains the nature of knowledge-how as follows: P: To know how to ϕ is to stand in a special propositional attitude relation to propositions about how to ϕ. To know how to ride a bike is to have the required propositional attitude to propositions about how to do so. Dispositionalism offers an alternative view.D: To know how to ϕ is to stand in a behavioral-dispositional relation, a being-able-to relation, to ϕ-ing. To know how to ride a bike is to (...) have an ability to do so in the form of a complex disposition to behave in ways that constitute bike riding. Objectualism presents a third option.O: To know how to ϕ is to stand in a non-propositional, non-behavioral-dispositional objective attitude relation to a way of j-ing. To know how to ride a bike is to have an objectual attitude, perhaps a form of knowledge of, to a way of doing so.Dispositionalism is often dismissed on the basis of two criticisms designed to show its shortcomings relative to Propositionalism and Objectualism. According to the Epistemic Improvement Objection, Dispositionalism cannot account for the fact that gaining knowledge-how is an improvement in our epistemic state. According to the Modified Ability Objection, it cannot account for the fact that being able to do something is neither necessary nor sufficient for knowing how to do it. I develop a form of Dispositionalism, the Special Ability View, that avoids both objections. (shrink)

A local hidden variable theory of quantum mechanics is formulated by adapting Gell-Mann and Hartle’s many-histories formulation. The resulting theory solves the measurement problem by exploiting the independence loophole in Bell’s theorem; it violates the independence of hidden variable values and measuring device settings. Although the theory is problematic in some respects, it provides a concrete example via which the tenability of this approach can be better evaluated.

The Sleeping Beauty paradox in epistemology and the many-worlds interpretation of quantum mechanics both raise problems concerning subjective probability assignments. Furthermore, there are striking parallels between the two cases; in both cases personal experience has a branching structure, and in both cases the agent loses herself among the branches. However, the treatment of probability is very different in the two cases, for no good reason that I can see. Suppose, then, that we adopt the same treatment of probability in each (...) case. Then the dominant ‘thirder’ solution to the Sleeping Beauty paradox becomes incompatible with the tenability of the many-worlds interpretation. (shrink)

The norm of assertion, to be in force, is a social norm. What is the content of our social norm of assertion? Various linguistic arguments purport to show that to assert is to represent oneself as knowing. But to represent oneself as knowing does not entail that assertion is governed by a knowledge norm. At best these linguistic arguments provide indirect support for a knowledge norm. Furthermore, there are alternative, non-normative explanations for the linguistic data (as in recent work from (...) Van Elswyk). Direct arguments would rely on normative judgments about the permissibility or impermissibility of assertions with and without the speaker knowing the content asserted. John Turri's work experimental results purport to show that our norm of assertion is factive, and probably knowledge. But as a number of recent experimentalists (Kneer, Reuter and Broessel, Marsili and Wiegmann) have shown, Turri's results rely on the problemmatic use of 'should' as in 'Maria should assert that she owns a 1990 watch.' Correcting for this, these experimentalists provide strong evidence that our norm of assertion is not factive. The standard reply to evidence like this from the assertion of unlucky falsehoods is the excuse maneuver. But Marsili and Wiegmann, following Turri's protocol for testing for excuse validation, show that participants who judge that assertions unlucky falsehoods are permissible are not guilty of excuse validation. Given our current understanding of the experimental evidence, knowledge is not our norm of assertion. (shrink)

Everettian accounts of quantum mechanics entail that people branch; every possible result of a measurement actually occurs, and I have one successor for each result. Is there room for probability in such an account? The prima facie answer is no; there are no ontic chances here, and no ignorance about what will happen. But since any adequate quantum mechanical theory must make probabilistic predictions, much recent philosophical labor has gone into trying to construct an account of probability for branching selves. (...) One popular strategy involves arguing that branching selves introduce a new kind of subjective uncertainty. I argue here that the variants of this strategy in the literature all fail, either because the uncertainty is spurious, or because it is in the wrong place to yield probabilistic predictions. I conclude that uncertainty cannot be the ground for probability in Everettian quantum mechanics. (shrink)