Decision-making assisted by algorithms developed by machine learning is increasingly determining our lives. Unfortunately, full opacity about the process is the norm. Would transparency contribute to restoring accountability for such systems as is often maintained? Several objections to full transparency are examined: the loss of privacy when datasets become public, the perverse effects of disclosure of the very algorithms themselves (“gaming the system” in particular), the potential loss of companies’ competitive edge, and the limited gains in answerability to be expected (...) since sophisticated algorithms usually are inherently opaque. It is concluded that, at least presently, full transparency for oversight bodies alone is the only feasible option; extending it to the public at large is normally not advisable. Moreover, it is argued that algorithmic decisions preferably should become more understandable; to that effect, the models of machine learning to be employed should either be interpreted ex post or be interpretable by design ex ante. (shrink)

It was to correct common misconceptions about his thought that Jean-Paul Sartre, the most dominent European intellectual of the post-World War II decades, accepted an invitation to speak on October 29, 1945, at the Club Maintenant in Paris. The unstated objective of his lecture was to expound his philosophy as a form of “existentialism,” a term much bandied about at the time. Sartre asserted that existentialism was essentially a doctrine for philosophers, though, ironically, he was about to make it (...) accessible to a general audience. The published text of his lecture quickly became one of the bibles of existentialism and made Sartre an international celebrity. The idea of freedom occupies the center of Sartre’s doctrine. Man, born into an empty, godless universe, is nothing to begin with. He creates his essence—his self, his being—through the choices he freely makes. Were it not for the contingency of his death, he would never end. Choosing to be this or that is to affirm the value of what we choose. In choosing, therefore, we commit not only ourselves but all of mankind. This book presents a new English translation of Sartre’s 1945 lecture and his analysis of Camus’s _The Stranger_, along with a discussion of these works by acclaimed Sartre biographer Annie Cohen-Solal. This edition is a translation of the 1996 French edition, which includes Arlette Elkaïm-Sartre’s introduction and a Q&A with Sartre about his lecture. (shrink)

The first volume of the Library of Living Philosophers (LLP) appeared in 1939, the brainchild of the late Professor Paul A. Schilpp. Schilpp saw that it would help to eliminate confusion and endless sterile disputes over interpretation if great philosophers could be confronted by their capable philosophical peers and asked to reply. As well as a number of critical essays with the chosen philosopher's replies to each essay, each volume would include an intellectual autobiography and an up-to-date bibliography The (...) LLP series has exceeded even Schilpp's expectations, enabling great philosophers to do more than clarify by extending and elaborating their thoughts. A volume in the Library of Living Philosophers is not merely a commentary on a philosopher's work; it is a critical part of that work. (shrink)

That we owe duties to others is a commonplace, the subject of countless philosophical treatises and monographs. Morality is interpersonal and other-directed, many claim. But what of what we owe ourselves? In Duty to Self, Paul Schofield flips the paradigm of interpersonal morality by arguing that there are moral duties we owe ourselves, and that in light of this, philosophers need to significantly rethink many of their views about practical reason, moral psychology, politics, and moral emotions. -/- Among these (...) views is the idea that divisions within a person's life enable her to relate to herself second-personally--that is, as though she were relating to a distinct other person--in the way required by morality. Further, there exist political duties owed to the self, which the state may coerce persons to perform. This amounts to a novel argument for paternalistic law, which appeals to considerations of right, justice, and freedom in order to justify coercing a person for their own sake--a liberal justification for an idea typically thought to be deeply at odds with liberalism. -/- Schofield untangles how this view would impact various issues in applied ethics and political philosophy, for example, financial prudence and risk, the pursuit of the good life, and medical ethics. Duty to Self is essential for anyone working in moral and political philosophy or political theory. (shrink)

We present a variety of (ω 1 ,∞)-distributive forcings which when applied to models of Martin's Maximum separate certain well known reflection principles. In particular, we do this for the reflection principles SR, SR α (α ≤ ω 1 ), and SRP.

Although images are pervasive in public policy debates in bioethics, few who work in the field attend carefully to the way that images function rhetorically. If the use of images is discussed at all, it is usually to dismiss appeals to images as a form of manipulation. Yet it is possible to speak meaningfully of visual arguments. Examining the appeal to images of the embryo and fetus in debates about abortion and stem cell research, I suggest that bioethicists would be (...) well served by attending much more carefully to how images function in public policy debates. (shrink)

We present a variation of the forcing S max as presented in Woodin [4]. Our forcing is a P max -style construction where each model condition selects one Souslin tree. In the extension there is a Souslin tree T G which is the direct limit of the selected Souslin trees in the models of the generic. In some sense, the generic extension is a maximal model of "there exists a minimal Souslin tree," with T G being this minimal tree. In (...) particular, in the extension this Souslin tree has the property that forcing with it gives a model of Souslin's Hypothesis. (shrink)

Open-source communities that focus on content rely squarely on the contributions of invisible strangers in cyberspace. How do such communities handle the problem of trusting that strangers have good intentions and adequate competence? This question is explored in relation to communities in which such trust is a vital issue: peer production of software (FreeBSD and Mozilla in particular) and encyclopaedia entries (Wikipedia in particular). In the context of open-source software, it is argued that trust was inferred from an underlying ‘hacker (...) ethic’, which already existed. The Wikipedian project, by contrast, had to create an appropriate ethic along the way. In the interim, the assumption simply had to be that potential contributors were trustworthy; they were granted ‘substantial trust’. Subsequently, projects from both communities introduced rules and regulations which partly substituted for the need to perceive contributors as trustworthy. They faced a design choice in the continuum between a high-discretion design (granting a large amount of trust to contributors) and a low-discretion design (leaving only a small amount of trust to contributors). It is found that open-source designs for software and encyclopaedias are likely to converge in the future towards a mid-level of discretion. In such a design the anonymous user is no longer invested with unquestioning trust. (shrink)

Philosophers have sometimes drawn a distinction between supererogation and duty. This paper considers the possibility that a religious understanding of hu- man life and history may require what would otherwise be considered praise worthy but not obligatory. The specific example here is forgiveness. The paper sketches a view of forgiveness and suggests that forgiveness is not, at least in contemporary Western thought, considered to be a moral obligation. Several reasons why this might be the case are considered as well as (...) how par- ticular Christian beliefs about God's justice and mercy may transform this situa- tion. The paper concludes that given certain religious beliefs, forgiveness may be both moral prerogative and religious duty. (shrink)

Can trust evolve on the Internet between virtual strangers? Recently, Pettit answered this question in the negative. Focusing on trust in the sense of ‘dynamic, interactive, and trusting’ reliance on other people, he distinguishes between two forms of trust: primary trust rests on the belief that the other is trustworthy, while the more subtle secondary kind of trust is premised on the belief that the other cherishes one’s esteem, and will, therefore, reply to an act of trust in kind (‘trust-responsiveness’). (...) Based on this theory Pettit argues that trust between virtual strangers is impossible: they lack all evidence about one another, which prevents the imputation of trustworthiness and renders the reliance on trust-responsiveness ridiculous. I argue that this argument is flawed, both empirically and theoretically. In several virtual communities amazing acts of trust between pure virtuals have been observed. I propose that these can be explained as follows. On the one hand, social cues, reputation, reliance on third parties, and participation in (quasi-) institutions allow imputing trustworthiness to varying degrees. On the other, precisely trust-responsiveness is also relied upon, as a necessary supplement to primary trust. In virtual markets, esteem as a fair trader is coveted while it contributes to building up one’s reputation. In task groups, a hyperactive style of action may be adopted which amounts to assuming (not: inferring) trust. Trustors expect that their virtual co-workers will reply in kind while such an approach is to be considered the most appropriate in cyberspace. In non-task groups, finally, members often display intimacies while they are confident someone else ‘out there’ will return them. This is facilitated by the one-to-many, asynchronous mode of communication within mailing lists. (shrink)

BackgroundThe use of genetic test results in risk-rated insurance is a significant concern internationally, with many countries banning or restricting the use of genetic test results in underwriting. In Australia, life insurers’ use of genetic test results is legal and self-regulated by the insurance industry (Financial Services Council (FSC)). In 2018, an Australian Parliamentary Inquiry recommended that insurers’ use of genetic test results in underwriting should be prohibited. In 2019, the FSC introduced an industry self-regulated moratorium on the use of (...) genetic test results. In the absence of government oversight, it is critical that the impact, effectiveness and appropriateness of the moratorium is monitored. Here we describe the protocol of our government-funded research project, which will serve that critical function between 2020 and 2023.MethodsA realist evaluation framework was developed for the project, using a context-mechanism-outcome (CMO) approach, to systematically assess the impact of the moratorium for a range of stakeholders. Outcomes which need to be achieved for the moratorium to accomplish its intended aims were identified, and specific data collection measures methods were developed to gather the evidence from relevant stakeholder groups (consumers, health professionals, financial industry and genetic research community) to determine if aims are achieved. Results from each arm of the study will be analysed and published in peer-reviewed journals as they become available.DiscussionThe A-GLIMMER project will provide essential monitoring of the impact and effectiveness of the self-regulated insurance moratorium. On completion of the study (3 years) a Stakeholder Report will be compiled. The Stakeholder Report will synthesise the evidence gathered in each arm of the study and use the CMO framework to evaluate the extent to which each of the outcomes have been achieved, and make evidence-based recommendations to the Australian federal government, life insurance industry and other stakeholders. (shrink)

We propose in this article some new elements for the interpretation of Heraclitus' doctrine, concerning in particular the role of the opposition of contraries as generator of harmony, that results from Fragments 8DK and 51DK. This interpretation is based on the conceptual tool of matrices of concepts. After having described the basic elements that govern the latter, we set out to define in this conceptual framework the notions of opposition and contrary, as well as of harmony. This allows us to (...) give an interpretation and also a justification of Heraclitus' specific doctrine, according to which the opposition of opposites generates harmony. (shrink)

The canonical function game is a game of length ω1 introduced by W. Hugh Woodin which falls inside a class of games known as Neeman games. Using large cardinals, we show that it is possible to force that the game is not determined. We also discuss the relationship between this result and Σ22 absoluteness, cardinality spectra and Π2 maximality for H(ω2) relative to the Continuum Hypothesis.

: Successful stem cell therapies might change the natural contours of human life. If that happened, it would unsettle our ethical commitments and encourage us to see the entire natural world merely as material to be manipulated.

Trust between transaction partners in cyberspace has come to be considered a distinct possibility. In this article the focus is on the conditions for its creation by way of assuming, not inferring trust. After a survey of its development over the years (in the writings of authors like Luhmann, Baier, Gambetta, and Pettit), this mechanism of trust is explored in a study of personal journal blogs. After a brief presentation of some technicalities of blogging and authors’ motives for writing their (...) diaries, I try to answer the question, ‘Why do the overwhelming majority of web diarists dare to expose the intimate details of their lives to the world at large?’ It is argued that the mechanism of assuming trust is at play: authors simply assume that future visitors to their blog will be sympathetic readers, worthy of their intimacies. This assumption then may create a self-fulfilling cycle of mutual admiration. Thereupon, this phenomenon of blogging about one’s intimacies is linked to Calvert’s theory of ‘mediated voyeurism’ and Mathiesen’s notion of ‘synopticism’. It is to be interpreted as a form of ‘empowering exhibitionism’ that reaffirms subjectivity. Various types of ‘synopticon’ are distinguished, each drawing the line between public and private differently. In the most ‘radical’ synopticon blogging proceeds in total transparency and the concept of privacy is declared obsolete; the societal gaze of surveillance is proudly returned and nullified. Finally it is shown that, in practice, these conceptions of blogging are put to a severe test, while authors often have to cope with known people from ‘real life’ complaining, and with ‘trolling’ strangers. (shrink)

This paper claims that recent attempts to draw on the maternal experiences of women in order to articulate an ethic of care and compassion is a new romanticism. Like earlier romantic views, it is both attractive and potentially dangerous. The paper examines the basic claims of this new romanticism in order to identify both its strengths and weaknesses. I conclude that there are at least two versions of this new romanticism, one that relies primarily on the experiences of child-bearing in (...) grounding an ethic of care and compassion, and a second that relies primarily on child-rearing. I suggest that the former version of the new romanticism is deeply flawed because such a view ought to be unacceptable to women and will be inaccessible to men. (shrink)

Its critics to the contrary, the “gift of life” metaphor is not to be blamed for the indebtedness and guilt that organ recipients often experience. It is certainly misused, however, both by post‐transplant caregivers, who exploit it to manipulate recipients' behavior, and by the organ procurement system, which has failed to understand that the decision to give the gift of life must be approached communally.

Current reproductive technology challenges us to think seriously about social values surrounding childbearing. Thoughtful discussion must combine careful attention to the experience of pursuing parenthood by technological means with principled reflection on the morality of this pursuit.

"L'espèce humaine est la seule qui sache qu'elle doit mourir, et elle ne le sait que par l'expérience" (Voltaire). Certes, mais que signifie cette "expérience" pour la personne humaine? Et d'abord, que signifie la mort de l'autre, du prochain? Pour Paul-Louis Landsberg, l'appropriation spirituelle de la mort est une tâche décisive pour toute personne humaine. Les voies de cette appropriation sont diverses, mais ce n'est qu'en relation avec une personnalisation progressive du tout de l'existence humaine qu'elle acquiert réellement un (...) sens nouveau. Et c'est dans l'expérience mystique que la proximité avec l'expérience de la mort est la plus forte. Le Problème moral du suicide (1942) est un texte précieux, plus encore aujourd'hui qu'il y a cinquante ans. A l'encontre de ceux qui soutiennent le "droit" à la mort volontaire, P.-L. Landsberg explique que "l'homme est l'être qui peut se tuer et qui ne doit pas le faire", et, en ce sens, le suicide est un " problème spécifiquement humain". (shrink)

A large U.S. government investigation into arms procurement procedures with corporate contractors has recently led to guilty pleas to fraud and illegal use of classified documents. Operation Ill Wind has brought public attention to the criminal and unethical conduct of large defense contractors in their dealings with the government. This article will review how the defense contract bidding process operates and why illegal activity has been able to compromise the process. We will offer proposals to improve the process in light (...) of the present inquiry. (shrink)

We show that the members of a certain class of semi-proper iterations do not add countable sets of ordinals. As a result, starting from suitable large cardinals one can obtain a model in which the Continuum Hypothesis holds and every function from ω1 to ω1 is bounded on a club by a canonical function for an ordinal less than ω2.

This paper claims that recent attempts to draw on the maternal experiences of women in order to articulate an ethic of care and compassion is a new romanticism. Like earlier romantic views, it is both attractive and potentially dangerous. The paper examines the basic claims of this new romanticism in order to identify both its strengths and weaknesses. I conclude that there are at least two versions of this new romanticism, one that relies primarily on the experiences of child-bearing in (...) grounding an ethic of care and compassion, and a second that relies primarily on child-rearing. I suggest that the former version of the new romanticism is deeply flawed because such a view ought to be unacceptable to women and will be inaccessible to men. (shrink)

The move in moral theory toward listening to and accommodating “experience” requires that we hear its diversity, take a closer look at its nature, and ask how it should function in moral deliberation.

How may feelings of love and hate impact people’s attention? We used a modified Attentional Blink (AB) task in which 300 participants were asked to categorise a name representing a person towards whom they felt either hate, love, or neutral (first target) plus identify a number word (second target), both embedded in a rapidly presented stream of other words. The lag to the second target was systematically varied. Contrary to our hypothesis, results revealed that both hated and loved names resulted (...) in higher accuracy for the second target than neutral names, which was largely independent of lag. Also, there we observed no sustained transfer effects of love and hate onto neutral name trials. The findings differ from prior research on attentional blink and transient, non-personal, stimulus-driven emotions, suggesting that interpersonal feelings activate different attention-relevant mechanisms. Relevant to future research, we speculate that love and hate are motivators of goal-directed behaviour that facilitate subsequent information processing. (shrink)

In [P. Larson, Martin’s Maximum and the axiom , Ann. Pure App. Logic 106 135–149], we modified a coding device from [W.H. Woodin, The Axiom of Determinacy, Forcing Axioms, and the Nonstationary Ideal, Walter de Gruyter & Co, Berlin, 1999] and the consistency proof of Martin’s Maximum from [M. Foreman, M. Magidor, S. Shelah, Martin’s Maximum. saturated ideals, and non-regular ultrafilters. Part I, Annal. Math. 127 1–47] to show that from a supercompact limit of supercompact cardinals one could force Martin’s (...) Maximum to hold while the axiom fails. Here we modify that argument to prove a stronger fact, that Martin’s Maximum is consistent with the existence of a wellordering of the reals definable in H without parameters, from the same large cardinal hypothesis. In doing so we give a much simpler proof of the original result. (shrink)

Hailed as revolutionary, the prospect of human cloning is actually the next logical step in a series of developments in reproductive technology that began with the first test-tube baby in 1978. This book addresses the debates over cloning in the context of new reproductive technology and human embryo research. It examines the status of preimplantation embryos, the ethical issues related to cloning and embryo research, and the formulation of public policy.

Japan's politieal, cultural, and geographic isolation, its symbiotic government-business arrangement, and its practice of practical, resources-oriented politics, trade, and diplomacy have led it to be the only major global economic power to strictIy comply with the Arab boycott. A brief history and description of the boycott are presented here, along with an overview of the responses of major economic trading nations. Three issues are addressed: Japan's global conscience, the framework appropriate to analyze the ethics of global economic boycotts, and the (...) Japanese government's excuse of leaving boycott decisions to business considering the historic relationship between the two. The logical conclusion of this analysis is that Japan as a nation must abandon its insularity and take a greater ethical responsibility in line with its economic power. From this comes the responsibility of the govenment to guide the business sector towards a corporate conscienee, one that is grounded in global awareness. (shrink)

Given a stationary subset T of $\omega_{1}$ , let $\tilde{T}$ be the set of ordinals in the interval $(\omega_{1}, \omega_{2})$ which are necessarily in the image of T by any embedding derived from the nonstationary ideal. We consider the question of the size of $\tilde{T}$ , givenT, and use Martin's Maximum and $\mathbb{P}_{max}$ to give some answers.

Given the dichotomy traditionally posited between reason and emotion, ethicists have generally downplayed or ignored the role of emotions in the moral life. In this paper I argue that the traditional dichotomy between reason and emotion should be abandoned, and that developing an account of emotions that attends to their cognitive structure can pave the way for a reassessment of the role emotions play in our efforts to live morally. I suggest that this reassessment is of particular interest to religious (...) ethicists because adopting a "constructivist" theory of emotions can help explain how a religious vision of human life and history may bring about significant moral changes in the life of the believer. I try to illustrate this point by showing how a religious conception of the nature of moral relations may have an effect on the emotion of anger. (shrink)

Assuming the existence of a supercompact limit of supercompact cardinals, we modify the original consistency proof of Martin's Maximum to obtain a model in which MM holds but the axiom fails.

In one of his most important books, Children, Ethics, and Modern Medicine, Richard B. Miller argues that medical ethicists have too frequently focused on abstract moral and legal principles in wrestling with the issues raised by contemporary medical practice. Drawing on the anthropologist, Clifford Geertz, Miller suggests that ethicists must attend to both the “experience-near” realities that patients and their families confront and the “experience-distant” work of connecting those realities to the theoretical principles that might help illuminate the existential and (...) ethical problems faced by patients and families. In a useful analogy, Miller argues that the best strategy is to tack back and forth between the near and the distant such that one artfully occupies the intermediate space between personal and impersonal perspectives. In this chapter, I follow Miller’s advice to seek out the intermediate space between the lived reality of the bedside and the reflective domain of the scholar’s office. For most bioethicists that space is found in one of three ways. One encounters patients and their families as a clinician or as an observer of the clinical encounter. One attends carefully to illness narratives as a source of experience-near material. Or one reflects on one’s own experience as a patient or family member encountering medical practice. This chapter suggests that it is possible to combine these approaches. Specifically, I draw on the experience of accompanying my wife through her illness and death from ovarian cancer, as well as on grief memoirs to illuminate a neglected area of health humanities scholarship. Drawing on Arthur Frank’s classic study of illness narratives in The Wounded Storyteller, this chapter delineates similarities and between grief narratives and illness narratives. A comparison of these two genres suggests why the grief of patients and families is so often overlooked in accounts of the clinical encounter. (shrink)

Genetic research into ageing, longevity and late-onset disease is becoming increasingly common. Yet, there is a paucity of knowledge related to clinical actionability and the return of pathogenic variants to otherwise healthy elderly individuals. Whether or not genetic research in the elderly should be managed differently from standard practices adapted for younger populations has not yet been defined. In this article, we provide an overview of ethical and practical challenges in preparing for a genetic study of over 14 000 healthy (...) Australians aged 70 years or older enrolled in the ASPirin in Reducing Events in the Elderly Healthy Ageing Biobank. At the time of consent, all participants in this study were free of life-threatening illness, cardiovascular disease or cognitive impairment. ASPREE is thus a cohort of healthy elderly individuals with seemingly minimal burden of genetic disease recruited without ascertainment bias. The cohort presents a unique opportunity to address the penetrance of known pathogenic variants in a population without disease symptoms; however, it also raises a number of ethical concerns regarding the interpretation and disclosure of variants with known clinical actionability. Some of the challenges include how to manage the interpretation, disclosure and actioning of pathogenic variants found in otherwise healthy elderly adults without disease symptoms, whether or not to disclose findings for the benefit of family members rather than elderly consented donors themselves, how to manage the return of genetic findings to the elderly individuals who are now in severe cognitive decline or terminal illness, how to ensure quality of information and clinical service upon disclosure of results to this demographic and how to prepare for the insurance implications of disclosing genetic information under Australian law. We discuss these and other dilemmas and propose a defensible plan of management. Trial registration number ISRCTN83772183. (shrink)

The overarching issue with this case study is poor regulation and quality control over direct-to-consumer genetic testing, delivered in the absence of any medical oversight.

Working in the context of restricted forms of the Axiom of Choice, we consider the problem of splitting the ordinals below λ of cofinality θ into λ many stationary sets, where θ < λ are regular cardinals. This is a continuation of [4].

The stationary set splitting game is a game of perfect information of length ω1 between two players, unsplit and split, in which unsplit chooses stationarily many countable ordinals and split tries to continuously divide them into two stationary pieces. We show that it is possible in ZFC to force a winning strategy for either player, or for neither. This gives a new counterexample to Σ22 maximality with a predicate for the nonstationary ideal on ω1, and an example of a consistently (...) undetermined game of length ω1 with payoff de.nable in the second-order monadic logic of order. We also show that the determinacy of the game is consistent with Martin's Axiom but not Martin's Maximum. (shrink)

In “Reason and the Republic of Opinion,” Leon Wieseltier bemoaned an age that reduces reason to utilitarian calculation and requires almost ritual genuflection before the altar of numbers. The spirit of this age is at work in the field of bioethics where, as Debra Mathews and colleagues point out in “A Conceptual Model for the Translation of Bioethics Research and Scholarship,” researchers and scholars are increasingly “being asked to demonstrate and also forecast the value and impact of their work.” Despite (...) the reductionism that typically accompanies the movements imbued with this spirit, the concern for accountability that stands behind the call for measuring success is legitimate. The bioethics community is thus fortunate to have such a distinguished group of scholars wrestling with these matters. Indeed, the effort of Mathews et al. to articulate a framework for determining success in bioethics research and scholarship is especially admirable precisely because they resist the temptation to reduce success to quantitative measures alone. That said, it is also important to say that it is nearly impossible to engage with the task these scholars have set for themselves and not succumb to a kind of data fetishism. It is well and good to talk about the complexity of bioethics as a field, but the language of “metrics,” “outputs,” “feedback loops,” “stakeholders,” and the like is not the language of the disciplines of history, literature, philosophy, or religious studies—all fields that Mathews et al. rightly credit with making important contributions to bioethics research and scholarship. (shrink)

Examines the political dimensions of Aristophanes’ comic poetry. This original and wide-ranging collection of essays offers, for the first time, a comprehensive examination of the political dimensions of that madcap comic poet Aristophanes. Rejecting the claim that Aristophanes is little more than a mere comedian, the contributors to this fascinating volume demonstrate that Aristophanes deserves to be placed in the ranks of the greatest Greek political thinkers. As these essays reveal, all of Aristophanes’ plays treat issues of fundamental political importance, (...) from war and peace, poverty and wealth, the relation between the sexes, demagoguery and democracy to the role of philosophy and poetry in political society. Accessible to students as well as scholars, The Political Theory of Aristophanes can be utilized easily in the classroom, but at the same time serve as a valuable source for those conducting more advanced research. Whether the field is political philosophy, classical studies, history, or literary criticism, this work will make it necessary to reconceptualize how we understand this great Athenian poet and force us to recognize the political ramifications and underpinnings of his uproarious comedies. Jeremy J. Mhire is Assistant Professor of Political Science at Louisiana Tech University. Bryan-Paul Frost is James A. and Kaye L. Crocker Endowed Professor of Political Science at the University of Louisiana at Lafayette and the coeditor (with Jeffrey Sikkenga) of History of American Political Thought. (shrink)

The role of acetylcholinesterase (AChE) in neurotransmission is well known. But long before synapses are formed in vertebrates, AChE is expressed in young postmitotic neuroblasts that are about to extend the first long tracts. AChE histochemistry can thus be used to map primary steps of brain differentiation. Preceding an possibly inducing AChE in avian brains, the closely related butyrylcholinesterase (BChE) spatially fore-shadows AChE-positive cell areas and the course of their axons. In particular, before spinal motor axons grow, their corresponding rostral (...) sclerotomes and myotomes express BChE, and both their neuronal source and myotomal target cells express AChE. Since axon growth has been found inhibited by acetylcholine, it is postulated that both cholinetsreases can attract neurite growth cones by neutralizing the inhibitor. Thus, the early expression of both cholinesterases that is at least partially independent from classical cholinergic synaptogenesis, sheds new light on the developmental and medical significance of these enzymes. (shrink)

When French philosopher Paul Ricoeur died in 2005, he bequeathed to the world a highly regarded, widely influential body of work which established him as one of the greatest thinkers of our time. He also left behind a number of unfinished projects that are gathered here and translated into English for the first time. Living Up to Death consists of one major essay and nine fragments. Composed in 1996, the essay is the kernel of an unrealized book on the (...) subject of mortality. Likely inspired by his wife’s approaching death, it examines not one’s own passing but one’s experience of others dying. Ricoeur notes that when thinking about death the imagination is paramount, since we cannot truly experience our own passing. But those we leave behind do, and Ricoeur posits that the idea of life after death originated in the awareness of our own end posthumously resonating with our survivors. The fragments in this volume were written over the course of the last few months of Ricoeur’s life as his health failed, and they represent his very last work. They cover a range of topics, touching on biblical scholarship, the philosophy of language, and the idea of selfhood he first addressed in Oneself as Another. And while they contain numerous philosophical insights, these fragments are perhaps most significant for providing an invaluable look at Ricoeur’s mind at work. As poignant as it is perceptive, Living Up to Death is a moving testimony to Ricoeur’s willingness to confront his own mortality with serious questions, a touching insouciance, and hope for the future. (shrink)

We show, using a variation of Woodin’s partial order ℙ max , that it is possible to destroy the saturation of the nonstationary ideal on ω 1 by forcing with a Suslin tree. On the other hand, Suslin trees typcially preserve saturation in extensions by ℙ max variations where one does not try to arrange it otherwise. In the last section, we show that it is possible to have a nonmeager set of reals of size ℵ1, saturation of the nonstationary (...) ideal, and no weakly Lusin sequences, answering a question of Shelah and Zapletal. (shrink)

Corporate violations of the law are occurring with increasing frequency and with increasing public attention. Solutions to date have proved ineffectual because of the problem of determining whom is to be punished for the offense of the corporation. Instead of individual jail terms or corporate fines, we propose that the dissolution of the corporation be considered as a more effectual means of conforming corporate behavior to the norms of the legal system.