The acidic (leucine‐rich) nuclear phosphoprotein 32 kDa (ANP32) family is composed of small, evolutionarily conserved proteins characterized by an N‐terminal leucine‐rich repeat domain and a C‐terminal low‐complexity acidic region. The mammalian family members (ANP32A, ANP32B, and ANP32E) are ascribed physiologically diverse functions including chromatin modification and remodelling, apoptotic caspase modulation, protein phosphatase inhibition, as well as regulation of intracellular transport. In addition to reviewing the widespread literature on the topic, we present a concept of the ANP32s as having a whip‐like (...) structure. We also present hypotheses that ANP32C and other intronless sequences should not currently be considered bona fide family members, that their disparate necessity in development may be due to compensatory mechanisms, that their contrasting roles in cancer are likely context‐dependent, along with an underlying hypothesis that ANP32s represent an important node of physiological regulation by virtue of their diverse biochemical activities. (shrink)

Papers presented at the Conference of the Cardinal Newman Society, November, 2001, the Catholic University of America, Washington, D.C.

In lieu of an abstract, here is a brief excerpt of the content:At St. Isidore’s Franciscan College in Rome, the following maxim attributed to St. Patrick is inscribed above the door-way of the church: Si quae difficiles quaestiones in hac insula oriantur ad Sedem Apostolicam referantur; ut Christiani ita et Romani sitis.1 The college was founded in 1625 by Luke Wadding, O.F.M. and, under his direction, became a major seat of theological learning and political influence for the Irish in (...) Rome.2 In the nineteenth century, the Friars Minor of the Province of Ireland assigned many documents from St. Isidore’s for use in their Irish friaries. In 1872, amid the unrest caused by the Risorgimento, medieval and early-modern Irish Franciscan manuscripts were transferred to Dublin.3 At the Merchants’ Quay Convent, the librarians T.A. O’Reilly, O.F.M. and E.B. Fitzmaurice, O.F.M. divided the manuscripts into sections with alphabetically ordered shelf-marks.4 This practical approach followed the long-established system used at Italian libraries and archives in Franciscan custody.5 From 1947 until 2000, the manuscripts of the Irish Friars Minor were kept at the Franciscans’ Dún Mhuire House of Studies in Killiney, County Dublin, before their transfer to the Archives, University College Dublin.The ‘D’ collection is preserved in twenty-six sets of volumes, folders and boxed papers. The greater part consists of Luke Wadding’s correspondence, relating to his activities as theologian, historian, Irish agent in Rome and consultor to several congregations and commissions at the papal secretariat.6 In the 1920s, Paul Grosjean, S.J. included four manuscripts then housed at Merchants’ Quay in a catalogue of hagiographical works.7 Clement Schmitt, O.F.M. treated of a collection of the Franciscan documents kept in Dublin in 1964.8Letters to and from Luke Wadding are also preserved at the Vatican Library; the Archivo Generale at the General Curia of Friars Minor, Rome; the Biblioteca Landiana, Piacenza; the Biblioteca Nazionale, Naples; the Biblioteca Ambrosiana, Milan; the Archives of the Bollandists, Brussels; the Archives Générales de Royaume, Brussels; the Von Harrach Archive, Vienna; and the Franciscan friary of St. Jerome in Vienna.9Compared to some six hundred that Luke Wadding received, “the text of approximately one hundred of his letters, in whole or in part, has survived.”10 Nearly all Wadding’s extant correspondence dates from the three decades after the publication of his Acta legationis on the doctrine of the Immaculate Conception in 1624. Most of his letters were sent from St. Isidore, some from the friaries of Aracoeli and San Pietro in Montorio, Rome, and a few from Naples.11Luke Wadding was born in Waterford on October 16, 1588, the eleventh of fourteen children.12 He was baptized two days later on the Feast of St. Luke. His father Walter was a well-established Waterford merchant and his mother Anastasia a kinswoman of the prominent Lombard family of Waterford. After the death of his parents, Luke left Ireland with his elder brother, Matthew, who enrolled him at the Irish Jesuits’ College in Lisbon. At seventeen years of age, Wadding made his way to Matozinhos in northern Portugal, near Oporto, where he entered the Franciscan Order. On completion of his novitiate, Wadding’s superiors sent him to the University of Coimbra and from there, to Salamanca. At Easter 1613, Luke Wadding was ordained to the priesthood after his studies. He was then appointed as a professor of theology at the Franciscan College of León and later at his own alma mater, Salamanca.13Called to the Spanish capital, Luke Wadding stayed at the Convent of Jesus and Mary in the south-east of Madrid where “lived not only the heads of the Franciscan Order in Spain but also the principal preachers.”14 Such was the distinction Wadding achieved that he was chosen by Philip III for the office of theologian in the embassy sent to defend the doctrine of the Immaculate Conception in Rome.15 He lived there for almost forty years, in which time he founded St. Isidore Franciscan College, the.. (shrink)

Health care in the United States, being a microcosm of the broader society in which it developed, possesses a sordid legacy concerning racial prejudices, biases, and the perpetuation of health and...

Some interpreters claim Kant distinguishes between organisms and living things. I argue that this claim is underdetermined by the textual evidence. Once this is recognized, it becomes a real possibility that Kant’s various remarks about the essential properties of living things generalize to organisms as such. This, in turn, generates a puzzle. Kant repeatedly claims that the capacity for representation is essential to the nature of a living thing. If he does not distinguish between living things and organisms, then how (...) might the capacity for representation be essential to the latter? Drawing on the writings of Kant and his contemporaries, I reconstruct a framework within which representational capacities might conceivably be thought to play this role. On this view, what distinguishes an organism from mechanically explicable products of nature is its capacity for endogenous behavior that is instinctual and representationally mediated. (shrink)

Innovative therapy is the name we give to novel medical interventions, radically different from the standard of care, provided in order to benefit a patient, rather than to acquire new knowledge. They are paradigmshifting, not incremental, responses to serious patient problems that standard medical care inadequately addresses. Innovative therapies are often devised by clinicians, not basic science researchers; they do not follow the linear model of basic research, to translation, to clinical research, to application. Instead, they come from thinking backwards (...) from the patient’s circumstances, and forward from deep knowledge of how the body functions, to challenge the limits of current mechanisms for effecting cures. (shrink)

The subject matter of this essay is a certain understanding of the value of equality which I will call ‘relational egalitarianism’ – a view which locates the value of equality not in distributions but in social and political relationships. This is a suitable topic for a contribution to a volume based on themes from the work of G.A. Cohen for two, somewhat contradictory, reasons.

Experimental research by social and cognitive psychologists has established that cooperative groups solve a wide range of problems better than individuals. Cooperative problem solving groups of scientific researchers, auditors, financial analysts, air crash investigators, and forensic art experts are increasingly important in our complex and interdependent society. This comprehensive textbook--the first of its kind in decades--presents important theories and experimental research about group problem solving. The book focuses on tasks that have demonstrably correct solutions within mathematical, logical, scientific, or verbal (...) systems, including algebra problems, analogies, vocabulary, and logical reasoning problems.The book explores basic concepts in group problem solving, social combination models, group memory, group ability and world knowledge tasks, rule induction problems, letters-to-numbers problems, evidence for positive group-to-individual transfer, and social choice theory. The conclusion proposes ten generalizations that are supported by the theory and research on group problem solving. Group Problem Solving is an essential resource for decision-making research in social and cognitive psychology, but also extremely relevant to multidisciplinary and multicultural problem-solving teams in organizational behavior, business administration, management, and behavioral economics. (shrink)

Animalism is the doctrine that we human beings are – are identical with – animals. Hylemorphism is a form of animalism. In this paper, I defend hylemorphism by showing that while other forms of animalism fall prey to the problem of ‘Remnant Persons,’ hylemorphism does not. But hylemorphism's account of personhood seems to have some very implausible implications. I address one of those implications, and argue that it isn't nearly as objectionable as it might at first appear.

Some claim Kant’s commitment to the explanatory priority of judgments over concepts is one of his most important contributions to the philosophy of mind. There is, however, extensive disagreement over the nature and extent of this commitment. Existing interpretations ignore a substantial body of textual evidence and offer no account of the origins of Kant’s view. This paper corrects for these deficiencies. I explain, first, the relevant accounts of concept possession Kant encountered in the writings of his predecessors; and, second, (...) how within this context he first expressed a commitment to the view that conceptual content is explanatorily dependent on acts of judgment. I then argue that Kant endorsed a second form of discursive primacy, namely, the view that every use of a concept in conscious thought about an object has the form of a judgment. (shrink)

Die Studie handelt von Nietzsches ursprünglicher Fragestellung, Sie geht von Nietzsches Satz in der vorrede zur Genealogie der Moral "Was habe ich mit Widerlegungen zu schaffen!" aus und zeigt, wie er zu verstehen ist. Nietzsche verschiebt sowohl die Fragestellung wie die Methode des Philosophierens: von der traditionellen Frage nach der Wahrheit über die Frage nach den Werten , nach der décadence, der Moral und der Rangordnung zur Frage nach der Kultur und zur Aufgabe der "Züchtung" im Sinne einer "Erhöhung der (...) Kultur". Diese Aufgabe ist das zweite Strukturmoment von Nietzches Denken neben der Genealogie.Diese bereitet die "Erhöhung der Kultur" nur vor.The purpose of this study is to identify the original problem which organizes the whole of Nietzsche's reflection. Starting from the statement, "what have I to do with refutations!" and the analysis of its meaning, it shows that Nietzsche imposes a mutation on both the problem of philosophy and its method; he dismisses the traditional question of truth and replaces it with the problem of culture, of which the questions of values , of morals, of décadence or hierarchy are particular aspects. Consequently, the task he assigns to the philosopher is that of Züchtung, which is to be understood as "the enhancement of culture". This task appears therefore as the second dimension of Nietzsche's reflection, in addition to geneology, which merely prepares the "enhancement of culture". (shrink)

The importance of enchancing metacognition and encouraging active learning in philosophy teaching has been increasingly recognised in recent years. Yet traditional teaching methods have not always centralised helping students to become reflectively and critically aware of the quality and consistency of their own thinking. This is particularly relevant when teaching moral philosophy, where apparently inconsistent intuitions and responses are common. In this paper I discuss the theoretical basis of the relevance of metacognition and active learning for teaching moral philosophy. Applying (...) recent discussions of metacognition, intuition conflicts and survey-based teaching techniques, I then outline a strategy for encouraging metacognitive awareness of tensions in students’ pretheoretical beliefs, and developing a critical self-awareness of their development as moral thinkers. (shrink)

From the standpoint of a Christian philosopher, heeding the teaching and exhortations of Pope John Paul II and previous popes, I examine three directions in which the recent philosophical debate has developed. In the last seven or eight years there has been 1) a renewed focus on the biological issue of when a human individual comes to be, 2) new arguments for the proposition that personhood is a characteristic acquired after birth, and 3) refinements of the early argument of Judith (...) Thomson. Replying to these developments, I defend, on philosophical grounds, the pro-life position. I argue that a distinct, whole (though immature) human individual comes to be at conception, that he or she is a person, with full moral worth, from the moment he or she comes to be, and the mothers and fathers have a special responsibility to their children which entails (at least) that they ought not to choose to abort them. I conclude by briefly indicating, from the standpoint of Christian faith, why Christian philosophers should vigorously pursue this debate. (shrink)

Constrained instrumentalist theories of punishment – those that seek to justify punishment by its good effects, but limit its scope – are an attractive alternative to pure retributivism or utilitarianism. One way in which we may be able to limit the scope of instrumental punishment is by justifying punishment through the concept of duty. This strategy is most clearly pursued in Victor Tadros’ influential ‘Duty View’ of punishment. In this paper, I show that the Duty View as it stands cannot (...) find any moral distinction between the permissible punishment of the guilty and the permissible punishment of the innocent in extreme circumstances, therefore undermining one the key pillars of its intuitive appeal. I canvass several ways to respond to this problem, arguing that a rights forfeiture theory which employs the distinction between rights forfeiture and rights infringement is the best solution. (shrink)

In a series of important papers, Galen Strawson has articulated a spectrum of “temporal temperaments,” populated at one end by “Diachronics”, who experience their selves (understood as the “mental entity” they are at this moment) as something that existed in the past and will exist in the future, and at the other end by “Episodics”, who lack any such sense of temporal extension. As a self-declared Episodic, Strawson provides lucid descriptions of what episodicity is like, but cannot furnish a corresponding (...) phenomenology of diachronic self-experience. He further argues that nothing normatively significant depends upon diachronicity, so Episodics can live fully moral (and fully satisfying) lives. I attempt to supply this missing phenomenology of diachronic self-experience using Kierkegaard’s account of “contemporaneity” (samtidighed). Kierkegaard operates with something quite close to Strawson’s “me/me*” (human/self) distinction, yet he nonetheless offers a compelling description of diachronic self-experience that is fully normative in character. I discuss some of the implications of this normativity for Strawson’s claim that there is nothing ethically or psychologically deficient in the Episodic’s self-experience. (shrink)

To make abstractions hold good in actuality means to destroy actuality.

We have a certain fascination with the incredible untapped potential of our minds. Some studies once suggested that we use only 10% of the mind's capacity. Today that estimate has been revised to about 2%-3%. Imagine what more we could do with all of that as yet unrealized potential. What is standing in our way? How do we move into a more full realization of who we are? These are the questions that this book seeks to answer.

Scheduling surgical procedures among operating rooms is mistakenly regarded as merely a tedious administrative task. However, the growing demand for surgical care and finite hours in a day qualify OR time as a limited resource. Accordingly, the objective of this manuscript is to reframe the process of OR scheduling as an ethical dilemma of allocating scarce medical resources. Recommendations for ethical allocation of OR time—based on both familiar and novel ethical values—are provided for healthcare institutions and individual surgeons.

There is a consensus among interpreters that Kant denies non-human animals possess discursive abilities but that he ascribes to them conscious representations in some more primitive sense. I argue this latter interpretive claim is not justified by the textual evidence. There is in Kant’s early published writings and unpublished remarks extensive evidence that he denies animals possess conscious representations. I examine this material in detail. I explain the competing view of Georg Friedrich Meier (1718-1777), at which some of Kant’s early (...) remarks are directed. I then explain Kant’s denial of animal consciousness with reference to his early views on the relation between faculty psychology, the capacity for judgment, and consciousness. Corroborating evidence for Kant’s denial of animal consciousness occurs in remarks in the student lecture notes that span thirty years. I explain why the strongest textual evidence to which interpreters have typically appealed is inadequate for ascribing to Kant a commitment to animal consciousness. This paper helps clarify the interpretive challenges for those who wish to claim the Critical Kant ascribes consciousness to animals. (shrink)

We investigate how changes to the payoffs of cooperative behavior affect the evolutionary dynamics. Paradoxically, the larger the benefits of cooperation, the less likely it is to evolve. This holds true even in cases where cooperation is strictly dominant. Increasing the benefits from prosocial behavior has two effects: first, in some circumstances it promotes the evolution of spite; and second, it can decrease the strength of selection leading to nearly neutral evolution of strategies. In light of these results we must (...) reevaluate standard philosophical perspectives on the evolution of cooperation and morality. (shrink)

The semantics for counterfactuals due to David Lewis has been challenged by appealing to miracles. Miracles may skew a given similarity order in favour of those possible worlds which exhibit them. Lewis responded with a system of priorities that mitigates the significance of miracles when constructing similarity relations. We propose a prioritised ceteris paribus analysis of counterfactuals inspired by Lewis’ system of priorities. By analysing the couterfactuals with a ceteris paribus clause one forces out, in a natural manner, those possible (...) worlds which do not satisfy the requirements of the clause, thus excluding miracles. If no world can satisfy the ceteris paribus clause in its entirety, then prioritisation is triggered to select worlds that maximise agreement on those things which are favoured most. (shrink)

The above passage, from Maternus' first speech, poses a number of rather intricate textual problems. J. F. Gronovius rightly divined that the meaningless vaticiniireferred to a person whose evil power Maternus had broken. Who else but Vatinius, Nero's notorious jester? To read Vatiniifor vaticiniiis intrinsically attractive, and in default of a better alternative has found almost universal approval. The contextual implications of this acclaimed conjecture have not, however, always been appreciated. It is with these that the present paper is concerned. (...) Discussing the conjecture imperante Nerone, and the interpretation of J. Stroux, it will attempt in the final section to relate the Vatinius incident to its original political and ideological context. (shrink)

ABSTRACT Nietzsche's investigation into the origins of morality bears some striking similarities to contemporary investigations into human evolution. Here I investigate these similarities, using a comparison between Nietzsche's GM and Gould and Lewontin's influential “Spandrels” essay as a departure point. I argue that Nietzsche defends a proto-evolutionary psychology about morality, where the inheritance of enduring biological drives conflicts with our culturally evolved moral system. While Nietzsche's claims about the evolution of morality fit well within a Darwinian framework of natural selection, (...) his claims about our underlying biology do not. Those claims cohere better with the non-Darwinian views found in nineteenth-century German biology and embryology. (shrink)

This article draws on Martha Nussbaum's distinction between basic, internal, and external capacities to better specify possible locations for children's ‘incapacity’ for autonomy. I then examine Maria Montessori's work on what she calls ‘normalization’, which involves a release of children's capacities for autonomy and self-governance made possible by being provided with the right kind of environment. Using Montessori, I argue that, in contrast to many ordinary and philosophical assumptions, children's incapacities for autonomy are best understood as consequences of an absence (...) of external conditions necessary for children to exercise capacities they already have internally, rather than intrinsic limitations based on their stage of life. In a closing section, I show how Montessori proposes a model wherein both children and adults have autonomy, power, and responsibility, but over different spheres, and suggest implications of these differences for who has responsibility for establishing the conditions under which children can flourish. (shrink)

Soren Kierkegaard is remembered chiefly in connection with the development of existentialist philosophy in this century, but that view is misleading. In a short and unhappy life he wrote many books and articles on themes that were literary, satirical, religious and psychological, but the diversity and idiosyncratic style of his writing have contributed to a misunderstanding of his ideas. In this book, the only introduction to the full range of Kierkegaard's thought, Patrick Gardiner demonstrates how Kierkegaard developed his ideas (...) and examines his thoughts in light of the doctrines on society that his contemporaries Marx and Feuerbach were creating. Finally he assesses how original and how important Kierkegaard's ideas were and how profoundly they have influenced modern ways of thinking. (shrink)