The purpose of this study was to evaluate the effectiveness of an educational intervention regarding end-of-life discussion directed at older Japanese adults and their attitude to and acceptance of this intervention. A quasi-experimental design was used. A total of 121 older adults, aged 65 years and over, consented to participate. Data from 55 intervention and 57 control participants were used for the analysis. The intervention consisted of an education program comprising a video, a lecture using a handout, and discussion among (...) participants. The control group received only the handout. Both groups were followed up after one month. The intervention group’s attitude became more favorable towards advance directives, especially living wills (P = 0.024). In addition, their expression of preference for life-sustaining treatment by means of artificial nutrition was less at follow up, demonstrating that these older adults had become more autonomous (P = 0.008). There was greater acceptance of the intervention as a whole by the intervention group compared with the control group (P = 0.011). Although few participants overall completed living wills, at follow up twice as many in the intervention group had discussed end-of-life matters with family members and/or their physician. (shrink)

文明の衰亡は必然なのか?衰退から逃れる道はないのか?本書ではローマ帝国、ビザンチン帝国、大英帝国、アメリカ、中国そして江戸時代の日本など独自の世界を確立した大国の興亡の光景を描き出し、その「文明衰退の 理」を歴史の教訓から導き出す。史上、外敵の侵入で滅んだ国はない。衰退はその国の「内なる原因」によってなされたと著者は論ずる。世界史的・文明史的視点から、日本の衰退と再生を洞察する「衰退学」の集大成であ る。.

In Japan, terminating life-sustaining treatment in non-terminal patients is legally and ethically problematic given the lack of legal regulations regarding the termination of LST, including dialysis treatment. This article describes an ethically problematic case that happened at a hospital in Tokyo in March 2019, in which a patient died after a physician withdrew kidney dialysis upon the patient’s request. Most national newspapers in Japan reported the case extensively and raised the question of ethical and legal permissibility of withdrawing dialysis treatment (...) from non-terminal patients. In this article, we first examine the case within the current policy framework in Japan and then discuss how Japan can improve its end-of-life practice, focusing specifically on the patient’s right to self-determination and treatment refusal. We recommend that policymakers consider legalizing the termination of LST and the patient’s right to refuse treatment based on the principle of respect for autonomy. (shrink)

BackgroundRegulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England.Main textFindings from a literature review are first presented to (...) describe the development of the regulatory frameworks surrounding the option of forgoing LST in each country. Based on the findings from the four countries, we suggest five ethically important points, reflection on which should help to inform the further development of regulatory frameworks concerning end-of-life care in these countries and beyond. There should be reflection on: (1) the definition of – and reasons for defining – the ‘terminal stage’ and associated criteria for making such judgements; Korea and Taiwan limit forgoing LST to patients in this stage, but there are risks associated with defining this too narrowly or broadly; (2) foregoing LST for patients who arenotin this stage, as is allowed in Japan and England, because here too there are areas of controversy, including (in England) whether the law in this area does enough to respect the autonomy of (now) incapacitated patients; (3) whether ‘foregoing’ LST should encompass withholdingandwithdrawing treatment; this is also an ethically disputed area, particularly in the Asian countries we examine; (4) the family’s role in end-of-life decision-making, particularly as, compared with England, the three Asian countries traditionally place a greater emphasis on families and communities than on individuals; and (5) decision-making with and for those incapacitated patients who lack families, surrogate decision-makers or ADs.ConclusionComparison of, and reflection on, the different legal positions that obtain in Japan, Korea, Taiwan, and England should prove informative and we particularly invite reflection on five areas, in the hope the ensuing discussions will help to establish better end-of-life regulatory frameworks in these countries and elsewhere. (shrink)

Minerals originated from eastern Democratic Republic of Congo (DRC) are blamed for financing violent conflict in the area over the past decade and have been called conflict minerals. They vividly demonstrate a key human rights issue facing responsible supply chain management. The conflict minerals issue has led to a significant shift in responsible supply chain management in two ways: extending producer responsibility to respect human rights in the total supply chain through establishing traceability and transparency; and developing legally binding supply (...) chain responsibility.This article examines an emerging effort to source conflict‐free minerals using closed‐pipe supply chain in the DRC as a new strategy to respond to the above paradigm shift. By exploring whether this new strategy can contribute to conflict prevention in the DRC, this article argues that the closed‐pipe supply chain allows building long‐term relationship with various stakeholders and has the potential to transform socio‐economic structures in the producing communities, thereby leading to peacebuilding in the long run. (shrink)

This paper examines some aspects of the grammar of measurement based on data from non-split and split measure phrase (MP) constructions in Japanese. I claim that the non-split MP construction involves measurement of individuals, while the split MP construction involves measurement of events as well as of individuals. This claim is based on the observation that, while both constructions are subject to some semantic restrictions in the nominal domain, only the split MP construction is sensitive to restrictions in the verbal (...) domain (namely, incompatibility with single-occurrence events and with individual-level predicates, and (un)availability of collective readings). It is shown that these semantic restrictions can be explained by a uniform semantic constraint on the measure function, namely, Schwarzschild’s [(2002). The grammar of measurement. The Proceedings of Semantics and Linguistics Theory, 24, 241–306] monotonicity constraint. In particular, I argue that, in the two constructions at issue, the measure function is subject to the monotonicity constraint, and that we observe different semantic restrictions depending on whether the measure function applies to a nominal or a verbal domain. (shrink)

This paper addresses the question of whether the preverbal even (VP-even) embedded in a nonfinite clause can take wide scope (e.g., Bill refused to even drink WATER). The paper presents novel evidence for wide scope VP-even that is independent of the presuppositions of even. The evidence is based on examples of antecedent-contained deletion (ACD), where embedded VP-even associates with a nominal constituent (or part of it) that raises out of the embedded clause via quantifier raising. Assuming that even must c-command (...) the focus that it associates with, the case at issue forces VP-even to have wide scope, and further shows that VP-even in NPI-licensing contexts is not necessarily an NPI. (shrink)

Early morphogenesis of mouse submandibular gland provides an excellent model for the formation of epithelial lobules as a consequence of epithelial‐mesenchymal interactions. Both proteoglycans and a glycosaminoglycan, high molecular weight components which contain amino‐sugars and hexuronic acids, seem to be important in maintaining the lobular structure through the formation of epithelial basal lamina. Collagen also appears to play a crucial role in this morphogenesis. By visualizing the distribution of collagen fibrils and by changing the concentration of collagen in the gland, (...) we have developed a new hypothesis which emphasizes the mechanical role of mesenchyme in epithelial cleft formation. Precise mechanisms for the involvement of these molecules have not been elucidated, yet it is now clear that knowledge of the function of the extracellular matrix components is a prerequisite for understanding the epithelial‐mesenchymal interactions. (shrink)

Early morphogenesis of mouse submandibular gland provides an excellent model for the formation of epithelial lobules as a consequence of epithelial‐mesenchymal interactions. Both proteoglycans and a glycosaminoglycan, high molecular weight components which contain amino‐sugars and hexuronic acids, seem to be important in maintaining the lobular structure through the formation of epithelial basal lamina. Collagen also appears to play a crucial role in this morphogenesis. By visualizing the distribution of collagen fibrils and by changing the concentration of collagen in the gland, (...) we have developed a new hypothesis which emphasizes the mechanical role of mesenchyme in epithelial cleft formation. Precise mechanisms for the involvement of these molecules have not been elucidated, yet it is now clear that knowledge of the function of the extracellular matrix components is a prerequisite for understanding the epithelial‐mesenchymal interactions. (shrink)

没後20年、いま必要な歴史に裏打ちされた予見力、現実政治に提言する率直さ、道義性と理想主義。.

We examined the differences between estimating the emotions of protagonists and evaluating those of readers in narrative comprehension. Half of the participants read stories and rated the emotional states of the protagonists, while the other half of the participants rated their own emotional states while reading the stories. The results showed that reading comprehension was facilitated when highly extraverted participants read stories about, and rated the emotional experiences of, extraverted protagonists, with personalities similar to their own. However, the same facilitative (...) effect was not observed for less extraverted participants, nor was it observed for either type of participants under the condition in which participants rated their own emotional experiences. Thus, at least for highly extraverted participants, readers both facilitated the construction of a situation model and correctly estimated the emotional states of protagonists who were similar to themselves, perhaps due to empathy. (shrink)

AimTo examine the association of body mass index (BMI) [kg/m2] and its classifications (underweight [BMI < 18.5], normal [18.5 ≤ BMI < 25], overweight [25 ≤ BMI < 30], and obese [BMI ≥ 30]) with brain structure in individuals with a wide range of BMI group.Materials and methodsThe participants included 382 right-handed individuals (mean age: 46.9 ± 14.3 years, 142 men and 240 women). The intelligence quotient was assessed using the Japanese Adult Reading Test. Voxel-based morphometry (VBM) and diffusion tensor (...) imaging (DTI) were performed to analyze the association of BMI and its classifications with gray and white matter structures, respectively.ResultsAccording to VBM, BMI was significantly and negatively correlated with the bilateral cerebellum exterior volumes. In group comparisons, the right cerebellum exterior volume was significantly lower in the overweight or obese group than in the underweight or normal group, while the bilateral cuneus and calcarine cortex, left cuneus, and left precuneus volume was significantly lower in the underweight group than in the non-underweight group. Sex-related stratification analyses for VBM revealed that BMI was significantly and negatively correlated with the bilateral cerebellum exterior volumes only in women. In group comparisons, the left cerebellum exterior volume was significantly lower in obese women than in non-obese women. The left thalamus proper and the right cerebellum exterior volumes were significantly lower in overweight or obese group than in underweight or normal group in men and women, respectively. The bilateral cuneus and calcarine cortex, left cuneus and carcarine cortex, and bilateral cuneus volume was significantly lower in underweight men than in non-underweight men. In contrast, there were no notable findings on DTI.ConclusionOur results suggest association of continuous BMI, being overweight or obese, and being underweight with decreased gray matter volume in individuals with a wide range of BMI group. Furthermore, sex-related differences are seen in the association of BMI and its classifications with regional gray matter volume reductions. Abnormally high or low BMIs may have a negative influence on regional gray matter volumes. (shrink)

Background The purpose of this study is to explore laypersons' attitudes toward the use of archived (existing) materials such as medical records and biological samples and to compare them with the attitudes of physicians who are involved in medical research. Methods Three focus group interviews were conducted, in which seven Japanese male members of the general public, seven female members of the general public and seven physicians participated. Results It was revealed that the lay public expressed diverse attitudes towards the (...) use of archived information and samples without informed consent. Protecting a subject's privacy, maintaining confidentiality, and communicating the outcomes of studies to research subjects were regarded as essential preconditions if researchers were to have access to archived information and samples used for research without the specific informed consent of the subjects who provided the material. Although participating physicians thought that some kind of prior permission from subjects was desirable, they pointed out the difficulties involved in obtaining individual informed consent in each case. Conclusions The present preliminary study indicates that the lay public and medical professionals may have different attitudes towards the use of archived information and samples without specific informed consent. This hypothesis, however, is derived from our focus groups interviews, and requires validation through research using a larger sample. (shrink)

Introduction Families of patients with dementia may need support in difficult end-of-life decision making. Such guidance may be culturally sensitive. Methods To support families in Canada, a booklet was developed to aid decision making on palliative care issues. For reasons of cost effectiveness and promising effects, we prepared for its implementation in Italy, the Netherlands and Japan. Local teams translated and adapted the booklet to local ethical, legal and medical standards where needed, retaining guidance on palliative care. Using qualitative content (...) analyses, we grouped and compared adaptations to understand culturally sensitive aspects. Results Three themes emerged: (1) relationships among patient, physician and other professionals—the authority of the physician was more explicit in adapted versions; (2) patient rights and family position—adding detail about local regulations; and (3) typology of treatments and decisions. Considerations underlying palliative care decisions were detailed (Dutch and Italian versions), and the Japanese version frequently referred to professional and legal standards, and life-prolongation was a competing goal. Text on artificial feeding or fluids and euthanasia was revised extensively. Conclusions Providing artificial feeding and fluids and discussing euthanasia may be particularly sensitive topics, and guidance on these subjects needs careful consideration of ethical aspects and possible adaptations to local standards and practice. The findings may promote cross-national debate on sensitive, core issues regarding end-of-life care in dementia. (shrink)

ABSTRACT Objectives: the purpose of this study is to explore laypersons’ attitudes towards and experiences of medical research, and to compare them with those of physicians in Japan. Designs and Participants: fourteen Japanese adults from the general public and seven physicians participated in one of three focus interviews. Setting: Osaka, Japan. Results: trust and distrust in the physician by whom the participants were invited to participate in research played a considerable role in their decisions about participation. That the participants felt (...) an obligation to participate was also expressed. The lay participants perceived medical research as something entirely outside of their world. A greater willingness to volunteer for research was expressed if there were direct benefits to themselves or their families. Research methods such as use of placebos, double blinds, and randomisations seemed to cause negative attitudes to medical research. All physicians were convinced of the need for medical research, including double‐blinded randomised control trials, and its significant role in medical progress. Most physicians thought that the greater awareness of the need for medical research in the community and a better understanding of the psychology of potential research participants were necessary and urgent. Conclusions: there is a good possibility that the lay public and medical professionals have sharply different beliefs about and attitudes towards every aspect of medical research. Building up a better and equal patient‐doctor relationship based on trust is a key issue in medical research, and it is mandatory to fill the gap in perception regarding medical research between them through fully informed debates. (shrink)

Dogs and cats have been domesticated through different processes. Dogs were the first domesticated animals, cooperating with humans by hunting and guarding. In contrast, cats were domesticated as predators of rodents and lived near human habitations when humans began to settle and farm. Although the domestication of dogs followed a different path from that of cats, and they have ancestors of a different nature, both have been broadly integrated into—and profoundly impacted—human society. The coexistence between dogs/cats and humans is based (...) on non-verbal communication. This review focuses on “gaze,” which is an important signal for humans and describes the communicative function of dogs’ and cats’ eye-gaze behavior with humans. We discuss how the function of the gaze goes beyond communication to mutual emotional connection, namely “bond” formation. Finally, we present a research approach to multimodal interactions between dogs/cats and humans that participate in communication and bond formation. (shrink)

Jecker and Au’s paper raises important issues concerning health equity in pandemic responses, and the importance of considering the long-term effects of pandemic strategy on population health and well-being.1 We welcome their focus on the experience of Asian countries, including Japan. However, we have some concerns with both the distinction which they draw between elimination and mitigation, and their account of the nature and origins of the Japanese response to the COVID-19 pandemic. First, we believe that the distinction between elimination (...) and mitigation is not fine grained enough to capture the various strategies which countries have taken towards the pandemic. Many of Jecker and Au’s criticisms of the elimination strategy relate to specific policies such as lockdowns, travel restrictions and restrictions on businesses, which have been employed by numerous countries irrespective of their end goal. By contrast to the simple elimination/mitigation dichotomy with which Jecker and Au work, Baker et al have identified five separate COVID-19 strategies, namely: exclusion, elimination, suppression, mitigation and no substantive strategy.2 Baker et al define an elimination strategy as ‘maximum action to exclude disease and eliminate community transmission’ with the goal of reaching ‘zero [disease] transmission in the community’. On this account, Japan’s strategy does …. (shrink)

Nakanishi :115–136, 2012) presents a novel argument for the so-called scope theory of English sentential even, based on examples with antecedent-contained deletion. Nakanishi’s argument is based on the assumption that even cannot associate with a focus which has moved out of its LF scope. I show that this assumption is incorrect, defusing Nakanishi’s argument. I propose that when even associates with a focus which has moved out of its surface scope, it actually associates with focused material in (...) the lower copies of movement. I show that a closer look at ACD examples of Nakanishi’s type in fact yields a new argument against the scope theory. I conclude that English sentential even must always be interpreted in its pronounced position. The patterns of focus association with even presented here constitute a new argument for the copy theory of movement. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Six Poems GEORGE KALOGERIS The Atomists To see what the matter is, in all of its dense, Teeming particulars, and not through the lens Of a microscope but by the most lucid, precise, Leap of imagination: the first was Leucíppus. But it was his student, Democritus, who stated That human understanding was truly futile, Given the random collisions of atoms. Still, He blinded himself to keep from being (...) distracted. When he broke the long-jump record by two whole feet, Bob Beamon dropped to his knees, buried his face In his hands, and wept in a pit of sand—the trace Of his human, Olympian flight still fresh as a heel-print. When the earthquake struck Kalamáta, and Uncle Sotíri Lost everything, he asked a taxi driver To take him to “a nice high place by the sea. And then come back for me in half an hour.” arion 28.3 winter 2021 58 six poems One Credit Seminar on the Odes of Horace We were sitting around a polished oak table, just getting to Those famous lines near the end of the Sestius Ode: Revenant whitefaced Death is walking not knowing whether He’s going to knock at a rich man’s door or a poor man’s When one of the students (Andrew) said it was “totally weird”— Which led us to look at the paleness of Death’s appearance, Whose pallor is what, when he comes, comes with him: the sickness and shock In his ghastly face. And that’s where we stopped. And then It was Jennifer’s email, saying “I’m sorry for missing class, But I’m having panic attacks. I keep flashing back To March 19th, when I entered my dorm-room and found my boyfriend Dead of an overdose... I can get you a note... What reading should I do to be prepared for next week?” O goodlooking fortunate Sestius, don’t put your hope in the future; The night is falling, the shades are gathering around; The walls of Pluto’s shadowy house are closing you in. There who will be lord of the feast? What will it matter, What will it matter there, whether you fell in love With Lycidas, this or that girl with him, or he With her? So David Ferry’s great translation goes, And its tone of tender, knowing, bemusement is Horace’s Pitying voice, but whose pity has come to speak to us Through the whitefaced mouth of revenant Death, still going From house to house, until he gets to Jennifer’s dorm-room. And what will it matter now if Andrew was drawn to the line About fishermen hauling their caulked boats to the water? It’s late September. We’re sitting around a polished oak table Whose wood is sacred to Jove, whose lightning-bolt Has already sounded deep in the heart of Indian summer. George Kalogeris 59 Greek School The very first poem I ever knew by heart: That sing-song forsaken one assigned to me. Recited on our other Independence Day. When some of the girls were dressed in peasant costumes, And some of the boys in kilts of the freedom fighters. And the timid rest of us in our Sunday best. In the church gym, where Father Mihos called us Up to the microphone, and one by one We showed the parents what we’d learned in Greek school. In Horace’s Ode to his Lyre, the poet prays That his song will serve as the medicine of sorrows, His stricken voice the trembling instrument— Schooled as he was in Sappho, who said the ancient Prescription left a bittersweet taste in her mouth: Glukopikron. For me it’s that first-grade poem I stammer to remember: Egwo tha geino Yiatrós... “I shall grow up to be a doctor...” Just saying that, my elders perk up their ears. And even if Poetry wasn’t the kind of calling Expected of me, and one by one they all Got sick and died, it’s still the medicine That keeps them leaning forward on their folding chairs. 60 six poems Money Doesn’t Grow On Trees But evergreen the... (shrink)