Introduction Families of patients with dementia may need support in difficult end-of-life decision making. Such guidance may be culturally sensitive. Methods To support families in Canada, a booklet was developed to aid decision making on palliative care issues. For reasons of cost effectiveness and promising effects, we prepared for its implementation in Italy, the Netherlands and Japan. Local teams translated and adapted the booklet to local ethical, legal and medical standards where needed, retaining guidance on palliative care. Using qualitative content (...) analyses, we grouped and compared adaptations to understand culturally sensitive aspects. Results Three themes emerged: (1) relationships among patient, physician and other professionals—the authority of the physician was more explicit in adapted versions; (2) patient rights and family position—adding detail about local regulations; and (3) typology of treatments and decisions. Considerations underlying palliative care decisions were detailed (Dutch and Italian versions), and the Japanese version frequently referred to professional and legal standards, and life-prolongation was a competing goal. Text on artificial feeding or fluids and euthanasia was revised extensively. Conclusions Providing artificial feeding and fluids and discussing euthanasia may be particularly sensitive topics, and guidance on these subjects needs careful consideration of ethical aspects and possible adaptations to local standards and practice. The findings may promote cross-national debate on sensitive, core issues regarding end-of-life care in dementia. (shrink)

This paper examines some aspects of the grammar of measurement based on data from non-split and split measure phrase (MP) constructions in Japanese. I claim that the non-split MP construction involves measurement of individuals, while the split MP construction involves measurement of events as well as of individuals. This claim is based on the observation that, while both constructions are subject to some semantic restrictions in the nominal domain, only the split MP construction is sensitive to restrictions in the verbal (...) domain (namely, incompatibility with single-occurrence events and with individual-level predicates, and (un)availability of collective readings). It is shown that these semantic restrictions can be explained by a uniform semantic constraint on the measure function, namely, Schwarzschild’s [(2002). The grammar of measurement. The Proceedings of Semantics and Linguistics Theory, 24, 241–306] monotonicity constraint. In particular, I argue that, in the two constructions at issue, the measure function is subject to the monotonicity constraint, and that we observe different semantic restrictions depending on whether the measure function applies to a nominal or a verbal domain. (shrink)

This paper addresses the question of whether the preverbal even (VP-even) embedded in a nonfinite clause can take wide scope (e.g., Bill refused to even drink WATER). The paper presents novel evidence for wide scope VP-even that is independent of the presuppositions of even. The evidence is based on examples of antecedent-contained deletion (ACD), where embedded VP-even associates with a nominal constituent (or part of it) that raises out of the embedded clause via quantifier raising. Assuming that even must c-command (...) the focus that it associates with, the case at issue forces VP-even to have wide scope, and further shows that VP-even in NPI-licensing contexts is not necessarily an NPI. (shrink)

Early morphogenesis of mouse submandibular gland provides an excellent model for the formation of epithelial lobules as a consequence of epithelial‐mesenchymal interactions. Both proteoglycans and a glycosaminoglycan, high molecular weight components which contain amino‐sugars and hexuronic acids, seem to be important in maintaining the lobular structure through the formation of epithelial basal lamina. Collagen also appears to play a crucial role in this morphogenesis. By visualizing the distribution of collagen fibrils and by changing the concentration of collagen in the gland, (...) we have developed a new hypothesis which emphasizes the mechanical role of mesenchyme in epithelial cleft formation. Precise mechanisms for the involvement of these molecules have not been elucidated, yet it is now clear that knowledge of the function of the extracellular matrix components is a prerequisite for understanding the epithelial‐mesenchymal interactions. (shrink)

Early morphogenesis of mouse submandibular gland provides an excellent model for the formation of epithelial lobules as a consequence of epithelial‐mesenchymal interactions. Both proteoglycans and a glycosaminoglycan, high molecular weight components which contain amino‐sugars and hexuronic acids, seem to be important in maintaining the lobular structure through the formation of epithelial basal lamina. Collagen also appears to play a crucial role in this morphogenesis. By visualizing the distribution of collagen fibrils and by changing the concentration of collagen in the gland, (...) we have developed a new hypothesis which emphasizes the mechanical role of mesenchyme in epithelial cleft formation. Precise mechanisms for the involvement of these molecules have not been elucidated, yet it is now clear that knowledge of the function of the extracellular matrix components is a prerequisite for understanding the epithelial‐mesenchymal interactions. (shrink)

没後20年、いま必要な歴史に裏打ちされた予見力、現実政治に提言する率直さ、道義性と理想主義。.

文明の衰亡は必然なのか?衰退から逃れる道はないのか?本書ではローマ帝国、ビザンチン帝国、大英帝国、アメリカ、中国そして江戸時代の日本など独自の世界を確立した大国の興亡の光景を描き出し、その「文明衰退の 理」を歴史の教訓から導き出す。史上、外敵の侵入で滅んだ国はない。衰退はその国の「内なる原因」によってなされたと著者は論ずる。世界史的・文明史的視点から、日本の衰退と再生を洞察する「衰退学」の集大成であ る。.

Nakanishi :115–136, 2012) presents a novel argument for the so-called scope theory of English sentential even, based on examples with antecedent-contained deletion. Nakanishi’s argument is based on the assumption that even cannot associate with a focus which has moved out of its LF scope. I show that this assumption is incorrect, defusing Nakanishi’s argument. I propose that when even associates with a focus which has moved out of its surface scope, it actually associates with focused material in (...) the lower copies of movement. I show that a closer look at ACD examples of Nakanishi’s type in fact yields a new argument against the scope theory. I conclude that English sentential even must always be interpreted in its pronounced position. The patterns of focus association with even presented here constitute a new argument for the copy theory of movement. (shrink)