Unlike inert objects, organisms and their cells have the ability to initiate activity by themselves and thus change their properties or states even in the absence of an external cause. This crucial difference led us to search for principles suitable for the study organisms. We propose that cells follow the default state of proliferation with variation and motility, a principle of biological inertia. This means that in the presence of sufficient nutrients, cells will express their default state. We also propose (...) a principle of variation that addresses two central features of organisms, variation and historicity. To address interdependence between parts, we use a third principle, the principle of organization, more specifically, the notion of the closure of constraints. Within this theoretical framework, constraints are specific theoretical entities defined by their relative stability with respect to the processes they constrain. Constraints are mutually dependent in an organized system and act on the default state.Here we discuss the application and articulation of these principles for mathematical modeling of morphogenesis in a specific case, that of mammary ductal morphogenesis, with an emphasis on the default state. Our model has both a biological component, the cells, and a physical component, the matrix that contains collagen fibers. Cells are agents that move and proliferate unless constrained; they exert mechanical forces that act (i) on collagen fibers and (ii) on other cells. As fibers are organized, they constrain the cells’ ability to move and to proliferate. This model exhibits a circularity that can be interpreted in terms of the closure of constraints. Implementing our mathematical model shows that constraints to the default state are sufficient to explain the formation of mammary epithelial structures. Finally, the success of this modeling effort suggests a stepwise approach whereby additional constraints imposed by the tissue and the organism can be examined in silico and rigorously tested by in vitro and in vivo experiments, in accordance with the organicist perspective we embrace. (shrink)

We characterize access to empirical objects in biology from a theoretical perspective. Unlike objects in current physical theories, biological objects are the result of a history and their variations continue to generate a history. This property is the starting point of our concept of measurement. We argue that biological measurement is relative to a natural history which is shared by the different objects subjected to the measurement and is more or less constrained by biologists. We call symmetrization the theoretical and (...) often concrete operation which leads to considering biological objects as equivalent in a measurement. Last, we use our notion of measurement to analyze research strategies. Some strategies aim to bring biology closer to the epistemology of physical theories, by studying objects as similar as possible, while others build on biological diversity. (shrink)

Emotive speech is a social act in which a speaker displays emotional signals with a specific intention; in the case of third-party complaints, this intention is to elicit empathy in the listener. The present study assessed how the emotivity of complaints was perceived in various conditions. Participants listened to short statements describing painful or neutral situations, spoken with a complaining or neutral prosody, and evaluated how complaining the speaker sounded. In addition to manipulating features of the message, social-affiliative factors which (...) could influence complaint perception were varied by adopting a cross-cultural design: participants were either Québécois or French and listened to utterances expressed by both cultural groups. The presence of a complaining tone of voice had the largest effect on participant evaluations, while the nature of statements had a significant, but smaller influence. Marginal effects of culture on explicit evaluation of complaints were found. A multiple mediation analysis suggested that mean fundamental frequency was the main prosodic signal that participants relied on to detect complaints, though most of the prosody effect could not be linearly explained by acoustic parameters. These results highlight a tacit agreement between speaker and listener: what characterizes a complaint is how it is said, more than what it is about or who produces it. More generally, the study emphasizes the central importance of prosody in expressive speech acts such as complaints, which are designed to strengthen social bonds and supportive responses in interactive behavior. This intentional and interpersonal aspect in the communication of emotions needs to be further considered in research on affect and communication. (shrink)

Conceptual analysis of health and disease is portrayed as consisting in the confrontation of a set of criteria—a “definition”—with a set of cases, called instances of either “health” or “ disease.” Apart from logical counter-arguments, there is no other way to refute an opponent’s definition than by providing counter-cases. As resorting to intensional stipulation is not forbidden, several contenders can therefore be deemed to have succeeded. This implies that conceptual analysis alone is not likely to decide between naturalism and normativism. (...) An alternative to this approach would be to examine whether the concept of disease can be naturalized. (shrink)

Zeno’s paradoxes of motion, allegedly denying motion, have been conceived to reinforce the Parmenidean vision of an immutable world. The aim of this article is to demonstrate that these famous logical paradoxes should be seen instead as paradoxes of immobility. From this new point of view, motion is therefore no longer logically problematic, while immobility is. This is convenient since it is easy to conceive that immobility can actually conceal motion, and thus the proposition “immobility is mere illusion of the (...) senses” is much more credible than the reverse thesis supported by Parmenides. Moreover, this proposition is also supported by modern depiction of material bodies: the existence of a ceaseless random motion of atoms—the ‘thermal agitation’—in the scope of contemporary atomic theory, can offer a rational explanation of this ‘illusion of immobility’. Our new approach to Zeno’s paradoxes therefore leads to presenting the novel concept of ‘impermobility’, which we think is a more adequate description of physical reality. (shrink)

This authored monograph introduces a genuinely theoretical approach to biology. Starting point is the investigation of empirical biological scaling including their variability, which is found in the literature, e.g. allometric relationships, fractals, etc. The book then analyzes two different aspects of biological time: first, a supplementary temporal dimension to accommodate proper biological rhythms; secondly, the concepts of protension and retention as a means of local organization of time in living organisms. Moreover, the book investigates the role of symmetry in biology, (...) in view of its ubiquitous importance in physics. In relation with the notion of extended critical transitions, the book proposes that organisms and their evolution can be characterized by continued symmetry changes, which accounts for the irreducibility of their historicity and variability. The authors also introduce the concept of anti-entropy as a measure for the potential of variability, being equally understood as alterations in symmetry. By this, the book provides a mathematical account of Gould's analysis of phenotypic complexity with respect to biological evolution. The target audience primarily comprises researchers interested in new theoretical approaches to biology, from physical, biological or philosophical backgrounds, but the book may also be beneficial for graduate students who want to enter this field. (shrink)

Aging is an elusive property of life, and many important questions about aging depend on its definition. This article proposes to draw a definition from the scientific literature on aging. First, a broad review reveals five features commonly used to define aging: structural damage, functional decline, depletion, typical phenotypic changes or their cause, and increasing probability of death. Anything that can be called ‘aging’ must present one of these features. Then, although many conditions are not consensual instances of aging, aging (...) is consensually described as a process of loss characterized by a rate and resulting from the counteraction of protective mechanisms against mechanisms that limit lifespan. Beyond such an abstract definition, no one has yet succeeded in defining aging by a specific mechanism of aging because of an explanatory gap between such a mechanism and lifespan, a consensual explanandum of a theory of aging. By contrast, a sound theoretical definition can be obtained by revisiting the evolutionary theory of aging. Based on this theory, aging evolves thanks to the impossibility that natural selection eliminates late traits that are neutral mainly due to decreasing selective pressure. Yet, the results of physiological research suggest that this theory should be revised to also account for the small number of different aging pathways and for the existence of mechanisms counteracting these pathways, that must, on the contrary, have been selected. A synthetic, but temporary definition of aging can finally be proposed. (shrink)

We provide a new perspective on the relation between the space of description of an object and the appearance of novelties. One of the aims of this perspective is to facilitate the interaction between mathematics and historical sciences. The definition of novelties is paradoxical: if one can define in advance the possibles, then they are not genuinely new. By analyzing the situation in set theory, we show that defining generic (i.e., shared) and specific (i.e., individual) properties of elements of a (...) set are radically different notions. As a result, generic and specific definitions of possibilities cannot be conflated. We argue that genuinely stating possibilities requires that their meaning has to be made explicit. For example, in physics, properties playing theoretical roles are generic; then, generic reasoning is sufficient to define possibilities. By contrast, in music, we argue that specific properties matter, and generic definitions become insufficient. Then, the notion of new possibilities becomes relevant and irreducible. In biology, among other examples, the generic definition of the space of DNA sequences is insufficient to state phenotypic possibilities even if we assume complete genetic determinism. The generic properties of this space are relevant for sequencing or DNA duplication, but they are inadequate to understand phenotypes. We develop a strong concept of biological novelties which justifies the notion of new possibilities and is more robust than the notion of changing description spaces. These biological novelties are not generic outcomes from an initial situation. They are specific and this specificity is associated with biological functions, that is to say, with a specific causal structure. Thus, we think that in contrast with physics, the concept of new possibilities is necessary for biology. (shrink)

Since the turn of the twenty-first century, biomedical psychiatry around the globe has embraced the so-called precision medicine paradigm, a model for medical research that uses innovative techniques for data collection and analysis to reevaluate traditional theories of disease. The goal of precision medicine is to improve diagnostics by restratifying the patient population on the basis of a deeper understanding of disease processes. This paper argues that precision is ill-fitting for psychiatry for two reasons. First, in psychiatry, unlike in fields (...) like oncology, precision medicine has been understood as an attempt to improve medicine by casting out, rather than merely revising, traditional taxonomic tools. Second, in psychiatry the term “biomarker” is often used in reference to signs or symptoms that allow patients to be classified and then matched with treatments; however, in oncology “biomarker” usually refers to a disease mechanism that is useful not only for diagnostics, but also for discovering causal pathways that drug therapies can target. Given these differences between how the precision medicine paradigm operates in psychiatry and in other medical fields like oncology, while precision psychiatry may offer successful rhetoric, it is not a promising paradigm. (shrink)

A survey is given of the concepts of interaction (force) and matter, i.e., of process and substance. The development of these concepts, first in antiquity, then in early modern times, and finally in the contemporary system of quantum field theory is described. After a summary of the basic phenomenological attributes (coupling strengths, symmetry quantities, charges), the common ground of concepts of quantum field theory for both interactions and matter entities is discussed. Then attention is focused on the gauge principle which (...) has been developed to describe all interaction fields in the same way, and hopefully to unite them all into one unified field. While a similar unification of all fundamental types of matter fields (quarks and leptons) into one family may be possible (SU 5), there still remains at this level a duality between interaction quanta (bosons with spin 1) and matter particles (fermions with spin 1/2). Whether this duality may be removed in some future supersymmetric theory is not discussed in this paper. Nor is Quantum Gravitation discussed, though the analogy of the gauge principle for the three fundamental non-gravitational interactions (hadronic, electromagnetic and weak) to Einstein's principle of equivalence for gravitation in spacetime is noted. However, the equivalence concept is applied not to spacetime but to the internal spaces for the matter (or charge) fields which are the sources between which the fundamental interactions operate. The gauge principle states that a change in the measures of the internal space charge of gauge or phases of the matter fields is equivalent to, and can be compensated by, suitably introduced interaction fields. From such an interaction field, the gauge potential field in the internal space, one may derive a gauge force field by exterior differentiation.Geometrically, the collection of all internal spaces, one over each point of spacetime, constitutes a fiber bundle. The gauge potential field represents a connection on the fiber bundle, and the gauge force field is the curvature (calculated by taking the exterior derivative of the connection and adding to it the exterior product of the connection with itself). Thus, just as gravitational force is interpreted as spacetime curvature, so the three other fundamental forces are interpretable as internal space curvature. The Standard Model which unites the three non-gravitational fields into an SU c 3 ×SU 2×U 1 structure, and the grand unified model, SU 5, are discussed briefly, and difficulties are noted. Finally it is suggested that a composite model, based on more subtle structure, may be needed to remove the present obscurities and difficulties that stand in the way of a unified theory. (shrink)

The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount. However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A (...) biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy. (shrink)

It is commonly believed that there is no equivalent of the Church–Turing thesis for computation over the reals. In particular, computational models on this domain do not exhibit the convergence of formalisms that supports this thesis in the case of integer computation. In the light of recent philosophical developments on the different meanings of the Church–Turing thesis, and recent technical results on analog computation, I will show that this current belief confounds two distinct issues, namely the extension of the notion (...) of effective computation to the reals on the one hand, and the simulation of analog computers by Turing machines on the other hand. I will argue that it is possible in both cases to defend an equivalent of the Church–Turing thesis over the reals. Along the way, we will learn some methodological caveats on the comparison of different computational models, and how to make it meaningful. (shrink)

According to the received view, the transportation view, animal extrapolation consists in inductive prediction of the outcome of a mechanism in a target, based on an analogical mechanism in a model. Through an analysis of the failure of preclinical studies of TGN1412, an innovative drug, to predict the tragic consequences of its first-in-man trial in 2006, the received view is challenged by a proposed view of animal extrapolation, the chimera view. According to this view, animal extrapolation is based on a (...) hypothesis about how human organisms work, supported by the amalgamation of results drawn from various experimental organisms, and only predicting the ‘predictive grid’, that is, a global framework of the effects to be expected. (shrink)

The analogy between living beings and computers was introduced with circumspection by Schrödinger and has been widely propagated since, rarely with a precise technical meaning. Critics of this perspective are numerous. We emphasize that this perspective is mobilized to justify what may be called a regressive reductionism by comparison with physics or the Cartesian method. Other views on the living are possible, and we focus on an epistemological and theoretical framework where historicity is central, and the regularities susceptible to mathematization (...) are constraints whose existence is fundamentally precarious and historically contingent. We then propose to reinterpret the computer, no longer as a Turing machine but as constituted by constraints. This move allows us to understand that computation in the sense of Church-Turing is only a part of the theoretical determination of what actually happens in a computer when considering them in their larger theoretical context where historicity is also central. (shrink)

While relatively unknown to Anglophone circles, there was a thriving Anabaptist community in Italy during the reformation. It is the scope of this article to help retrace the origins of the Anabaptist movement in Italy and to set straight some misconceptions unintentionally perpetuated by some who have attempted this journey in the past. This is done in the hopes of raising appreciation for the movement and of enticing future research interest in this forgotten branch of the Radical Reformation.

Science starts by using terms such as ‘temperature’ or ‘fish’ or ‘gene’ to preliminarily delimitate the extension of a phenomenon, and concludes by giving most of them a technical meaning based on an explanatory model. This transforma- tion of the meaning of the term is an essential part of its naturalization. Debating on the definition of ‘disease’, what most philosophers of medicine have examined is the pre-naturalized meaning of the term: for that reason they have focused on the task of (...) delimiting disease and non-disease (health), mainly used conceptual analysis as a method of choice, and considered the nosological level of ‘disease judgments’ rather than the pathophysiological or psychopathological level of disease mechanisms, thus making them impervious to most scientific discoveries. By focusing instead on the naturalized concept of disease and following some suggestions by philosophers of biology and scientists in cutting-edge fields of biomedical research, they could gar- ner results from a comparison of the mechanisms of diseases. This would ultimately result in a general theory of disease linked with our most general theories on living beings, among them, systems biology and network medicine. Before undertaking such a task, preliminary questions arise: is it likely that there are biological features common to different types of disease? Is it a philosopher’s job to determine what they consist in? What use would such a general theoretical definition of disease be? (shrink)

The main thesis of this paper is that mental health practitioners can legitimately infer that a patient's given condition is a case of mental disorder without having diagnosed any specific mental disorder. The article shows how this is justifiable by relying either on psychopathological reasoning, on 'intentional' analysis or possibly on other modes of reasoning. In the end, it highlights the clinical and philosophical consequences of the plurality of modes of 'inferences to mental disorder'.

Cet article présente un état de l'art critique du sous-champ de l'éthique de l'Intelligence Artificielle nommé "équité algorithmique". Il se concentre en particulier sur un objet récent, mais faisant objet d'une activité intense, à savoir les critières statistiques de l'équité algorithmique. Il s'agit de critères permettant de déterminer si un algorithme ou modèle prédictif de ML ne présente pas de biais défavorable à l'égard d'une population donnée en examinant les caractéristiques statistiques de son comportement entrées-sortie. Nous commençons par présenter les (...) diverses définitions au centre des conversations récentes, ainsi qu'un résultat crucial d'impossibilité d'optimisation simultanée de toutes ces métriques, nommé "résultat d'incompatibilité." Nous discutons ensuite les leçons philosophiques à tirer de cette pluralité de définitions et du résultat d'incompatibilité. Nous finissons par une discussion critique portant sur les difficultés provenant de la représentation par des variables mathématiques de réalités sociales complexes comme l'appartenance identitaire à une population donnée, ou la caractérisation d'un discours comme discours de haine. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes ? Ou existe-t-il un moyen empirique (...) d’effectuer un calcul qu’aucun algorithme ne permet d’effectuer ? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes? Ou existe-t-il un moyen empirique d’effectuer (...) un calcul qu’aucun algorithme ne permet d’effectuer? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

La route antique de Mégare à Thèbes par le défilé du Kandili, dont on a contesté à tort l'existence, correspond à un chemin encore très utilisé au xixe siècle, le Koulouriotiko monopati. Description des restes antiques de cette route et des sites antiques situés tout le long. Les témoignages des historiens antiques sur son utilisation.

Despite its vagueness Personalized, Precision, P4, P5, individualized, stratified medicine—or p-medicine in short—has become an increasingly popular term in biomedical literature. Philosophers have attempted to analyze what these various terms involve and have discussed consequences for medical practices. In this article, I argue that an important question remains unaddressed: what has made this project of p-medicine convincing to so many? My argument is that without real achievements, it would never have been. I also make the case that these achievements stem (...) from the domain of monoclonal antibodies, a new type of drug that justifies talks of personalized, precise, stratified, etc., medicine. In conclusion, while it may be possible to label any projection in the future of medicine as ‘p-medicine’, it is impossible to overlook mab-medicine as the spearhead. (shrink)

The Anthropocene crisis is frequently described as the rarefaction of resources or resources per capita. However, both energy and minerals correspond to fundamentally conserved quantities from the perspective of physics. A specific concept is required to understand the rarefaction of available resources. This concept, entropy, pertains to energy and matter configurations and not just to their sheer amount. However, the physics concept of entropy is insufficient to understand biological and social organizations. Biological phenomena display both historicity and systemic properties. A (...) biological organization, the ability of a specific living being to last over time, results from history, expresses itself by systemic properties, and may require generating novelties The concept of anti-entropy stems from the combination of these features. We propose that Anthropocene changes disrupt biological organizations by randomizing them, that is, decreasing anti-entropy. Moreover, second-order disruptions correspond to the decline of the ability to produce functional novelties, that is, to produce anti-entropy. (shrink)

La thèse de Church-Turing stipule que toute fonction calculable est calculable par une machine de Turing. En distinguant, à la suite de nombreux auteurs, une forme algorithmique de la thèse de Church-Turing portant sur les fonctions calculables par un algorithme d’une forme empirique de cette même thèse, portant sur les fonctions calculables par une machine, il devient possible de poser une nouvelle question : les limites empiriques du calcul sont-elles identiques aux limites des algorithmes? Ou existe-t-il un moyen empirique d’effectuer (...) un calcul qu’aucun algorithme ne permet d’effectuer? Je montrerai ici la pertinence philosophique de cette question. Elle interroge la capacité de processus symboliques comme les calculs à simuler certains processus empiriques. Elle permet également d’étudier le statut épistémologique des calculs réalisés par des machines. S’il existait une fonction calculable par une machine sans être calculable par un algorithme, il existerait un problème mathématique qui serait soluble par un dispositif empirique, sans être soluble par aucune méthode mathématique a priori. (shrink)

CRAN R code to analyze disruption of plant-pollinator networks for the article: Disruption of biological processes in the Anthropocene: the case of phenological mismatch Cite as Montévil, M. 2020, code for: Disruption of biological processes in the Anthropocene: the case of phenological mismatch DOI: 10.5281/zenodo.4290412.

Biologists increasingly report anthropogenic disruptions of both organisms and ecosystems, suggesting that these processes are a fundamental, qualitative component of the Anthropocene. Nonetheless, the notion of disruption has not yet been theorized in biology. To progress in that regard, we work on a special case. Relatively minor temperature changes impact plant-pollinator synchrony, disrupting mutualistic interaction networks. Understanding this phenomenon requires a specific rationale since models describing them use both historical and systemic reasoning. Specifically, history justifies that the system is initially (...) in a very narrow part of the possibility space where it is viable, and the disruption randomizes this configuration. Building on this rationale, we develop a formal framework inspired by Boltzmann's entropy. With empirical networks, we show historical trends depending on latitude. Then we propose an initial definition of disruption in ecology. When a specific historical outcome contributes to a system's viability, disruption randomizes this outcome, decreasing viability. (shrink)

The doctrine of the three orders which distinguishes and hierarchizes flesh, spirit and charity is obviously one of the major themes of Pascal’s thought. But it appears that Pascal meditates as much on the disorder – and dis-order – induced by sin and the corruption of our nature as on the hierarchy and the heterogeneity of these three kinds of reality. In the world he describes, in fact, not only is everything overturned – the lowest order, that of the flesh, (...) now dominating the other two – but also everything is confused – pleasure, for example, obtaining the credence that normally belongs to science, and the flesh invading the order of the spirit through custom and imagination. To maintain then, as several commentators do, that no interference between the orders is possible, so that tyranny can only exist in the state of desire, is in our view to adopt a more Stoic than Pascalian point of view. For to deny disorder is also, according to Pascal, to deny sin by projecting into the second nature the memory of the first. (shrink)

Open peer commentary on the article “What Is a Cognizing Subject? Construction, Autonomy and Original Causation” by Niall Palfreyman & Janice Miller-Young. Upshot: I discuss convergences between the approach of the authors and my work aiming for a theory of organisms. I also discuss some pitfalls and challenges pertaining to biological randomness, which, I argue, require original developments.

« Un coworking sans communauté n’existe pas. » Qu’est-ce qui sépare les nous du tiers-lieu de ceux de la start-up (plus ou moins nationalisée)? Qu’est-ce qui distingue les bretelles (d’un nous relativement dilaté, diffracté ou bifurquant) des autoroutes (du je au cœur du développement personnel comme du nous des team buildings et atelier de we design)? L’auto-affectation d’un soi mis au pluriel tente, par un simple jeu pronominal, de cacher son intention de relier tout le monde. À travers les reflets (...) de ces belles âmes dans leurs variations esthétiques, cet article se propose de penser les réactualisations de la standardisation psychique mondiale en montrant comme elles brouillent de quel entre-nous ça parle. On part d’une série de citations des stars de la république des lettres. Direct, on multiplie les formes de déterritorialisations énonciatives comme autant de traversées d’un nous attaché à son incertitude d’échelle et excité par ses anachronismes : expérience originelle de l’autre comme soi, atelier alter-constructiviste, méditation auto-décentrante, réunion anti-facilitatrice, contre-point sur la situation actuelle. (shrink)

English summary: Based on the famous essay by Georges Canguilhem on what is normal and pathological (originally published in 1943), extensive philosophical literature (mainly Anglo-Saxon) has attempted to define these concepts and analyze their status. The main discussion focuses on the following question: can you describe health and illness as natural phenomena or are they states that are determined by values? French text. French description: Depuis le celebre essai de Georges Canguilhem sur le normal et le pathologique publie initialement en (...) 1943 et dont l'un des objectifs etait la clarification des concepts de sante et de maladie, une litterature philosophique abondante, principalement anglo-saxonne, s'est attachee a definir ces concepts et a analyser leur statut. Le principal debat de ce domaine emergent de la philosophie de la medecine porte sur la question: peut-on decrire la sante et la maladie comme des phenomenes naturels ou s'agit-il d'etats qui sont determines par des valeurs? Tous les textes presentes dans ce volume ont participe de cette controverse. Ceux de la premiere section accordent une part importante a la composante biologique. Ceux de la seconde donnent le primat a la notion d'action. Ceux de la derniere section mettent en question l'utilite ou la possibilite meme de definir les deux concepts. (shrink)

Philosophers of science have recently focused on the scientific activity of modeling phenomena, and explicated several of its properties, as well as the activities embedded into it. A first approach to modeling has been elaborated in terms of representing a target system: yet other epistemic functions, such as producing data or detecting phenomena, are at least as relevant. Additional useful distinctions have emerged, such as the one between phenomenological and mechanistic models. In biological sciences, besides mathematical models, models now come (...) in three forms: in vivo, in vitro and in silico. Each has been investigated separately, and many specific problems they raised have been laid out. Another relevant distinction is disciplinary: do models differ in significant ways according to the discipline involved—medicine or biology, evolutionary biology or earth science? Focusing on either this threefold distinction or the disciplinary boundaries reveals that they might not be sufficient from a philosophical perspective. On the contrary, focusing on the interaction between these various kinds of models, some interesting forms of explanation come to the fore, as is exemplified by the papers included in this issue. On the other hand, a focus on the use of models, rather than on their content, shows that the distinction between biological and medical models is theoretically sound. (shrink)

In this paper we introduce a stochastic model for a population living and migrating between s sites without distinction in the states between residents and immigrants. The evolutionary stable strategies is characterized by the maximization of a stochastic growth rate. We obtain that the expectation of reproductive values, normalized by some random quantity, are constant on all sites and that the expectation of the normalized vector population structure is proportional to eigenvector of the dispersion matrix associated to eigenvalue one, which (...) are, in some way, analogous to the results obtained in the deterministic case. (shrink)

In recent years, most studies of human memory systems have placed the emphasis on differences rather than on similarities. The present study sought to assess the impact of perceptual priming on the creation of new episodic memories. It was composed of three distinct experimental phases: an initial study phase, during which the number of repetitions of target words was manipulated; a perceptual priming test phase, involving both target and new control words, which constituted the incidental encoding phase of a subsequent (...) Remember/Know/Guess recognition task. Results showed that the greater the perceptual priming at encoding, the more the episodic memory performance was enhanced, whereas no such relation was found for know judgments or feeling of familiarity. Furthermore, the words that were associated with the creation of new episodic memories had been perceptually primed to a greater extent during the incidental encoding phase than the words that were subsequently judged to be known or forgotten. These results suggest that the perceptual contents of episodic memories are constituted by the very perceptual representations that generate priming effects. Potential mechanisms linking perceptual priming to the creation of episodic memories are discussed. (shrink)

Symmetries play a major role in physics, in particular since the work by E. Noether and H. Weyl in the first half of last century. Herein, we briefly review their role by recalling how symmetry changes allow to conceptually move from classical to relativistic and quantum physics. We then introduce our ongoing theoretical analysis in biology and show that symmetries play a radically different role in this discipline, when compared to those in current physics. By this comparison, we stress that (...) symmetries must be understood in relation to conservation and stability properties, as represented in the theories. We posit that the dynamics of biological organisms, in their various levels of organization, are not just processes, but permanent (extended, in our terminology) critical transitions and, thus, symmetry changes. Within the limits of a relative structural stability (or interval of viability), variability is at the core of these transitions. (shrink)

La justice prédictive est ici sommairement définie comme une justice prédite par des algorithmes et, partant, envisagée comme une justice simplement virtuelle, c’est-à-dire seulement probable, non acquise dans son existence et dont l’actualisation est laissée à la création, à l’imagination et à l’intuition des utilisateurs qui feront que la prédiction restera « une » solution proposée ou deviendra « la » solution finalement adoptée. La justice prédictive apparaît ainsi comme un espace de prospective juridique pour les justiciables, les professions juridiques (...) et la science du droit. Cette introduction à une justice simplement virtuelle étudie, d’une part, le risque qui reste mesuré d’une domination du virtuel, lorsque celui-ci devient prescriptif pour les professionnels ou dissuasif pour les justiciables ; elle envisage, d’autre part, l’avenir espéré d’une responsabilisation face au virtuel, par une nécessaire compréhension technique de l’outil de justice prédictive et une essentielle respiration éthique de ses acteurs. (shrink)

Spécialiste reconnu de la poésie épique, à laquelle il a consacré plusieurs études et traductions commentées (ainsi celle de l’Alexandra de Lycophron aux PUR, précédant de quelques années l’édition d’André Hurst aux Belles Lettres), Gérard Lambin (GL) sort de sa zone de confort pour chasser sur les terres de Kernos, en commettant un essai consacré au « divin » dans le monde grec. En quelques deux cents pages de texte, complétées d’une bibliographie et d’une table des matières, GL développe de...

Les écrits du XVIIIe siècle sur l’habitude de manger de la viande affrontent certains problèmes qui ne sont abordés aujourd’hui que dans une optique de défense de la cause animale, comme la sensibilité des animaux tués pour la viande ou le devenir de l’être humain lorsqu’il consomme de la chair. Ce discours au XVIIIe siècle n’est cependant pas le fait de défenseurs des animaux, et se trouve même paradoxalement exempt de conséquences pratiques : les auteurs qui déplorent la consommation de (...) chair n’appellent pas pour autant à abandonner celle-ci. Comment les penseurs occidentaux du XVIIIe siècle résolvent-ils le paradoxe qui consiste à souligner l’empathie avec les animaux tout en les tuant pour s’en nourrir? À travers des textes de philosophes et de médecins du XVIIIe siècle sur les effets de la consommation de viande, il s’agit ici d’interroger la représentation de l’être humain sous-jacente à un discours qui appartient aujourd’hui à l’inconscient de l’alimentation carnée. (shrink)

When scholars inquire into the inspirational sources of Nietzschean perspectivism, they most often credit Leibniz's monadology. However, this overlooks the fact that Pascal — whose writings Leibniz had read — was the first person to introduce the idea of perspective into philosophy. Above all, it overlooks Nietzsche's own indications: he praises Pascal as one of those “good Europeans” who precipitate the devaluation of Christian values and, in particular, of truth, while on the contrary he considers Leibniz to be one of (...) the “greatest obstacles to intellectual probity in Europe.”. (shrink)