Circadian rhythms are responsible for 24‐hour oscillations in diverse biological processes. While the central genes governing circadian pacemaker rhythmicity have largely been identified, clock‐controlled output molecules responsible for regulating rhythmic behaviors remain largely unknown. Two recent reports from McDonald and Rosbash1 and Claridge‐Chang et al.2 address this issue. By identifying a large number of genes whose mRNA levels show circadian oscillations, the reports provide important new information on the biology of circadian rhythm. In addition, the reports illustrate both the power (...) and limitations of microarray‐based methods for profiling mRNA expression on a genomic scale. BioEssays 24:494–498, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Objective tests of olfaction are widely available to aid in the assessment of olfaction. Their clearest role is in the characterization of olfactory changes, either reported by or suspected in a patient. There is a rapidly growing literature concerned with the association of olfactory changes with certain neuropsychiatric conditions and the use of olfactory testing to supplement conventional assessments in clinical and research practice is evolving. Neural pathways important for olfactory processing overlap extensively with pathways important for cognitive functioning, and (...) especially those important for executive functioning, many of which are concentrated in the frontal lobes. Previous work has identified associations between performance on certain olfactory tests and executive functioning and behavioral measures. More recently, similar associations have also been identified in non-clinical samples, raising new questions as to the utility of olfactory test scores as proxy measures for non-olfactory phenomena. In this systemic review, we sought to identify studies, both clinical and non-clinical, that investigated the associations of olfaction with performance on tasks sensitive to frontal lobe functioning. Our search criteria led to the identification of 70 studies published in English. We examined in detail and tabulated the data from these studies, highlighted each study's key findings, and critically evaluated these studies. We use the results of this review to reflect on some of the current and future challenges concerning the use of olfactory testing in clinical neuropsychiatric practice and research and speculate on the potential benefits of administering phonemic fluency in combination with olfactory testing to enhance its predictive value. (shrink)

. Speaker recognition has been an active research area for many years. Methods to represent and quantify information embedded in speech signal are termed as features of the signal. The features are obtained, modeled and stored for further reference when the system is to be tested. Decision whether to accept or reject speakers are taken based on parameters of the data modeling techniques. Real world offers various degradations to the signal that hamper the signal quality. The degradations may be due (...) to ambient background noise, reverberation or multispeaker scenario. This paper presents a survey of various feature extraction, data modeling methods, metrics that are used to take the decisions and methods that can be used to preprocess the degraded data that have been used to perform the task of speaker recognition. (shrink)

This article presents an overview of the single-channel dereverberation methods suitable for distant speech recognition application. The dereverberation methods are mainly classified based on the domain of enhancement of speech signal captured by a distant microphone. Many single-channel speech enhancement methods focus on either denoising or dereverberating the distorted speech signal. There are very few methods that consider both noise and reverberation effects. Such methods are discussed under a multistage approach in this article. The article concludes with a hypothesis that (...) the methods that do not require an a priori reverberation impulse response is desirable in varying the environmental conditions for DSR applications such as intelligent home and office environments, humanoid robots, and automobiles rather than the methods that require an a priori reverberation impulse response. (shrink)

This book discusses major milestones in Rohit Jivanlal Parikh’s scholarly work. Highlighting the transition in Parikh’s interest from formal languages to natural languages, and how he approached Wittgenstein’s philosophy of language, it traces the academic trajectory of a brilliant scholar whose work opened up various new avenues in research. This volume is part of Springer’s book series Outstanding Contributions to Logic, and honours Rohit Parikh and his works in many ways. Parikh is a leader in the realm of ideas, offering (...) concepts and definitions that enrich the field and lead to new research directions. Parikh has contributed to a variety of areas in logic, computer science and game theory. In mathematical logic his contributions have been in recursive function theory, proof theory and non-standard analysis; in computer science, in the areas of modal, temporal and dynamic logics of programs and semantics of programs, as well as logics of knowledge; in artificial intelligence in the area of belief revision; and in game theory in the formal analysis of social procedures, with a strong undercurrent of philosophy running through all his work.This is not a collection of articles limited to one theme, or even directly connected to specific works by Parikh, but instead all papers are inspired and influenced by Parikh in some way, adding structures to and enriching “Parikh-land”. The book presents a brochure-like overview of Parikh-land before providing an “introductory video” on the sights and sounds that you experience when reading the book. (shrink)

ABSTRACT:In this qualitative study we examine the role of caste, class, and Dalit janitorial labor in the aftermath of floods in Chennai, India, in 2015. Drawing from a variety of sources including interviews, social media, and news coverage, we studied how Dalit janitors were treated during the performance of janitorial labor for cleaning the city. Our study focuses on two theoretical premises: caste-based social relations reproduce inequalities by devaluing Dalit labor as ‘dirty work’; and Dalit subjectivities, labor, and sufferings including (...) occupational hazards become invisible and ungrievable forcing Dalits to provide a counter narrative to preserve the memory of their trauma and dignity injuries. We find that the discursive construction of janitorial labor as dirty work forced Dalit janitors to work in appalling and unsafe working conditions. Janitors suffered several dignity injuries in terms of social exclusion and a lack of recognition for their efforts and accomplishments. Specifically, we examine various ways through which caste, dirty work, and dignity intersected in the narrative accounts of Dalit janitors. We also explore memory and how processes of remembering and forgetting affected the dignity claims of Dalit janitors. (shrink)

We investigate the semantics of messages, and argue that the meaning ofa message is naturally and usefully given in terms of how it affects theknowledge of the agents involved in the communication. We note thatthis semantics depends on the protocol used by the agents, and thus not only the message itself, but also the protocol appears as a parameter in the meaning. Understanding this dependence allows us to give formal explanations of a wide variety of notions including language dependence, implicature, (...) and the amount of information in a message. (shrink)

In this paper, using Ambedkar’s pioneering vision for engaged Buddhism, we developed the notion of radical interdependence, which consists of four interrelated processes: dialogical recognition; negating invisibilities; dignity as an embodied praxis; ordinary cosmopolitanism. Our research primarily focused on women janitors’ lives in a Mumbai Mall using this conception. Our participants experienced four different kinds of dignity injuries. They used various strategies to preserve personal, intersubjective, and processual dignities. We also found horizontal and vertical ordinary cosmopolitanism strategies to bridge social (...) boundaries between colleagues and mall customers. We further discuss the implications of radical interdependence for organizational research. (shrink)

This Collection Of Twenty Essays Dealing With A Wide Variety Of Authors And Texts Concentrates On The Concept Of Self.

It is generally believed that through one-person one vote the diverse groups within society would be integrated into a shared identity. But the multiculturalists- Kymlicka, Parekh, Taylor, Young- argue that in well established democracies, some groups like African-American, indigenous peoples, ethnic and religious minorities and women feel marginalized and as a remedy, propose measures that the political system could mirror the distinct cultural identity of the different people. The critics of multiculturalism- Miller, Barry- argue that Liberalism accommodates cultural plurality and (...) stresses on the need for shared identity and common public space, which multiculturalism overlooks. (shrink)

Downsizing remains a topic of great interest to both academics and practitioners. Yet, the impact of layoff decisions on perceptions of corporate social responsibility (CSR) has hardly been studied. We examine the impact of responsibility of business leaders making these layoff decisions, and characteristics of the downsizing implementation on convergence and divergence in (1) CSR perceptions, (2) victims’ perceptions of fairness, and (3) survivor commitment, in four countries. Using an experimental design, sixteen scenarios were distributed to (1) 163 managers in (...) Estonia, (2) 152 MBA students in India and 125 MBA students in France, and (3) 186 (non-traditional) undergraduate students in the USA. Results suggest that when top managers are attributed with the responsibility for downsizing, the resulting perceptions of CSR are negative. A similar pattern of results is obtained for victims’ perceptions of fairness and survivor commitment. In addition, although there are differences in effect-size based on differences in power distance, these results hold good (are similar) across the four countries, from four different society clusters. We discuss implications, limitations, and future research directions. (shrink)

Specific inhibition of gene expression by antisense agents provides the basis for rational drug discovery based on molecular targets. Due to the specificity of Watson‐Crick base‐pair hybridization, antisense oligodeoxynucleotides have been used extensively in attempts to inhibit gene expression in both in vitro and in vivo models. Analogues modified from normal phosphodiester oligodeoxynucleotides have entered clinical trials against diseases including AIDS and cancer. Although the precise mechanism of action of these drugs has not been clarified, these oligodeoxynucleotides offer considerable promise (...) as novel molecular therapeutics. We review the recent attempts to harness the therapeutic potential of these oligodeoxynucleotides and appraise the near‐term prospects for antisense technology. (shrink)

The Tattvabindu of Vacaspatimisra with the commentary called Tattvavibhavand of Paramesvara II of Payyur Bhattamana. This edition of Vacaspatimisra's Tattvabindu and of its commentary Tattvavibhavana by Paramesvara II is based on (1) a transcript of a manuscript Tattvavibhavana preserved in the Madras Government Oriental Manuscripts Library, and (2) the Benares Edition of the Tattvabindu. Since the commentator has made it a rule to quote the full text by parts before commenting on it. Vacaspatimisra's Tattvabindu is a short and highly difficult (...) text. In his characteristically rhythmic and stately diction, Vacaspatimisra reviews in the Tattvabindu, the vaiyakarana doctrine of Sphota, mainly as expounded by Bhartrhari and Mandanamisra, and amplifies and reaffirms Kumarila's criticism of Sphota doctrine. The elaborate and scholarly introduction, giving a historical sketch of the Mimamsa literature, and the thoroughgoing analysis of the Tattvabindu, in English, which the learned editor has prefixed to his edition of the work. (shrink)

As the annual air passenger traffic in India is increasing steeply, an environmental impact assessment on important cities connected by air is becoming increasingly indispensable. This study proposes an innovative screening method that uses a modified Environmental Vulnerability Index. This modified EVI calculator includes aviation-related parameters and can be used to assess the environmental vulnerabilities of political states and cities, in addition to countries as is being already done. This study also suggests the need to include aspects of human comfort (...) in the screening process through the use of state-of-the-art computational fluid dynamical software and large eddy simulations which can be used to estimate forces experienced by aircraft of different sizes during in-flight turbulence for various weather conditions. A comparative analysis is presented on how changing the size of the aircraft operating in a particular route between the cities of Chennai and Bengaluru has better implications on both passenger comfort and the environment. It is observed that if commercial airlines incorporated fewer medium-sized aircraft, there would be a significant reduction in the environmental vulnerability of the two connected cities. (shrink)

We introduce an abstract framework for general rough set theory from a mereological perspective and consider possible concepts of ’a priori’ granules and granulation in the same. The framework is ideal for relaxing many of the relatively superfluous set-theoretic axioms and for improving the semantics of many relation based, cover-based and dialectical rough set theories. This is a relatively simplified presentation of a section in three different recent research papers by the present author.

Rough sets are used in numerous knowledge representation contexts and are then empowered with varied ontologies. These may be intrinsically associated with ideas of rationality under certain conditions. In recent papers, specific granular generalisations of graded and variable precision rough sets are investigated by the present author from the perspective of rationality of approximations (and the associated semantics of rationality in approximate reasoning). The studies are extended to ideal-based approximations (sometimes referred to as subsethood-based approximations). It is additionally shown that (...) co-granular or point-wise approximations defined by σ-ideals/filters (for an arbitrary relation σ) fit easily into the entire scheme. Concepts of the rationality of objects (vague or crisp) and their types are introduced and are shown to be applicable to most general rough sets by the present author. Surprising results on these are proved on these by her in this part of the research paper. The present paper is the first of a three part study on the topic. (shrink)

In Sinners in the Presence of a Loving God, R. Zachary Manis examines in detail the several facets of the problem of hell, considers the reasons why the usual responses to the problem are unsatisfying, and suggests how an adequate solution to the problem can be constructed.

One of the most important recent developments in the discussion of Kierkegaard's ethics is an interpretation defended, in different forms, by Philip Quinn and Stephen Evans. Both argue that a divine-command theory of moral obligation is to be found in Works of Love . Against this view, I argue that, despite significant overlap between DCT and the view of moral obligation found in Works of Love , there is at least one essential difference between the two: the former, but not (...) the latter, is committed to the claim that, necessarily, p is morally obligatory only if God commands that p. (shrink)