The continuous revaluation of rewards lies at the core of Ainslie's account of willpower. Yet, he does not explicate the underlying experiential mechanisms. We draw upon theoretical, neuroscientific, and computational evidence to demonstrate that boredom evokes revaluation. By biasing behavior toward exploration, boredom necessitates effortful willpower to balance it against exploitation, thereby rendering suppression a highly adaptive function of willpower.

The history of moral philosophy has been dominated by attempts to find and defend the correct moral principle or set of principles. However, over the last two decades the assumption that morality can and should be understood in terms of principles has come under attack from several quarters. The most radical attack has come from so-called moral particularists according to whom principles are at best useless and at worst a hindrance to successful moral reasoning and action.Why should - and how (...) can - morality be based on principles? These are the leading questions of this book. Moral Principles offers a historically informed, in-depth examination of the current particularist/generalist debate and presents a novel account of the place of principles in our moral thought and action. (shrink)

Recent evidence indicates that transcriptional bursts are intrinsically amplified by messenger RNA cytoplasmic processing to generate large stochastic fluctuations in protein levels. These fluctuations can be exploited by cells to enable probabilistic bet‐hedging decisions. But large fluctuations in gene expression can also destabilize cell‐fate commitment. Thus, it is unclear if cells temporally switch from high to low noise, and what mechanisms enable this switch. Here, the discovery of a post‐transcriptional mechanism that attenuates noise in HIV is reviewed. Early in its (...) life cycle, HIV amplifies transcriptional fluctuations to probabilistically select alternate fates, whereas at late times, HIV utilizes a post‐transcriptional feedback mechanism to commit to a specific fate. Reanalyzing various reported post‐transcriptional negative feedback architectures reveals that they attenuate noise more efficiently than classic transcriptional autorepression, leading to the derivation of an assay to detect post‐transcriptional motifs. It is hypothesized that coupling transcriptional and post‐transcriptional autoregulation enables efficient temporal noise control to benefit developmental bet‐hedging decisions. (shrink)

There are cases such as climate change where the cumulative effects of the actions of several agents lead to grave harm but where no individual agent can make a perceptible difference for the better or worse. According to Derek Parfit, dealing with such imperceptible difference cases requires substantial changes to the way we think about morality. In On What Matters, Parfit builds on Kantian Ethics to address the problem of imperceptible differences, but the transformation that Kant's theory undergoes in his (...) hands is radical. I argue that Parfit's changes to Kant's theory are not only unnecessary but also detrimental to making sense of the ethical dimensions of action in collective contexts. Building on the notion of imperfect duties, I offer an alternative solution to the problem of imperceptible difference cases that remains closer to Kant's original theory and avoids the difficulties of Parfit's approach. (shrink)

Despite its age, quantum theory still suffers from serious conceptual difficulties. To create clarity, mathematical physicists have been attempting to formulate quantum theory geometrically and to find a rigorous method of quantization, but this has not resolved the problem. In this article we argue that a quantum theory recursing to quantization algorithms is necessarily incomplete. To provide an alternative approach, we show that the Schrödinger equation is a consequence of three partial differential equations governing the time evolution of a given (...) probability density. These equations, discovered by Madelung, naturally ground the Schrödinger theory in Newtonian mechanics and Kolmogorovian probability theory. A variety of far-reaching consequences for the projection postulate, the correspondence principle, the measurement problem, the uncertainty principle, and the modeling of particle creation and annihilation are immediate. We also give a speculative interpretation of the equations following Bohm, Vigier and Tsekov, by claiming that quantum mechanical behavior is possibly caused by gravitational background noise. (shrink)

Collective migration is a key process that is critical during development, as well as in physiological and pathophysiological processes including tissue repair, wound healing and cancer. Studies in genetic model organisms have made important contributions to our current understanding of the mechanisms that shape cells into different tissues during morphogenesis. Recent advances in high‐resolution and live‐cell‐imaging techniques provided new insights into the social behavior of cells based on careful visual observations within the context of a living tissue. In this review, (...) we will compare Drosophila testis nascent myotube migration with established in vivo model systems, elucidate similarities, new features and principles in collective cell migration. (shrink)

ZusammenfassungAuf dem Wiesbadener Internistenkongress von 1949 forderten Alexander Mitscherlich und Viktor von Weizsäcker eine Erweiterung des naturwissenschaftlichen Kausalitätsbegriffs um die Suche nach dem Sinn von Krankheit in der Lebensgeschichte. Hiermit wurde ein traditionelles psychiatrisches Paradigma infrage gestellt: die vermutete somatische Ursache psychischer Erkrankungen. Damit standen auch psychiatrische Evidenzpraktiken auf dem Prüfstand. Im ersten Teil dieses Beitrags werden im Sinne eines Querschnitts drei psychiatrische Positionen rekonstruiert, die auf dem Kongress zur Darstellung kamen. Im zweiten Teil wird die Entwicklung eines der beteiligten (...) Psychiater, Jürg Zutt, im Längsschnitt untersucht, wobei der Fokus auf der Frage nach möglichen Auswirkungen der Wiesbadener Debatte auf seine wissenschaftliche Neuausrichtung sowie den Konsequenzen für seine Auffassung von psychiatrischer Evidenz liegt. (shrink)

ZusammenfassungAuf dem Wiesbadener Internistenkongress von 1949 forderten Alexander Mitscherlich und Viktor von Weizsäcker eine Erweiterung des naturwissenschaftlichen Kausalitätsbegriffs um die Suche nach dem Sinn von Krankheit in der Lebensgeschichte. Hiermit wurde ein traditionelles psychiatrisches Paradigma infrage gestellt: die vermutete somatische Ursache psychischer Erkrankungen. Damit standen auch psychiatrische Evidenzpraktiken auf dem Prüfstand. Im ersten Teil dieses Beitrags werden im Sinne eines Querschnitts drei psychiatrische Positionen rekonstruiert, die auf dem Kongress zur Darstellung kamen. Im zweiten Teil wird die Entwicklung eines der beteiligten (...) Psychiater, Jürg Zutt, im Längsschnitt untersucht, wobei der Fokus auf der Frage nach möglichen Auswirkungen der Wiesbadener Debatte auf seine wissenschaftliche Neuausrichtung sowie den Konsequenzen für seine Auffassung von psychiatrischer Evidenz liegt. (shrink)

The compound eyes of insects exhibit stunning variation in size, structure, and function, which has allowed these animals to use their vision to adapt to a huge range of different environments and lifestyles, and evolve complex behaviors. Much of our knowledge of eye development has been learned from Drosophila, while visual adaptations and behaviors are often more striking and better understood from studies of other insects. However, recent studies in Drosophila and other insects, including bees, beetles, and butterflies, have begun (...) to address this gap by revealing the genetic and developmental bases of differences in eye morphology and key new aspects of compound eye structure and function. Furthermore, technical advances have facilitated the generation of high‐resolution connectomic data from different insect species that enhances our understanding of visual information processing, and the impact of changes in these processes on the evolution of vision and behavior. Here, we review these recent breakthroughs and propose that future integrated research from the development to function of visual systems within and among insect species represents a great opportunity to understand the remarkable diversification of insect eyes and vision. (shrink)

A widely shared view in the literature on first-person thought is that the ability to entertain first-person thoughts requires prior non-conceptual forms of self-consciousness. Many philosophers maintain that the distinctive awareness which accompanies the use of the first person already presupposes a non-conceptual consciousness of the fact that oneself is the owner of a first-person thought. I call this argument The Argument for Non-Conceptual Self-Consciousness based on the Meaning of “I” and will demonstrate that most proponents of the presented argument (...) fail to establish their conclusion, even though I believe that the conclusion is actually true. The argument only justifies the claim that contextual information is needed in order to recognize oneself as the referent of an occurrence of the first person. However, it does not justify the thesis that this information needs to be given consciously and thus the existence of any non-conceptual self-consciousness. Finally, I shall present an argument for the assumption that some form of self-consciousness is needed to reflexively think about oneself via the first-person concept. In order to do so, I will draw on the general discussion about the functional role of consciousness. In particular, I will rely on results recently proposed by Frith and Metzinger (2016), Frith (Pragmatics & Cognition 18:497–551, 2010, Cognitive Neuroscience 2:117–118, 2011), Graziano (2013, Frontiers in Robotics and AI 4:article 60, 2017), and Graziano and Kastner (Cognitive Neuroscience 2:98–113, 2011), which suggest that one of the central functions of consciousness is to provide information about mental states for communication. (shrink)

The “self” shapes the way in which we process the world around us. It makes sense then, that self-related information is reliably prioritised over non self-related information in cognition. How mig...

Background Transcranial direct current stimulation (tDCS) is a brain stimulation technique currently being researched as an alternative or complimentary treatment for various neurological disorders. There is little knowledge about experiences of the participants of tDCS clinical research, especially from pediatric studies. Methods An interview study with typically developing minors (n = 19, mean age 13,66 years) participating in a tDCS study, and their parents (n = 18) was conducted to explore their views and experiences and inform the ethical analysis. Results (...) Children (10–13 years old) and adolescents (14–18 years old) reported good experiences with the stimulation. Next to financial incentives, main motives to participate in the study were curiosity and the possibility to help develop treatments for children affected by neurological disorders. They could also see a potential of using tDCS in a non-medical setting, especially regarding the provision of equal opportunity, e.g. in education. Parents also presented a positive attitude towards tDCS and their children participation in the basic research study. Nevertheless, their understanding of tDCS was rather poor. Even though many of them understood the techniques, they often did not see the link between the (current) lack of side effects and an absence of longitudinal studies. Parents were also cautious about using tDCS for non-medical/enhancement purposes. Conclusions The study findings show a need for more transparent information about the state of the art of tDCS, its function and what it might be able to offer, especially considering the good acceptability of tDCS. (shrink)

This paper juxtaposes Asian spiritual narratives on meditation alongside medical and scientific narratives that emphasize meditation's efficacy in mitigating distress and increasing well-being. After proposing a working definition of meditation that enables it usefully to be distinguished from categories of similar practices such as prayer, I examine meditation's role in Mind/Body medicine in the West. Here, I survey a number of scientific studies of meditation, including the work of Dr. Herbert Benson and his colleagues who examine a meditational variant they (...) call the ‘Relaxation Response', to examine the breadth of efficacy claims made on behalf of the complex and multidimensional grouping of diverse practices we have come to as ‘meditation'. Among other positive outcomes, meditation has been credited with reducing blood pressure, anxiety, addiction, and stress, while Relaxation Response has been shown to decrease sympathetic nervous system activity, metabolism, pain, anxiety, depression, hostility, and stress. I conclude the paper by suggesting that findings from cognitive neuroscience on the subject of visual imagery can be used to elucidate genres of meditative practice that focus on internal visualization sequences, and I use practices from the Rnying ma tradition of Tibetan Buddhism to illustrate why certain integral aspects of meditation forever will remain beyond scientific grasp. (shrink)

It is widely acknowledged that moral principles are not sufficient to guide moral thought and action: they need to be supplemented by a capacity for judgement. However, why can we not rely on this capacity for moral judgement alone? Why do moral principles need to be supplemented, but are not supplanted, by judgement? So-called moral particularists argue that we can, and should, make moral decisions on a case-by-case basis without any principles. According to particularists, the person of moral judgement is (...) a person of empathy, sensibility and virtue, rather than a person of principle. In this paper I argue that this is a false dichotomy. The person of good moral judgement is a person of principle. I propose that we think of moral principles as internalised long-term commitments that form our moral character and sensitivity, and, as such, are constitutive of moral judgement. (shrink)

This article investigates the constructions of Hebrew, classical, and “Northern” antiquities put forward by an eighteenth-century network of Anglo-German scholars. It asks to what extent these constructions propose a cultural equality between these competing “antiquities”, how such equality relates to the contemporaneous conception of universal history, and to what extent this development is driven by emancipatory tendencies within Enlightenment thinking. By discussing the changing approaches to Homer, Old Testament texts, and “early” European literature, the article relates the emergence of primitivism (...) and orientalism to Enlightenment historicism and an interest in the sublime, which produces a growing focus on the importance of authentic culture and the role of the bard-poet. By discussing the connections between the work of Joseph Trapp, Thomas Blackwell, Robert Lowth, and Thomas Percy on the one hand, and Johann David Michaelis, Christian Gottlob Heyne, Johann Jakob Bodmer, and Johann Gottfried Herder on the other, the article illustrates the significance in this context of newly emerging Anglo-German scholarly networks and illuminates lesser-known aspects of Anglo-German relations in the second half of the eighteenth century. (shrink)

Abstract The debate on corporate social responsibility (CSR) has been going on for decades, without leading to a clearer understanding of the term. Furthermore, the current literature on the topic remains relatively silent on the actual impact of CSR, especially the impact on issues of international development, for example poverty reduction in the Global South. By developing a conceptual assessment framework with a bipolar differentiated definition of CSR and a Sen-based notion of poverty, the article analyses the effects and impact (...) of two different types of CSR-strategies on the reduction of poverty. For this, two case studies have been conducted in Phnom Penh, Cambodia. The results imply that CSR measures which are built into the core business of a company (both transnational companies and small/medium sized companies) have larger effects on poverty than CSR measures which are located outside of the core business activities. Content Type Journal Article Pages 1-33 DOI 10.1007/s13520-012-0016-6 Authors Maike J. Schölmerich, Institute for Development and Peace, University of Duisburg-Essen, Duisburg, Germany Journal Asian Journal of Business Ethics Online ISSN 2210-6731 Print ISSN 2210-6723. (shrink)

This paper seeks to unveil the agency of widows in late antiquity beyond prevailing limits of asceticism and euergetism. Based on a Bourdieu’ian field-analysis this approach seeks to illustrate that some widows used their recently achieved liberty not for withdrawing from society, i.e. living an ascetic life among their peers, praying all night and day. They used their liberty to actively engage within this society, within the elite in particular, instead. In so doing, these (wealthy) widows constructed, contested, and negotiated (...) power relations by appropriating and nuancing communication strategies of allegedly male domains of practice, i. e. the daily business of the household. These widows, strictly speaking, set up new power relations with which they started negotiating and maintaining, indeed creating new field positions, through which new interactions occurred that rendered her agency. An exemplary context in this respect is that of inheritance hunting in the widows’ households. (shrink)

With his now famous regress argument, Sydney Shoemaker (1968) aimed to provide justification for the assumption that at least some cases of self-awareness cannot be based on identification. The overall goal of this paper is to discuss two possible worries one may have about Shoemaker’s argument. I will show that these problems have far-reaching consequences that may diminish the argument’s importance for an adequate theory of self-awareness and that another conclusion Shoemaker and other philosophers draw may be unwarranted.

There is widespread agreement among many contemporary philosophers of mind that, in addition to their qualitative character, phenomenally conscious states contain some kind of subjective character. The subjective character of experience is most commonly characterized as a subject’s awareness that it is currently undergoing a specific experience. This idea is nothing new, of course, and something similar has been proposed quite some time ago by Franz Brentano, among others, under the name of “secondary consciousness”. That fact hasn’t remained unnoticed. Indeed, (...) a number of competing contemporary accounts of subjective character refer to Brentano as an early proponent of their particular view. This article pursues two objectives. First, it argues that the so-called self-mode account of subjective character is, for systematical reasons, superior to self-representational and pre-reflective accounts. Second, the article briefly suggests a novel interpretation of Brentano’s concept of secondary consciousness that sets it in relation to the previously introduced self-mode account and bears some similarities with Thomasson’s adverbial interpretation of Brentano’s concept of secondary consciousness. (shrink)

The book offers new answers to two central questions that have been heavily debated, especially in recent years, in the debate on so-called de se skepticism: Is there something special about first-person thinking? And how does it relate to other forms of self-consciousness? The answer to the first question is a resounding "yes." This assertion is justified by the double-reflexive structure, motivational force, and specific concern that first-personal thinking involves. Regarding the second question, the book concludes that there are non-linguistic (...) forms of self-consciousness. However, these should not be understood as representational contents or non-relational properties, but as mental relations that, without themselves being represented, can contribute to the phenomenal character of conscious states. In this respect, the book also provides a justification for the rarely considered impure intentionalism. (shrink)

It is widely believed that the phenomenal character of conscious mental states is composed of two different components: its qualitative character and its subjective character, with the latter also being referred to as ‘mineness’, ‘for-me-ness’ or ‘me-ishness’. While many researchers agree that the subjective character is an essential part of conscious life, there is great disagreement about what the metaphysical nature of this component of experience has to be like. One answer to this question, originally presented in Smith (1986), conceptualizes (...) the subjective character as being part of the modality of experience rather than as a constituent of its representational content. I call the branch of theories developed along these lines ‘the self-mode approach to the subjective character of experience’. This self-mode approach to the metaphysics underlying the subjective character appears to be promising, yet it can still be developed in a number of different ways – some of which are fraught with problems, while others less so. Here I will introduce three different approaches to the idea that the subjective character is grounded in the modality of experience. I name these distinct accounts ‘evaluatism’ (Musholt 2015; Pereira 2018; Recanati 2007, 2012), ‘adverbialism’ (Thomasson 2000), and ‘relationalism’. I am going to argue for relationalism, and explore how this position relates to a general representational theory of consciousness and different views about the metaphysics of the subjects of experiences, i.e. the entities in relation to which experiences are instantiated. Relationalism consists of the very simple idea that the subjective character is grounded in a sui generis mental relation that holds between a conscious mental state and the subject of experience having this state. In contrast to most of the existing accounts of subjective character, relationalism aims to account for the subjective character not by introducing something additional to our ontology of the mind and consciousness (such as a self-representational content or a higher-order state), but by adopting a different view on the grounding or basing relation holding between the representational structure of a conscious mental state and its phenomenal character. (shrink)

Carl Andresen (1909-1985) widmete sich seit seiner bahnbrechenden Studie Logos und Nomos (1955) dem Verhältnis von Antike und Christentum. Die gesammelten Studien leuchten dieses Feld der Begegnung in vielfältigen Facetten aus, von der Zuordnung von Theologie und Philosophie in den Debatten über die Trinität über Fragen der Ethik und Seelsorge bis zur Verteidigung des Wahrheitsanspruchs der Bibel gegenüber der philosophischen, besonders der platonischen Tradition. Die Apologeten der frühen Kirche sowie Augustin als integrale Gestalt der Spätantike stehen dabei im Mittelpunkt. (...) Andresen zeigt, dass und wie die Wahrheit der christlichen Botschaft sich im Horizont antiker Geistigkeit bewährte. Möglich war dies nur durch Anknüpfung und Kritik zugleich. Jenseits der Frage nach einer einlinigen Hellenisierung des Christentums macht Andresen deutlich, wie die Rezeption der Antike nicht nur Kirche und Theologie, sondern auch die Antike selbst neu gestaltete. (shrink)

How the Study of Consciousness and Mapping Spiritual Experiences Can Reshape Religious Methodology This special issue of the Journal of Consciousness Studies throws down a methodological challenge to the field of Religious Studies. Over the last half century, the academic study of religion has developed a variety of angles and approaches: structuralist, Eliadian, Marxist, feminist, and so on. Recently, approaches popular in many institutions and departments have centred on linguistic and cultural analysis, notably the postmodern and deconstructivist approaches championed by (...) Derrida and others. With the dawn of the interdisciplinary field of the study of human consciousness, and with this issue of the Journal of Consciousness Studies, we challenge this prevailing approach by presenting readers with articles analysing religion, spirituality, and spiritual experience, not solely as cultural phenomena, but as phenomena that can be related to human physiology, and a kind of pan-human technology of human spiritual development. (shrink)

Trade-offs between competitive priorities are often seen as exogenous – managers accept them as a given downside while simultaneously addressing multiple competitive priorities. However, some companies seem to face fewer trade-offs than others. The question is how companies reduce their trade-offs to successfully compete on multiple competitive priorities simultaneously. We address this question by theorising that bundles of action programmes are needed to reduce trade-offs between competitive priorities. We examine four Swiss manufacturing plants and show how the selection of action (...) programmes influences the simultaneous competition on multiple competitive priorities. We show that successful competition on multiple competitive priorities does not happen by accident but is achieved by aligning competitive priorities, action programmes, infrastructural/structural changes and contextual factors. (shrink)

In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity based (...) on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63–76 years completed an at-home intervention study in either an exercise group (EG;n= 40) or in an active control group (ACG;n= 35). Measures of peak oxygen uptake (VO2peak) taken before and after the intervention revealed a time-by-group interaction, with positive average change in the EG and no reliable mean change in the ACG. Significant group differences in structural brain integrity changes were observed in the right and left ACC, right posterior cingulate cortex (PCC), and left juxtapositional lobule cortex (JLC). In all instances, average changes in the EG did not differ reliably from zero, whereas average changes in the ACG were negative, pointing to maintenance of structural brain integrity in the EG, and to losses in the ACG. Significant individual differences in change were observed for right ACC and left JLC. Following up on these differences, we found that exercising participants with greater fitness gains also showed more positive changes in structural integrity. We discuss the benefits and limitations of a latent-factor approach to changes in structural brain integrity, and conclude that aerobic fitness interventions are likely to contribute to brain maintenance in old age. (shrink)