(No abstract is available for this citation).

Neuroscience communication is increasingly taking place on multidirectional social media platforms, creating new opportunities but also calling for critical ethical considerations. Twitter, one of the most popular social media applications in the world, is a leading platform for the dissemination of all information types, including emerging areas of neuroscience such as optogenetics, a technique aimed at the control of specific neurons. Since its discovery in 2005, optogenetics has been featured in the public eye and discussed extensively on social media, but (...) little is known about how this new technique is portrayed and who the users participating in the conversation are. To address this gap, we conducted content analysis of a sample of 1000 tweets mentioning “optogenetics” over a one-year period between 2014 and 2015. We found that academic researchers are the largest group contributing to the conversation, that the tweets often contain links to third-party websites from news organizations and peer-reviewed journals, and that common thematic motifs include the applications of optogenetics specifically for the control of brain activity and the treatment of disease. We also found that the majority of the tweets are neutral in their tone regarding optogenetics. As Twitter serves as a current and dynamic forum for exchange about advances in neuroscience, the conversation about optogenetics on this engaging platform can inform socially-responsive knowledge dissemination efforts in this area. (shrink)

Building on research that analyzes how social relations and networks shape the Chinese market, this article asks a less-studied question: How is the market changing guanxi? The authors trace the transformation of guanxi from communal, kin-based ties to a cultural metaphor with which diverse individuals build flexible social relationships in late-socialist China. As a “generalized particularism,” this cultural metaphor provides something analogous to the culture of civility in Western societies. The authors discuss the political potential of guanxi in terms of (...) its dual tendency toward the “publicization” and “privatization” of power. The development of guanxi civility suggests the diverse cultural origins of civility and serves as a reminder of the particularistic roots in the universalistic assumption of Western civility. (shrink)

Recently, we reported that melanoma risk in redheads is linked not only to pale skin, but also to the synthesis of the pigment – called pheomelanin – that gives red hair its color. We demonstrated that pheomelanin synthesis is associated with increased oxidative stress in the skin, yet we have not uncovered the chemical pathway between the molecule pheomelanin and the DNA damage that drives melanoma formation. Here, we hypothesize two possible pathways. On one hand, pheomelanin might generate reactive oxygen (...) species (ROS) that directly or indirectly cause oxidative DNA damage. On the other hand, pheomelanin synthesis might consume cellular antioxidant stores and make the cell nucleus more vulnerable to other endogenous ROS. Uncovering the mechanistic pathway between pheomelanin and oxidative DNA damage will be an important step in developing strategies to lower melanoma risk in redheads. (shrink)

Leitmotiv -- Some highlights in the history of natural sciences -- The institutionalization of science and its new socioeonomic conditions -- Knowledge -- Orthodox and heterodox science -- The decline of science -- Philosophizing about science -- Nonsense and the search for a new humanity.

When applied in the health sector, AI-based applications raise not only ethical but legal and safety concerns, where algorithms trained on data from majority populations can generate less accurate or reliable results for minorities and other disadvantaged groups.

Scholars have established that cultural codes and styles of expression in civil society must be recognized as informal mechanisms of exclusion, calling into question the possibility of the Habermasian normative ideal of the public sphere. This article joins theoretical discussions of how to remedy this problem. Going beyond Alexander's model of "multicultural incorporation" and borrowing from Sewell's theory of the duality of structure, we develop a theoretical framework of code hybridization to conceptualize how civil society participants achieve civil solidarity amid (...) multiple, potentially contradictory cultural legacies. Code hybridization is a process whereby social actors not only incorporate the cultural codes of subordinate groups into the public sphere, but in doing so also potentially transform dominant codes. We conceptualize code hybridization in terms of three analytic steps: enlargement of the terrains of signification; reinterpretation of codes; and mixing of schemas. The resulting hybridized schemas and frameworks are particularly useful cultural tools for developing visions of civil inclusiveness for young, unstable civil societies. Using a brief comparative study of the representation of women in political cartoons in Hong Kong and Taiwan, we offer a concrete example of code hybridization—a process linking the codes of liberty and caring while producing alternative and more inclusive narratives during moments of political agitation. (shrink)

Latin American social protection systems show that the fundamental ambivalence of modernity is captured by the twin notion of liberty and discipline in the context of a plurality of modes of socio-political organization. According to this understanding, this article analyses the potential of the so-called Conditional Cash Transfer programmes, which are widespread in the region, to strength or reduce personal autonomy. These programmes are promoted by claiming their virtues to reduce poverty and impose good behaviour on poor people in order (...) to improve the ‘human capital’ of future generations. However, numerous elements challenge these alleged virtues: arbitrary selection of beneficiaries, interference in people’s lives, stigmatization of recipients, inability to achieve universal coverage and act in a preventive manner with regards to urgent needs, the creation of poverty traps and informal working, etc. Taking these elements into account, this article explains how these programmes do not improve people’s autonomy and political independence. (shrink)

En su Teoría postmetafísica del conocimiento, Antonio M. López Molina muestra detallada y rigurosamente que el vaciamiento sustantivo de la razón y, junto con él, el desmoronamiento de la vieja pretensión filosófica de acceder de manera privilegiada a la verdad (como al Bien o a Dios), no comportan su definitiva quiebra, sino más bien la urgencia de reelaborarla en términos falibilistas y procedimentales; con tal fin –y, a su vez, para asignarle a la filosofía el papel que le ha de (...) corresponder tras el ocaso de todas y cada una de las ilusiones metafísicas– analiza López Molina el concepto de acción comunicativa, capaz de imbricar a las ciencias positivas con el mundo de la vida y proveer el fin –ni utópico ni teológico– de una intersubjetividad no falseada, apoyada en relaciones simétricas de libre reconocimiento recíproco. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

El presente documento tiene como propósito central analizar los discursos deotredad en la experiencia migratoria hacia Estados Unidos en personas mayoresretornadas a Durango. En un intento por vincular las metáforas queaparecen en el pensamiento del autor, se discuten las anécdotas de 18 participantes mayores de 60 años que trabajaron o vivieron en Estados Unidos, y quienes fueron seleccionados por medio de una muestra intencional. Dentro de los principales resultados se advierten tramas lingüísticas que aparecen en lascomunicaciones orales, donde se manifiestan (...) tensiones entre el territorio, los nacionalismos, el lenguaje y la producción de mismidad como mecanismos que utilizaron los sujetos para hacer frente a las múltiples violencias, segregaciones y desigualdad del contexto migratorio. (shrink)

Abordamos en este trabajo la imagen de Dios que nos revela el cántico evangélico del Magnificat (Lucas 1, 46-55) y la imagen de María que en él aparece. Partiendo de su contexto en la obra de Lucas y de un breve análisis exegético del cántico, los autores profundizan en sus claves teológicas en relación con dos núcleos: la imagen de Dios y la figura de María introducida por el evangelista. El trabajo concluye con una propuesta de relectura del Magnficat acorde (...) con nuestro tiempo, centrada en su dimensión profética y liberadora. (shrink)

Este artículo afronta el concepto de “laicidad”. El primer paso es clarificar los distintos términos y sobre todo los conceptos que se usan en este argumento. Después se hace un recorrido por la historia del cristianismo sobre la laicidad, comenzando por el comportamiento del mismo Jesús. En la Iglesia se fue pasando de esta situación a la más rígida sacralización del cristianismo hasta convertirlo en una verdadera “religión”, aunque por encima de todas las demás. En este camino, después de siglos, (...) el Concilio Vaticano II ha superado la situación anterior de sociedad sacralizada, a la distinción y separación neta entre el plano social y el plano eclesial. Este cambio lleva a consecuencias claras y concretas tanto de puertas adentro de la Iglesia, como en su relación con la sociedad laica en que vive la propia institución eclesial como cada cristiano personalmente. (shrink)

Partiendo de la invitación hecha por el Papa Juan Pablo II en su Carta Apostólica "Tertio Millennio Adveniente" a reflexionar sobre la estrecha relación existente entre los misterios de la Encarnación y de la Eucaristía (perspectiva central del Jubileo 2000: TM 55), este trabajo estudia en profundidad las claves bíblicas y teológicas desde las que estos dos misterios que se pueden ver y considerar. Entre las muchas claves desde las que sería posible leer e interpretar estos misterios, este trabajo ha (...) seleccionado seis de ellas, que perfectamente aplicables a ambos misterios, y que constituyen el hilo conductor de la presente reflexión: el trinitario, el pascual, la unidad, la presencia mutuamente vinculante y redentora, la plenitud y las claves marianas. (shrink)

¿Quiénes son los laicos en la Iglesia? ¿Encajan en la estructura de la vida religiosa? Este artículo intenta responder a estas preguntas analizando el significado como la teoría y connotaciones prácticas de los legos para la vida del Inspectoría Salesiana de Córdoba (España) después del Concilio.

En la actualidad podemos observar –en algunos sectores cualificados de la Iglesia Católica– un tipo de interés por devaluar la fuerza reformista con la que el Papa Juan XXIII imprimió al Concilio Vaticano II desde su convocatoria (25 de enero de 1959). La celebración de este Concilio Ecuménico (1962-1965) provocó una ola de entusiasmo y optimismo dentro de la Iglesia, y no poca expectación en el resto del mundo. En el post-concilio encontraríamos luces y sombras. Incluso podemos escuchar voces (no (...) muy fuertes, pero desde instituciones significativas de la Iglesia) que indican que el concilio se equivocó al tomar ciertas posiciones reformistas dentro del cristianismo católico. Este artículo surge de este contexto y –declarando el Concilio Vaticano II como un regalo preciosode Dios a su Iglesia- desea ser una clara e inequívoca reivindicación de la “letra” y especialmente del “espíritu” que iluminaron este Concilio en la Iglesia Católica. La “letra” del Concilio sin su espíritu es un cuerpo muerto. El “espíritu” sin la letra, una fuerza verdaderamente ineficaz. (shrink)

ABSTRACTDifficulties with inhibiting fear have been associated with the emergence of anxiety problems and poor response to cognitive–behavioural treatment. Fear inhibition problems measured using experimental paradigms involving aversive stimuli may be inappropriate for vulnerable samples and may not capture fear inhibition problems evident in everyday life. We present the Fear Inhibition Questionnaire, a self-report measure of fear inhibition abilities. We assess the FIQ’s factor structure across two cultures and how well it correlates with fear inhibition indices derived experimentally. Adolescent participants (...) from Hong Kong and England completed the FIQ, with the English participants also completing a conditioning and extinction task to assess fear inhibition problems. Across both cultures, the FIQ showed a single factor structure and low FIQ scores, or worse fear inhibition problems, were associated with self-reports of heightened anxiety. Correlation of FIQ scores with experimental indices, whi... (shrink)

Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)