A long‐standing debate in the study of human communication centers on the degree to which communicators tune their communicative signals (e.g., speech, gestures) for specific addressees, as opposed to taking a neutral or egocentric perspective. This tuning, called recipient design, is known to occur under special conditions (e.g., when errors in communication need to be corrected), but several researchers have argued that it is not an intrinsic feature of human communication, because that would be computationally too demanding. In this study, (...) we contribute to this debate by studying a simple communicative behavior, communicative pointing, under conditions of successful (error‐free) communication. Using an information‐theoretic measure, called legibility, we present evidence of recipient design in communicative pointing. The legibility effect is present early in the movement, suggesting that it is an intrinsic part of the communicative plan. Moreover, it is reliable only from the viewpoint of the addressee, suggesting that the motor plan is tuned to the addressee. These findings suggest that recipient design is an intrinsic feature of human communication. (shrink)

While slowness of movement is an obligatory characteristic of Parkinson’s disease (PD), there are conditions in which patients move uncharacteristically fast, attributed to deficient motor inhibition. Here we investigate deficient inhibition in an optimal sensory-motor integration framework, using a game in which subjects used a paddle to catch a virtual ball. Display of the ball was extinguished as soon as the catching movement started, segregating the task into a sensing and acting phase. We analyzed the behavior of 9 PD patients (...) (ON medication) and 10 age-matched controls (HC). The switching times (between sensing and acting phase) were compared to the predicted optimal switching time, based on the individual estimates of sensory and motor uncertainties. The comparison showed that deviation from predicted optimal switching times were similar between groups. However, PD patients showed a weaker correlation between variability in switching time and sensory-motor uncertainty, indicating a reduced propensity to generate exploratory behavior for optimizing goal-directed movements. Analysis of the movement kinematics revealed that PD patients, compared to controls, used a lower peak velocity of the paddle and intercepted the ball with greater velocity. Adjusting the trial duration to the time for the paddle to stop moving, we found that PD patients spent a smaller proportion of the trial duration for observing the ball. Altogether, the results do not show the premature movement initiation and truncated sensory processing that we predicted to ensue from deficient inhibition in PD. (shrink)

The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In the second (...) part of the paper, I examine the most important examples of adaptation in cancer cells. I argue that they are not significant accumulations of evolutionary changes, and that as a consequence natural selection plays a lesser role in their explanation. Their explanation, I argue, is best sought in the previously existing wiring of the healthy cells. (shrink)

The notion of biological function is fraught with difficulties—intrinsically and irremediably so, we argue. The physiological practice of functional ascription originates from a time when organisms were thought to be designed and remained largely unchanged since. In a secularized worldview, this creates a paradox which accounts of functions as selected effect attempt to resolve. This attempt, we argue, misses its target in physiology and it brings problems of its own. Instead, we propose that a better solution to the conundrum of (...) biological functions is to abandon the notion altogether, a prospect not only less daunting than it appears, but arguably the natural continuation of the naturalisation of biology. (shrink)

Considering cultural policy it is very important to have a multi-level policy concerning cultural facilities and an active involvement of the citizen at local level. To optimize local cultural policy one should aim for an interactive or complementary policy. This means that each policy level has to take its own responsabilities; that there has to be a mutual consultation between all policy levels and a mutual reinforcement of the policy effects at each level. The role of local governments is to (...) provide for basic facilities and to install efficient frameworks for consultation and cooperation. Future challenges are the reinforcement of cooperation between cultural actors and to support innovating work. (shrink)

The ways in which other animal species can be informative about human biology are not exhausted by the traditional picture of the animal model. In this paper, I propose to distinguish two roles which laboratory organisms can have in biomedical research. In the more traditional case, organisms act as surrogates for human beings, and as such are expected to be more manageable replicas of humans. However, animal models can inform us about human biology in a much less straightforward way, by (...) being used as measuring devices—what I call their instrumental role. I first characterize this role and provide criteria for it, before illustrating it with some examples from biomedical research, especially cancer research. In such an instrumental role, phenotypes are not expected to phenocopy human phenomena, but instead have the purely instrumental value of detecting or measuring differences. I argue that the instrumental role is more prevalent than might first be suspected, and that some characteristics of contemporary biomedical research are increasingly shifting the use of laboratory organisms to the instrumental role. Finally, in light of the distinction proposed, I discuss the meaning of the expression “animal model”. (shrink)

Le doute cartésien – théorique, généralisé, hyperbolique et volontaire – reprend et renforce tout d’abord les raisons sceptiques traditionnelles de douter, afin de mettre pour la première fois en doute tout le sensible, mais aussi de montrer que ces raisons buttent sur les naturae simplicissimae et la certitude de la mathesis universalis. Descartes forge alors un nouvel argument sceptique : le « Dieu qui peut tout », qui permet de penser que, lorsque je me rends à l’évidence des natures simples, (...) je peux me tromper du point de vue d’une autre rationalité et d’une évidence supérieure à la mienne. Mais le doute n’est pas seulement chez Descartes un moment et un moyen provisoires qu’il s’agirait de vaincre, et qui serait effectivement vaincu par la certitude du cogito. Puisqu’il ne dévoile aucune chose, n’énonce aucune proposition et n’engage pas la moindre prédication, le doute laisse en effet la parole ne dire qu’elle-même et se manifester ce qui y parle, c’est-à-dire celui qui parle, ego. On peut donc soutenir que c’est directement du doute, véritable premier principe cartésien, que provient l’existence. (shrink)

Jean-Luc Nancy provides an analysis of the anti-Semitic aspects of Heidegger's recently published Black Notebooks. Nancy refers to a philosophical or "historial" anti-Semitism marked, nonetheless, by the "banality" of ordinary anti-Semitism pervading Europe. Heidegger's thought is placed in the broader context of the European (especially Christian) impulse toward new beginnings.

René Girard’s breakthrough consists in uncovering the mechanism of violence, namely the mimesis and rivalry it permits. Yet, mimetic violence still leaves the very origin of evil and murder unquestioned. Here Lévinas plays a decisive role: the call to murder only becomes possible as one of the versions of the call of the face, the call of the other. This is what Girard should have taken up in order to clarify his final allusions to a “good mimesis”—this other, properly Christic, (...) possibility of the call of the face. (shrink)

In this essay Luc Van den Berge and Stefan Ramaekers take the idea of “scientific parenting” as an example of ambiguities that are typical of our late-modern condition. On the one hand, parenting seems like a natural thing to do, which makes “scientific parenting” sound like an oxymoron; on the other hand, a disengaged stance informed by the latest scientific findings is uncritically demanded of parents, as such an approach is conceived of as a panacea. Instead of taking sides in (...) this discussion, the authors seek a way to make sense of it, drawing upon the work of Charles Taylor, who offers a striking account of our contingent modern condition as well as of our ontological human constitution. They focus particularly on two examples Taylor gives where the contingent self-understanding does not coincide with our timeless human features. This opens a space for what might be considered paradoxes in our late-modern Western culture. This essay thus confronts Taylor's philosophy with the new parenting discourse to reveal how our moral horizons have evolved. Following this approach, the authors both expand on Taylor's thinking about our late modernity and at the same time try to assess the new scientific parenting discourse. (shrink)

Business Ethics, the Environment &Responsibility, Volume 33, Issue 2, Page 157-169, April 2024.

Tom Sorell and Luc Foisneau bring together original essays by the world's leading Hobbes scholars to discuss Hobbes's masterpiece after three and a half centuries. The contributors address three different themes. The first is the place of Leviathan within Hobbes's output as a political philosopher. What does Leviathan add to The Elements of Law (1640) and De Cive (1642; 1647)? What is the relation between the English Leviathan and the Latin version of the book (1668)? Does Leviathan deserve its pre-eminence? (...) The second theme concerns the connections between Hobbes's psychology and Hobbes's politics. The essays discuss Hobbes's curious views on the significance of laughter, evidence that he connected life in the state with passionlessness; the ways in which such things as fear for one's life entitle subjects to rebel; and the question of how the sovereign's personal passions are to be squared with his personifying a multitude. The third theme is Hobbes's views on the Bible and the Church: contributors examine the tensions between any allowance for ecclesiastical and (differently) biblical authority on the one hand, and political authority on the other. This is a book which anyone working on Hobbes or on this period of intellectual history will want to read. (shrink)

Historically, "Healing Methods" (HMS) have not been based on rational theories. Of the thousands of HMs that have arisen over the ages, only a small number survive today, drawing their power and longevity mostly from their superior ability to act as a placebo within the context of modern-day culture, rather than through any other mode of action.When it comes to HMs, Western scientific culture has not yet evolved beyond a pre-scientific stage (Fancher 1995). A scientific analysis of the part played (...) by practitioner/subject empathy and other emotional influences within the healing situation is needed. Furthermore, the question "Does 'it'work?" should be reformulated as "Is 'it' an effective placebo?"Once one accepts .. (shrink)

Contrary to mammalian DNA, which is thought to contain only 5-methylcytosine (m5C), bacterial DNA contains two additional methylated bases, namely N6-methyladenine (m6A), and N4-methylcytosine (m4C). However, if the main function of m5C and m4C in bacteria is protection against restriction enzymes, the roles of m6A are multiple and include, for example, the regulation of virulence and the control of many bacterial DNA functions such as the replication, repair, expression and transposition of DNA. Interestingly, even if adenine methylation is usually considered (...) a bacterial DNA feature, the presence of m6A has been found in protist and plant DNAs. Furthermore, indirect evidence suggests the presence of m6A in mammal DNA, raising the possibility that this base has remained undetected due to the low sensitivity of the analytical methods used. This highlights the importance of considering m6A as the sixth element of DNA. BioEssays 28: 309–315, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Rousseau, dans le Discours sur l’économie politique, reprenant une image de Diderot dans son article « Droit naturel » de l’Encyclopédie, relève le paradoxe du sens social que les brigands observent dans leurs sociétés parallèles sur le mode d’un véritable rituel : « C’est ainsi que les hommes les..

Un entretien avec Jean-Luc Gleyze, président du Conseil départemental de la Gironde, qui porte avec une vingtaine de départements français un projet d’expérimentation d’un revenu de base d’un montant suffisant, d’au moins mille euros, automatique, inconditionnel, mais dégressif, c’est-à-dire dépendant des revenus de chacun.

Créativité et mathématiques ne font pas bon ménage dans l'inconscient collectif. Pourtant à l'heure d'Internet, il existe bien une manière de revisiter la géométrie, l'algèbre ou même la logique. Il suffit de prendre un peu de distance par rapport aux calculs, de se donner quelques libertés par rapport à l'histoire, de changer de point de vue... En vagabondant à travers l'histoire et l'application des mathématiques, les auteurs se livrent ici à un jeu de vulgarisation d'une saveur et d'une subtilité inédites. (...) [4e de couv.]. (shrink)

Traditional health sciences (including nursing) paradigms, conceptual models, and theories have relied heavily upon notions of the ‘person’ or ‘patient’ that are deeply rooted in humanistic principles. Our intention here, as a collective academic assemblage, is to question taken‐for‐granted definitions and assumptions of the ‘person’ from a critical posthumanist perspective. To do so, the cinematic works of filmmaker David Cronenberg offer a radical perspective to revisit our understanding of the ‘person’ in nursing and beyond. Cronenberg's work explores bodily transformation and (...) mutation, with the body as a fragile and malleable vessel. Cronenberg's work allows us to interrogate the body in all its complexity, contingency, and hybridity and provides avenues of rupture within current understandings of ‘the person’. Reinventing the definition of what it means to be human, critical posthumanism offers opportunities to both critique humanist theories and build affirmative futurities. Also drawing on the work of Deleuze and Guattari, specifically, their concept of becoming, we propose a critical posthumanist alternative to the conceptualization of the person in the health sciences, that of the becoming‐mutant, so frequently explored in Cronenberg's films. Such a conceptualization permits the inclusion of various technological interventions of the contemporary subject: The postperson. This position offers the health science disciplines a radical reconceptualization of the conceptual and theoretical approaches, extending beyond those trapped within the quagmire of humanistic principles. (shrink)

Cet article propose d'utiliser le concept d'utopie rationnelle pour rendre compte des pratiques managériales et tout particulièrement de la production de réformes répétées dans les organisations. Dans cette perspective, après avoir décrit une décennie de transformations au sein d'une organisation publique, certaines caractéristiques de la « culture managériale » sont dégagées de sa pratique réformatrice. Dans un second temps, le concept d'utopie rationnelle est construit à partir de textes canoniques et des travaux d'« utopologues ». Dans un troisième temps, utopie (...) rationnelle et culture managériale sont comparées, afin de préciser l'apport cognitif de cet outil à la compréhension du fonctionnement des organisations. (shrink)

On ne sera pas surpris que le monde, que l’idée même de monde reste aporétique. Non seulement parce que, comme l’un des objets de la metaphysica specialis, il puisse entrer dans la même crise que la métaphysique tout entière, mais aussi parce qu’en particulier, de tous ces objets, le monde paraît le plus irréductible à une idée, encore plus à une idée. D’emblée, le monde hésite entre deux...

Les textes présents dans cet ouvrage mettent en lumière l’importance des deux volumes d’inédits publiés récemment : Carnets de captivité et autres inédits et Parole et Silence et autres conférences inédites au Collège philosophique (Paris, Grasset – IMEC, 2009 et 2011). La philosophie est par essence système et si tous les écrits d’un auteur n’ont pas à entrer dans le système, ces deux volumes d’inédits relèvent directement du système de cette pensée en...

The aim of J.-L. Marion’s article is to revisit the important debate on the place of Augustine in the history of metaphysics. Often, quibbles arise upon considering the use of substance (substantia) by Augustine, not only as approximative of essentia and as synonymous with ousia, but in deciding whether in so doing Augustine effectuates a ‘metaphysical turn’. While he elsewhere argues that Augustine is a pre-metaphysical thinker, in this article Marion focuses on showing the diverse range of usages of the (...) term substance in the Augustinian corpus. Marion observes: first, whenever substance seems a fixed definition, the term allows for equivocity; second, God is substance in an indeterminate sense or by negation; third, human beings are substances fundamentally to capture the mutability of human existence. As such, Marion concludes, the Augustinian use of substance is insufficient to inelude Augustine in the history of metaphysics. (shrink)

This essay traces the phenomenon of revelation beginning with the humblest, to the most personal, to the most exalted. Through this analysis, we discover several qualities of revelation: it reveals itself from itself, reveals a new world to me, and reveals another me to myself and to others. Turning to divine Revelation, a further set of concepts is uncovered: the witness who encounters a Revelation without understanding it, a resistance to the testimony of the witness, and a paradox that provokes (...) this resistance by exceeding expectations. These qualities make Revelation both more intelligible and meaningful. For, while holding an exceptional privilege, divine Revelation nonetheless remains in continuity with phenomenality in general and, in arriving from elsewhere by its own initiative, it opens my eyes to the unfolding of its unseen reserves. (shrink)

That which we call “negative theology” inspires within us both fascination and unease. We can either challenge all “negative theology” as a language game that is both impractical and contradictory, as many contemporaries do, or we can explore the question in light of the recent arguments of Derrida. The primary thesis in this paper is that we should reject “negative theology” as a descriptor and replace it, following the nomenclature of the Dionysian corpus, with “mystical theology.” In doing this, we (...) will come to realize that “mystical theology” no longer has the ambition to make constative use of language; its ambition is rather to be freed from such use. Thus, we move from a constative (and predicative) use of language toward a strictly pragmatic usage. This movement has yet to be proved, and what follows is an attempt to do just that. (shrink)

Dans quelle mesure la « crise » actuelle de la politique (taux d’abstention élevé, décrédibilisation du personnel politique, etc.) est-elle liée à la mise en œuvre des politiques macroéconomiques? Pour répondre, nous présentons, tout d’abord, ce que nous entendons par gouvernementalité gestionnaire. Puis, nous élaborons, à partir des travaux d’Hannah Arendt sur les promesses de la politique, un cadre pour analyser l’agir politique. Enfin, en mobilisant ce cadre, nous suggérons qu’en réduisant la diversité des points de vue et en ravivant (...) des rapports de dépendance, la gouvernementalité gestionnaire peut constituer l’un des facteurs de la crise. Code JEL : M10. (shrink)

Nancy's The Speculative Remark played a significant role in transforming the practice of philosophy away from system building to analysis of specific linguistic detail.