The developing mammalian heart responds to a variety of conditions, including changes in nutrient availability, blood oxygenation, hemodynamics, or tissue homeostasis, with impressive growth plasticity. This ensures the formation of a functional and normal sized organ by birth. During embryonic and fetal development the heart is exposed to various physiological and potentially pathological changes in the intrauterine environment which dramatically impact on normal cardiac function, tissue composition, and morphology. This paper summarizes the mechanisms employed by the embryonic and fetal heart (...) to adapt to various intrauterine challenges to prevent or minimize postnatal consequences of impaired cardiac development. Future investigations of this growth plasticity might lead to new therapeutic strategies for the prevention of cardiac disease in postnatal life. (shrink)

Using the lens of positive organizational ethics, we theorized that empathy affects decisions in ethical dilemmas that concern the well-being of not only the organization but also other stakeholders. We hypothesized and found that empathetic managers were less likely to comply with requests by an authority figure to cut the wages of their employees than were non-empathetic managers. However, when an authority figure requested to hold wages constant, empathy did not affect wage cut decisions. These findings imply that empathy can (...) serve as a safeguard for ethical decision making in organizations during trying times without generally undermining organizational effectiveness. We conclude by discussing the implications of our research. (shrink)

An important part of friendships are the so-called special obligations generated by them. Friends owe things to each other that they do not owe to strangers. While such special obligations are an important part of our everyday practice, they raise several philosophical questions. These questions include the status of special obligations (are such obligations sui generis or is it possible to reduce them to general moral principles?), the source of such special obligations (what grounds special obligations of friendship?), and the (...) content of special obligations (what is the content of special obligations of friendship?). This chapter gives an overview of some of the most important positions in the literature with regard to these questions. (shrink)

The Colombian-born photographer and artist Guadalupe Ruiz has undertaken a project to document the social and economic inequity in her native city of Bogotá. She explores six houses from the city's six different taxation classes whose residents range from extremely affluent to impoverished. By taking photographs of apartments and streetscapes, whole interiors and single pieces of furniture, Ruiz creates a cohesive and multilayered portrait of the city as a whole. She also examines personal and decorative objects, such as family portraits (...) and Catholic icons found in both slums and luxurious villas, and highlights the differences and some surprising cultural parallels between socioeconomic classes. Guadalupe Ruiz— Bogotá D. C. is a subtle, thought-provoking examination of urban life and includes over a hundred stunning images arranged by neighborhood. A map of the neighborhoods and a complementary essay are included to provide context for Ruiz's impressive photographs. Text in English, French, Spanish, and German. (shrink)

Immigrants now compose approximately 12 of the population of the United States and a sizable proportion of the workforce. Yet in contrast to research on other traditionally under-represented groups (e.g., women, African Americans), there are relatively few studies on issues related to being an immigrant in the U.S. workforce. This study examined English-only workplace policies, focusing on reactions to business justifications – explanations that justify managerial decisions as business necessities – for these policies. We contrasted the reactions of individuals coming (...) from immigrant families, where at least one parent was an immigrant to the U.S., with those of persons from non-immigrant families. Results of an experiment indicated that business justifications were successful in influencing the attitudes of non-immigrants toward the English-only policies, but did not influence the attitudes of individuals from immigrant families. Probing the reasons for this effect, a thought-listing protocol suggested that non-immigrants mentioned more of the business benefits of the English-only policy than did individuals from immigrant families. Further, business justifications for the English-only policy led individuals from immigrant families, but not those from non-immigrant families, to view the organization as being less ethical and less concerned with the welfare of its workers. The implications of messages from management being understood differently by different demographic groups are discussed. (shrink)

Das Wirken Gabriel Biels, eines der bedeutendsten Theologen des Spatmittelalters, ist nicht nur durch scharfsinniges, vor allem an Ockham, aber auch an Scotus orientiertes theologisches Nachdenken gekennzeichnet. Es ist ebenso gepragt durch die Devotio moderna. Aus dieser Quelle speist sich sein unermuedlicher Einsatz fuer eine Kirchenreform wie auch seine tiefe Frommigkeit. Trotz Kenntnis der Bedeutung dieser Linie fuer Biels Frommigkeitspraxis blieb sein Verhaltnis zur Mystik bisher unerforscht. Das vorliegende Buch fuellt diese Luecke. Es sammelt aus Biels Hauptwerken, dem Collectorium und (...) der Auslegung des Meakanons, die mystischen Elemente (wie z.B. raptus, Einwohnung, unio, transformatio) und analysiert deren Rezeption. Dabei beruecksichtigt es auch das Vorfeld von Mystik in Gebet und Meditation. Einen anderen Schwerpunkt bildet Biels Stellung zum Phanomen religioser und mystischer Erfahrung. Einen qualifizierten Begriff religioser Erfahrung entwickelt Biel nicht. Er wertet sie durchaus positiv, doch gilt ihm als das Hochste im Christenleben die Liebe. Betrachtet man aber die Funktion der Mystik in Biels Werken, so ist seine Theologie im weiteren Sinne mystagogisch. In devoter Tradition stehend, will er zur Frommigkeit hinfuehren. Nicht zu hoch veranschlagt werden darf die Relevanz des Nominalismus fuer Biels Mystik-Rezeption. Mit Register. "Es ist M. gelungen, in seiner grundgelehrten Untersuchung einmal die Forschung der Theologie Biels erheblich weiter voranzutreiben, und er hat zugleich zu uebergeordneten Fragen substantielle Beitrage geleistet." Theologische Rundschau "a ein solider und fuer die Erforschung der spatmittelalterlichen Theologie und Frommigkeit unentbehrlicher Beitraga" Rottenburger Jahrbuch fuer Kirchengeschichte "Durch sorgfaltige Analysen diesen verkannten theologischen Denker in die Gegenwart geholt zu haben - dies ist ein Verdienst dieser Arbeit." Hulda "Die beeindruckenden Starken der Arbeit liegen in der behutsamen, differenzierten Einzelanalyse" Theologische Literaturzeitung. (shrink)

Quantum philosophy, a peculiar twentieth-century malady, is responsible for most of the conceptual muddle plaguing the foundations of quantum physics. When this philosophy is eschewed, one naturally arrives at Bohmian mechanics, which is what emerges from Schrodinger's equation for a nonrelativistic system of particles when we merely insist that 'particles' means particles. While distinctly non-Newtonian, Bohmian mechanics is a fully deterministic theory of particles in motion, a motion choreographed by the wave function. The quantum formalism emerges when measurement situations are (...) analyzed according to this theory. When the quantum formalism is regarded as arising in this way, the paradoxes and perplexities so often associated with quantum theory simply evaporate.Bohr's ... approach to atomic problems ... is really remarkable. He is completely convinced that any understanding in the usual sense of the word is impossible. Therefore the conversation is almost immediately driven into philosophical questions, and soon you no longer know whether you really take the position he is attacking, or whether you really must attack the position he is defending. (shrink)

En este trabajo sobre los pensadores novohispanos Alonso de la Veracruz y Tomás de Mercado se seguirá la argumentación de un tema escasamente explorado: el papel fundacional de la ley natural y su interpretabilidad a través de la ley humana. Se mostrará que ambos autores, basados en las tradiciones salamantinas del siglo XVI, introducen un método que afirmaría la validez de la ley natural y, al mismo tiempo, permitir aplicaciones diversas de los parámetros normativos de la ley humana. Esto es (...) posible, como lo sostiene Veracruz en su crítica al diezmo para los pueblos indígenas, cuando la ley natural tenga que reinterpretarse a partir de hechos sociales concretos o cuando, como en el caso de Mercado, la ley humana sea congruente con la ley natural y, no obstante, tenga que desacatarse para evitar perjuicios personales o públicos en el plano comercial. (shrink)

Detlef Breitenband gibt in seinem Buch einen problemorientierten Überblick über die Rechtstheorien von Immanuel Kant und Jürgen Habermas. Im Zentrum steht die Frage nach der Leistungsfähigkeit beider Rechtstheorien, da diese den Konsens aller Rechtsadressaten zur Grundlage haben, aber nicht davon ausgegangen wird, dass jemals über eine Rechtsnorm ein faktischer Konsens erzeugt wird. Der Autor arbeitet die radikal-demokratischen Implikationen des Kantischen Republikanismus heraus und leistet einen wichtigen Beitrag zur Klärung des Begriffs der Legitimation von Rechtsnormen.

Classical physics is about real objects, like apples falling from trees, whose motion is governed by Newtonian laws. In standard quantum mechanics only the wave function or the results of measurements exist, and to answer the question of how the classical world can be part of the quantum world is a rather formidable task. However, this is not the case for Bohmian mechanics, which, like classical mechanics, is a theory about real objects. In Bohmian terms, the problem of the classical (...) limit becomes very simple: when do the Bohmian trajectories look Newtonian? (shrink)

To what extent do aesthetic taste and our interest in the arts constitute who we are? In this paper, we present a series of empirical findings that suggest an Aesthetic Self Effect supporting the claim that our aesthetic engagements are a central component of our identity. Counterfactual changes in aesthetic preferences, for example, moving from liking classical music to liking pop, are perceived as altering us as a person. The Aesthetic Self Effect is as strong as the impact of moral (...) changes, such as altering political partisanship or religious orientation, and significantly stronger than for other categories of taste, such as food preferences. Using a multidimensional scaling technique to map perceived aesthetic similarities among musical genres, we determined that aesthetic distances between genres correlate highly with the perceived difference in identity. Further studies generalize the Aesthetic Self Effect beyond the musical domain: general changes in visual art preferences, for example from more traditional to abstract art, also elicited a strong Self Effect. Exploring the breadth of this effect we also found an Anaesthetic Self Effect. That is, hypothetical changes from aesthetic indifference to caring about music, art, or beauty are judged to have a significant impact on identity. This effect on identity is stronger for aesthetic fields compared to leisure activities, such as hiking or playing video games. Across our studies, the Anaesthetic Self Effect turns out to be stronger than the Aesthetic Self Effect. Taken together, we found evidence for a link between aesthetics and identity: we are aesthetic selves. When our tastes in music and the arts or our aesthetic interests change we take these to be transformative changes. (shrink)

It is well known that density matrices can be used in quantum mechanics to represent the information available to an observer about either a system with a random wave function (“statistical mixture”) or a system that is entangled with another system (“reduced density matrix”). We point out another role, previously unnoticed in the literature, that a density matrix can play: it can be the “conditional density matrix,” conditional on the configuration of the environment. A precise definition can be given in (...) the context of Bohmian mechanics, whereas orthodox quantum mechanics is too vague to allow a sharp definition, except perhaps in special cases. In contrast to statistical and reduced density matrices, forming the conditional density matrix involves no averaging. In Bohmian mechanics with spin, the conditional density matrix replaces the notion of conditional wave function, as the object with the same dynamical significance as the wave function of a Bohmian system. (shrink)

This article makes a contribution to debates in recognition theory by expanding the taxonomy of (mis-)recognition in the economic sphere. It argues that doing justice to the variety of ways in which recognition is engaged in economic relationships requires: (1) taking into consideration not just the recognition principle of esteem, but also (various aspects of) need and respect; (2) distinguishing a productive from a consumptive dimension with regards to each principle of recognition (need, esteem and respect); and (3) identifying the (...) specific economic relationship at stake (e.g. between consumers and producers, or between employers and employees). In this way, we can account for the diversity of demands for recognition made in the economic sphere, explain what underpins them, and bring structure into these diverse phenomena. What is more, this expanded taxonomy is a useful tool for social pathology theorists, who should appreciate the full range of variants of misrecognition when diagnosing pathologies of misrecognition in the economic sphere. (shrink)

Climate change poses a serious problem for established ethical theories. There is no dearth of literature on the subject of climate ethics that break down the complexity of the issue, thereby enabling one to arrive at partial conclusions such as: 'historical justice demands us to do this...' or 'intergenerational justice demands us to do that...'. In contrast, this article attempts to face up to this complexity, that is: to end with a synthesis of the arguments into what can be considered (...) to be the most reasonable and fairest approach to the politics of climate change on a global scale. A significant part of the paper is devoted to the questions whether or not a) historical emissions and b) population changes are relevant to how emissions rights should be distributed. I discuss the merits and drawbacks of each perspective and briefly outline the normative justifications. (shrink)

A source of much difficulty and confusion in the interpretation of quantum mechanics is a naive realism about operators. By this we refer to various ways of taking too seriously the notion of operator-as-observable, and in particular to the all too casual talk about measuring operators that occurs when the subject is quantum mechanics. Without a specification of what should be meant by measuring a quantum observable, such an expression can have no clear meaning. A definite specification is provided by (...) Bohmian mechanics, a theory that emerges from Schrödinger's equation for a system of particles when we merely insist that particles means particles. Bohmian mechanics clarifies the status and the role of operators as observables in quantum mechanics by providing the operational details absent from standard quantum mechanics. It thereby allows us to readily dismiss all the radical claims traditionally enveloping the transition from the classical to the quantum realm — for example, that we must abandon classical logic or classical probability. The moral is rather simple: Beware naive realism, especially about operators! (shrink)

Indian Epistemology and Metaphysics introduces the reader to new perspectives on Indian philosophy based on philological research within the last twenty years. Concentrating on topics such as perception, inference, skepticism, consciousness, self, mind, and universals, some of the most notable scholars working in classical Indian philosophy today examine core epistemological and metaphysical issues. Philosophical theories and arguments from a comprehensive range of Indian philosophical traditions (including the Nyaya, Mimamsa, Saiva, Vedanta, Samkhya, Jain, Buddhist, materialist and skeptical traditions, as well as (...) some 20th century thought) are covered. The contributors to this volume approach the topics from both a philosophical and a philological perspective. They demonstrate the importance of the subject matter for an understanding of Indian thought in general and they highlight its wider philosophical significance. By developing an appreciation of classical Indian philosophy in its own terms, set against the background of its unique assumptions and historical and cultural development, Indian Epistemology and Metaphysics is an invaluable guide to the current state of scholarship on Indian philosophy. It is a timely and much-needed reference resource, the first of its kind. (shrink)

Two kinds of membrane contacts in the vertebrate lens are described. Fiber gap junctions are domains where small molecules can pass between lens cells. Membrane structures of ball‐and‐socket type interlock adjacent lens fibers and thus contribute to the structural integrity of the lens. Both of these membrane contacts appear crucial for the maintenance of lens transparency.

The intercellular junctions connecting the cytoplasms of fibre cells in the mammalian lens have until recently been regarded as a class of junction which is fundamentally different from that of the gap junctions in other organs. Recent observations, however, suggest that the lens junctions fit protein topology predictions common for all gap junctions. While the homologous peptide portions are predicted to form the channels, the divergent peptide portions of the gap junction polypeptides may adapt channel activity to the special tissue (...) requirements. (shrink)