This collection of articles and associated discussion papers focuses on a problem that has attracted increasing attention from linguists and psychologists throughout the world during the past several years. Reduced to essentials, the problem is that of discovering the character of the mental capacities that make it possible for human beings to attain knowledge of their language on the basis of fragmentary and haphazard early linguistic experience. A fundamental assumption running through all of these contributions is that people possess strong (...) innate predispositions that are critical for success in this task. (shrink)

Circadian rhythm abnormalities in bipolar disorder have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However, no significant clock gene findings have emerged from genome-wide association studies. At least three factors could account for this discrepancy: complex traits are polygenic, the organization of the clock is more complex than previously recognized, and/or genetic risk for BD may be shared across multiple illnesses. To investigate these issues, we considered the clock gene network at three levels: (...) essential "core" clock genes, upstream circadian clock modulators, and downstream clock controlled genes. Using relaxed thresholds for GWAS statistical significance, we determined the rates of clock vs. control genetic associations with BD, and four additional illnesses that share clinical features and/or genetic risk with BD. Then we compared the results to a set of lithium-responsive genes. Associations with BD-spectrum illnesses and lithium-responsiveness were both enriched among core clock genes but not among upstream clock modulators. Associations with BD-spectrum illnesses and lithium-responsiveness were also enriched among pervasively rhythmic clock-controlled genes but not among genes that were less pervasively rhythmic or non-rhythmic. Our analysis reveals previously unrecognized associations between clock genes and BD-spectrum illnesses, partly reconciling previously discordant results from past GWAS and candidate gene studies. (shrink)

Although living conditions have improved throughout history, protest, at least in the last few decades, seems to have increased to the point of becoming a normal phenomenon in modern societies. Contributors to this volume examine how and why this is the case and argue that although problems such as poverty, hunger, and violations of democratic rights may have been reduced in advanced Western societies, a variety of other problems and opportunities have emerged and multiplied the reasons and possibilities for protest.

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

A special road sign bearing the legend of the title greeted visitors to the Stanford Artificial Intelligence Laboratory during the time it was housed in the starship that parked on a Stanford hill from the mid sixties to the mid eighties. The sign, near the periphery of SAIL's grounds, referred to the Stanford Cart, a guerrilla research project near the periphery of John McCarthy 's core interests, but motivated by his desire for autonomous vision-guided automatic cars. In a (...) 1969 essay \cite{JMC69} {\em Computer Controlled Cars}, John suggested that the power of a PDP-10 was adequate for the job. I think John still favors this estimate. John is guided by a strong and principled intuition that has proven itself correct in very many things. But in this paper I will present accumulating experimental evidence that hints that in this one opinion John's intuition misled him by more than a few orders of magnitude. (shrink)

John J. McDermott's anthology, _The Philosophy of John Dewey_, provides the best general selection available of the writings of America's most distinguished philosopher and social critic. This comprehensive collection, ideal for use in the classroom and indispensable for anyone interested in the wide scope of Dewey's thought and works, affords great insight into his role in the history of ideas and the basic integrity of his philosophy. This edition combines in one book the two volumes previously published separately. (...) Volume 1, "The Structure of Experience," contains essays on metaphysics, the logic of inquiry, the problem of knowledge, and value theory. In volume 2, "The Lived Experience," Dewey's writings on pedagogy, ethics, the aesthetics of the "live creature," politics, and the philosophy of culture are presented. McDermott has prefaced each essay with a helpful explanatory note and has written an excellent general introduction to the anthology. (shrink)

Book review of contributions from scholars of 19th-century German.

This volume is devoted entirely to exploring the role of animals in the thought of Immanuel Kant. Leading scholars address questions regarding the possibility of objective representation and intentionality in animals, the role of animals in Kant's scientific picture of nature, the status of our moral responsibilities to animals' welfare, and more.

John Clarke of Hull, one of the eighteenth century's staunchest proponents of psychological egoism, defended that theory in his Foundation of Morality in Theory and Practice. He did so mainly by opposing the objections to egoism in the first two editions of Francis Hutcheson's Inquiry into Virtue. But Clarke also produced a challenging, direct argument for egoism which, regrettably, has received virtually no scholarly attention. In this paper I give it some of the attention it merits. In addition to (...) reconstructing it and addressing interpretive issues about it, I show that it withstands a tempting objection. I also show that although Clarke's argument ultimately fails, to study it is instructive. It illuminates, for example, Hutcheson's likely intentions in a passage relevant to egoism. (shrink)

John J. Stuhr, a leading voice in American philosophy, sets forth a view of pragmatism as a personal work of art or fashion. Stuhr develops his pragmatism by putting pluralism forward, setting aside absolutism and nihilism, opening new perspectives on democracy, and focusing on love. He creates a space for a philosophy that is liable to failure and that is experimental, pluralist, relativist, radically empirical, radically democratic, and absurd. Full color illustrations enhance this lyrical commitment to a new version (...) of pragmatism. (shrink)

Stemming from two conferences, held in 1994, and 1996, Prophecy and Diplomacy: The Moral Doctrine of John Paul II explores the general orientations and the specific applications of the moral teaching of Pope John Paul II. The first part of the book places the Pope's moral theory within a broader theological framework, attempting to identify the overarching philosophical and theological attitudes that shape the Pope's fundamental moral perspective. In part two, the work studies the Pope's teaching in the (...) areas of applied ethics. Both the major lecturers and the respondents focus upon those areas of applied ethics that have provoked the greatest tension between the magisterium and the academy and between the Church and the state in the West. The volume concludes by presenting a homily that places the ethics of John Paul II within a spiritual framework of repentance and redemption. The Pope's moral teaching is not an academic survey of ethical themes. Nor is it a Pelagian call to human self-regeneration. The ultimate truth concerning human conduct and moral judgement emerges only with the proclamation of God's grace. (shrink)

The rift which has long divided the philosophical world into opposed schools-the "Continental" school owing its origins to the phenomenology of Husserl and the "analytic" school derived from Frege-is finally closing.

Based on a close reading of Fides et Ratio and Salvifici Doloris, this paper argues that John Paul II challenges the power and range of metaphysical reason in certain neglected passages. Such challenges include the critique of the idolatry of philosophical systems, the emphasis on the irreducible mystery of God, and the rejection of efforts to construct a theodicy in the face of human suffering. The challenge especially emerges in John Paul II’s emphasis on the Cross as a (...) stumbling block to metaphysical affirmation. Against certain rationalistic interpretations of the Pope, this paper attempts to excavate the critique of metaphysical reason embedded in John Paul II’s arguments on the limits of philosophical speculation. (shrink)

Among the most animating debates in eighteenth-century British ethics was the debate over psychological egoism, the view that our most basic desires are self-interested. An important episode in that debate, less well known than it should be, was the exchange between Francis Hutcheson and John Clarke of Hull. In the early editions of his Inquiry into Virtue, Hutcheson argued ingeniously against psychological egoism; in his Foundation of Morality, Clarke argued ingeniously against Hutcheson’s arguments. Later, Hutcheson attempted new arguments against (...) psychological egoism, designed to overcome Clarke’s objections. This article examines the exchange between these philosophers. Its conclusion, influenced partly by Clarke, is that psychological egoism withstands Hutcheson’s arguments. This is not to belittle those arguments—indeed, they are among the most resourceful and plausible of their kind. The fact that egoism withstands them is thus not a mere negative result, but a stimulus to consider carefully the ways in which progress in this area may be possible. (shrink)

In this paper I refute the chief arguments for cultural relativism, meaning the moral (not the descriptive) theory that goes by that name. In doing this I walk some oft-trodden paths, but I also break new ones. For instance, I take unusual pains to produce an adequate formulation of cultural relativism, and I distinguish that thesis from the relativism of present-day anthropologists, with which it is often conflated. In addition, I address not one or two, but eleven arguments for cultural (...) relativism, many of which contribute to its popularity but receive scant attention from its critics. To elicit the failings of these arguments I deploy a host of pertinent but often neglected distinctions. (shrink)