All eukaryotic cellular mRNAs, and most viral mRNAs, are blocked at their 5′ ends with a cap structure (m7GpppX, where × is any nucleotide). Poliovirus, along with a small number of other animal and plant viral mRNAs, does not contain a 5′ cap structure. Since the cap structure functions to facilitate ribosome binding to mRNA, translation of poliovirus must proceed by a cap‐independent mechanism. Consistent with this, recent studies have shown that ribosomes can bind to an internal region within the (...) long 5′ noncoding sequence of poliovirus RNA. Possible mechanisms for cap‐independent translation are discussed. Cap‐independent translation of poliovirus RNA is of major importance to the mechanism of shut‐off of host protein synthesis after infection. Moreover, it is likely to play a role in determining poliovirus neurovirulence and attenuation. (shrink)

David Hume's philosophy is notoriously naturalistic. It is an attempt to give an account of man and his world relying only on evidence which can be gleaned from sense observation and introspection. Whatever can be inferred from this evidence is a proper philosophical conclusion.

Jerry Fodor is one of the leading philosophers of mind and language in the world today. He is best known for his work developing two theses which give theirnames to his books The Modularity of Mind and The Language of Thought. He teaches philosophy at Rutgers and at the CUNY Graduate Center.

Jerry Fodor is one of the leading philosophers of mind and language in the world today. He is best known for his work developing two theses which give theirnames to his books The Modularity of Mind and The Language of Thought. He teaches philosophy at Rutgers and at the CUNY Graduate Center.

The renowned philosopher Jerry Fodor, a leading figure in the study of the mind for more than twenty years, presents a strikingly original theory on the basic constituents of thought. He suggests that the heart of cognitive science is its theory of concepts, and that cognitive scientists have gone badly wrong in many areas because their assumptions about concepts have been mistaken. Fodor argues compellingly for an atomistic theory of concepts, deals out witty and pugnacious demolitions of rival theories, (...) and suggests that future work on human cognition should build upon new foundations. This lively, conversational, and superbly accessible book is the first volume in the Oxford Cognitive Science Series, where the best original work in this field will be presented to a broad readership. Concepts will fascinate anyone interested in contemporary work on mind and language. Cognitive science will never be the same again. (shrink)

Coherence in conversations and in texts can be partially characterized by a set of coherence relations, motivated ultimately by the speaker's or writer's need to be understood. In this paper, formal definitions are given for several coherence relations, based on the operations of an inference system; that is, the relations between successive portions of a discourse are characterized in terms of the inferences that can be drawn from each. In analyzing a discourse, it is frequently the case that we would (...) recognize it as coherent, in that it would satisfy the formal definition of some coherence relation, if only we could assume certain noun phrases to be coreferential. In such cases, we will simply assume the identity of the entities referred to, in what might be called a “petty conversational implicature,” thereby solving the coherence and coreference problems simultaneously. Three examples of different kinds of reference problems are presented. In each, it is shown how the coherence of the discourse can be recognized, and how the reference problems are solved, almost as a by‐product, by means of these petty conversational implicatures. (shrink)

Preface 1 Introduction: The Persistence of the Attitudes 2 Individualism and Supervenience 3 Meaning Holism 4 Meaning and the World Order Epilogue Creation Myth Appendix Why There Still Has to be a Language of Thought Notes References Author Index.

Jerry Fodor argues against the widely held view that mental processes are largely computations, that the architecture of cognition is massively modular, and...

Jerry Fodor presents a new development of his famous Language of Thought hypothesis, which has since the 1970s been at the centre of interdisciplinary debate about how the mind works. Fodor defends and extends the groundbreaking idea that thinking is couched in a symbolic system realized in the brain. This idea is central to the representational theory of mind which Fodor has established as a key reference point in modern philosophy, psychology, and cognitive science. The foundation stone of our (...) present cognitive science is Turing's suggestion that cognitive processes are not associations but computations; and computation requires a language of thought. So the latest on the Language of Thought hypothesis, from its progenitor, promises to be a landmark in the study of the mind. LOT 2 offers a more cogent presentation and a fuller explication of Fodor 's distinctive account of the mind, with various intriguing new features. The central role of compositionality in the representational theory of mind is revealed: most of what we know about concepts follows from the compositionality of thoughts. Fodor shows the necessity of a referentialist account of the content of intentional states, and of an atomistic account of the individuation of concepts. Not least among the new developments is Fodor 's identification and persecution of pragmatism as the leading source of error in the study of the mind today. LOT 2 sees Fodor advance undaunted towards the ultimate goal of a theory of the cognitive mind, and in particular a theory of the intentionality of cognition. No one who works on the mind can ignore Fodor 's views, expressed in the coruscating and provocative style which has delighted and disconcerted countless readers over the years. (shrink)

This volume is a collection of original contributions about the core knowledge in fundamental domains. It includes work on naive physics, such as formal specifications of intuitive theories of spatial relations, time causality, substance and physical objects, and on naive psychology.

Counter to the popular impression that Adam Smith was a champion of selfishness and greed, Jerry Muller shows that the Inquiry into the Nature and Causes of the Wealth of Nations maintained that markets served to promote the well-being of ...

Jerry L. Walls aims to demonstrate in his book Hell: The Logic of Damnation that some traditional views of hell are still defensible and can be believed with intellectual and moral integrity. Focusing on the issues from the standpoint of philosophical theology, Walls explores the doctrine of hell in relation to both the divine nature and human nature. He argues, with respect to the divine nature, that some traditional versions of the doctrine are compatible not only with God's omnipotence (...) and omniscience, but also with a strong account of His perfect goodness. The concept of divine goodness receives special attention since the doctrine of hell is most often rejected on moral grounds. (shrink)

This study synthesizes current information from the various fields of cognitive science in support of a new and exciting theory of mind. Most psychologists study horizontal processes like memory and information flow; Fodor postulates a vertical and modular psychological organization underlying biologically coherent behaviors. This view of mental architecture is consistent with the historical tradition of faculty psychology while integrating a computational approach to mental processes. One of the most notable aspects of Fodor's work is that it articulates features not (...) only of speculative cognitive architectures but also of current research in artificial intelligence. (shrink)

In this paper, planning models developed in artificial intelligence are applied to the kind of planning that must be carried out by participants in a conversation. A planning mechanism is defined, and a short fragment of a free‐flowing videotaped conversation is described. The bulk of the paper is then devoted to an attempt to understand the conversation in terms of the planning mechanism. This microanalysis suggests ways in which the planning mechanism must be augmented, and reveals several important conversational phenomena (...) that deserve further investigation. (shrink)

Introduction: Something on the State of the Art 1 I. Functionalism and Realism 1. Operationalism and Ordinary Language 35 2. The Appeal to Tacit Knowledge in Psychological Explanations 63 3. What Psychological States are Not 79 4. Three Cheers for Propositional Attitudes 100 II. Reduction and Unity of Science 5. Special Sciences 127 6. Computation and Reduction 146 III. Intensionality and Mental Representation 7. Propositional Attitudes 177 8. Tom Swift and His Procedural Grandmother 204 9. Methodological Solipsism Considered as a (...) Research Strategy in Cognitive Psychology 225 IV. Nativism 10. The Present Status of the Innateness Controversy 257 Notes 317. (shrink)

Jerry L. Walls argues that the doctrine of heaven is ripe for serious reconsideration. He contends not only that the orthodox view of heaven can be defended from objections commonly raised against it, but also that heaven is a powerful resource for addressing persistent philosophical problems, not the least of which concern the ground of morality and the meaning of life. Walls shows how heaven is integrally related to central Christian doctrines, particularly those related to salvation, and tackles the (...) difficult problem of why faith in Christ is necessary to save us from our sins. In addition, heaven is shown to illumine thorny problems of personal identity and to be an essential component of a satisfactory theodicy. Walls goes on to examine data from near-death experiences from the standpoint of some important recent work in epistemology and argues that they offer positive evidence for heaven. He concludes that we profoundly need to recover the hope of heaven in order to recover our very humanity. (shrink)

One of the most notable aspects of Fodor's work is that it articulates features not only of speculative cognitive architectures but also of current research in ...

This paper explores the difference between Connectionist proposals for cognitive a r c h i t e c t u r e a n d t h e s o r t s o f m o d e l s t hat have traditionally been assum e d i n c o g n i t i v e s c i e n c e . W e c l a i m t h a t t h (...) e m a j o r d i s t i n c t i o n i s t h a t , w h i l e b o t h Connectionist and Classical architectures postulate representational mental states, the latter but not the former are committed to a symbol-level of representation, or to a ‘language of thought’: i.e., to representational states that have combinatorial syntactic and semantic structure. Several arguments for combinatorial structure in mental representations are then reviewed. These include arguments based on the ‘systematicity’ of mental representation: i.e., on the fact that cognitive capacities always exhibit certain symmetries, so that the ability to entertain a given thought implies the ability to entertain thoughts with semantically related contents. We claim that such arguments make a powerful case that mind/brain architecture is not Connectionist at the cognitive level. We then consider the possibility that Connectionism may provide an account of the neural (or ‘abstract neurological’) structures in which Classical cognitive architecture is implemented. We survey a n u m b e r o f t h e s t a n d a r d a r g u m e n t s t h a t h a v e b e e n o f f e r e d i n f a v o r o f Connectionism, and conclude that they are coherent only on this interpretation. (shrink)

Preface and Acknowledgments Introduction PART I Intentionality Chapter 1 Fodor’ Guide to Mental Representation: The Intelligent Auntie’s Vade-Mecum Chapter 2 Semantics, Wisconsin Style Chapter 3 A Theory of Content, I: The Problem Chapter 4 A Theory of Content, II: The Theory Chapter 5 Making Mind Matter More Chapter 6 Substitution Arguments and the Individuation of Beliefs Chapter 7 Stephen Schiffer’s Dark Night of The Soul: A Review of Remnants of Meaning PART II Modularity Chapter 8 Précis of The Modularity of (...) Mind Chapter 9 Why Should the Mind Be Modular? Chapter 10 Observation Reconsidered Appendix: A Reply to Churchland’s ‘Perceptual Plasticity and Theoretical Neutrality" References Index of Names. (shrink)

Written in a highly readable, irreverent style, The Elm and the Expert provides a lively discussion of semantic issues about mental representation, with special attention to issues raised by Frege's problem, Twin cases, and the putative indeterminacy of reference. Bound to be widely read and much discussed, The Elm and the Expert, written in Jerry Fodor's usual highly readable, irreverent style, provides a lively discussion of semantic issues about mental representation, with special attention to issues raised by Frege's problem, (...) Twin cases, and the putative indeterminacy of reference. The book extends and revises a view of the relation between mind and meaning that the author has been developing since his 1975 book, The Language of Thought. There is a general consensus among philosophers that a referential semantics for mental representation cannot support a robust account of intentional explanation. Fodor has himself espoused this view in previous publications, and it is widespread (if tacit) throughout the cognitive science community. This book is largely a reconsideration of the arguments that are supposed to ground this consensus. Fodor concludes that these considerations are far less decisive than has been supposed. He offers a theory sketch in which psychological explanation is intentional, psychological processes are computational, and the semantic properties of mental representations are referential. Connections with the problem of "naturalizing" intentionality are also explored. The four lectures in The Elm and the Expert were originally delivered in Paris in the spring of 1993 to inaugurate the Jean Nicod Lecture series. The Jean Nicod Lectures are delivered annually by a leading philosopher of mind or philosophically oriented cognitive scientist. The 1993 lectures marked the centenary of the birth of the French philosopher and logician Jean Nicod (1893-1931). The lectures are sponsored by the Centre National de la Recherche Scientifique (CNRS) as part of its effort to develop the interdisciplinary field of cognitive science in France. Jean Nicod series. (shrink)

There are themes in Wittgenstein's later work which are extremely radical. By ‘radical’ I mean both that they cut to the very root of crucial philosophical issues, and that they tend to be ignored by the established philosophical positions of the day. More specifically, these themes focus on the understanding of epistemological bedrock, and they lead in directions about which it is difficult to get a hearing in major philosophical circles.

At a time when the label "conservative" is indiscriminately applied to fundamentalists, populists, libertarians, fascists, and the advocates of one or another orthodoxy, this volume offers a nuanced and historically informed presentation of ...

Jerry L. Walls argues that the doctrine of heaven is ripe for serious reconsideration. He contends not only that the orthodox view of heaven can be defended from objections commonly raised against it, but also that heaven is a powerful resource for addressing persistent philosophical problems, not the least of which concern the ground of morality and the meaning of life. Walls shows how heaven is integrally related to central Christian doctrines, particularly those related to salvation, and tackles the (...) difficult problem of why faith in Christ is necessary to save us from our sins. In addition, heaven is shown to illumine thorny problems of personal identity and to be an essential component of a satisfactory theodicy. Walls goes on to examine data from near-death experiences from the standpoint of some important recent work in epistemology and argues that they offer positive evidence for heaven. He concludes that we profoundly need to recover the hope of heaven in order to recover our very humanity. (shrink)

Ernie Lepore and Jerry Fodor have published a series of original and controversial essays on issues relating to compositionality in language and mind; they have...

We take it that Brandom’s sense of the geography is that our way of proceeding is more or less the first and his is more or less the second. But we think this way of describing the situation is both unclear and misleading, and we want to have this out right at the start. Our problem is that we don’t know what “you start with” means either in formulations like “you start with the content of words and proceed to the (...) content of sentences” or in formulations like “you start with the content of sentences and you proceed to the content of words.” Brandom’s official view seems to be that he’s talking about explanatory priorities (see the preceding quote); but we think that can’t really be what he has in mind, and we can’t find any alternative interpretation that seems plausible. Speaking just for ourselves, we’re inclined towards a relatively pragmatic view of explanation; what explanation we should “start with” depends, inter alia, on what it’s an explanation of and whom it’s an explanation for. But, in any case, we would have thought that explanatory priority is of more than heuristic interest only if it reflects a priority of some other kind: ontological, semantical, psychological, or whatever. In talking about what one “starts with”, Brandom must be claiming more than. (shrink)

Abstract:In this paper we highlight the emergence of organizational ethics issues in health care as an important outcome of the changing structure of health care delivery. We emphasize three core themes related to business ethics and health care ethics: integrity, responsibility, and choice. These themes are brought together in a discussion of the process of Mission Discernment as it has been developed and implemented within an integrated health care system. Through this discussion we highlight how processes of institutional reflection, such (...) as Mission Discernment, can help health care organizations, as well as corporations, make critical choices in turbulent environments that further the core mission and values and fulfill institutional responsibilities to a broad range of stakeholders. (shrink)