The times required to develop new drugs is growing continuously and most drugs fail in the development process because we lack the detailed knowledge of biology and physiology needed to understand the result of a proposed treatment. The problem is one of complexity—we do not know the full complexity of living organisms, neither does traditional biology have the language to capture and integrate complexity. As a result, the life sciences are undergoing a period of radical change as the technological and (...) mathematical methods developed for the analysis of physical sciences are being adapted for use in understanding living systems. This introduction of quantitative mathematical methods to represent and understand a previously descriptive subject resembles the Newtonian revolution in physics and its subsequent impact upon industry and manufacture. And just as in the post-Newtonian developments, the new ways are being resisted as the traditional reductionist biologists argue against a system level analysis. The comparison between the industrial revolution and the emerging revolution in life sciences is so strong that it can be usefully employed to explain the current process—the industrialisation of biology—in a way that informs the traditionalist movement. In particular, we draw upon ideas from innovation cycles and the staging of change in science and industry to clarify the current change processes in life science. Using specific examples in technology development we outline lessons that can be learnt in order to smooth the process of change and make it a harmonious one, rather than one of conflict. (shrink)

Laurent Henninger intervenant sur les « révolutions militaires » (notion située au carrefour du débat historique lancé dans les années 1980 par Geoffrey Parker – en polémique avec Jeremy Black – et du débat stratégique américain dans les années 1990) souligne que les avancées dans l’art de la guerre ont été depuis cinq siècles une des composantes majeures de la barbarisation et du totalitarisme. La notion de « révolution militaire » est aujourd’hui contestée par ceux qui y voient un outil (...) interprétatif de trop longue durée et lui préfèrent l’idée de « mutations militaires » (selon laquelle l’accumulation de changements millimétriques sur la longue durée débouche sur des ruptures). Après avoir passé en revue la première révolution militaire – XVe-XVIIe siècles – fondée sur la mise à distance de la cavalerie grâce à l’infanterie nouvelle, à l’artillerie du champ de bataille, Henninger s’interroge sur le critère discriminant pour qualifier les nouvelles guerres de la Renaissance (l’hyperviolence n’en est pas un à ses yeux) et voit dans les armes à feu la vraie rupture car elles influent de façon radicale sur la peur et le courage des combattants et sont source d’une véritable « inhumanité » dans la mesure où leur feu est « imparable ». Il insiste sur l’émergence d’un nouveau type de courage guerrier non archaïque et plus « stoïcien » marqué par l’acceptation de la mort. Dans cette perspective, l’« inhumanisation » technique porterait en elle la possibilité de la barbarisation. L. Henninger développe ensuite cette thèse à partir de l’examen des guerres mécanisées de la période 1860-1950 en s’attardant sur la guerre de Sécession puis sur la Grande Guerre. Il relie aussi la question du totalitarisme à la réflexion sur les « bombardements stratégiques massifs » et les débuts de la dissuasion nucléaire (terme qui ne s’impose que vers 1960). Il conclut en insistant sur le fait que, selon lui, la brutalisation des conflits naît toujours d’un retard de la pensée de la guerre et sur le paradoxe d’une culture occidentale qui produit en même temps barbarie de la guerre et codes qui tentent de l’enrayer. (shrink)

L’idée selon laquelle le temps, son organisation, sa discipline est un facteur discriminant permettant de séparer nettement la période industrielle de celle qui la précède a longtemps prévalu chez les historiens. Cet article s’inscrit en faux contre cette thèse : les conflits autour du temps de travail doivent être inscrits dans la longue durée des rapports sociaux de production. Nous dressons ici une esquisse large des conflits où le temps est un élément de la mobilisation des travailleurs, du XIVe au (...) premier XIXe siècle. Alors qu’au Moyen-Âge, certains conflits portent clairement sur la remise en cause de la définition du temps de travail, à partir du XVIIe siècle, le thème semble s’estomper. Mais apparaissent alors des conflits qui portent sur le contenu du travail effectué dans un temps donné. La première industrialisation ne change pas véritablement la nature des revendications. Elles proviennent encore majoritairement d’ouvriers engagés dans des activités traditionnelles. Les ouvriers d’usine, quant à eux, ne sortent globalement pas de leur mutisme avant les décennies 1860/1870. (shrink)

Dans les nations industrialisées, les goûts des individus sont désormais employés à doper la consommation. L'industrialisation de la jouissance privilégie le superflu au nécessaire, la sensibilité à la raison, la séduction à la faculté de juger. Pourtant, avec l'exploitation du goût, le capitalisme est loin d'avoir découvert une terre inconnue. A l'âge classique, la noblesse de cour cultivait un style de vie commandé par les loisirs et le goût, tout en faisant du bon goût un critère de distinction et (...) de promotion individuelle. Ces relations de compétition entre courtisans ont-elles été les premières notes en prélude au libéralisme? Si l'improductivité, au sens économique, a pu constituer une valeur fondatrice du goût, comment l'industrie a-t-elle pu transformer le goût en moteur économique de la consommation? Le devenir esthétique du capitalisme repose sur la captation et la conversion de ce qu'il aurait de plus individuel en valeurs mesurables, échangeables et massifiables, susceptibles de coloniser les moindres recoins de l'existence et de al culture. L'ouvrage montre que les enjeux du capitalisme esthétique excèdent le territoire angélique des agréments : les batailles esthétiques sont au cœur d'une guerre économique pour le contrôle des émotions et des affections. (shrink)

A child poverty rate of ten percent could mean that every tenth child is always poor, or that all children are in poverty for one month in every ten. Knowing where reality lies between these extremes is vital to understanding the problem facing many countries of poverty among the young. This unique study goes beyond the standard analysis of child poverty based on poverty rates at one point in time and documents how much movement into and out of poverty by (...) children there actually is, covering a range of industrialised countries - the USA, UK, Germany, Ireland, Spain, Hungary and Russia. Five main topics are addressed: conceptual and measurement issues associated with a dynamic view of child poverty; cross-national comparisons of child poverty rates and trends; cross-national comparisons of children's movements into and out of poverty; country-specific studies of child poverty dynamics; and the policy implications of taking a dynamic perspective. (shrink)

Baumard's thesis that the English Industrial Revolution can be explained by Life History Theory's predictions for psychological development is a progression of much literature in economic and social history. However, the theory suffers from its reliance on increasingly fragile data indicators for “wealth” and its focus on “innovation” as new research begins to explore sectoral dynamics in long run growth.

You think that a wall as solid as the earth separates civilisation from barbarism. I tell you the division is a thread, a sheet of glass’... This essay is a biography of this traumatic Edwrdian image, expressed in J. G. Fraser and H. G. Wells as well as in John Buchan's first thriller, The Power‐House of 1913. It traces the creer of the volcanic metaphor, particularly eruptive in Scotland, beyond Carlyle's French Revolution to the scientific controversies of the Enlightenment.

ABSTRACT This article examines how Owen’s ideas and their application in his factory in New-Lanark were understood and judged by the two leading members of Geneva’s liberal élite, J.C.L. Simonde de Sismondi and Marc-Auguste Pictet, who wrote extensively on questions pertaining to the development of industry. While Pictet and Sismondi shared Owen’s concerns over the deleterious consequences of industrialisation, and examined with interest his proposals to resolve these problems, they were quick to distance themselves from his solutions, and rejected (...) his ideas on co-operation and shared ownership. The article concludes with an analysis of Sismondi’s work and his reflections on the two courses open to industrial civilisation: it could be either liberal, with all that entailed – competition, antagonism, conflict, but also liberty, imaginative and creative development – or ‘planned’, with the consequences that flowed from that: collective ownership, peace, security, but also an extinguishing of creative impulses, of inventiveness, and of the human spirit. (shrink)

Industrialisation, urbanisation and economic development have produced unprecedented improvements in human health. They have also produced unprecedented exploitation of Earth’s life support systems, moving the planet into a new geological epoch, the Anthropocene—one defined by human influence on natural systems. The health sector has been complicit in this influence. Bioethics, too, must acknowledge its role—the environmental threats that will shape human health in this century represent a ‘perfect moral storm’ challenging the ethical theories of the last. The US conservationist (...) Aldo Leopold saw this gathering storm more clearly than many, and in his Land Ethic describes the beginnings of a route to safe passage. Its starting point is a reinterpretation of the ethical relationship between humanity and the ‘land community’, the ecosystems we live within and depend upon; moving us from ‘conqueror’ to ‘plain member and citizen’ of that community. The justice of the Land Ethic questions many presuppositions implicit to discussions of the topic in biomedical ethics. By valuing the community in itself—in a way irreducible to the welfare of its members—it steps away from the individualism axiomatic in contemporary bioethics. Viewing ourselves as citizens of the land community also extends the moral horizons of healthcare from a solely human focus. Taking into account the ‘stability’ of the community requires intergenerational justice. The resulting vision of justice in healthcare—one that takes climate and environmental justice seriously—could offer health workers an ethic fit for the future. (shrink)

The industrialisation of agriculture has led to considerable alterations at both the technological and economical levels of animal farming. Several animal welfare issues of modern animal agriculture – e.g. stress and stereotypical behaviour – can be traced back to the industrialised intensification of housing and numbers of animals in production. Although these welfare issues dictate ethical criticism, it is the claim of this article that such direct welfare issues are only the forefront of a greater systemic ethical problem inherent (...) to industrialisation. Consequently, this article provides an analysis of the foundational ethical problems in animal agriculture which derive from overly positivistic science and free-market ideology. It will be argued that both these ways of thinking allow for a systematic reification and commodification of animals and that this contributes to language and attitudes which cannot encompass ethical consideration of animals. (shrink)

Eschewing a Marxist interpretation of the French Revolution, Jeff Horn’s work is nonetheless interesting in stressing the widespread prevalence of machine-breaking by workers in France as compared to England during industrialisation. Likewise notable is Horn’s argument that the resultant state-intervention forced France onto a path of industrialisation which differed from England’s and which has been underestimated. Breaking with the revisionist consensus, Horn further demonstrates that the effect of the Revolution was positive for French economic development. Refreshing in its (...) stress on working-class militancy, Horn’s work nonetheless exaggerates the influence of machine-breaking on French economic change as compared to other forms of working-class struggle, the slow pace of primitive accumulation and the resistance to industrialisation by small-scale urban producers. (shrink)

Background: Increasing collaboration between industrialised and developing countries in human research studies has led to concerns regarding the potential exploitation of resource deprived countries. This study, commissioned by the former National Bioethics Advisory Commission of the United States, surveyed developing country researchers about their concerns and opinions regarding ethical review processes and the performance of developing country and US international review boards .Methods: Contact lists from four international organisations were used to identify and survey 670 health researchers in developing countries. (...) A questionnaire with 169 questions explored issues of IRB review, informed consent, and recommendations.Results: The majority of the developing country researchers were middle aged males who were physicians and were employed by educational institutions, carrying out research on part time basis. Forty four percent of the respondents reported that their studies were not reviewed by a developing country IRB or Ministry of Health and one third of these studies were funded by the US. During the review process issues such as the need for local language consent forms and letters for approval, and confidentiality protection of participants were raised by US IRBs in significantly higher proportions than by host country IRBs.Conclusion: This survey indicates the need for the ethical review of collaborative research in both US and host countries. It also reflects a desire for focused capacity development in supporting ethical review of research. (shrink)

At the beginning of Western philosophy, Aristotle contrasted made objects, which did not have the source of their own production within themselves, with beings formed by nature. This distinction persisted until Marx, who conceived of the possibility of an evolution of the technical object. This philosophy developed while industrialisation was in the process of overthrowing the contemporary order of social organisation, which highlighted technology's new place in philosophical enquiry. Bernard Stiegler goes back to the beginning of Western philosophy and (...) revises the Aristotelian assessment, developing a complex argument whereby the technical object can be seen as having an essential, distinctive temporality and dynamic of its own. The author engages the ideas of Rousseau, Husserl, and Heidegger, the paleo-ontologist Leroi-Gourhan, the anthropologists Vernant and Detienne, the sociologists Weber and Habermas, and the systems analysts Maturana and Varela. (shrink)

In this commentary, we discuss the nature of reversible and irreversible questions, that is, questions that may enable one to identify the nature of the source of their answers. We then introduce GPT-3, a third-generation, autoregressive language model that uses deep learning to produce human-like texts, and use the previous distinction to analyse it. We expand the analysis to present three tests based on mathematical, semantic, and ethical questions and show that GPT-3 is not designed to pass any of them. (...) This is a reminder that GPT-3 does not do what it is not supposed to do, and that any interpretation of GPT-3 as the beginning of the emergence of a general form of artificial intelligence is merely uninformed science fiction. We conclude by outlining some of the significant consequences of the industrialisation of automatic and cheap production of good, semantic artefacts. (shrink)

In common with most industrialised countries, France has undertaken an ambitious programme of education reform over the last fifteen years. This book uses key extracts from contemporary writing to examine exactly how and why that process has happened, focusing on all stages of the education system. Sections cover the main characteristics of school reform in France, its aims and objectives, a discussion of the desirability of and politics surrounding the reform process, and explorations of classroom practice, the changing role of (...) parents, standards in schools, and the curriculum. Because of its high quality, wide and up-to-date coverage of the area, this book will be a vital reference text for all those working in this field. (shrink)

This paper proposes an answer to what Sandler calls ‘the problem of inconsequentialism’; the problem of providing justification for the claim that individuals should engage in unilateral reductions of their personal consumption, even though doing so will make an inconsequential contribution to mitigating the harmful impacts of the global environmental problems that the aggregate of such consumption causes. I provide an answer to this problem by developing a virtue ethics-based argument that a limited but significant class of consumption actions performed (...) by typical consumers in rich, industrialised economies in the global North are moral wrongdoings, and the corresponding unilateral reductions in personal consumption are morally obligatory. I make this argument by drawing an analogy between a typical Northern consumer and a member of a golf club who has discovered that his club causes harm—by dumping used golf balls into a nature reserve—to which he inconsequentially contributes. I advance a moral evaluation of remaining a member of a harming group, based on the attitudes to the harm expressed by so remaining, and on Sandler’s virtue-grounded agent-relative target principle of right action. I examine a number of objections to this argument. I use Elizabeth Cripps’s notion of a ‘harming putative group’ to respond to the objection that the set of individuals whose aggregated consumption causes environmental problems is merely an arbitrary abstract set, membership of which is not justifiable grounds for moral evaluation. I then present two responses to the objection that withdrawal from this harming putative group—by refraining to perform those consumption actions which constitute membership—is unduly demanding. (shrink)

The availability of and demand for water in China is an extreme case of uneven distribution in time and space. In response, the South to North Water Diversion project, the largest inter-basin water transfer scheme in the world, channels large amounts of fresh water from the Yangtze River in southern China to the more arid and industrialised north. In order to keep the SNWD project running smoothly, a comprehensive governance system has been implemented and innovative institutional arrangements have been created (...) to facilitate the transfer of water itself. By taking the SNWD project’s Middle Route as one case study and drawing on primary and secondary data, this article examines the project’s emerging institutional arrangements. The article outlines the establishment of new institutions for the SNWD project with high administrative rankings at both central and local levels, the encouragement of inter-department cooperation, the adoption of a market mechanism and the integration of market functions into administrative functions. We argue that these institutional arrangements have to some extent overcome common challenges in water governance in China, including an engineering-heavy approach and what Chinese commentators have traditionally called the problem of water being managed by multiple government ministries and municipal authorities as the common metaphor of ‘nine dragons managing the water’. Our findings have significant implications for understanding the continuing evolution of water governance in China. (shrink)

In their landmark 2010 paper, “The weirdest people in the world?”, Henrich, Heine, and Norenzayan outlined a serious methodological problem for the psychological and behavioural sciences. Most of the studies produced in the field use people from Western, Educated, Industrialised, Rich and Democratic (WEIRD) societies, yet inferences are often drawn to the species as a whole. In drawing such inferences, researchers implicitly assume that either there is little variation across human populations, or that WEIRD populations are generally representative of the (...) species. Yet neither of these assumptions is justified. In many psychological and behavioural domains, cultural variation begets cognitive variation, and WEIRD samples are recurrently shown to be outliers. In the years since the article was published, attention has focused on the implications this has for research on extant human populations. Here we extend those implications to the study of ancient _H. sapiens_, their hominin forebears, and cousin lineages. We assess a range of characteristic arguments and key studies in the cognitive archaeology literature, identifying issues stemming from the problem of sample diversity. We then look at how worrying the problem is, and consider some conditions under which inferences to ancient populations via cognitive models might be provisionally justified. (shrink)

Many people living in highly industrialised countries and elsewhere emit greenhouse gases at a certain high level as a by-product of their activities, and they expect to be able to continue to emit at that level. This level is far above the just per capita level. We investigate whether that expectation is legitimate and permissible. We argue that the expectation is epistemically legitimate. Given certain assumptions, we can also think of it as politically legitimate. Also, the expectation is shown to (...) be morally permissible but with major qualifications. The interpretation of the significance of the expectation is compatible with the understanding that historical emissions should count in terms of fairly distributing the benefits of emission-generating activities over people’s lifetimes but constrains the way in which we may collectively respond to climate change. (shrink)

Climate change is an ethical issue, because it involves the distribution of a scarce resource – the capacity of the atmosphere to absorb our waste gases without producing consequences that no one wants. Various principles might be used to decide what distribution is just. This commentary argues that on any plausible principle, the industrialised nations should be doing much more than they are doing now, and much more than they are required to do by the Kyoto protocol, to reduce their (...) greenhouse gas emissions. The commentary also responds specifically to some issues raised by MacCracken, Toman and Gardiner, including feasibility, the discount rate, and grounds for pessimism. (shrink)

Climate change can be interpreted as a unique case of historical injustice involving issues of both intergenerational and global justice. We split the issue into two separate questions. First, how should emission rights be distributed? Second, who should come up for the costs of coping with climate change? We regard the first question as being an issue of pure distributive justice and argue on prioritarian grounds that the developing world should receive higher per capita emission rights than the developed world. (...) This is justified by the fact that the latter already owns a larger share of benefits associated with emission generating activities because of its past record of industrialisation. The second question appears to be an issue of compensatory justice. After defining what we mean by compensation, we show that different kinds of compensatory principles run into problems when used to justify payments by historical emitters of the North to people suffering from climate change in the South. As an alternative, we propose to view payments from wealthy countries for adaptation to climate change in vulnerable countries rather as a measure based on concerns of global distributive justice. (shrink)

O'Brien provides a critical assessment of Ernest Mandel's 1975 monograph Late Capitalism. In so doing, he offers a historical narrative that puts into question Mandel's framing of 'waves' of capitalist development as a process of capital accumulation that was dependent upon uneven development in the Third World. O'Brien starts by problematising Mandel's argument that an initial concentration of money, capital and bullion in the hands of Europeans explains combined and uneven development. He goes on to demonstrate that Mandel's notion of (...) imperialism as a necessary conduit for the flow of surplus capital from industrialising Europe does not stand up to the historical evidence. In fact, O'Brien maintains an alternative thesis, namely that these marginalised regions were insuffciently penetrated by European capital. (shrink)

En février 2024, le Parlement européen a voté l’autorisation partielle d’utilisation des NGT ( New Genomic Techniques ). À la différence des OGM, interdites, les NGT ne visent pas à injecter dans une plante les gènes d’une autre, mais à modifier le séquençage de son propre génome en imitant l’évolution génétique « spontanée » qui ne prend plus des milliers d’années, mais quelques minutes. Du coup, elles sont peu « traçables ». Les techniques d’hybridation ont, depuis les années 50, été (...) imposées aux agriculteurs du Nord puis du Sud au prétexte de meilleurs rendements pour nourrir le monde et, aujourd’hui, de la protection de l’environnement. En fait, les semences hybrides sont brevetées et constituent une rente exceptionnelle pour les industries chimiques et pharmaceutiques, tout en maintenant dans la dépendance de leur utilisation les paysans du monde entier astreints à l’industrialisation agricole, ce qui provoque de profondes inégalités. Il s’agit de briser le lien mortel qui soumet les États (qui leur accordent un soutien massif) aux entreprises privées qui s’approprient les brevets. (shrink)

Background Paediatric clinical research faces unique challenges that compromise optimal recruitment of children into clinical trials. A main barrier to enrolment of children is parental misconceptions about the research process. In developing countries, there is a knowledge gap regarding parental perceptions of and attitudes towards their children's participation in clinical trials. Objective To explore such perceptions and attitudes in Lebanese parents. Study design 33 in-depth interviews were conducted with parents with and without previous research experience. Interviews were tape-recorded, transcribed in (...) colloquial Arabic, and later subjected to thematic analysis. Results Benefit/risk ratio assessment was a major determinant of parental consent. Fear of adverse events or painful procedures in research was a recurring theme in most interviews. Whereas perception of direct benefit to the child, trust in the physician or institution, financial gains or having a positive previous experience in research facilitated consent, a complex informed consent form and misunderstanding of the term ‘randomisation’ hindered parental approval of participation. Conclusion Lebanese parents have perceptions of and attitudes towards children's participation in clinical trials that are similar to those reported from the industrialised world. Improving communication with parents and building trust between researchers and parents is important for successful recruitment. Investigators planning to conduct paediatric trials in developing countries need to simplify consent forms and devise new ways to explain randomisation. (shrink)

Aujourd'hui nous vivons un nouveau stade de la longue histoire de l'évolution technique de l'humanité : le stade du capitalisme hyperindustriel. Depuis le XXe siècle, l'homme n'a cessé de vivre les bouleversements des conditions de la temporalité, c'est-à-dire aussi bien de son individuation. Ce nouveau stade induit déjà une profonde transformation de nos existences. Loin de disparaître, l'industrialisation se poursuit et se renforce, elle investit de nouveaux champs, invisibles, qui vont des nanostructures jusqu'aux fondements neurologiques de l'insconscient, en passant (...) par les biotechnologies : les champs de l'hypermatériel, où la matière est toujours déjà une forme, où la forme est toujours déjà une information et où l'" immatériel " apparaît pour ce qu'il est : une fable qui enfume les esprits. Bernard Stiegler formule à nouveaux frais les enjeux des technologies culturelles et cognitives, mais aussi des biotechnologies et des nanotechnologies. Elles ne vont pas sans péril pour l'humanité, pour le " devenir non inhumain " de l'espèce humaine, comme il l'écrit. Demain, l'homme sera-t-il désemparé de lui-même, de sa conscience et de sa libido, ou saura-t-il exister avec les technologies de l'hypermatériel? S'il se laisse subsumer, s'il laisse son désir être capté par les puissantes machines et réseaux qui cherchent déjà à instaurer un psychopouvoir, l'une des conséquences pourrait bien être l'auto-destruction du capitalisme, déjà bien engagé sur cette pente. Bernard Stiegler n'est pas un technophobe. Il n'en est que plus autorisé à nous alerter. (shrink)

Science has always engaged with the worldviews of societies and cultures. The theme is of particular importance at the present time as many national and provincial education authorities are requiring that students learn about the nature of science (NOS) as well as learning science content knowledge and process skills. NOS topics are being written into national and provincial curricula. Such NOS matters give rise to at least the following questions about science, science teaching and worldviews: -/- What is a worldview? (...) -/- Does science have a worldview? -/- Are there specific ontological, epistemological and ethical prerequisites for the conduct of science? -/- Does science lack a worldview but nevertheless have implications for worldviews? -/- How can scientific worldviews and practice be reconciled with seemingly discordant religious and cultural worldviews? -/- In which ways do the worldviews of students impact on their interest and learning of science? -/- Should science teachers engage with the worldviews of students? -/- In addition to the NOS curricular impetus for refining understanding of science and worldviews, there are also pressing cultural and social forces that give prominence to questions about science, worldviews and education. There is something of an avalanche of popular literature on the subject that teachers and students are variously engaged by. Additionally the modernisation and science-based industrialisation of huge non-Western populations whose traditional religions and beliefs are different from those that have been associated with orthodox science make very pressing the questions of whether, and how, science is committed to and hence promotes particular worldviews and contradicts others. Hopefully this chapter, and others in the section, will contribute to a more informed understanding of the relationship between science, worldviews and education and provide assistance to teachers who are routinely engaged with the subject. (shrink)

In the Global North, Urban Agriculture is being considered as a way to overcome malnutrition and promote local, ethical production. UA can be understood through two phenomena integral to the capitalist mode of production: capital centralisation and rent. Centralisation explains why capitalist agriculture industrialises, while rent provides a theoretical framework for understanding how social and spatial relations structure urban land uses. Urban farming can occupy niches of the capitalist marketplace; however, its prospects for replacing large-scale agriculture and providing similar use-values (...) are limited. Its expansion is bounded by rising land values expressed in rent, as Detroit’s urban farm, Markham’s food belt, Los Angeles’s community garden, and initiatives in other cities demonstrate. The key tasks for political ecologists are two-fold: situating UA within capital’s drive to accumulate and proposing strategic perspectives that challenge these inherent tendencies. (shrink)