Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n (...) = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. (shrink)

Spontaneous activity levels prior to stimulus presentation can determine how that stimulus will be perceived. It has also been proposed that such spontaneous activity, particularly in the default-mode network (DMN), is involved in self-related processing. We therefore hypothesised that pre-stimulus activity levels in the DMN predict whether a stimulus is judged as self-related or not. Method: Participants were presented in the MRI scanner with a white noise stimulus that they were instructed contained their name or another. They then had to (...) respond with which name they thought they heard. Regions where there was an activity level difference between self and other response trials two seconds prior to the stimulus being presented were identified. Results: Pre-stimulus activity levels were higher in the right temporoparietal junction (RTPJ), the right temporal pole (RTP), and the left superior temporal gyrus in trials where the participant responded that they heard their own name than trials where they responded that they heard another. Conclusion: Pre-stimulus spontaneous activity levels in particular brain regions, largely overlapping with the DMN, predict the subsequent judgement of stimuli as self-related. This extends our current knowledge of self-related processing and its apparent relationship with intrinsic brain activity in what can be termed a rest-self overlap. (shrink)

Disorders of consciousness (DoC)—that is, unresponsive wakefulness syndrome/vegetative state and minimally conscious state—are debilitating conditions for which no reliable markers of consciousness recovery have yet been identified. Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker.

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...) stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli. (shrink)

Most mental disorders affect only a small segment of the population. On the reasonable assumption that minds or brains are prone to occasional malfunction, these disorders do not seem to pose distinctive explanatory problems. Depression, however, because it is so prevalent and costly, poses a conundrum that some try to explain by characterizing it as an adaptation—a trait that exists because it performed fitness-enhancing functions in ancestral populations. Heretofore, proposed evolutionary explanations of depression did not focus on thought processes; instead, (...) they emphasized that it facilitates navigation of adverse social circumstances or promotes immune response to infectious agents. According to a new hypothesis, the “analytical rumination hypothesis” (ARH), however, depression’s crucial adaptive trait is rumination—negative, intrusive thought. ARH holds that, (i) social dilemmas trigger depressed mood; (ii) depressed mood induces changes in body systems that facilitate ruminative analysis aimed at solving dilemmas; and, (iii) depressive rumination is a fitness-enhancing trait that was selected for in evolutionary time. Jointly, (i)~(iii) imply that we should not think of rumination as a disorder; instead, it is a trade-off, an eminently rational one. In the same way that fever solves a problem—coordination of the immune system in response to infection—so too does depressive rumination solve a problem, a social dilemma, albeit at the cost of inducing anhedonia and other maladies. But they argue that the cost is worthwhile, something that should be endured “until the problem is solved.” First, we argue that there are two distinct types of rumination, brooding and pondering; the former is associated with a disposition for depression, not the latter. But only the latter has the problem-solving capabilities that ARH requires. Second, recent brain imaging studies of depression reveal resting state hypoactivity in lateral regions and hyperactivity in paralimbic regions; this asymmetric pattern correlates with heightened levels of brooding, self-focused rumination. In other words, on the personal level, patients are trapped within self, isolated from the external world and suffused with negative affect; on the subpersonal level, this pattern is reflected by an asymmetric pattern of lateral vs. paralimbic resting state activity. Third, we proceed to conjecture that rational responses (e.g., pondering) to social dilemmas are those that strike a balance between internal and external considerations in the process of belief formation. Fourth, because the asymmetric resting state activity blocks those who suffer with depression from accessing and processing potentially positive stimuli from the external world, the capacity for rational, analytic response—hence, problem-solving—is constrained. Fifth, it follows that, although there might be conditions for which suffering should be endured rather than pharmacologically alleviated, depression is not one of those. Indeed, in view of the effects of the asymmetric resting state pattern, it is unlikely that depressive rumination would have been useful even for ancestral populations. (shrink)

Time is an essential feature in bipolar disorder (BP). Manic and depressed BP patients perceive the speed of time as either too fast or too slow. The present article combines theoretical and empirical approaches to integrate phenomenological, psychological, and neuroscientific accounts of abnormal time perception in BP. Phenomenology distinguishes between perception of inner time, ie, self-time, and outer time, ie, world-time, that desynchronize or dissociate from each other in BP: inner time speed is abnormally slow (as in depression) or fast (...) (as in mania) and, by taking on the role as default-mode function, impacts and modulates the perception of outer time speed in an opposite way, ie, as too fast in depression and too slow in mania. Complementing, psychological investigation show opposite results in time perception, ie, time estimation and reproduction, in manic and depressed BP. Neuronally, time speed can be indexed by neuronal variability, ie, SD. Our own empirical data show opposite changes in manic and depressed BP (and major depressive disorder [MDD]) with abnormal SD balance, ie, SD ratio, between somatomotor and sensory networks that can be associated with inner and outer time. Taken together, our combined theoretical-empirical approach demonstrates that desynchronization or dissociation between inner and outer time in BP can be traced to opposite neuronal variability patterns in somatomotor and sensory networks. This opens the door for individualized therapeutic “normalization” of neuronal variability pattern in somatomotor and sensory networks by stimulation with TMS and/or tDCS. (shrink)

In a recent Opinion article, Sui and Humphreys [1] argue that experimental findings suggest self is ‘special’, in that self-reference serves a binding function within human cognitive economy. Contrasting their view with other functionalist positions, chiefly Dennett's [2], they deny that self is a convenient fiction and adduce findings to show that a ‘core self representation’ serves as an ‘integrative glue’ helping to bind distinct types of information as well as distinct stages of psycho- logical processing. In other words, where (...) Dennett regards self as analogous to a center of gravity, a simplification posited by observers, Sui and Humphreys regard self as a function that modulates mental processes. In practice, however, the concept of ‘self’ they employ is not unlike Dennett's. We side with Sui and Humphreys in hold- ing that self-reference modulates mental processes: reference to self during a task can bind memory to source, increase perceptual integration, and link attention to decision making, among other things. What is more, these functions are not reducible to other factors such as semantic coding, familiarity, or reward [3]. But whereas Sui and Humphreys contribute important empirical detail, the binding functions they describe are compatible with Dennett's version of functionalism, which treats self as an artifact of social process. (shrink)

In 1850, Bastiat outlined the original notion of “man’s aversion to uncertainty” and used it to explain why people freely associated or cooperated in the world of uncertainty where they lived. He dealt with two special instances of association, mutual insurance and wage system. His analysis, which can be termed “Bastiat’s law of association”, has been evicted by economists and is unknown by most of them today.Several decades before Bastiat, Ricardo had already expounded an explanation of association, but within a (...) theoretical framework of certainty, and founded it on the notion of “labor cost”. Contrary to Bastiat’s law, Ricardo’s law has always been well known by economists.The article does not only describe Bastiat’s law but also shows that it is both coherent with “Ricardo’s law” and even more general since it includes it. Finally, it is claimed that Bastiat’s law heralded what will happen in the second half of the twentieth century: from 1950’s, the aversion to uncertainty will become a theoretical economic notion widely used; from 1970’s, the theory of organizations/associations will be developed within an explicit context of uncertainty.En 1850, Bastiat a délimité le concept original d’”aversion de la personne pour l’incertitude” et s’en est servi pour expliquer la libre association ou coopération des gens dans le monde d’incertitu- de où ils vivent. Il s’est intéressé à deux exemples particuliers d’association, l’assurance mutuelle et le salariat. Force est de constater que son analyse, qu’on dénommera “loi de Bastiat”, a été mise de côté par les économistes et qu’aujourd’hui elle est inconnue de la plupart d’entre eux.Plusieurs décennies avant Bastiat, Ricardo avait déjà proposé une explication de l’association, mais dans un cadre théorique de certitude, et l’avait bâtie sur la notion de “coût du travail”. Contrairement à la loi de Bastiat, la loi de Ricardo a toujours été bien connue des économistes.Non seulement, l’article présente la “loi de Bastiat”, mais encore il montre qu’elle est à la fois compatible avec la “loi de Ricardo’ et plus générale puisqu’elle l’inclut. Il revendique enfin que la loi de Bastiat a annoncé ce qui va arriver dans la seconde moitié du vingtième siècle: à partir de la décennie 1950, l’aversion pour l’incertitude va devenir une notion de théorie économique largement employée et à partir de la décennie 1970, la théorie des organisations/associations sera développée dans un contexte d’incertitude explicite. (shrink)

In this excellent book, drawing on previously published articles, George Duke gathers the scattered threads of Aristotle's discussions of law while defending clear stances in the various philosophical debates they have engendered. The book works within Aristotelian methodology and metaphysics, developing the view that a politeia should be understood as a formal cause that is worked out in terms of the successive definitions offered in book III of Politics. Building on studies of the evolution of the meaning of nomos and (...) making occasional reference to Greek legal history and practice, primarily in Athens, it treats what I see as three themes, spread across seven chapters.In chapters 1 and 2, Duke addresses the... (shrink)

Part guide and part spiritual journey, this visually stunning book celebrates America's statewide system of historic back country roads. It takes armchair travelers on a richly illustrated journey thorough the most beautiful landscapes of one of the nation's most geographically diverse states, and serves as a guide for those who decide to embark on an actual trip over these charming lanes. The project began when photographer Bob Rashid undertook a two year odyssey to preserve the remarkable sights along the 67 (...) official Rustic Roads in Wisconsin. Wisconsin's Rustic Roads, in the images of Rashid and the words of five of Wisconsin's most recognized and cherished authors, is a testiment to places where the efficiency of a road is not measured by its speed, nor its purpose necessarily defined by a destination, and which beckons the reader to linger. (shrink)

L’homme occidental est hanté par le deuil d’une origine qu’il ne cesse de vouloir comprendre à travers les mythes, les fables et les religions qui en constituent le récit. Si chaque peuple a son identité, sa manière de vivre, de penser et de sentir, l’homme est-il pour autant prisonnier de sa culture, identifié à ses valeurs, aliéné à ses représentations, assigné à ses croyances? Si toutes les cultures se valent sont-elles pour autant égales?Aujourd’hui, le débat sur l’identité traduit un malaise (...) dans la culture. Il s’agit de distinguer entre le pluralisme nécessaire à toute vie démocratique et un multiculturalisme qui peut en être la limite. L’effacement des repères symboliques, le décloisonnement des cultures, le brassage des populations ont favorisé l’émergence d’une identité cosmopolite, clanique. L’homme cosmopolite est un homme sans qualité, de toutes les mémoires mais d’aucune histoire, semblable aux autres mais ne ressemblant à personne. A l’inverse, et dans le même temps, les communautarismes revendiquent une identité inaltérable qui fait du Même l’organisateur du lien social, tandis que les fondamentalismes font des Ecritures le nouveau livre de sciences naturelles et de Dieu l’immense marché mondial des fanatismes. Une identité qui prétend à l’immuabilité ne menace pas seulement le corps social mais porte atteinte à l’idée même d’humanité. (shrink)

Title on added t.p.: Saint-Simon & son uvre.

I was brought up to believe that, in the “great debate” with the Rationalists, the Empiricists had largely won, particularly in view of Quine's holistic conception of justification, whereby even the claims of logic, though remote from experience, are indirectly tested by it. But some years ago I awoke to the possibility that there was something fishy in all this, and that the fallibilistic banalities that have played such a large role in driving the Quinean conception couldn't plausibly have such (...) dramatic consequences. “Everything can be revised in the light of experience” is good advice for someone who hasn't noticed just how rich, complex and indirect our reasonings about any issue, including logic and mathematics, can be; but does it really tell against what Kant and the others had in mind when they believed that there were some claimswhose justification needn't appeal to experience(which, it's crucial to remember, is how he and others thought of it, until the Positivists and Quine revised it to “unrevisability“)? (shrink)

Innovation has become a buzzword that promises dramatic changes in almost every field of business. Absent from this attention is a serious discussion of the ethical sides of dramatic change. To address this, editors Georges Enderle and Patrick E. Murphy gather a team of experts to fully examine the ethics of innovation within business and the economy in this standout addition to the Studies in TransAtlantic Business Ethics series. The book opens with an exploration and clarification of several key (...) concepts necessary for a thorough study of innovation such as business ethics, moral innovation, creativity, and wealth creation. The opening chapters also propose a novel theoretical foundation and methodological approach with which to address ethical innovation. Subsequently, the contributors discuss challenges and opportunities of innovation for individuals, organizations, and systems while zoning in on a wide range of specific examples, including but not limited to: managerial responsibilities, morality and imagination of leaders, as well as the ethics of the Maker Movement. This comprehensive book evaluates organizational innovations from diverse parts of the world including Egypt, India, Latin America, the UK, and the US. Ethical Innovation in Business and the Economy concludes with a presentation of methods for improving economic systems, such as tracing Adam Smith in emerging enterprises, developing a justice model of marketing to the poor, and bridging the formal and informal economies in an African context. This in-depth examination of innovation, and its involvement in the business and economic world, is an invaluable reference tool for students, teachers, and researchers in business and economic ethics, as well as executives in business and other organizations who search for new and more responsible ways to address globalization, sustainability, and financialization. (shrink)

David Hume's _Treatise on Human Nature_ and _Enquiry Concerning Human Understanding_ are amongst the most widely-studies texts on philosophy. _Hume's Epistemology and Metaphysics: An Introduction_ presents in a clear, concise and accessible manner the key themes of these texts. Georges Dicker clarifies Hume's views on meaning, knowledge, causality, and sense perception step by step and provides us with a sharp picture of how philosophical thinking has been influenced by Hume. Accessible to anyone coming to Hume for the first time, (...) _Hume's Epistemology and Metaphysics_ is an indispensible guide to Hume's philosophical thinking. (shrink)

t. 1. Présentation de l'univers politique. v. 1. Société, politique et droit. --t. 3. La dynamique politique. v. 1. Les forces politiques. v. 2. La dialectique de l'ordre et du mouvement.--t. 4. Le statut du pouvoir dans l'Etat.--t. 5. Les régimes politiques.--t. 6. L'Etat libéral et les techniques politiques de la démocratie gouvernée. --t. 10. La révolte des colonisés.

"Après des années de voyages en divers continents, j'ai éprouvé le besoin d'un "voyage intérieur". On suivra ici les étapes de ce cheminement, jalonnées par les fragments d'une autobiographie que je n'écrirai jamais. On trouvera aussi, communiquées par un homme qui croit connaître ses faiblesses, ses échecs, et ne les cachera pas, quelques réponses appelées par de grandes questions qu'il a tenté de vivre".

1. La philosophie et les mythes.--2. Les fondements de la psychologie.

Source et limites de l'unité dans la mathématique, par Georges Bouligand. Bibliographie (p. 16)--La crise de l'unité dans la physique contemporaine, par Jean Abelé.--A la recherche de l'unité de la matière; point de vue du chimiste, par Jean Moretti.--Le problème de l'unité de la vie. Polygénisme ou monogénisme; le problème de l'unité de l'espèc humaine, par J. Carles.

This paper examines the work of Nāgārjuna as interpreted by later Madhyamaka tradition, including the Tibetan Buddhist Tsongkhapa (1357–1419). It situates Madhyamaka skepticism in the context of Buddhist philosophy, Indian philosophy more generally, and Western equivalents. Find it broadly akin to Pyrrhonism, it argues that Madhyamaka skepticism still differs from its Greek equivalents in fundamental methodologies. Focusing on key hermeneutical principles like the two truths and those motivating the Svātantrika/Prāsaṅgika schism (i.e., whether followers of Nāgārjuna should offer positive arguments or (...) should proceed on a purely “negative” basis), it argues that the Svātantrika commitment to mere conventional practice is robust and allows for a skepticism consistent with the scientific practices we must take seriously in the modern world. These findings are put forth as an illustration of what the Western tradition might gain by better understanding of non-Western philosophy. (shrink)

This paper is a personal dialogue of maneuvering the landscape of scholarship in the United States as a nurse faculty. The principal thesis of this paper is that a discursive shift from margins to mainstream literature has occurred within nursing discourse during the past 20 years as the result of a growing body of work by nurse philosophers. I utilize my own work in nursing philosophy as an exemplar and provide a narrative situated in a feminist‐critical paradigm. This paper: (1) (...) presents a historical background through a critical‐feminist lens of the discursive shift using my own work and lived experiences as exemplars; (2) examines a contemporary mainstream ‘authoritative’ text as an exemplar of this discursive shift and (3) proposes both potential positive intersections and threats in the future development of nursing philosophy resulting from this discursive shift. (shrink)